메뉴 건너뛰기




Volumn 10, Issue 5, 2015, Pages 541-556

Designing drugs that combat kidney damage

Author keywords

Clinical trials; Drug discovery; Kidney damage; Nanomedicine; Nephrology

Indexed keywords

ANTIPROTEINURIC AGENT; CCX140; ENDOTHELIN RECEPTOR ANTAGONIST; ERYTHROPOIETIN; IMMUNOSUPPRESSIVE AGENT; IRON CHELATING AGENT; PROTEIN INHIBITOR; QPI 1002; UNCLASSIFIED DRUG;

EID: 84928350591     PISSN: 17460441     EISSN: 1746045X     Source Type: Journal    
DOI: 10.1517/17460441.2015.1033394     Document Type: Review
Times cited : (25)

References (164)
  • 1
    • 84920703518 scopus 로고    scopus 로고
    • Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: A systematic analysis for the Global Burden of Disease Study 2013
    • GBD 2013 Mortality and Causes of Death Collaborators. Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet 2015;385(9963):117-71
    • (2015) Lancet , vol.385 , Issue.9963 , pp. 117-171
  • 2
    • 84865389203 scopus 로고    scopus 로고
    • Acute kidney injury
    • Bellomo R, Kellum JA, Ronco C. Acute kidney injury. Lancet 2012;380(9843):756-66
    • (2012) Lancet , vol.380 , Issue.9843 , pp. 756-766
    • Bellomo, R.1    Kellum, J.A.2    Ronco, C.3
  • 3
    • 84867270998 scopus 로고
    • Peritoneal dialysis for acute renal failure
    • Fine J, Seligman A, Frank HA. Peritoneal dialysis for acute renal failure. NY Med 1949;5(10):16-20
    • (1949) NY Med , vol.5 , Issue.10 , pp. 16-20
    • Fine, J.1    Seligman, A.2    Frank, H.A.3
  • 6
    • 84928326763 scopus 로고    scopus 로고
    • Translational Nephrology: What translational research is and a bird's-eye view on translational research in Nephrology
    • Ortiz A. Translational Nephrology: what translational research is and a bird's-eye view on translational research in Nephrology. Clin Kidney J 2015;8(1):14-22
    • (2015) Clin Kidney J , vol.8 , Issue.1 , pp. 14-22
    • Ortiz, A.1
  • 7
    • 0942287104 scopus 로고    scopus 로고
    • The number, quality, and coverage of randomized controlled trials in nephrology
    • Strippoli GF, Craig JC, Schena FP. The number, quality, and coverage of randomized controlled trials in nephrology. J Am Soc Nephrol 2004;15(2):411-19
    • (2004) J Am Soc Nephrol , vol.15 , Issue.2 , pp. 411-419
    • Strippoli, G.F.1    Craig, J.C.2    Schena, F.P.3
  • 8
    • 84874644599 scopus 로고    scopus 로고
    • KDIGO 2012 clinical practice guideline for the evaluation and management of chronic kidney disease
    • KDIGO CKD Work Group. KDIGO 2012 clinical practice guideline for the evaluation and management of chronic kidney disease. Kidney Int Suppl 2013;3:1-150
    • (2013) Kidney Int Suppl , vol.3 , pp. 1-150
  • 9
    • 84901228028 scopus 로고    scopus 로고
    • Epidemiology, contributors to, and clinical trials of mortality risk in chronic kidney failure
    • Ortiz A, Covic A, Fliser D, et al. Epidemiology, contributors to, and clinical trials of mortality risk in chronic kidney failure. Lancet 2014;383(9931):1831-43
    • (2014) Lancet , vol.383 , Issue.9931 , pp. 1831-1843
    • Ortiz, A.1    Covic, A.2    Fliser, D.3
  • 10
    • 84879334306 scopus 로고    scopus 로고
    • Progress in the development of animal models of acute kidney injury and its impact on drug discovery
    • Sanz AB, Sanchez-Niño MD, Martín-Cleary C, et al. Progress in the development of animal models of acute kidney injury and its impact on drug discovery. Expert Opin Drug Discov 2013;8(7):879-95
    • (2013) Expert Opin Drug Discov , vol.8 , Issue.7 , pp. 879-895
    • Sanz, A.B.1    Sanchez-Niño, M.D.2    Martín-Cleary, C.3
  • 11
    • 77649223876 scopus 로고    scopus 로고
    • End-stage renal disease in patients with Fabry disease: Natural history data from the Fabry Registry
    • Ortiz A, Cianciaruso B, Cizmarik M, et al. End-stage renal disease in patients with Fabry disease: natural history data from the Fabry Registry. Nephrol Dial Transplant 2010;25(3):769-75
    • (2010) Nephrol Dial Transplant , vol.25 , Issue.3 , pp. 769-775
    • Ortiz, A.1    Cianciaruso, B.2    Cizmarik, M.3
  • 12
    • 84865194855 scopus 로고    scopus 로고
    • Implementation of proteomic biomarkers: Making it work
    • Mischak H, Ioannidis JP, Argiles A, et al. Implementation of proteomic biomarkers: making it work. Eur J Clin Invest 2012;42(9):1027-36
    • (2012) Eur J Clin Invest , vol.42 , Issue.9 , pp. 1027-1036
    • Mischak, H.1    Ioannidis, J.P.2    Argiles, A.3
  • 13
    • 84901689853 scopus 로고    scopus 로고
    • Therapeutic approaches to diabetic nephropathy beyond the RAS
    • Fernandez-Fernandez B, Ortiz A, Gomez-Guerrero C, et al. Therapeutic approaches to diabetic nephropathy beyond the RAS. Nat Rev Nephrol 2014;10(6):325-46
    • (2014) Nat Rev Nephrol , vol.10 , Issue.6 , pp. 325-346
    • Fernandez-Fernandez, B.1    Ortiz, A.2    Gomez-Guerrero, C.3
  • 14
    • 84856626648 scopus 로고    scopus 로고
    • Targeting of a platinum-bound sunitinib analog to renal proximal tubular cells
    • Dolman ME, Harmsen S, Pieters EH, et al. Targeting of a platinum-bound sunitinib analog to renal proximal tubular cells. Int J Nanomedicine 2012;7:417-33
    • (2012) Int J Nanomedicine , vol.7 , pp. 417-433
    • Dolman, M.E.1    Harmsen, S.2    Pieters, E.H.3
  • 15
    • 84867335395 scopus 로고    scopus 로고
    • Targeted inhibition of renal Rho kinase reduces macrophage infiltration and lymphangiogenesis in acute renal allograft rejection
    • Poosti F, Yazdani S, Dolman ME, et al. Targeted inhibition of renal Rho kinase reduces macrophage infiltration and lymphangiogenesis in acute renal allograft rejection. Eur J Pharmacol 2012;694(1-3):111-19
    • (2012) Eur J Pharmacol , vol.694 , Issue.1-3 , pp. 111-119
    • Poosti, F.1    Yazdani, S.2    Dolman, M.E.3
  • 16
    • 84907205505 scopus 로고    scopus 로고
    • Epac-Rap signaling reduces oxidative stress in the tubular epithelium
    • Stokman G, Qin Y, Booij TH, et al. Epac-Rap signaling reduces oxidative stress in the tubular epithelium. J Am Soc Nephrol 2014;25(7):1474-85
    • (2014) J Am Soc Nephrol , vol.25 , Issue.7 , pp. 1474-1485
    • Stokman, G.1    Qin, Y.2    Booij, T.H.3
  • 17
    • 84919627533 scopus 로고    scopus 로고
    • Local therapeutic efficacy with reduced systemic side effects by rapamycin-loaded subcapsular microspheres
    • Falke LL, van Vuuren SH, Kazazi-Hyseni F, et al. Local therapeutic efficacy with reduced systemic side effects by rapamycin-loaded subcapsular microspheres. Biomaterials 2015;42:151-60
    • (2015) Biomaterials , vol.42 , pp. 151-160
    • Falke, L.L.1    Van Vuuren, S.H.2    Kazazi-Hyseni, F.3
  • 18
    • 84859299752 scopus 로고    scopus 로고
    • Rip1 (receptor-interacting protein kinase 1) mediates necroptosis and contributes to renal ischemia/reperfusion injury
    • Linkermann A, Bräsen JH, Himmerkus N, et al. Rip1 (receptor-interacting protein kinase 1) mediates necroptosis and contributes to renal ischemia/reperfusion injury. Kidney Int 2012;81(8):751-61
    • (2012) Kidney Int , vol.81 , Issue.8 , pp. 751-761
    • Linkermann, A.1    Bräsen, J.H.2    Himmerkus, N.3
  • 19
    • 84880357849 scopus 로고    scopus 로고
    • Two independent pathways of regulated necrosis mediate ischemia-reperfusion injury
    • Linkermann A, Bräsen JH, Darding M, et al. Two independent pathways of regulated necrosis mediate ischemia-reperfusion injury. Proc Natl Acad Sci USA 2013;110(29):12024-9
    • (2013) Proc Natl Acad Sci USA , vol.110 , Issue.29 , pp. 12024-12029
    • Linkermann, A.1    Bräsen, J.H.2    Darding, M.3
  • 20
    • 84913594747 scopus 로고    scopus 로고
    • Regulated cell death in AKI
    • Linkermann A, Chen G, Dong G, et al. Regulated cell death in AKI. J Am Soc Nephrol 2014;25(12):2689-701
    • (2014) J Am Soc Nephrol , vol.25 , Issue.12 , pp. 2689-2701
    • Linkermann, A.1    Chen, G.2    Dong, G.3
  • 21
    • 54749155653 scopus 로고    scopus 로고
    • Mechanisms of renal apoptosis in health and disease
    • Sanz AB, Santamaría B, Ruiz-Ortega M, et al. Mechanisms of renal apoptosis in health and disease. J Am Soc Nephrol 2008;19(9):1634-42
    • (2008) J Am Soc Nephrol , vol.19 , Issue.9 , pp. 1634-1642
    • Sanz, A.B.1    Santamaría, B.2    Ruiz-Ortega, M.3
  • 22
    • 68949131186 scopus 로고    scopus 로고
    • A nanoconjugate Apaf-1 inhibitor protects mesothelial cells from cytokine-induced injury
    • Santamaría B, Benito-Martin A, Ucero AC, et al. A nanoconjugate Apaf-1 inhibitor protects mesothelial cells from cytokine-induced injury. PLoS One 2009;4(8):e6634
    • (2009) PLoS One , vol.4 , Issue.8 , pp. e6634
    • Santamaría, B.1    Benito-Martin, A.2    Ucero, A.C.3
  • 23
    • 84871729531 scopus 로고    scopus 로고
    • A polymeric nanomedicine diminishes inflammatory events in renal tubular cells
    • Ucero AC, Berzal S, Ocaña-Salceda C, et al. A polymeric nanomedicine diminishes inflammatory events in renal tubular cells. PLoS One 2013;8(1):e51992
    • (2013) PLoS One , vol.8 , Issue.1 , pp. e51992
    • Ucero, A.C.1    Berzal, S.2    Ocaña-Salceda, C.3
  • 24
    • 84908191401 scopus 로고    scopus 로고
    • Apaf-1 inhibitors protect from unwanted cell death in in vivo models of kidney ischemia and chemotherapy induced ototoxicity
    • Orzáez M, Sancho M, Marchán S, et al. Apaf-1 inhibitors protect from unwanted cell death in in vivo models of kidney ischemia and chemotherapy induced ototoxicity. PLoS One 2014;9(10):e110979
    • (2014) PLoS One , vol.9 , Issue.10 , pp. e110979
    • Orzáez, M.1    Sancho, M.2    Marchán, S.3
  • 25
    • 84922394053 scopus 로고    scopus 로고
    • Regulated cell death and inflammation: An auto-amplification loop causes organ failure
    • Linkermann A, Stockwell BR, Krautwald S, et al. Regulated cell death and inflammation: an auto-amplification loop causes organ failure. Nat Rev Immunol 2014;14(11):759-67
    • (2014) Nat Rev Immunol , vol.14 , Issue.11 , pp. 759-767
    • Linkermann, A.1    Stockwell, B.R.2    Krautwald, S.3
  • 26
    • 84897059782 scopus 로고    scopus 로고
    • Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease models
    • Skouta R, Dixon SJ, Wang J, et al. Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease models. J Am Chem Soc 2014;136(12):4551-6
    • (2014) J Am Chem Soc , vol.136 , Issue.12 , pp. 4551-4556
    • Skouta, R.1    Dixon, S.J.2    Wang, J.3
  • 27
    • 84913582286 scopus 로고    scopus 로고
    • Synchronized renal tubular cell death involves ferroptosis
    • Linkermann A, Skouta R, Himmerkus N, et al. Synchronized renal tubular cell death involves ferroptosis. Proc Natl Acad Sci USA 2014;111(47):16836-41
    • (2014) Proc Natl Acad Sci USA , vol.111 , Issue.47 , pp. 16836-16841
    • Linkermann, A.1    Skouta, R.2    Himmerkus, N.3
  • 28
    • 77950622473 scopus 로고    scopus 로고
    • BASP1 promotes apoptosis in diabetic nephropathy
    • Sanchez-Niño MD, Sanz AB, Lorz C, et al. BASP1 promotes apoptosis in diabetic nephropathy. J Am Soc Nephro 2010;21(4):610-21
    • (2010) J Am Soc Nephro , vol.21 , Issue.4 , pp. 610-621
    • Sanchez-Niño, M.D.1    Sanz, A.B.2    Lorz, C.3
  • 30
    • 84890483229 scopus 로고    scopus 로고
    • Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) and kidney disease
    • Ruiz-Ortega M, Ortiz A, Ramos AM. Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) and kidney disease. Curr Opin Nephrol Hypertens 2014;23(1):93-100
    • (2014) Curr Opin Nephrol Hypertens , vol.23 , Issue.1 , pp. 93-100
    • Ruiz-Ortega, M.1    Ortiz, A.2    Ramos, A.M.3
  • 31
    • 69349093225 scopus 로고    scopus 로고
    • Interleukin-17 and type 17 helper T cells
    • Miossec P, Korn T, Kuchroo VK. Interleukin-17 and type 17 helper T cells. N Engl J Med 2009;361(9):888-98
    • (2009) N Engl J Med , vol.361 , Issue.9 , pp. 888-898
    • Miossec, P.1    Korn, T.2    Kuchroo, V.K.3
  • 33
    • 79551668389 scopus 로고    scopus 로고
    • The emergence of TH17 cells as effectors of renal injury
    • Kitching AR, Holdsworth SR. The emergence of TH17 cells as effectors of renal injury. J Am Soc Nephrol 2011;22(2):235-8
    • (2011) J Am Soc Nephrol , vol.22 , Issue.2 , pp. 235-238
    • Kitching, A.R.1    Holdsworth, S.R.2
  • 34
    • 84879646795 scopus 로고    scopus 로고
    • The C-terminal module IV of connective tissue growth factor is a novel immune modulator of theTh17 response
    • Rodrigues-Díez R, Rodrigues-Díez RR, Rayego-Mateos S, et al. The C-terminal module IV of connective tissue growth factor is a novel immune modulator of theTh17 response. Lab Invest 2013;93(7):812-24
    • (2013) Lab Invest , vol.93 , Issue.7 , pp. 812-824
    • Rodrigues-Díez, R.1    Rodrigues-Díez, R.R.2    Rayego-Mateos, S.3
  • 35
    • 33646577466 scopus 로고    scopus 로고
    • Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
    • Bettelli E, Carrier Y, Gao W, et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 2006;441(7090):235-8
    • (2006) Nature , vol.441 , Issue.7090 , pp. 235-238
    • Bettelli, E.1    Carrier, Y.2    Gao, W.3
  • 36
    • 33749260151 scopus 로고    scopus 로고
    • CD4 +CD25+ regulatory T cells protect against injury in an innate murine model of chronic kidney disease
    • Mahajan D, Wang Y, Qin X, et al. CD4 +CD25+ regulatory T cells protect against injury in an innate murine model of chronic kidney disease. J Am Soc Nephrol 2006;17(10):2731-41
    • (2006) J Am Soc Nephrol , vol.17 , Issue.10 , pp. 2731-2741
    • Mahajan, D.1    Wang, Y.2    Qin, X.3
  • 37
    • 80051946918 scopus 로고    scopus 로고
    • CD4+CD25+Foxp3+ regulatory T cells suppress cardiac fibrosis in the hypertensive heart
    • Kanellakis P, Dinh TN, Agrotis A, et al. CD4+CD25+Foxp3+ regulatory T cells suppress cardiac fibrosis in the hypertensive heart. J Hypertens 2011;29(9):1820-8
    • (2011) J Hypertens , vol.29 , Issue.9 , pp. 1820-1828
    • Kanellakis, P.1    Dinh, T.N.2    Agrotis, A.3
  • 38
    • 84905496884 scopus 로고    scopus 로고
    • IL-17A is a novel player in dialysis-induced peritoneal damage
    • Rodrigues-Díez R, Aroeira LS, Orejudo M, et al. IL-17A is a novel player in dialysis-induced peritoneal damage. Kidney Int 2014;86(2):303-15
    • (2014) Kidney Int , vol.86 , Issue.2 , pp. 303-315
    • Rodrigues-Díez, R.1    Aroeira, L.S.2    Orejudo, M.3
  • 39
    • 84904545875 scopus 로고    scopus 로고
    • Secukinumab in plaque psoriasis-results of two phase 3 trials
    • Langley RG, Elewski BE, Lebwohl M, et al. Secukinumab in plaque psoriasis-results of two phase 3 trials. N Engl J Med 2014;371(4):326-38
    • (2014) N Engl J Med , vol.371 , Issue.4 , pp. 326-338
    • Langley, R.G.1    Elewski, B.E.2    Lebwohl, M.3
  • 40
    • 34447534187 scopus 로고    scopus 로고
    • Inhibition of MCP-1/CCR2 pathway ameliorates the development of diabetic nephropathy
    • Kanamori H, Matsubara T, Mima A, et al. Inhibition of MCP-1/CCR2 pathway ameliorates the development of diabetic nephropathy. Biochem Biophys Res Commun 2007;360(4):772-7
    • (2007) Biochem Biophys Res Commun , vol.360 , Issue.4 , pp. 772-777
    • Kanamori, H.1    Matsubara, T.2    Mima, A.3
  • 41
    • 77958102050 scopus 로고    scopus 로고
    • CCR2 antagonism improves insulin resistance, lipid metabolism, and diabetic nephropathy in type 2 diabetic mice
    • Kang YS, Lee MH, Song HK, et al. CCR2 antagonism improves insulin resistance, lipid metabolism, and diabetic nephropathy in type 2 diabetic mice. Kidney Int 2010;78(9):883-94
    • (2010) Kidney Int , vol.78 , Issue.9 , pp. 883-894
    • Kang, Y.S.1    Lee, M.H.2    Song, H.K.3
  • 42
    • 84886415833 scopus 로고    scopus 로고
    • Experimental evidence for the use of CCR2 antagonists in the treatment of type 2 diabetes
    • Sullivan TJ, Miao Z, Zhao BN, et al. Experimental evidence for the use of CCR2 antagonists in the treatment of type 2 diabetes. Metabolism 2013;62(11):1623-32
    • (2013) Metabolism , vol.62 , Issue.11 , pp. 1623-1632
    • Sullivan, T.J.1    Miao, Z.2    Zhao, B.N.3
  • 43
    • 84887006703 scopus 로고    scopus 로고
    • CCR2 antagonist CCX140-B provides renal and glycemic benefits in diabetic transgenic human CCR2 knock-in mice
    • Sullivan T, Miao Z, Dairaghi DJ, et al. CCR2 antagonist CCX140-B provides renal and glycemic benefits in diabetic transgenic human CCR2 knock-in mice. Am J Physiol Renal Physiol 2013;305(9):F1288-97
    • (2013) Am J Physiol Renal Physiol , vol.305 , Issue.9 , pp. F1288-F1297
    • Sullivan, T.1    Miao, Z.2    Dairaghi, D.J.3
  • 45
  • 46
    • 33846830051 scopus 로고    scopus 로고
    • Urinary TWEAK and the activity of lupus nephritis
    • Schwartz N, Su L, Burkly LC, et al. Urinary TWEAK and the activity of lupus nephritis. J Autoimmun 2006;27(4):242-50
    • (2006) J Autoimmun , vol.27 , Issue.4 , pp. 242-250
    • Schwartz, N.1    Su, L.2    Burkly, L.C.3
  • 47
    • 84866085652 scopus 로고    scopus 로고
    • Inhibition of the TWEAK/Fn14 pathway attenuates renal disease in nephrotoxic serum nephritis
    • Xia Y, Campbell SR, Broder A, et al. Inhibition of the TWEAK/Fn14 pathway attenuates renal disease in nephrotoxic serum nephritis. Clin Immunol 2012;145(2):108-21
    • (2012) Clin Immunol , vol.145 , Issue.2 , pp. 108-121
    • Xia, Y.1    Campbell, S.R.2    Broder, A.3
  • 48
    • 84929307614 scopus 로고    scopus 로고
    • Deficiency of fibroblast growth factor-inducible 14 (Fn14) preserves the filtration barrier and ameliorates lupus nephritis
    • [Epub ahead of print]
    • Xia Y, Herlitz LC, Gindea S, et al. Deficiency of fibroblast growth factor-inducible 14 (Fn14) preserves the filtration barrier and ameliorates lupus nephritis. J Am Soc Nephrol 2014. [Epub ahead of print]
    • (2014) J Am Soc Nephrol
    • Xia, Y.1    Herlitz, L.C.2    Gindea, S.3
  • 51
    • 44349155996 scopus 로고    scopus 로고
    • The cytokine TWEAK modulates renal tubulointerstitial inflammation
    • Sanz AB, Justo P, Sanchez-Niño MD, et al. The cytokine TWEAK modulates renal tubulointerstitial inflammation. J Am Soc Nephrol 2008;19(4):695-703
    • (2008) J Am Soc Nephrol , vol.19 , Issue.4 , pp. 695-703
    • Sanz, A.B.1    Justo, P.2    Sanchez-Niño, M.D.3
  • 52
    • 76749108324 scopus 로고    scopus 로고
    • Tweak induces proliferation in renal tubular epithelium: A role in uninephrectomy induced renal hyperplasia
    • Sanz AB, Sanchez-Niño MD, Izquierdo MC, et al. Tweak induces proliferation in renal tubular epithelium: a role in uninephrectomy induced renal hyperplasia. J Cell Mol Med 2009;13(9B):3329-42
    • (2009) J Cell Mol Med , vol.13 , Issue.9 B , pp. 3329-3342
    • Sanz, A.B.1    Sanchez-Niño, M.D.2    Izquierdo, M.C.3
  • 53
    • 84884345439 scopus 로고    scopus 로고
    • Fn14 in podocytes and proteinuric kidney disease
    • Sanchez-Niño MD, Poveda J, Sanz AB, et al. Fn14 in podocytes and proteinuric kidney disease. Biochim Biophys Acta 2013;1832(12):2232-43
    • (2013) Biochim Biophys Acta , vol.1832 , Issue.12 , pp. 2232-2243
    • Sanchez-Niño, M.D.1    Poveda, J.2    Sanz, A.B.3
  • 54
    • 84879595462 scopus 로고    scopus 로고
    • TNF-related weak inducer of apoptosis (TWEAK) promotes kidney fibrosis and Ras-dependent proliferation of cultured renal fibroblast
    • Ucero AC, Benito-Martin A, Fuentes-Calvo I, et al. TNF-related weak inducer of apoptosis (TWEAK) promotes kidney fibrosis and Ras-dependent proliferation of cultured renal fibroblast. Biochim Biophys Acta 2013;1832(10):1744-55
    • (2013) Biochim Biophys Acta , vol.1832 , Issue.10 , pp. 1744-1755
    • Ucero, A.C.1    Benito-Martin, A.2    Fuentes-Calvo, I.3
  • 55
    • 84903575719 scopus 로고    scopus 로고
    • Relevant role of PKG in the progression of fibrosis induced by TNF-like weak inducer of apoptosis
    • Martín P, Mora I, Cortes MA, et al. Relevant role of PKG in the progression of fibrosis induced by TNF-like weak inducer of apoptosis. Am J Physiol Renal Physiol 2014;307(1):F75-85
    • (2014) Am J Physiol Renal Physiol , vol.307 , Issue.1 , pp. F75-85
    • Martín, P.1    Mora, I.2    Cortes, M.A.3
  • 56
    • 57049173519 scopus 로고    scopus 로고
    • Nitro-oleic acid protects the mouse kidney from ischemia and reperfusion injury
    • Liu H, Jia Z, Soodvilai S, et al. Nitro-oleic acid protects the mouse kidney from ischemia and reperfusion injury. Am J Physiol Renal Physiol 2008;295(4):F942-9
    • (2008) Am J Physiol Renal Physiol , vol.295 , Issue.4 , pp. F942-F949
    • Liu, H.1    Jia, Z.2    Soodvilai, S.3
  • 57
    • 77649164395 scopus 로고    scopus 로고
    • Nitro-oleic acid protects against endotoxin-induced endotoxemia and multiorgan injury in mice
    • Wang H, Liu H, Jia Z, et al. Nitro-oleic acid protects against endotoxin-induced endotoxemia and multiorgan injury in mice. Am J Physiol Renal Physiol 2010;298(3):F754-62
    • (2010) Am J Physiol Renal Physiol , vol.298 , Issue.3 , pp. F754-F762
    • Wang, H.1    Liu, H.2    Jia, Z.3
  • 58
    • 84884250469 scopus 로고    scopus 로고
    • Nitro-oleic acid protects against adriamycin-induced nephropathy in mice
    • Liu S, Jia Z, Zhou L, et al. Nitro-oleic acid protects against adriamycin-induced nephropathy in mice. Am J Physiol Renal Physiol 2013;305(11):F1533-41
    • (2013) Am J Physiol Renal Physiol , vol.305 , Issue.11 , pp. F1533-F1541
    • Liu, S.1    Jia, Z.2    Zhou, L.3
  • 59
    • 84888804713 scopus 로고    scopus 로고
    • Combined losartan and nitro-oleic acid remarkably improves diabetic nephropathy in mice
    • Liu Y, Jia Z, Liu S, et al. Combined losartan and nitro-oleic acid remarkably improves diabetic nephropathy in mice. Am J Physiol Renal Physiol 2013;305(11):F1555-62
    • (2013) Am J Physiol Renal Physiol , vol.305 , Issue.11 , pp. F1555-F1562
    • Liu, Y.1    Jia, Z.2    Liu, S.3
  • 61
    • 84928330652 scopus 로고    scopus 로고
    • [Last accessed 20 March 2015]
    • Oral CXA-10 study in healthy volunteers. Available from: https://clinicaltrials.gov/ct2/results?term=NCT02313064&Search=Search [Last accessed 20 March 2015]
    • Oral CXA-10 Study in Healthy Volunteers
  • 62
    • 84901498139 scopus 로고    scopus 로고
    • Alkaline phosphatase: A possible treatment for sepsis-associated acute kidney injury in critically ill patients
    • Peters E, Heemskerk S, Masereeuw R, et al. Alkaline phosphatase: a possible treatment for sepsis-associated acute kidney injury in critically ill patients. Am J Kidney Dis 2014;63(6):1038-48
    • (2014) Am J Kidney Dis , vol.63 , Issue.6 , pp. 1038-1048
    • Peters, E.1    Heemskerk, S.2    Masereeuw, R.3
  • 65
    • 84863624021 scopus 로고    scopus 로고
    • Angiotensin II contributes to renal fibrosis independently of Notch pathway activation
    • Lavoz C, Rodrigues-Diez R, Benito-Martin A. Angiotensin II contributes to renal fibrosis independently of Notch pathway activation. PLoS One 2012;7(7):e40490
    • (2012) PLoS One , vol.7 , Issue.7 , pp. e40490
    • Lavoz, C.1    Rodrigues-Diez, R.2    Benito-Martin, A.3
  • 66
    • 77952116121 scopus 로고    scopus 로고
    • Methylation determines fibroblast activation and fibrogenesis in the kidney
    • Bechtel W, McGoohan S, Zeisberg EM, et al. Methylation determines fibroblast activation and fibrogenesis in the kidney. Nat Med 2010;16(5):544-50
    • (2010) Nat Med , vol.16 , Issue.5 , pp. 544-550
    • Bechtel, W.1    McGoohan, S.2    Zeisberg, E.M.3
  • 67
    • 84858008133 scopus 로고    scopus 로고
    • Activin-like kinase 3 is important for kidney regeneration and reversal of fibrosis
    • Sugimoto H, LeBleu VS, Bosukonda D, et al. Activin-like kinase 3 is important for kidney regeneration and reversal of fibrosis. Nat Med 2012;18(3):396-404
    • (2012) Nat Med , vol.18 , Issue.3 , pp. 396-404
    • Sugimoto, H.1    Lebleu, V.S.2    Bosukonda, D.3
  • 69
    • 84893408316 scopus 로고    scopus 로고
    • Origin of regenerating tubular cells after acute kidney injury
    • Berger K, Bangen JM, Hammerich L, et al. Origin of regenerating tubular cells after acute kidney injury. Proc Natl Acad Sci USA 2014;111(4):1533-8
    • (2014) Proc Natl Acad Sci USA , vol.111 , Issue.4 , pp. 1533-1538
    • Berger, K.1    Bangen, J.M.2    Hammerich, L.3
  • 70
    • 84899738750 scopus 로고    scopus 로고
    • Unraveling the role of podocyte turnover in glomerular aging and injury
    • Wanner N, Hartleben B, Herbach N, et al. Unraveling the role of podocyte turnover in glomerular aging and injury. J Am Soc Nephrol 2014;25(4):707-16
    • (2014) J Am Soc Nephrol , vol.25 , Issue.4 , pp. 707-716
    • Wanner, N.1    Hartleben, B.2    Herbach, N.3
  • 71
    • 84886677947 scopus 로고    scopus 로고
    • Proteinuria impairs podocyte regeneration by sequestering retinoic acid
    • Peired A, Angelotti ML, Ronconi E, et al. Proteinuria impairs podocyte regeneration by sequestering retinoic acid. J Am Soc Nephrol 2013;24(11):1756-68
    • (2013) J Am Soc Nephrol , vol.24 , Issue.11 , pp. 1756-1768
    • Peired, A.1    Angelotti, M.L.2    Ronconi, E.3
  • 72
    • 84861471421 scopus 로고    scopus 로고
    • GSK3, snail, and adhesion molecule regulation by cyclosporine A in renal tubular cells
    • Berzal S, Alique M, Ruiz-Ortega M, et al. GSK3, snail, and adhesion molecule regulation by cyclosporine A in renal tubular cells. Toxicol Sci 2012;127(2):425-37
    • (2012) Toxicol Sci , vol.127 , Issue.2 , pp. 425-437
    • Berzal, S.1    Alique, M.2    Ruiz-Ortega, M.3
  • 73
    • 84899140966 scopus 로고    scopus 로고
    • Renal replacement therapy associated with lithium nephrotoxicity in Australia
    • Roxanas M, Grace BS, George CR. Renal replacement therapy associated with lithium nephrotoxicity in Australia. Med J Aust 2014;200(4):226-8
    • (2014) Med J Aust , vol.200 , Issue.4 , pp. 226-228
    • Roxanas, M.1    Grace, B.S.2    George, C.R.3
  • 74
    • 84896836596 scopus 로고    scopus 로고
    • Delayed administration of a single dose of lithium promotes recovery from AKI
    • Bao H, Ge Y, Wang Z, et al. Delayed administration of a single dose of lithium promotes recovery from AKI. J Am Soc Nephrol 2014;25(3):488-500
    • (2014) J Am Soc Nephrol , vol.25 , Issue.3 , pp. 488-500
    • Bao, H.1    Ge, Y.2    Wang, Z.3
  • 75
    • 84904969665 scopus 로고    scopus 로고
    • Formoterol restores mitochondrial and renal function after ischemia-reperfusion injury
    • Jesinkey SR, Funk JA, Stallons LJ, et al. Formoterol restores mitochondrial and renal function after ischemia-reperfusion injury. J Am Soc Nephrol 2014;25(6):1157-62
    • (2014) J Am Soc Nephrol , vol.25 , Issue.6 , pp. 1157-1162
    • Jesinkey, S.R.1    Funk, J.A.2    Stallons, L.J.3
  • 76
    • 84906539304 scopus 로고    scopus 로고
    • Toll-like receptor 4-induced IL-22 accelerates kidney regeneration
    • Kulkarni OP, Hartter I, Mulay SR, et al. Toll-like receptor 4-induced IL-22 accelerates kidney regeneration. J Am Soc Nephrol 2014;25(5):978-89
    • (2014) J Am Soc Nephrol , vol.25 , Issue.5 , pp. 978-989
    • Kulkarni, O.P.1    Hartter, I.2    Mulay, S.R.3
  • 77
    • 43749111585 scopus 로고    scopus 로고
    • AP214, an analogue of alpha-melanocyte-stimulating hormone, ameliorates sepsis-induced acute kidney injury and mortality
    • Doi K, Hu X, Yuen PS, et al. AP214, an analogue of alpha-melanocyte-stimulating hormone, ameliorates sepsis-induced acute kidney injury and mortality. Kidney Int 2008;73(11):1266-74
    • (2008) Kidney Int , vol.73 , Issue.11 , pp. 1266-1274
    • Doi, K.1    Hu, X.2    Yuen, P.S.3
  • 78
    • 77949294719 scopus 로고    scopus 로고
    • Alpha-melanocyte stimulating hormone analogue AP214 protects against ischemia induced acute kidney injury in a porcine surgical model
    • Simmons MN, Subramanian V, Crouzet S, et al. Alpha-melanocyte stimulating hormone analogue AP214 protects against ischemia induced acute kidney injury in a porcine surgical model. J Urol 2010;183(4):1625-9
    • (2010) J Urol , vol.183 , Issue.4 , pp. 1625-1629
    • Simmons, M.N.1    Subramanian, V.2    Crouzet, S.3
  • 79
    • 84875697942 scopus 로고    scopus 로고
    • Adrenocorticotropic hormone ameliorates acute kidney injury by steroidogenic-dependent and-independent mechanisms
    • Si J, Ge Y, Zhuang S, et al. Adrenocorticotropic hormone ameliorates acute kidney injury by steroidogenic-dependent and-independent mechanisms. Kidney Int 2013;83(4):635-46
    • (2013) Kidney Int , vol.83 , Issue.4 , pp. 635-646
    • Si, J.1    Ge, Y.2    Zhuang, S.3
  • 80
    • 1042292029 scopus 로고    scopus 로고
    • Erythropoietin protects against ischaemic acute renal injury
    • Vesey DA, Cheung C, Pat B, et al. Erythropoietin protects against ischaemic acute renal injury. Nephrol Dial Transplant 2004;19(2):348-55
    • (2004) Nephrol Dial Transplant , vol.19 , Issue.2 , pp. 348-355
    • Vesey, D.A.1    Cheung, C.2    Pat, B.3
  • 81
    • 33646696626 scopus 로고    scopus 로고
    • Delayed administration of darbepoetin or erythropoietin protects against ischemic acute renal injury and failure
    • Johnson DW, Pat B, Vesey DA, et al. Delayed administration of darbepoetin or erythropoietin protects against ischemic acute renal injury and failure. Kidney Int 2006;69(10):1806-13
    • (2006) Kidney Int , vol.69 , Issue.10 , pp. 1806-1813
    • Johnson, D.W.1    Pat, B.2    Vesey, D.A.3
  • 82
    • 48249136580 scopus 로고    scopus 로고
    • Antiapoptotic properties of erythropoiesis-stimulating proteins in models of cisplatin-induced acute kidney injury
    • Salahudeen AK, Haider N, Jenkins J, et al. Antiapoptotic properties of erythropoiesis-stimulating proteins in models of cisplatin-induced acute kidney injury. Am J Physiol Renal Physiol 2008;294(6):F1354-65
    • (2008) Am J Physiol Renal Physiol , vol.294 , Issue.6 , pp. F1354-F1365
    • Salahudeen, A.K.1    Haider, N.2    Jenkins, J.3
  • 83
    • 84859764858 scopus 로고    scopus 로고
    • Erythropoietin prevents sepsis-related acute kidney injury in rats by inhibiting NF-kB and upregulating endothelial nitric oxide synthase
    • Souza AC, Volpini RA, Shimizu MH, et al. Erythropoietin prevents sepsis-related acute kidney injury in rats by inhibiting NF-kB and upregulating endothelial nitric oxide synthase. Am J Physiol Renal Physiol 2012;302(8):F1045-54
    • (2012) Am J Physiol Renal Physiol , vol.302 , Issue.8 , pp. F1045-F1054
    • Souza, A.C.1    Volpini, R.A.2    Shimizu, M.H.3
  • 84
    • 72749093288 scopus 로고    scopus 로고
    • Antiapoptotic properties of recombinant human erythropoietin protects against tubular cyclosporine toxicity
    • Pallet N, Bouvier N, Legendre C, et al. Antiapoptotic properties of recombinant human erythropoietin protects against tubular cyclosporine toxicity. Pharmacol Res 2010;61(1):71-5
    • (2010) Pharmacol Res , vol.61 , Issue.1 , pp. 71-75
    • Pallet, N.1    Bouvier, N.2    Legendre, C.3
  • 85
    • 84877960065 scopus 로고    scopus 로고
    • Recombinant human erythropoietin attenuates renal tubulointerstitial injury in murine adriamycin-induced nephropathy
    • Nakazawa Y, Nishino T, Obata Y, et al. Recombinant human erythropoietin attenuates renal tubulointerstitial injury in murine adriamycin-induced nephropathy. J Nephrol 2013;26(3):527-33
    • (2013) J Nephrol , vol.26 , Issue.3 , pp. 527-533
    • Nakazawa, Y.1    Nishino, T.2    Obata, Y.3
  • 86
    • 80455164628 scopus 로고    scopus 로고
    • Erythropoietin gene-enhanced marrow mesenchymal stromal cells decrease cisplatin-induced kidney injury and improve survival of allogeneic mice
    • Eliopoulos N, Zhao J, Forner K, et al. Erythropoietin gene-enhanced marrow mesenchymal stromal cells decrease cisplatin-induced kidney injury and improve survival of allogeneic mice. Mol Ther 2011;19(11):2072-83
    • (2011) Mol Ther , vol.19 , Issue.11 , pp. 2072-2083
    • Eliopoulos, N.1    Zhao, J.2    Forner, K.3
  • 87
    • 84879882648 scopus 로고    scopus 로고
    • Effect of erythropoietin on the migration of bone marrow-derived mesenchymal stem cells to the acute kidney injury microenvironment
    • Liu N, Tian J, Cheng J, et al. Effect of erythropoietin on the migration of bone marrow-derived mesenchymal stem cells to the acute kidney injury microenvironment. Exp Cell Res 2013;319(13):2019-27
    • (2013) Exp Cell Res , vol.319 , Issue.13 , pp. 2019-2027
    • Liu, N.1    Tian, J.2    Cheng, J.3
  • 88
    • 84883457788 scopus 로고    scopus 로고
    • Erythropoietin attenuates acute kidney dysfunction in murine experimental sepsis by activation of the b-common receptor
    • Coldewey SM, Khan AI, Kapoor A, et al. Erythropoietin attenuates acute kidney dysfunction in murine experimental sepsis by activation of the b-common receptor. Kidney Int 2013;84(3):482-90
    • (2013) Kidney Int , vol.84 , Issue.3 , pp. 482-490
    • Coldewey, S.M.1    Khan, A.I.2    Kapoor, A.3
  • 89
    • 84873522898 scopus 로고    scopus 로고
    • Delayed administration of pyroglutamate helix B surface peptide (pHBSP), a novel nonerythropoietic analog of erythropoietin, attenuates acute kidney injury
    • Patel NS, Kerr-Peterson HL, Brines M, et al. Delayed administration of pyroglutamate helix B surface peptide (pHBSP), a novel nonerythropoietic analog of erythropoietin, attenuates acute kidney injury. Mol Med 2012;18:719-27
    • (2012) Mol Med , vol.18 , pp. 719-727
    • Patel, N.S.1    Kerr-Peterson, H.L.2    Brines, M.3
  • 90
    • 70949108082 scopus 로고    scopus 로고
    • A trial of darbepoetin alfa in type 2 diabetes and chronic kidney disease
    • Pfeffer MA, Burdmann EA, Chen CY, et al. A trial of darbepoetin alfa in type 2 diabetes and chronic kidney disease. N Engl J Med 2009;361(21):2019-32
    • (2009) N Engl J Med , vol.361 , Issue.21 , pp. 2019-2032
    • Pfeffer, M.A.1    Burdmann, E.A.2    Chen, C.Y.3
  • 91
    • 80053894694 scopus 로고    scopus 로고
    • The role of catalytic iron in acute kidney injury
    • Shah SV, Rajapurkar MM, Baliga R. The role of catalytic iron in acute kidney injury. Clin J Am Soc Nephrol 2011;6(10):2329-31
    • (2011) Clin J Am Soc Nephrol , vol.6 , Issue.10 , pp. 2329-2331
    • Shah, S.V.1    Rajapurkar, M.M.2    Baliga, R.3
  • 92
    • 84876809204 scopus 로고    scopus 로고
    • Impact of catalytic iron on mortality in patients with acute coronary syndrome exposed to iodinated radiocontrast-The Iscom Study
    • Lele SS, Mukhopadhyay BN, Mardikar MM, et al. Impact of catalytic iron on mortality in patients with acute coronary syndrome exposed to iodinated radiocontrast-The Iscom Study. Am Heart J 2013;165(5):744-51
    • (2013) Am Heart J , vol.165 , Issue.5 , pp. 744-751
    • Lele, S.S.1    Mukhopadhyay, B.N.2    Mardikar, M.M.3
  • 93
    • 84861541814 scopus 로고    scopus 로고
    • Ferroptosis: An iron-dependent form of nonapoptotic cell death
    • Dixon SJ, Lemberg KM, Lamprecht MR, et al. Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell 2012;149(5):1060-72
    • (2012) Cell , vol.149 , Issue.5 , pp. 1060-1072
    • Dixon, S.J.1    Lemberg, K.M.2    Lamprecht, M.R.3
  • 94
    • 84925286831 scopus 로고    scopus 로고
    • Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice
    • Friedmann Angeli JP, Schneider M, Proneth B, et al. Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice. Nat Cell Biol 2014;16(12):1180-91
    • (2014) Nat Cell Biol , vol.16 , Issue.12 , pp. 1180-1191
    • Friedmann Angeli, J.P.1    Schneider, M.2    Proneth, B.3
  • 97
    • 84881152296 scopus 로고    scopus 로고
    • Endothelin antagonists for diabetic and non-diabetic chronic kidney disease
    • Kohan DE, Pollock DM. Endothelin antagonists for diabetic and non-diabetic chronic kidney disease. Br J Clin Pharmacol 2013;76(4):573-9
    • (2013) Br J Clin Pharmacol , vol.76 , Issue.4 , pp. 573-579
    • Kohan, D.E.1    Pollock, D.M.2
  • 98
    • 84901282021 scopus 로고    scopus 로고
    • [Last accessed 20 March 2015]
    • Study of diabetic nephropathy with atrasentan. Available from: https://clinicaltrials.gov/ct2/results?term=NCT01858532&Search=Search [Last accessed 20 March 2015]
    • Study of Diabetic Nephropathy with Atrasentan
  • 100
    • 35348823128 scopus 로고    scopus 로고
    • Vasopressin V2 receptor expression along rat, mouse, and human renal epithelia with focus on TAL
    • Mutig K, Paliege A, Kahl T, et al. Vasopressin V2 receptor expression along rat, mouse, and human renal epithelia with focus on TAL. Am J Physiol Renal Physiol 2007;293(4):F1166-77
    • (2007) Am J Physiol Renal Physiol , vol.293 , Issue.4 , pp. F1166-F1177
    • Mutig, K.1    Paliege, A.2    Kahl, T.3
  • 101
    • 30944442525 scopus 로고    scopus 로고
    • Vasopressin antagonists in polycystic kidney disease
    • Torres VE. Vasopressin antagonists in polycystic kidney disease. Kidney In 2005;68(5):2405-18
    • (2005) Kidney in , vol.68 , Issue.5 , pp. 2405-2418
    • Torres, V.E.1
  • 102
    • 0031835665 scopus 로고    scopus 로고
    • Regulation of cAMP production in initial and terminal inner medullary collecting ducts
    • Yasuda G, Jeffries WB. Regulation of cAMP production in initial and terminal inner medullary collecting ducts. Kidney Int 1998;54(1):80-6
    • (1998) Kidney Int , vol.54 , Issue.1 , pp. 80-86
    • Yasuda, G.1    Jeffries, W.B.2
  • 103
    • 0030723843 scopus 로고    scopus 로고
    • Renal accumulation and excretion of cyclic adenosine monophosphate in a murine model of slowly progressive polycystic kidney disease
    • Yamaguchi T, Nagao S, Kasahara M, et al. Renal accumulation and excretion of cyclic adenosine monophosphate in a murine model of slowly progressive polycystic kidney disease. Am J Kidney Dis 1997;30(5):703-9
    • (1997) Am J Kidney Dis , vol.30 , Issue.5 , pp. 703-709
    • Yamaguchi, T.1    Nagao, S.2    Kasahara, M.3
  • 104
    • 0034126459 scopus 로고    scopus 로고
    • CAMP stimulates the in vitro proliferation of renal cyst epithelial cells by activating the extracellular signal-regulated kinase pathway
    • Yamaguchi T, Pelling JC, Ramaswamy NT, et al. cAMP stimulates the in vitro proliferation of renal cyst epithelial cells by activating the extracellular signal-regulated kinase pathway. Kidney Int 2000;57(4):1460-71
    • (2000) Kidney Int , vol.57 , Issue.4 , pp. 1460-1471
    • Yamaguchi, T.1    Pelling, J.C.2    Ramaswamy, N.T.3
  • 105
    • 1942486801 scopus 로고    scopus 로고
    • Effective treatment of an orthologous model of autosomal dominant polycystic kidney disease
    • Torres VE, Wang X, Qian Q, et al. Effective treatment of an orthologous model of autosomal dominant polycystic kidney disease. Nat Med 2004;10(4):363-4
    • (2004) Nat Med , vol.10 , Issue.4 , pp. 363-364
    • Torres, V.E.1    Wang, X.2    Qian, Q.3
  • 106
    • 23944515994 scopus 로고    scopus 로고
    • Effectiveness of vasopressin V2 receptor antagonists OPC-31260 and OPC-41061 on polycystic kidney disease development in the PCK rat
    • Wang X, Gattone V II, Harris PC, et al. Effectiveness of vasopressin V2 receptor antagonists OPC-31260 and OPC-41061 on polycystic kidney disease development in the PCK rat. J Am Soc Nephrol 2005;16(4):846-51
    • (2005) J Am Soc Nephrol , vol.16 , Issue.4 , pp. 846-851
    • Wang, X.1    Gattone, V.2    Harris, P.C.3
  • 107
    • 38149005366 scopus 로고    scopus 로고
    • Vasopressin directly regulates cyst growth in polycystic kidney disease
    • Wang X, Wu Y, Ward CJ, et al. Vasopressin directly regulates cyst growth in polycystic kidney disease. J Am Soc Nephrol 2008;19(1):102-8
    • (2008) J Am Soc Nephrol , vol.19 , Issue.1 , pp. 102-108
    • Wang, X.1    Wu, Y.2    Ward, C.J.3
  • 108
    • 0032956538 scopus 로고    scopus 로고
    • Developmental expression of urine concentration-associated genes and their altered expression in murine infantile-type polycystic kidney disease
    • Gattone VH II, Maser RL, Tian C, et al. Developmental expression of urine concentration-associated genes and their altered expression in murine infantile-type polycystic kidney disease. Dev Genet 1999;24(3-4):309-18
    • (1999) Dev Genet , vol.24 , Issue.3-4 , pp. 309-318
    • Gattone, V.H.1    Maser, R.L.2    Tian, C.3
  • 109
    • 33746566597 scopus 로고    scopus 로고
    • Increased water intake decreases progression of polycystic kidney disease in the PCK rat
    • Nagao S, Nishii K, Katsuyama M, et al. Increased water intake decreases progression of polycystic kidney disease in the PCK rat. J Am Soc Nephrol 2006;17(8):2220-7
    • (2006) J Am Soc Nephrol , vol.17 , Issue.8 , pp. 2220-2227
    • Nagao, S.1    Nishii, K.2    Katsuyama, M.3
  • 110
    • 84871303897 scopus 로고    scopus 로고
    • Tolvaptan in patients with autosomal dominant polycystic kidney disease
    • Torres VE, Chapman AB, Devuyst O, et al. Tolvaptan in patients with autosomal dominant polycystic kidney disease. N Engl J Med 2012;367(25):2407-18
    • (2012) N Engl J Med , vol.367 , Issue.25 , pp. 2407-2418
    • Torres, V.E.1    Chapman, A.B.2    Devuyst, O.3
  • 111
    • 84894469357 scopus 로고    scopus 로고
    • CKD of unknown origin in Central America: The case for a Mesoamerican nephropathy
    • Correa-Rotter R, Wesseling C, Johnson RJ. CKD of unknown origin in Central America: the case for a Mesoamerican nephropathy. Am J Kidney Dis 2014;63(3):506-20
    • (2014) Am J Kidney Dis , vol.63 , Issue.3 , pp. 506-520
    • Correa-Rotter, R.1    Wesseling, C.2    Johnson, R.J.3
  • 112
    • 84903528840 scopus 로고    scopus 로고
    • Hyperosmolarity drives hypertension and CKD-water and salt revisited
    • Johnson RJ, Rodriguez-Iturbe B, Roncal-Jimenez C, et al. Hyperosmolarity drives hypertension and CKD-water and salt revisited. Nat Rev Nephrol 2014;10(7):415-20
    • (2014) Nat Rev Nephrol , vol.10 , Issue.7 , pp. 415-420
    • Johnson, R.J.1    Rodriguez-Iturbe, B.2    Roncal-Jimenez, C.3
  • 113
    • 84894506176 scopus 로고    scopus 로고
    • Resolving the enigma of the mesoamerican nephropathy: A research workshop summary
    • Wesseling C, Crowe J, Hogstedt C, et al. Resolving the enigma of the mesoamerican nephropathy: a research workshop summary. Am J Kidney Dis 2014;63(3):396-404
    • (2014) Am J Kidney Dis , vol.63 , Issue.3 , pp. 396-404
    • Wesseling, C.1    Crowe, J.2    Hogstedt, C.3
  • 114
    • 84899795495 scopus 로고    scopus 로고
    • Risk factors for reduced glomerular filtration rate in a Nicaraguan community affected by Mesoamerican nephropathy
    • Raines N, González M, Wyatt C, et al. Risk factors for reduced glomerular filtration rate in a Nicaraguan community affected by Mesoamerican nephropathy. MEDICC Rev 2014;16(2):16-22
    • (2014) MEDICC Rev , vol.16 , Issue.2 , pp. 16-22
    • Raines, N.1    González, M.2    Wyatt, C.3
  • 116
    • 84907188863 scopus 로고    scopus 로고
    • Role of podocyte B7-1 in diabetic nephropathy
    • Fiorina P, Vergani A, Bassi R, et al. Role of podocyte B7-1 in diabetic nephropathy. J Am Soc Nephrol 2014;25(7):1415-29
    • (2014) J Am Soc Nephrol , vol.25 , Issue.7 , pp. 1415-1429
    • Fiorina, P.1    Vergani, A.2    Bassi, R.3
  • 117
    • 51349162919 scopus 로고    scopus 로고
    • The actin cytoskeleton of kidney podocytes is a direct target of the antiproteinuric effect of cyclosporine A
    • Faul C, Donnelly M, Merscher-Gomez S, et al. The actin cytoskeleton of kidney podocytes is a direct target of the antiproteinuric effect of cyclosporine A. Nat Med 2008;14(9):931-8
    • (2008) Nat Med , vol.14 , Issue.9 , pp. 931-938
    • Faul, C.1    Donnelly, M.2    Merscher-Gomez, S.3
  • 118
    • 79957836560 scopus 로고    scopus 로고
    • Rituximab targets podocytes in recurrent focal segmental glomerulosclerosis
    • Fornoni A, Sageshima J, Wei C. Rituximab targets podocytes in recurrent focal segmental glomerulosclerosis. Sci Transl Med 2011;3(85):85ra46
    • (2011) Sci Transl Med , vol.3 , Issue.85 , pp. 85ra46
    • Fornoni, A.1    Sageshima, J.2    Wei, C.3
  • 119
    • 85047691168 scopus 로고    scopus 로고
    • Induction of B7-1 in podocytes is associated with nephrotic syndrome
    • Reiser J, von Gersdorff G, Loos M, et al. Induction of B7-1 in podocytes is associated with nephrotic syndrome. J Clin Invest 2004;113(10):1390-7
    • (2004) J Clin Invest , vol.113 , Issue.10 , pp. 1390-1397
    • Reiser, J.1    Von Gersdorff, G.2    Loos, M.3
  • 120
    • 84890409760 scopus 로고    scopus 로고
    • Abatacept in B7-1-positive proteinuric kidney disease
    • Yu CC, Fornoni A, Weins A, et al. Abatacept in B7-1-positive proteinuric kidney disease. N Engl J Med 2013;369(25):2416-23
    • (2013) N Engl J Med , vol.369 , Issue.25 , pp. 2416-2423
    • Yu, C.C.1    Fornoni, A.2    Weins, A.3
  • 121
    • 78649361177 scopus 로고    scopus 로고
    • Last accessed 20 March 2015]
    • Efficacy and safety study of abatacept to treat lupus nephritis. Available from: https://clinicaltrials.gov/ct2/results?term=NCT01714817.&Search=Searchhttps://clinicaltrials.gov/ct2/results?term=NCT01714817.&Search=Search [Last accessed 20 March 2015]
    • Efficacy and Safety Study of Abatacept to Treat Lupus Nephritis
  • 122
    • 79960948754 scopus 로고    scopus 로고
    • Rituximab-induced depletion of anti-PLA2R autoantibodies predicts response in membranous nephropathy
    • Beck LH Jr, Fervenza FC, Beck DM, et al. Rituximab-induced depletion of anti-PLA2R autoantibodies predicts response in membranous nephropathy. J Am Soc Nephrol 2011;22(8):1543-50
    • (2011) J Am Soc Nephrol , vol.22 , Issue.8 , pp. 1543-1550
    • Beck, Jr.L.H.1    Fervenza, F.C.2    Beck, D.M.3
  • 123
    • 84928325954 scopus 로고    scopus 로고
    • [Last accessed 20 March 2015]
    • Rituximab in progressive IgA nephropathy. Available from: https://clinicaltrials.gov/ct2/results?term=NCT00498368&Search=Search [Last accessed 20 March 2015]
    • Rituximab in Progressive IgA Nephropathy
  • 124
    • 84928324365 scopus 로고    scopus 로고
    • [Last accessed 20 March 2015]
    • Rituximab to prevent recurrence of proteinuria. Available from: https://clinicaltrials.gov/ct2/results?term=NCT01164098&Search=Search [Last accessed 20 March 2015]
    • Rituximab to Prevent Recurrence of Proteinuria
  • 127
    • 57349158456 scopus 로고    scopus 로고
    • Proteinuria and immunity-an overstated relationship?
    • Mathieson PW. Proteinuria and immunity-an overstated relationship? N Engl J Med 2008;359(23):2492-4
    • (2008) N Engl J Med , vol.359 , Issue.23 , pp. 2492-2494
    • Mathieson, P.W.1
  • 128
    • 33748904355 scopus 로고    scopus 로고
    • The complement inhibitor eculizumab in paroxysmal nocturnal hemoglobinuria
    • Hillmen P, Young NS, Schubert J, et al. The complement inhibitor eculizumab in paroxysmal nocturnal hemoglobinuria. N Engl J Med 2006;355(12):1233-43
    • (2006) N Engl J Med , vol.355 , Issue.12 , pp. 1233-1243
    • Hillmen, P.1    Young, N.S.2    Schubert, J.3
  • 129
    • 84901316827 scopus 로고    scopus 로고
    • Role of monoclonal antibodies in the treatment of immune-mediated glomerular diseases
    • Manrique J, Cravedi P. Role of monoclonal antibodies in the treatment of immune-mediated glomerular diseases. Nefrologia 2014;34(3):388-97
    • (2014) Nefrologia , vol.34 , Issue.3 , pp. 388-397
    • Manrique, J.1    Cravedi, P.2
  • 130
    • 84922373286 scopus 로고    scopus 로고
    • Thrombotic microangiopathy in systemic lupus erythematosus: Efficacy of eculizumab
    • El-Husseini A, Hannan S, Awad A, et al. Thrombotic microangiopathy in systemic lupus erythematosus: efficacy of eculizumab. Am J Kidney Dis 2015;65(1):127-30
    • (2015) Am J Kidney Dis , vol.65 , Issue.1 , pp. 127-130
    • El-Husseini, A.1    Hannan, S.2    Awad, A.3
  • 131
    • 84858661698 scopus 로고    scopus 로고
    • Eculizumab for the treatment of dense-deposit disease
    • Vivarelli M, Pasini A, Emma F. Eculizumab for the treatment of dense-deposit disease. N Engl J Med 2012;366(12):1163-5
    • (2012) N Engl J Med , vol.366 , Issue.12 , pp. 1163-1165
    • Vivarelli, M.1    Pasini, A.2    Emma, F.3
  • 132
    • 84924119716 scopus 로고    scopus 로고
    • Eculizumab for treatment of rapidly progressive c3 glomerulopathy
    • Le Quintrec M, Lionet A, Kandel C, et al. Eculizumab for treatment of rapidly progressive c3 glomerulopathy. Am J Kidney Dis 2015;65(3):484-9
    • (2015) Am J Kidney Dis , vol.65 , Issue.3 , pp. 484-489
    • Le Quintrec, M.1    Lionet, A.2    Kandel, C.3
  • 134
    • 0029764359 scopus 로고    scopus 로고
    • Amelioration of lupus-like autoimmune disease in NZB/WF1 mice after treatment with a blocking monoclonal antibody specific for complement component C5
    • Wang Y, Hu Q, Madri JA, et al. Amelioration of lupus-like autoimmune disease in NZB/WF1 mice after treatment with a blocking monoclonal antibody specific for complement component C5. Proc Natl Acad Sci USA 1996;93(16):8563-8
    • (1996) Proc Natl Acad Sci USA , vol.93 , Issue.16 , pp. 8563-8568
    • Wang, Y.1    Hu, Q.2    Madri, J.A.3
  • 135
    • 68049136123 scopus 로고    scopus 로고
    • SiRNA targeted to p53 attenuates ischemic and cisplatin-induced acute kidney injury
    • Molitoris BA, Dagher PC, Sandoval RM, et al. siRNA targeted to p53 attenuates ischemic and cisplatin-induced acute kidney injury. J Am Soc Nephrol 2009;20(8):1754-64
    • (2009) J Am Soc Nephrol , vol.20 , Issue.8 , pp. 1754-1764
    • Molitoris, B.A.1    Dagher, P.C.2    Sandoval, R.M.3
  • 136
    • 84922873973 scopus 로고    scopus 로고
    • Targeted deletion of p53 in the proximal tubule prevents ischemic renal injury
    • Ying Y, Kim J, Westphal SN, et al. Targeted deletion of p53 in the proximal tubule prevents ischemic renal injury. J Am Soc Nephrol 2014;25(12):2707-160
    • (2014) J Am Soc Nephrol , vol.25 , Issue.12 , pp. 2707-3160
    • Ying, Y.1    Kim, J.2    Westphal, S.N.3
  • 137
    • 77952174830 scopus 로고    scopus 로고
    • Epithelial cell cycle arrest in G2/M mediates kidney fibrosis after injury
    • Yang L, Besschetnova TY, Brooks CR, et al. Epithelial cell cycle arrest in G2/M mediates kidney fibrosis after injury. Nat Med 2010;16(5):535-43
    • (2010) Nat Med , vol.16 , Issue.5 , pp. 535-543
    • Yang, L.1    Besschetnova, T.Y.2    Brooks, C.R.3
  • 138
    • 0037218760 scopus 로고    scopus 로고
    • P53 mediates the apoptotic response to GTP depletion after renal ischemia-reperfusion: Protective role of a p53 inhibitor
    • Kelly KJ, Plotkin Z, Stacey L, et al. P53 mediates the apoptotic response to GTP depletion after renal ischemia-reperfusion: protective role of a p53 inhibitor. J Am Soc Nephrol 2003;14(1):128-38
    • (2003) J Am Soc Nephrol , vol.14 , Issue.1 , pp. 128-138
    • Kelly, K.J.1    Plotkin, Z.2    Stacey, L.3
  • 139
    • 84865442084 scopus 로고    scopus 로고
    • Toxicological and pharmacokinetic properties of chemically modified siRNAs targeting p53 RNA following intravenous administration
    • Thompson JD, Kornbrust DJ, Foy JW, et al. Toxicological and pharmacokinetic properties of chemically modified siRNAs targeting p53 RNA following intravenous administration. Nucleic Acid Ther 2012;22(4):255-64
    • (2012) Nucleic Acid Ther , vol.22 , Issue.4 , pp. 255-264
    • Thompson, J.D.1    Kornbrust, D.J.2    Foy, J.W.3
  • 144
    • 84873719954 scopus 로고    scopus 로고
    • Protective actions of administered mesenchymal stem cells in acute kidney injury: Relevance to clinical trials
    • Westenfelder C, Togel FE. Protective actions of administered mesenchymal stem cells in acute kidney injury: relevance to clinical trials. Kidney Int Suppl 2011;1(3):103-6
    • (2011) Kidney Int Suppl , vol.1 , Issue.3 , pp. 103-106
    • Westenfelder, C.1    Togel, F.E.2
  • 148
    • 84878637915 scopus 로고    scopus 로고
    • Nanomedicines as cancer therapeutics: Current status
    • Akhter S, Ahmad I, Ahmad MZ, et al. Nanomedicines as cancer therapeutics: current status. Curr Cancer Drug Targets 2013;13(4):362-78
    • (2013) Curr Cancer Drug Targets , vol.13 , Issue.4 , pp. 362-378
    • Akhter, S.1    Ahmad, I.2    Ahmad, M.Z.3
  • 149
    • 44049096503 scopus 로고    scopus 로고
    • The death ligand TRAIL in diabetic nephropathy
    • Lorz C, Benito-Martín A, Boucherot A, et al. The death ligand TRAIL in diabetic nephropathy. J Am Soc Nephrol 2008;19(5):904-1
    • (2008) J Am Soc Nephrol , vol.19 , Issue.5 , pp. 904-911
    • Lorz, C.1    Benito-Martín, A.2    Boucherot, A.3
  • 150
    • 67649658244 scopus 로고    scopus 로고
    • M-type phospholipase A2 receptor as target antigen in idiopathic membranous nephropathy
    • Beck LH Jr, Bonegio RG, Lambeau G, et al. M-type phospholipase A2 receptor as target antigen in idiopathic membranous nephropathy. N Engl J Med 2009;361(1):11-21
    • (2009) N Engl J Med , vol.361 , Issue.1 , pp. 11-21
    • Beck, Jr.L.H.1    Bonegio, R.G.2    Lambeau, G.3
  • 151
    • 84923864006 scopus 로고    scopus 로고
    • Identification of a major epitope recognized by PLA2R autoantibodies in primary membranous nephropathy
    • Fresquet M, Jowitt TA, Gummadova J, et al. Identification of a major epitope recognized by PLA2R autoantibodies in primary membranous nephropathy. J Am Soc Nephrol 2015;26(2):302-13
    • (2015) J Am Soc Nephrol , vol.26 , Issue.2 , pp. 302-313
    • Fresquet, M.1    Jowitt, T.A.2    Gummadova, J.3
  • 152
    • 84923919539 scopus 로고    scopus 로고
    • Identification of the immunodominant epitope region in phospholipase a2 receptor-mediating autoantibody binding in idiopathic membranous nephropathy
    • Kao L, Lam V, Waldman M, et al. Identification of the immunodominant epitope region in phospholipase a2 receptor-mediating autoantibody binding in idiopathic membranous nephropathy. J Am Soc Nephrol 2014;26(2):291-301
    • (2014) J Am Soc Nephrol , vol.26 , Issue.2 , pp. 291-301
    • Kao, L.1    Lam, V.2    Waldman, M.3
  • 153
    • 84864415082 scopus 로고    scopus 로고
    • Combination therapy with an angiotensin II receptor blocker and an HMG-CoA reductase inhibitor in experimental subtotal nephrectomy
    • Alvarez-Prats A, Hernández-Perera O, Díaz-Herrera P, et al. Combination therapy with an angiotensin II receptor blocker and an HMG-CoA reductase inhibitor in experimental subtotal nephrectomy. Nephrol Dial Transplant 2012;27(7):2720-33
    • (2012) Nephrol Dial Transplant , vol.27 , Issue.7 , pp. 2720-2733
    • Alvarez-Prats, A.1    Hernández-Perera, O.2    Díaz-Herrera, P.3
  • 154
    • 84890806222 scopus 로고    scopus 로고
    • Dual RAS blockade-controversy resolved
    • Ruggenenti P, Remuzzi G. Dual RAS blockade-controversy resolved. Nat Rev Nephrol 2013;9(11):640
    • (2013) Nat Rev Nephrol , vol.9 , Issue.11 , pp. 640
    • Ruggenenti, P.1    Remuzzi, G.2
  • 155
    • 84877930774 scopus 로고    scopus 로고
    • Analogs of bardoxolone methyl worsen diabetic nephropathy in rats with additional adverse effects
    • Zoja C, Corna D, Nava V, et al. Analogs of bardoxolone methyl worsen diabetic nephropathy in rats with additional adverse effects. Am J Physiol Renal Physiol 2013;304(6):F808-19
    • (2013) Am J Physiol Renal Physiol , vol.304 , Issue.6 , pp. F808-F819
    • Zoja, C.1    Corna, D.2    Nava, V.3
  • 156
    • 84904041193 scopus 로고    scopus 로고
    • Risk factors for heart failure in patients with type 2 diabetes mellitus and stage 4 chronic kidney disease treated with bardoxolone methyl
    • Chin MP, Wrolstad D, Bakris G, et al. Risk factors for heart failure in patients with type 2 diabetes mellitus and stage 4 chronic kidney disease treated with bardoxolone methyl. J Card Fail 2014;20(12):953-8
    • (2014) J Card Fail , vol.20 , Issue.12 , pp. 953-958
    • Chin, M.P.1    Wrolstad, D.2    Bakris, G.3
  • 157
    • 64049100064 scopus 로고    scopus 로고
    • Additive effects of soluble TWEAK and inflammation on mortality in hemodialysis patients
    • Carrero JJ, Ortiz A, Qureshi AR, et al. Additive effects of soluble TWEAK and inflammation on mortality in hemodialysis patients. Clin J Am Soc Nephrol 2009;4(1):110-18
    • (2009) Clin J Am Soc Nephrol , vol.4 , Issue.1 , pp. 110-118
    • Carrero, J.J.1    Ortiz, A.2    Qureshi, A.R.3
  • 158
    • 73849087983 scopus 로고    scopus 로고
    • Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) enhances vascular and renal damage induced by hyperlipidemic diet in ApoE-knockout mice
    • Muñoz-García B, Moreno JA, López-Franco O, et al. Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) enhances vascular and renal damage induced by hyperlipidemic diet in ApoE-knockout mice. Arterioscler Thromb Vasc Biol 2009;29(12):2061-8
    • (2009) Arterioscler Thromb Vasc Biol , vol.29 , Issue.12 , pp. 2061-2068
    • Muñoz-García, B.1    Moreno, J.A.2    López-Franco, O.3
  • 159
    • 77749282951 scopus 로고    scopus 로고
    • TWEAK activates the non-canonical NFkappaB pathway in murine renal tubular cells: Modulation of CCL21
    • Sanz AB, Sanchez-Niño MD, Izquierdo MC, et al. TWEAK activates the non-canonical NFkappaB pathway in murine renal tubular cells: modulation of CCL21. PLoS One 2010;5(1):e8955
    • (2010) PLoS One , vol.5 , Issue.1 , pp. e8955
    • Sanz, A.B.1    Sanchez-Niño, M.D.2    Izquierdo, M.C.3
  • 160
    • 79960144041 scopus 로고    scopus 로고
    • The inflammatory cytokines TWEAK and TNFa reduce renal Klotho expression through NFkB
    • Moreno JA, Izquierdo MC, Sanchez-Niño MD, et al. The inflammatory cytokines TWEAK and TNFa reduce renal Klotho expression through NFkB. J Am Soc Nephrol 2011;22(7):1315-25
    • (2011) J Am Soc Nephrol , vol.22 , Issue.7 , pp. 1315-1325
    • Moreno, J.A.1    Izquierdo, M.C.2    Sanchez-Niño, M.D.3
  • 161
    • 84861192529 scopus 로고    scopus 로고
    • TWEAK (tumor necrosis factor-like weak inducer of apoptosis) activates CXCL16 expression during renal tubulointerstitial inflammation
    • Izquierdo MC, Sanz AB, Mezzano S, et al. TWEAK (tumor necrosis factor-like weak inducer of apoptosis) activates CXCL16 expression during renal tubulointerstitial inflammation. Kidney Int 2012;81(11):1098-107
    • (2012) Kidney Int , vol.81 , Issue.11 , pp. 1098-1107
    • Izquierdo, M.C.1    Sanz, A.B.2    Mezzano, S.3
  • 162
    • 84887506537 scopus 로고    scopus 로고
    • TWEAK transactivation of the epidermal growth factor receptor mediates renal inflammation
    • Rayego-Mateos S, Morgado-Pascual JL, Sanz AB, et al. TWEAK transactivation of the epidermal growth factor receptor mediates renal inflammation. J Pathol 2013;231(4):480-94
    • (2013) J Pathol , vol.231 , Issue.4 , pp. 480-494
    • Rayego-Mateos, S.1    Morgado-Pascual, J.L.2    Sanz, A.B.3
  • 163
    • 84925689973 scopus 로고    scopus 로고
    • TNF-related weak inducer of apoptosis (TWEAK) regulates junctional proteins in tubular epithelial cells via canonical NF-kB pathway and ERK activation
    • [Epub ahead of print]
    • Berzal S, González-Guerrero C, Rayego-Mateos S, et al. TNF-related weak inducer of apoptosis (TWEAK) regulates junctional proteins in tubular epithelial cells via canonical NF-kB pathway and ERK activation. J Cell Physiol 2014. [Epub ahead of print]
    • (2014) J Cell Physiol
    • Berzal, S.1    González-Guerrero, C.2    Rayego-Mateos, S.3
  • 164
    • 42049107348 scopus 로고    scopus 로고
    • Telmisartan ramipril or both in patients at high risk for vascular events
    • ONTARGET Investigators. Yusuf S, Teo KK, Pogue J, et al. Telmisartan, ramipril, or both in patients at high risk for vascular events. N Engl J Med 2008;358(15):1547-59
    • (2008) N Engl J Med , vol.358 , Issue.15 , pp. 1547-1559
    • Yusuf, S.1    Teo, K.K.2    Pogue, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.