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Ucero AC, Benito-Martin A, Fuentes-Calvo I, et al. TNF-related weak inducer of apoptosis (TWEAK) promotes kidney fibrosis and Ras-dependent proliferation of cultured renal fibroblast. Biochim Biophys Acta 2013; 1832:1744-1755. A recent original study exploring in-depth the role of TWEAK in kidney fibrosis when the insult is persistent and delineating the TWEAK actions on renal fibroblast.
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Inflammatory cytokines and survival factors from serum modulate TWEAK-induced apoptosis in PC-3 prostate cancer cells
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Sanz AB, Sanchez-Nino MD, Carrasco S, et al. Inflammatory cytokines and survival factors from serum modulate TWEAK-induced apoptosis in PC-3 prostate cancer cells. PLoS One 2012; 7:e47440. This study explores how altering the tumor cell microenvironment may turn a proliferative response to TWEAK into a lethal signal. It may have application to kidney cancer.
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Ucero AC, Berzal S, Ocana-Salceda C, et al. A polymeric nanomedicine diminishes inflammatory events in renal tubular cells. PLoS One 2013; 8:e51992. This study describes the key role of JAK2 in TWEAK-induced inflammation and therapeutic modulation of TWEAK-elicited responses by the nanomolecule QM-56.
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A recent finding showing a novel mechanism involved in TWEAK-mediated renal inflammation, the activation of the EGFR pathway, which is independent of NF-kB activation
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