Ligustilide ameliorates neuroinflammation and brain injury in focal cerebral ischemia/reperfusion rats: Involvement of inhibition of TLR4/peroxiredoxin 6 signaling

Free Radical Biology and Medicine

Volumn 71, Issue , 2014, Pages 165-175

  Kuang, Xi ^a   Wang, Liang Fen ^a   Yu, Lu ^a   Li, Yong Jie ^a   Wang, Yan Nan ^a   He, Qian ^a   Chen, Chu ^a   Du, Jun Rong ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

Free radicals; Immunomodulation; Ischemic stroke; Ligustilide; Neuroinflammation; NF B; Peroxiredoxin 6; STAT3; TLR4 signaling

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIGUSTILIDE; MITOGEN ACTIVATED PROTEIN KINASE 1; MYELOPEROXIDASE; PEROXIREDOXIN 6; STAT3 PROTEIN; TOLL LIKE RECEPTOR 4; GAMMA BUTYROLACTONE; MITOGEN ACTIVATED PROTEIN KINASE 3; NONSTEROID ANTIINFLAMMATORY AGENT; PRDX6 PROTEIN, RAT; STAT3 PROTEIN, RAT; TLR4 PROTEIN, RAT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTROCYTE; BRAIN INFARCTION SIZE; BRAIN INJURY; BRAIN ISCHEMIA; CELL INVASION; CONTROLLED STUDY; DISEASE SEVERITY; ENZYME PHOSPHORYLATION; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MACROPHAGE ACTIVATION; MALE; MICROGLIA; MIDDLE CEREBRAL ARTERY OCCLUSION; MOTOR DYSFUNCTION; NERVOUS SYSTEM INFLAMMATION; NEUROPROTECTION; NEUTROPHIL; NONHUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RAT; REAL TIME POLYMERASE CHAIN REACTION; REPERFUSION INJURY; SIGNAL TRANSDUCTION; T LYMPHOCYTE; WESTERN BLOTTING; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL MOTION; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; INFLAMMATION; INTRAPERITONEAL DRUG ADMINISTRATION; METABOLISM; NERVE CELL; OXIDATIVE STRESS; PATHOLOGY; SPRAGUE DAWLEY RAT;

4-BUTYROLACTONE; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ASTROCYTES; BRAIN ISCHEMIA; CELL MOVEMENT; GENE EXPRESSION REGULATION; INFLAMMATION; INJECTIONS, INTRAPERITONEAL; MACROPHAGE ACTIVATION; MALE; MICROGLIA; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; NEURONS; NF-KAPPA B; OXIDATIVE STRESS; PEROXIREDOXIN VI; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; T-LYMPHOCYTES; TOLL-LIKE RECEPTOR 4;

EID: 84907990013     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2014.03.028     Document Type: Article

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