Adrenocorticotropic hormone ameliorates acute kidney injury by steroidogenic-dependent and-independent mechanisms

Kidney International

Volumn 83, Issue 4, 2013, Pages 635-646

  Si, Jin ^a,b   Ge, Yan ^a   Zhuang, Shougang ^a   Juan Wang, Li ^c   Chen, Shan ^d   Gong, Rujun ^a  

^a RHODE ISLAND HOSPITAL   (United States)

^b THE SECOND AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

^c ROGER WILLIAMS MEDICAL CENTER   (United States)

^d THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

acute kidney injury; adrenocorticotropic hormone; apoptosis; melanocortin; melanocortin receptor; rodent

Indexed keywords

CILASTATIN PLUS IMIPENEM; CORTICOTROPIN; MELANOCORTIN 1 RECEPTOR; TUMOR NECROSIS FACTOR;

ACUTE KIDNEY FAILURE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; DRUG DOSE COMPARISON; DRUG MECHANISM; FLUOROMETRY; HOMEOSTASIS; IMMUNOCYTOCHEMISTRY; KIDNEY DYSFUNCTION; KIDNEY TUBULE; MALE; MEAN ARTERIAL PRESSURE; MORPHOLOGY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OPTIMAL DRUG DOSE; PRIORITY JOURNAL; PROBABILITY; PROTEIN EXPRESSION; RAT; RENAL PROTECTION; RNA INTERFERENCE; STEROIDOGENESIS; SURVIVAL RATE;

EID: 84875697942     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/ki.2012.447     Document Type: Article

References (45)

1. Devarajan P. Biomarkers for the early detection of acute kidney injury. Curr Opin Pediatr 2011; 23: 194-200.
2. Siew ED, Ware LB, Ikizler TA. Biological markers of acute kidney injury. J Am Soc Nephrol 2011; 22: 810-820.
3. Vaidya VS, Ford GM, Waikar SS et al. A rapid urine test for early detection of kidney injury. Kidney Int 2009; 76: 108-114.
4. Murray P, Udani S, Koyner JL. Does renal replacement therapy improve outcome? Controversies in acute kidney injury. Contrib Nephrol 2011; 174: 212-221.
5. Palevsky PM. Renal support in acute kidney injury-how much is enough? N Engl J Med 2009; 361: 1699-1701.
6. Jo SK, Rosner MH, Okusa MD. Pharmacologic treatment of acute kidney injury: why drugs haven't worked and what is on the horizon. Clin J Am Soc Nephrol 2007; 2: 356-365.
7. Sharfuddin AA, Molitoris BA. Pathophysiology of ischemic acute kidney injury. Nat Rev Nephrol 2011; 7: 189-200.
8. Dores RM. Adrenocorticotropic hormone, melanocyte-stimulating hormone, and the melanocortin receptors: revisiting the work of Robert Schwyzer: a thirty-year retrospective. Ann N Y Acad Sci 2009; 1163: 93-100.
9. Gong R. The renaissance of corticotropin therapy in proteinuric nephropathies. Nat Rev Nephrol 2012; 8: 122-128.
10. Arneil GC, Wilson HE. A.C.T.H. in nephrosis. Arch Dis Child 1953; 28: 372-380.
11. Berg AL, Arnadottir M. ACTH revisited-potential implications for patients with renal disease. Nephrol Dial Transplant 2000; 15: 940-942.
12. Bomback AS, Radhakrishnan J. Treatment of nephrotic syndrome with adrenocorticotropic hormone (ACTH). Discov Med 2011; 12: 91-96.
13. Cone RD. Studies on the physiological functions of the melanocortin system. Endocr Rev 2006; 27: 736-749.
14. Blagaic V, Houra K, Turcic P et al. The influence of alpha-, beta-, and gamma-melanocyte stimulating hormone on acetaminophen induced liver lesions in male CBA mice. Molecules 2010; 15: 1232-1241.
15. Kohda Y, Chiao H, Star RA. Alpha-melanocyte-stimulating hormone and acute renal failure. Curr Opin Nephrol Hypertens 1998; 7: 413-417.
16. Doi K, Hu X, Yuen PS et al. AP214, an analogue of alpha- melanocytestimulating hormone, ameliorates sepsis-induced acute kidney injury and mortality. Kidney Int 2008; 73: 1266-1274.
17. Vecsernyes M, Juhasz B, Der P et al. The administration of alphamelanocyte-stimulating hormone protects the ischemic/reperfused myocardium. Eur J Pharmacol 2003; 470: 177-183.
18. Huang Q, Tatro JB. Alpha-melanocyte stimulating hormone suppresses intracerebral tumor necrosis factor-alpha and interleukin-1beta gene expression following transient cerebral ischemia in mice. Neurosci Lett 2002; 334: 186-190.
19. Hassoun HT, Zou L, Moore FA et al. Alpha-melanocyte-stimulating hormone protects against mesenteric ischemia-reperfusion injury. Am J Physiol Gastrointest Liver Physiol 2002; 282: G1059-G1068.
20. Kettelhut IC, Fiers W, Goldberg AL. The toxic effects of tumor necrosis factor in vivo and their prevention by cyclooxygenase inhibitors. Proc Natl Acad Sci USA 1987; 84: 4273-4277.
21. Cauwels A, Janssen B, Waeytens A et al. Caspase inhibition causes hyperacute tumor necrosis factor-induced shock via oxidative stress and phospholipase A2. Nat Immunol 2003; 4: 387-393.
22. Gong R, Rifai A, Dworkin LD. Hepatocyte growth factor suppresses acute renal inflammation by inhibition of endothelial E-selectin. Kidney Int 2006; 69: 1166-1174.
23. Doi K, Leelahavanichkul A, Yuen PS et al. Animal models of sepsis and sepsis-induced kidney injury. J Clin Invest 2009; 119: 2868-2878.
24. Zarjou A, Agarwal A. Sepsis and acute kidney injury. J Am Soc Nephrol 2011; 22: 999-1006.
25. Bao H, Ge Y, Zhuang S et al. Inhibition of glycogen synthase kinase-3beta prevents NSAID-induced acute kidney injury. Kidney Int 2012; 81: 662-673.
26. Nelson PJ, Cantley L. GSK3beta plays dirty in acute kidney injury. J Am Soc Nephrol 2010; 21: 199-200.
27. Catania A. The melanocortin system in leukocyte biology. J Leukoc Biol 2007; 81: 383-392.
28. Kumar S, Allen DA, Kieswich JE et al. Dexamethasone ameliorates renal ischemia-reperfusion injury. J Am Soc Nephrol 2009; 20: 2412-2425.
29. Turner S, Derham C, Orsi NM et al. Randomized clinical trial of the effects of methylprednisolone on renal function after major vascular surgery. Br J Surg 2008; 95: 50-56.
30. Rhen T, Cidlowski JA. Antiinflammatory action of glucocorticoids-new mechanisms for old drugs. N Engl J Med 2005; 353: 1711-1723.
31. Chiao H, Kohda Y, McLeroy P et al. Alpha-melanocyte-stimulating hormone protects against renal injury after ischemia in mice and rats. J Clin Invest 1997; 99: 1165-1172.
32. Chiao H, Kohda Y, McLeroy P et al. Alpha-melanocyte-stimulating hormone inhibits renal injury in the absence of neutrophils. Kidney Int 1998; 54: 765-774.
33. Gong H, Wang W, Kwon TH et al. EPO and alpha-MSH prevent ischemia/reperfusion-induced down-regulation of AQPs and sodium transporters in rat kidney. Kidney Int 2004; 66: 683-695.
34. Kolgazi M, Arbak S, Alican I. The effect of alpha-melanocyte stimulating hormone on gentamicin-induced acute nephrotoxicity in rats. J Appl Toxicol 2007; 27: 183-188.
35. Lee SY, Jo SK, Cho WY et al. The effect of alpha-melanocyte-stimulating hormone on renal tubular cell apoptosis and tubulointerstitial fibrosis in cyclosporine A nephrotoxicity. Transplantation 2004; 78: 1756-1764.
36. Li C, Shi Y, Wang W et al. Alpha-MSH prevents impairment in renal function and dysregulation of AQPs and Na-K-ATPase in rats with bilateral ureteral obstruction. Am J Physiol Renal Physiol 2006; 290: F384-F396.
37. Maaser C, Kannengiesser K, Specht C et al. Crucial role of the melanocortin receptor MC1R in experimental colitis. Gut 2006; 55: 1415-1422.
38. Hauser JE, Kadekaro AL, Kavanagh RJ et al. Melanin content and MC1R function independently affect UVR-induced DNA damage in cultured human melanocytes. Pigment Cell Res 2006; 19: 303-314.
39. Abdel-Malek ZA, Ruwe A, Kavanagh-Starner R et al. Alpha-MSH tripeptide analogs activate the melanocortin 1 receptor and reduce UV-induced DNA damage in human melanocytes. Pigment Cell Melanoma Res 2009; 22: 635-644.
40. Kinsey GR, Li L, Okusa MD. Inflammation in acute kidney injury. Nephron Exp Nephrol 2008; 109: e102-e107.
41. Goncalves GM, Zamboni DS, Camara NO. The role of innate immunity in septic acute kidney injuries. Shock 2010; 34(Suppl 1): 22-26.
42. Chen S, Ge Y, Si J et al. Candesartan suppresses chronic renal inflammation by a novel antioxidant action independent of AT1R blockade. Kidney Int 2008; 74: 1128-1138.
43. Whitesall SE, Hoff JB, Vollmer AP et al. Comparison of simultaneous measurement of mouse systolic arterial blood pressure by radiotelemetry and tail-cuff methods. Am J Physiol Heart Circ Physiol 2004; 286: H2408-H2415.
44. Rojas M, Woods CR, Mora AL et al. Endotoxin-induced lung injury in mice: structural, functional, and biochemical responses. Am J Physiol Lung Cell Mol Physiol 2005; 288: L333-L341.
45. Keppler A, Gretz N, Schmidt R et al. Plasma creatinine determination in mice and rats: an enzymatic method compares favorably with a highperformance liquid chromatography assay. Kidney Int 2007; 71: 74-78.