Neuroprotective effects of madecassoside against focal cerebral ischemia reperfusion injury in rats

Brain Research

Volumn 1565, Issue , 2014, Pages 37-47

  Luo, Yuan ^a   Yang, Yi Ping ^a   Liu, Jie ^b   Li, Wan Hua ^a   Yang, Jun ^a   Sui, Xin ^a   Yuan, Xin ^a   Nie, Zhi Yong ^a   Liu, Yan Qin ^a   Chen, Ding ^c   Lin, Shao Hui ^c   Wang, Yong An ^a  

^a BEIJING INSTITUTE OF MICROBIOLOGY AND EPIDEMIOLOGY   (China)

^b CHINESE PLA GENERAL HOSPITAL   (China)

^c Beijing SL Pharmaceutical Co Ltd   (China)

Author keywords

Apoptosis; Cerebral ischemia reperfusion; Inflammatory; Madecassoside; NF B pathway; Oxidative stress

Indexed keywords

CYCLOPHOSPHAMIDE; DNA NUCLEOTIDYLEXOTRANSFERASE; GLUTATHIONE; INTERLEUKIN 1BETA; INTERLEUKIN 6; MADECASSOSIDE; MALONALDEHYDE; NEUROPROTECTIVE AGENT; NIMODIPINE; NITRIC OXIDE; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR RELA; TRITERPENOID; UNCLASSIFIED DRUG; TRITERPENE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; BRAIN CORTEX; BRAIN DAMAGE; BRAIN INFARCTION; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; BRAIN TISSUE; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; LIPID PEROXIDATION; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NERVE CELL; NEUROLOGIC DISEASE; NEUROPROTECTION; NICK END LABELING; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REPERFUSION; REPERFUSION INJURY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; ANIMAL; DRUG EFFECTS; METABOLISM; PATHOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; APOPTOSIS; BRAIN ISCHEMIA; CEREBRAL CORTEX; MALE; NEURONS; NEUROPROTECTIVE AGENTS; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; TRITERPENES;

EID: 84900309235     PISSN: 00068993     EISSN: 18726240     Source Type: Journal    
DOI: 10.1016/j.brainres.2014.04.008     Document Type: Article

References (55)

1. Y.T. An, Z. Zhao, Y.C. Sheng, Y. Min, and Y.Y. Xia Therapeutic time window of YGY-E neuroprotection of cerebral ischemic injury in rats Drug Discov. Ther. 5 2011 76 83
2. S. Babykutty, J. Padikkala, P.P. Sathiadevan, V. Vijayakurup, T.K. Azis, P. Srinivas, and S. Gopala Apoptosis induction of Centella asiatica on human breast cancer cells Afr. J. Tradit. Complement Altern. Med. 6 2008 9 16
3. D. Bian, M. Liu, Y. Li, Y. Xia, Z. Gong, and Y. Dai Madecassoside, a triterpenoid saponin isolated from Centella asiatica herbs, protects endothelial cells against oxidative stress J. Biochem. Mol. Toxicol. 26 2012 399 406
4. D. Bian, J. Zhang, X. Wu, Y. Dou, Y. Yang, Q. Tan, Y. Xia, Z. Gong, and Y. Dai Asiatic acid isolated from Centella asiatica inhibits TGF-beta1-induced collagen expression in human keloid fibroblasts via PPAR-gamma activation Int. J. Biol. Sci. 9 2013 1032 1042
5. G.X. Bian, G.G. Li, Y. Yang, R.T. Liu, J.P. Ren, L.Q. Wen, S.M. Guo, and Q.J. Lu Madecassoside reduces ischemia-reperfusion injury on regional ischemia induced heart infarction in rat Biol. Pharm. Bull. 31 2008 458 463
6. R.P. Bowler, H. Sheng, J.J. Enghild, R.D. Pearlstein, D.S. Warner, and J.D. Crapo A catalytic antioxidant (AEOL 10150) attenuates expression of inflammatory genes in stroke Free Radic. Biol. Med. 33 2002 1141 1152
7. X.M. Chen, H.S. Chen, M.J. Xu, and J.G. Shen Targeting reactive nitrogen species: a promising therapeutic strategy for cerebral ischemia-reperfusion injury Acta Pharmacol. Sin. 34 2013 67 77
8. Y. Chen, T. Han, Y. Rui, M. Yin, L. Qin, and H. Zheng Effects of total triterpenes of Centella asiatica on the corticosterone levels in serum and contents of monoamine in depression rat brain Zhong Yao Cai 28 2005 492 496
9. J.A. Clemens, D.T. Stephenson, E.B. Smalstig, E.P. Dixon, and S.P. Little Global ischemia activates nuclear factor-kappa B in forebrain neurons of rats Stroke 28 1997 1073 1080 (discussion 1080-1081)
10. M. Dhanasekaran, L.A. Holcomb, A.R. Hitt, B. Tharakan, J.W. Porter, K.A. Young, and B.V. Manyam Centella asiatica extract selectively decreases amyloid beta levels in hippocampus of Alzheimers disease animal model Phytother. Res. 23 2009 14 19
11. K.P. Doyle, R.P. Simon, and M.P. Stenzel-Poore Mechanisms of ischemic brain damage Neuropharmacology 55 2008 310 318
12. A.T. Ermertcan, S. Inan, S. Ozturkcan, C. Bilac, and S. Cilaker Comparison of the effects of collagenase and extract of Centella asiatica in an experimental model of wound healing: an immunohistochemical and histopathological study Wound Repair Regen. 16 2008 674 681
13. C. Gabriel, C. Justicia, A. Camins, and A.M. Planas Activation of nuclear factor-kappa B in the rat brain after transient focal ischemia Brain Res. Mol. Brain Res. 65 1999 61 69
14. K.A. Gauss, L.K. Nelson-Overton, D.W. Siemsen, Y. Gao, F.R. DeLeo, and M.T. Quinn Role of NF-kappaB in transcriptional regulation of the phagocyte NADPH oxidase by tumor necrosis factor-alpha J. Leukoc. Biol. 82 2007 729 741
15. R. Gill, A. Tsung, and T. Billiar Linking oxidative stress to inflammation: toll-like receptors Free Radic. Biol Med. 48 2010 1121 1132
16. L.C. Green, D.A. Wagner, J. Glogowski, P.L. Skipper, J.S. Wishnok, and S.R. Tannenbaum Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids Anal. Biochem. 126 1982 131 138
17. P. Hashim, H. Sidek, M.H. Helan, A. Sabery, U.D. Palanisamy, and M. Ilham Triterpene composition and bioactivities of Centella asiatica Molecules 16 2011 1310 1322
18. F. Hussin, S.A. Eshkoor, A. Rahmat, F. Othman, and A. Akim The Centella asiatica juice effects on DNA damage, apoptosis and gene expression in hepatocellular carcinoma (HCC) BMC Complement Altern. Med. 2014 10.1186/1472-6882-14-32
19. U. Jana, T.K. Sur, L.N. Maity, P.K. Debnath, and D. Bhattacharyya A clinical study on the management of generalized anxiety disorder with Centella asiatica Nepal Med. College J. 12 2010 8 11
20. M.G. Kim, J.H. Choi, J.P. Lim, D.K. Kim, T.Y. Shin, Y. Boo, S.Y. Kim, H. Kim, E. Ha, H.K. Park, J. Kim, H.S. Lim, E.H. Kim, J.B. Kim, and K.H. Leem Protective effects of a novel herbal decoction on focal cerebral ischemia in a rodent model Neurol. Res. 29 Suppl. 1 2007 S16 22
21. H. Kitazawa, T. Numakawa, N. Adachi, E. Kumamaru, T. Tuerxun, M. Kudo, and H. Kunugi Cyclophosphamide promotes cell survival via activation of intracellular signaling in cultured cortical neurons Neurosci. Lett. 470 2010 139 144
22. A. Kumar, S. Dogra, and A. Prakash Neuroprotective effects of Centella asiatica against intracerebroventricular colchicine-induced cognitive impairment and oxidative stress Int. J. Alzheimers Dis. 2009 2009 10.4061/2009/972178
23. G.P. Kumar, and F. Khanum Neuroprotective potential of phytochemicals Pharmacogn. Rev. 6 2012 81 90
24. H. Li, X. Gong, L. Zhang, Z. Zhang, F. Luo, Q. Zhou, J. Chen, and J. Wan Madecassoside attenuates inflammatory response on collagen-induced arthritis in DBA/1 mice Phytomedicine 16 2009 538 546
25. M. Liu, Y. Dai, Y. Li, Y. Luo, F. Huang, Z. Gong, and Q. Meng Madecassoside isolated from Centella asiatica herbs facilitates burn wound healing in mice Planta Med. 74 2008 809 815
26. M. Liu, Y. Dai, X. Yao, Y. Li, Y. Luo, Y. Xia, and Z. Gong Anti-rheumatoid arthritic effect of madecassoside on type II collagen-induced arthritis in mice Int. Immunopharmacol. 8 2008 1561 1566
27. E.H. Lo, T. Dalkara, and M.A. Moskowitz Neurological diseases: mechanisms, challenges and opportunities in stroke Nat. Rev. Neurosci. 4 2003 399 414
28. K.P. Loh, J. Qi, B.K. Tan, X.H. Liu, B.G. Wei, and Y.Z. Zhu Leonurine protects middle cerebral artery occluded rats through antioxidant effect and regulation of mitochondrial function Stroke 41 2010 2661 2668
29. E.Z. Longa, P.R. Weinstein, S. Carlson, and R. Cummins Reversible middle cerebral artery occlusion without craniectomy in rats Stroke 20 1989 84 91
30. M.P. Mattson, and M.K. Meffert Roles for NF-kappaB in nerve cell survival, plasticity, and disease Cell Death Differ. 13 2006 852 860
31. H. Meena, H.K. Pandey, P. Pandey, M.C. Arya, and Z. Ahmed Evaluation of antioxidant activity of two important memory enhancing medicinal plants Baccopa monnieri and Centella asiatica Indian J. Pharmacol. 44 2012 114 117
32. T. Nishi, C.M. Maier, T. Hayashi, A. Saito, and P.H. Chan Superoxide dismutase 1 overexpression reduces MCP-1 and MIP-1 alpha expression after transient focal cerebral ischemia J. Cereb. Blood Flow Metab. 25 2005 1312 1324
33. A. Nurmi, P.J. Lindsberg, M. Koistinaho, W. Zhang, E. Juettler, M.L. Karjalainen-Lindsberg, F. Weih, N. Frank, M. Schwaninger, and J. Koistinaho Nuclear factor-kappaB contributes to infarction after permanent focal ischemia Stroke 35 2004 987 991
34. H. Ohkawa, N. Ohishi, and K. Yagi Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction Anal. Biochem. 95 1979 351 358
35. J.M. Roda, F. Carceller, E. Diez-Tejedor, and C. Avendano Reduction of infarct size by intra-arterial nimodipine administered at reperfusion in a rat model of partially reversible brain focal ischemia Stroke 26 1995 1888 1892
36. Y. Shou, N. Li, L. Li, J.L. Borowitz, and G.E. Isom NF-kappaB-mediated up-regulation of Bcl-X(S) and Bax contributes to cytochrome c release in cyanide-induced apoptosis J. Neurochem. 81 2002 842 852
37. M. Sobrado, M.G. Lopez, F. Carceller, A.G. Garcia, and J.M. Roda Combined nimodipine and citicoline reduce infarct size, attenuate apoptosis and increase bcl-2 expression after focal cerebral ischemia Neuroscience 118 2003 107 113
38. J. Somboonwong, M. Kankaisre, B. Tantisira, and M.H. Tantisira Wound healing activities of different extracts of Centella asiatica in incision and burn wound models: an experimental animal study BMC Complement Altern. Med. 2012 10.1186/1472-6882-12-103
39. A. Soumyanath, Y.P. Zhong, E. Henson, T. Wadsworth, J. Bishop, B.G. Gold, and J.F. Quinn Centella asiatica extract improves behavioral deficits in a mouse model of Alzheimers disease: investigation of a possible mechanism of action Int. J. Alzheimers Dis. 2012 10.1155/2012/381974
40. Y. Sun, L.W. Oberley, and Y. Li A simple method for clinical assay of superoxide dismutase Clin. Chem. 34 1988 497 500
41. R. Tabassum, K. Vaibhav, P. Shrivastava, A. Khan, M. Ejaz Ahmed, H. Javed, F. Islam, S. Ahmad, M. Saeed Siddiqui, M.M. Safhi, and F. Islam Centella asiatica attenuates the neurobehavioral, neurochemical and histological changes in transient focal middle cerebral artery occlusion rats Neurol. Sci. 34 2013 925 933
42. P.P. Tak, and G.S. Firestein NF-kappaB: a key role in inflammatory diseases J. Clin. Invest. 107 2001 7 11
43. A. Tuttolomondo, R. Di Sciacca, D. Di Raimondo, C. Renda, A. Pinto, and G. Licata Inflammation as a therapeutic target in acute ischemic stroke treatment Curr. Top. Med. Chem. 9 2009 1240 1260
44. G. Visweswari, K.S. Prasad, P.S. Chetan, V. Lokanatha, and W. Rajendra Evaluation of the anticonvulsant effect of Centella asiatica (gotu kola) in pentylenetetrazol-induced seizures with respect to cholinergic neurotransmission Epilepsy Behav. 17 2010 332 335
45. A. Wanasuntronwong, M.H. Tantisira, B. Tantisira, and H. Watanabe Anxiolytic effects of standardized extract of Centella asiatica (ECa 233) after chronic immobilization stress in mice J. Ethnopharmacol. 143 2012 579 585
46. W.-W. Wang, S.-Q. Hu, C. Li, C. Zhou, S.-H. Qi, and G.-Y. Zhang Transduced PDZ1 domain of PSD-95 decreases Src phosphorylation and increases nNOS (Ser847) phosphorylation contributing to neuroprotection after cerebral ischemia Brain Res. 1328 2010 162 170
47. P. Wijeweera, J.T. Arnason, D. Koszycki, and Z. Merali Evaluation of anxiolytic properties of Gotukola - (Centella asiatica) extracts and asiaticoside in rat behavioral models Phytomedicine 13 2006 668 676
48. J.H. Won, J.S. Shin, H.J. Park, H.J. Jung, D.J. Koh, B.G. Jo, J.Y. Lee, K. Yun, and K.T. Lee Anti-inflammatory effects of madecassic acid via the suppression of NF-kappaB pathway in LPS-induced RAW 264.7 macrophage cells Planta Med. 76 2010 251 257
49. C.H. Wong, and P.J. Crack Modulation of neuro-inflammation and vascular response by oxidative stress following cerebral ischemia-reperfusion injury Curr. Med. Chem. 15 2008 1 14
50. F. Wu, D. Bian, Y. Xia, Z. Gong, Q. Tan, J. Chen, and Y. Dai Identification of major active ingredients responsible for burn wound healing of Centella asiatica herbs Evid. Based Complement Alternat. Med. 2012 2012 84893 10.1155/2012/848093
51. P.F. Wu, Z. Zhang, F. Wang, and J.G. Chen Natural compounds from traditional medicinal herbs in the treatment of cerebral ischemia/reperfusion injury Acta Pharmacol. Sin. 31 2010 1523 1531
52. C.L. Xu, R. Qu, J. Zhang, L.F. Li, and S.P. Ma Neuroprotective effects of madecassoside in early stage of Parkinsons disease induced by MPTP in rats Fitoterapia 90 2013 112 118
53. M.F. Xu, Y.Y. Xiong, J.K. Liu, J.J. Qian, L. Zhu, and J. Gao Asiatic acid, a pentacyclic triterpene in Centella asiatica, attenuates glutamate-induced cognitive deficits in mice and apoptosis in SH-SY5Y cells Acta Pharmacol. Sin. 33 2012 578 587
54. H. Zhu, X.M. Ji, S.T. Li, and Y.M. Luo Neuroprotective effects of the combination of nimodipine and cyclophosphamide on focal cerebral ischemia/reperfusion injury in rats Chin. J. Cerebrovasc. Dis. 5 2008 456 460
55. Y. Zhu, P.M. Carvey, and Z. Ling Age-related changes in glutathione and glutathione-related enzymes in rat brain Brain Res. 1090 2006 35 44