Concentrations of unmetabolized folic acid and primary folate forms in plasma after folic acid treatment in older adults

Metabolism: Clinical and Experimental

Volumn 60, Issue 5, 2011, Pages 673-680

  Obeid, Rima ^a   Kirsch, Susanne H ^a   Kasoha, Mariz ^a   Eckert, Rudolf ^b   Herrmann, Wolfgang ^a  

^a SAARLAND UNIVERSITY   (Germany)

^b Geriatric Centre   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

5 METHYLTETRAHYDROFOLIC ACID; CYANOCOBALAMIN; FOLIC ACID; HOMOCYSTEINE; PLACEBO; PYRIDOXINE; S ADENOSYLMETHIONINE; TETRAHYDROFOLIC ACID;

AGED; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG METABOLISM; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TREATMENT RESPONSE; VITAMIN SUPPLEMENTATION;

AGED; AGED, 80 AND OVER; AGING; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; FEMALE; FOLIC ACID; HOMOCYSTEINE; HUMANS; MALE; S-ADENOSYLMETHIONINE; TETRAHYDROFOLATES; VITAMIN B COMPLEX;

EID: 79955004113     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.metabol.2010.06.020     Document Type: Article

References (39)

1. Tamura T., and Picciano M.F. Folate and human reproduction Am J Clin Nutr 83 2006 993 1016 (Pubitemid 44713098)
2. Reynolds E. Vitamin B12, folic acid, and the nervous system Lancet Neurol 5 2006 949 960 (Pubitemid 44556551)
3. Duthie S.J., and Hawdon A. DNA instability (strand breakage, uracil misincorporation, and defective repair) is increased by folic acid depletion in human lymphocytes in vitro FASEB J 12 1998 1491 1497 (Pubitemid 28506718)
4. Fioravanti M., Ferrario E., and Massaia M. Low folate levels in the cognitive decline of elderly patients and the efficacy of folate as a treatment for improving memory deficits Arch Gerontol Geriatr 26 1998 1 13 (Pubitemid 27511030)
5. Institute of Medicine Dietary reference intakes for thiamin, riboflavin, niacin, vitamin B6, folate, vitamin B12, pantothenic acid, biotin, and choline. 150-195 2000 National Academy Press Washington, DC
6. Food and Drug Administration. Food Standards Amendment of standards of identity for enriched grain products to require addition of folic acid Fed Regist 61 No. 44, 21 CFR Parts 136, 137, and 139 1996 8781 8807
7. Freire W.B., Hertrampf E., and Cortes F. Effect of folic acid fortification in Chile: preliminary results Eur J Pediatr Surg 10 Suppl 1 2000 42 43 (Pubitemid 32127560)
8. Health Canada Regulations amending the food and drug regulations (1066) Can Gaz I 131 48 1997 3702 3737
9. Bailey S.W., and Ayling J.E. The extremely slow and variable activity of dihydrofolate reductase in human liver and its implications for high folic acid intake Proc Natl Acad Sci U S A 106 2009 15424 15429
10. Ford A.H., Flicker L., and McCaul K. The B-VITAGE trial: a randomized trial of homocysteine lowering treatment of depression in later life Trials 11 2010 8
11. Obeid R., Kostopoulos P., and Knapp J.P. Biomarkers of folate and vitamin B12 are related in blood and cerebrospinal fluid Clin Chem 53 2007 326 333 (Pubitemid 46338278)
12. Houghton L.A., Yang J., and O'Connor D.L. Unmetabolized folic acid and total folate concentrations in breast milk are unaffected by low-dose folate supplements Am J Clin Nutr 89 2009 216 220
13. Kalmbach R.D., Choumenkovitch S.F., and Troen A.M. Circulating folic acid in plasma: relation to folic acid fortification Am J Clin Nutr 88 2008 763 768
14. Smith A.D., Kim Y.I., and Refsum H. Is folic acid good for everyone? Am J Clin Nutr 87 2008 517 533 (Pubitemid 351364531)
15. Hirsch S., Sanchez H., and Albala C. Colon cancer in Chile before and after the start of the flour fortification program with folic acid Eur J Gastroenterol Hepatol 21 2009 436 439
16. Mason J.B., Dickstein A., and Jacques P.F. A temporal association between folic acid fortification and an increase in colorectal cancer rates may be illuminating important biological principles: a hypothesis Cancer Epidemiol Biomarkers Prev 16 2007 1325 1329 (Pubitemid 47076861)
17. Saposnik G., Ray J.G., and Sheridan P. Homocysteine-lowering therapy and stroke risk, severity, and disability: additional findings from the HOPE 2 trial Stroke 40 2009 1365 1372
18. Grosse S.D., and Collins J.S. Folic acid supplementation and neural tube defect recurrence prevention Birth Defects Res A Clin Mol Teratol 79 2007 737 742 (Pubitemid 350271820)
19. Durga J., van Boxtel M.P., and Schouten E.G. Effect of 3-year folic acid supplementation on cognitive function in older adults in the FACIT trial: a randomised, double blind, controlled trial Lancet 369 2007 208 216 (Pubitemid 46107683)
20. Ebbing M., Bonaa K.H., and Nygard O. Cancer incidence and mortality after treatment with folic acid and vitamin B12 JAMA 302 2009 2119 2126
21. Bonaa K.H., Njolstad I., and Ueland P.M. Homocysteine lowering and cardiovascular events after acute myocardial infarction N Engl J Med 354 2006 1578 1588
22. Lonn E., Yusuf S., and Arnold M.J. Homocysteine lowering with folic acid and B vitamins in vascular disease N Engl J Med 354 2006 1567 1577
23. Stabler S.P., Marcell P.D., and Podell E.R. Elevation of total homocysteine in the serum of patients with cobalamin or folate deficiency detected by capillary gas chromatography-mass spectrometry J Clin Invest 81 1988 466 474 (Pubitemid 18075242)
24. Kirsch S.H., Knapp J.P., and Geisel J. Simultaneous quantification of S-adenosyl methionine and S-adenosyl homocysteine in human plasma by stable-isotope dilution ultra performance liquid chromatography tandem mass spectrometry J Chromatogr B Analyt Technol Biomed Life Sci 877 2009 3865 3870
25. Orning L., Rian A., and Campbell A. Characterization of a monoclonal antibody with specificity for holo-transcobalamin Nutr Metab (Lond) 3 2006 3
26. Holm P.I., Ueland P.M., and Kvalheim G. Determination of choline, betaine, and dimethylglycine in plasma by a high-throughput method based on normal-phase chromatography-tandem mass spectrometry Clin Chem 49 2003 286 294 (Pubitemid 36143452)
27. Kirsch S.H., Knapp J.P., and Herrmann W. Quantification of key folate forms in serum using stable-isotope dilution ultra performance liquid chromatography-tandem mass spectrometry J Chromatogr B Analyt Technol Biomed Life Sci 878 2010 68 75
28. Duthie S.J., Horgan G., and De R.B. Blood folate status and expression of proteins involved in immune function, inflammation and coagulation: biochemical and proteomic changes in the plasma of humans in response to long-term synthetic folic acid supplementation J Proteome Res 9 2010 1941 1950
29. Zhang S.M., Cook N.R., and Albert C.M. Effect of combined folic acid, vitamin B6, and vitamin B12 on cancer risk in women: a randomized trial JAMA 300 2008 2012 2021
30. Buccianti G., Raselli S., and Baragetti I. 5-Methyltetrahydrofolate restores endothelial function in uraemic patients on convective haemodialysis Nephrol Dial Transplant 17 2002 857 864 (Pubitemid 34521138)
31. Loehrer F.M., Angst C.P., and Haefeli W.E. Low whole-blood S-adenosylmethionine and correlation between 5-methyltetrahydrofolate and homocysteine in coronary artery disease Arterioscler Thromb Vasc Biol 16 1996 727 733
32. Nguyen P., Tam C., and O'Connor D.L. Steady state folate concentrations achieved with 5 compared with 1.1 mg folic acid supplementation among women of childbearing age Am J Clin Nutr 89 2009 844 852
33. Kalmbach R.D., Choumenkovitch S.F., and Troen A.P. A 19-base pair deletion polymorphism in dihydrofolate reductase is associated with increased unmetabolized folic acid in plasma and decreased red blood cell folate J Nutr 138 2008 2323 2327
34. Melse-Boonstra A., Holm P.I., and Ueland P.M. Betaine concentration as a determinant of fasting total homocysteine concentrations and the effect of folic acid supplementation on betaine concentrations Am J Clin Nutr 81 2005 1378 1382 (Pubitemid 41710241)
35. Troen A.M., Mitchell B., and Sorensen B. Unmetabolized folic acid in plasma is associated with reduced natural killer cell cytotoxicity among postmenopausal women J Nutr 136 2006 189 194 (Pubitemid 43156507)
36. Kelly P., McPartlin J., and Goggins M. Unmetabolized folic acid in serum: acute studies in subjects consuming fortified food and supplements Am J Clin Nutr 65 1997 1790 1795 (Pubitemid 27240695)
37. Wright A.J., Dainty J.R., and Finglas P.M. Folic acid metabolism in human subjects revisited: potential implications for proposed mandatory folic acid fortification in the UK Br J Nutr 98 2007 667 675 (Pubitemid 47487933)
38. Achon M., Reyes L., and onso-Aperte E. High dietary folate supplementation affects gestational development and dietary protein utilization in rats J Nutr 129 1999 1204 1208 (Pubitemid 29250172)
39. Lindzon G.M., Medline A., and Sohn K.J. Effect of folic acid supplementation on the progression of colorectal aberrant crypt foci Carcinogenesis 30 2009 1536 1543