Dioscin, a natural steroid saponin, shows remarkable protective effect against acetaminophen-induced liver damage in vitro and in vivo

Toxicology Letters

Volumn 214, Issue 1, 2012, Pages 69-80

  Zhao, Xiaoming ^a   Cong, Xiaonan ^a   Zheng, Lingli ^a   Xu, Lina ^a   Yin, Lianhong ^a   Peng, Jinyong ^a  

^a DALIAN MEDICAL UNIVERSITY   (China)

Author keywords

Acetaminophen; Dioscin; Hepatotoxicity; Liver damage; Mitochondrial

Indexed keywords

ADENOSINE TRIPHOSPHATASE (CALCIUM); CALCIUM ION; CARDIOLIPIN; CYTOCHROME P450 2E1; CYTOKERATIN 18; DIOSCIN; LIVER PROTECTIVE AGENT; MALATE DEHYDROGENASE; PARACETAMOL; PEROXIREDOXIN 1; PROTEIN BAK; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BID; PROTEIN P53; PURINE NUCLEOSIDE PHOSPHORYLASE; REGUCALCIN; SAPONIN DERIVATIVE; SULFITE OXIDASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DEATH; CELL STRAIN HEPG2; CONTROLLED STUDY; DRUG MECHANISM; DRUG STRUCTURE; HUMAN; HUMAN CELL; LIVER INJURY; LIVER MITOCHONDRION; LIVER PROTECTION; LIVER TOXICITY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TREATMENT OUTCOME;

ACETAMINOPHEN; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BCL-2 HOMOLOGOUS ANTAGONIST-KILLER PROTEIN; BCL-2-ASSOCIATED X PROTEIN; BIOLOGICAL AGENTS; COMET ASSAY; DIOSGENIN; DRUG-INDUCED LIVER INJURY; GENE EXPRESSION REGULATION; HEP G2 CELLS; HEPATOCYTES; HUMANS; MALE; MICE; MITOCHONDRIA; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

MUS;

EID: 84865589387     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2012.08.005     Document Type: Article

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