Regulation of de novo purine biosynthesis by methenyltetrahydrofolate synthetase in neuroblastoma

Journal of Biological Chemistry

Volumn 281, Issue 7, 2006, Pages 4215-4221

  Field, Martha S ^a   Szebenyi, Doletha M E ^a   Stover, Patrick J ^a  

^a Department of Obstetrics Gynecology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; CELLS; CONCENTRATION (PROCESS); ENZYME KINETICS; METABOLISM; REACTION KINETICS;

DE NOVO PURINE; ENZYME COFACTOR; ISOTOPE TRACER; METHENYLTETRAHYDROFOLATE SYNTHETASE;

ENZYMES;

10 FORMYLTETRAHYDROFOLIC ACID; 5,10 METHENYLTETRAHYDROFOLATE; ADENOSINE TRIPHOSPHATE; FOLIC ACID DERIVATIVE; FOLINIC ACID; METHENYLTETRAHYDROFOLATE SYTHETASE; SYNTHETASE; UNCLASSIFIED DRUG; 5 FORMYLTETRAHYDROFOLATE CYCLOLIGASE; 5,10-METHENYLTETRAHYDROFOLATE SYNTHETASE; LIGASE; PURINE; PURINE DERIVATIVE;

ARTICLE; BINDING KINETICS; CONTROLLED STUDY; ENZYME BINDING; ENZYME INHIBITION; ENZYME KINETICS; FEEDBACK SYSTEM; HUMAN; HUMAN CELL; IN VITRO STUDY; NEUROBLASTOMA; NEUROBLASTOMA CELL; PRIORITY JOURNAL; PROTEIN BINDING; PURINE SYNTHESIS; STEADY STATE; BINDING SITE; BIOSYNTHESIS; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; ENZYME SPECIFICITY; ENZYMOLOGY; MOUSE; PHYSIOLOGY; TUMOR CELL LINE;

MAMMALIA;

BINDING SITES; CARBON-NITROGEN LIGASES; CELL LINE, TUMOR; HUMANS; MICE; MODELS, MOLECULAR; NEUROBLASTOMA; PURINES; SUBSTRATE SPECIFICITY;

EID: 33645213880     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M510624200     Document Type: Article

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