Identification of the immunodominant epitope region in phospholipase a2 receptor-mediating autoantibody binding in idiopathic membranous nephropathy

Journal of the American Society of Nephrology

Volumn 26, Issue 2, 2015, Pages 291-301

  Kao, Liyo ^a   Lam, Vinson ^a   Waldman, Meryl ^b   Glassock, Richard J ^a   Zhu, Quansheng ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; BIOLOGICAL MARKER; C TYPE LECTIN LIKE DOMAIN 1 PROTEIN; CYSTEINE; EPITOPE; FIBRONECTIN; FIBRONECTIN II; PHOSPHOLIPASE A2 RECEPTOR; UNCLASSIFIED DRUG; LECTIN;

ANTIGEN BINDING; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; GENETIC POLYMORPHISM; HUMAN; IMMUNOBLOTTING; MEMBRANOUS GLOMERULONEPHRITIS; MOLECULAR RECOGNITION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN ISOLATION; PROTEIN STRUCTURE; BLOOD; CHEMISTRY; HEK293 CELL LINE; IMMUNOLOGY; PATHOLOGY; PODOCYTE;

AUTOANTIBODIES; CYSTEINE; FIBRONECTINS; GLOMERULONEPHRITIS, MEMBRANOUS; HEK293 CELLS; HUMANS; IMMUNODOMINANT EPITOPES; LECTINS, C-TYPE; PODOCYTES; RECEPTORS, PHOSPHOLIPASE A2;

EID: 84923919539     PISSN: 10466673     EISSN: 15333450     Source Type: Journal    
DOI: 10.1681/ASN.2013121315     Document Type: Article

References (29)

1. Glassock RJ: Pathogenesis of membranous nephropathy: A new paradigm in evolution. Contrib Nephrol 181: 131-142, 2013
2. Glassock RJ: The pathogenesis of membranous nephropathy: Evolution and revolution. Curr Opin Nephrol Hypertens 21: 235-242, 2012
3. Glassock RJ: Secondary membranous glomerulonephritis. Nephrol Dial Transplant 7[Suppl 1]: 64-71, 1992
4. Ronco P, Debiec H: Membranous glomerulopathy: The evolving story. Curr Opin Nephrol Hypertens 19: 254-259, 2010
5. Ronco P, Debiec H: Molecular pathomechanisms of membranous nephropathy: From Heymann nephritis to alloimmunization. J Am Soc Nephrol 16: 1205-1213, 2005
6. Makker SP, Tramontano A: Idiopathic membranous nephropathy: An autoimmune disease. Semin Nephrol 31: 333-340, 2011
7. Jefferson JA, Pippin JW, Shankland SJ: Experimental models of membranous nephropathy. Drug Discov Today Dis Models 7: 27-33, 2010
8. Beck LH Jr., Bonegio RG, Lambeau G, Beck DM, Powell DW, Cummins TD, Klein JB, Salant DJ: M-type phospholipase A2 receptor as target antigen in idiopathic membranous nephropathy. N Engl J Med 361: 11-21, 2009
9. Ma H, Beck LH Jr., Salant DJ: Membranous nephropathy-associated anti-phospholipase A2 receptor IgG4 autoantibodies activate the lectin complement pathway. J Am Soc Nephrol 22: 62A, 2011
10. Kerjaschki D, Farquhar MG: The pathogenic antigen of Heymann nephritis is a membrane glycoprotein of the renal proximal tubule brush border. Proc Natl Acad Sci U S A 79: 5557-5561, 1982
11. Kerjaschki D, Farquhar MG: Immunocytochemical localization of the Heymann nephritis antigen (GP330) in glomerular epithelial cells of normal Lewis rats. J Exp Med 157: 667-686, 1983
12. Beck LH Jr., Salant DJ: Membranous nephropathy: Recent travels and new roads ahead. Kidney Int 77: 765-770, 2010
13. Ronco P, Debiec H: Target antigens and nephritogenic antibodies in membranous nephropathy: Of rats and men. Semin Immunopathol 29: 445-458, 2007
14. Debiec H, Guigonis V, Mougenot B, Decobert F, Haymann JP, Bensman A, Deschênes G, Ronco PM: Antenatal membranous glomerulonephritis due to anti-neutral endopeptidase antibodies. N Engl J Med 346: 2053-2060, 2002
15. Kanigicherla D, Gummadova J, McKenzie EA, Roberts SA, Harris S, Nikam M, Poulton K, McWilliam L, Short CD, Venning M, Brenchley PE: Anti-PLA2R antibodies measured by ELISA predict long-term outcome in a prevalent population of patients with idiopathic membranous nephropathy. Kidney Int 83: 940-948, 2013
16. Yokota Y, Higashino K, Nakano K, Arita H, Hanasaki K: Identification of group X secretory phospholipase A(2) as a natural ligand for mouse phospholipase A(2) receptor. FEBS Lett 478: 187-191, 2000
17. Silliman CC, Moore EE, Zallen G, Gonzalez R, Johnson JL, Elzi DJ, Meng X, Hanasaki K, Ishizaki J, Arita H, Ao L, England KM, Banerjee A: Presence of the M-type sPLA(2) receptor on neutrophils and its role in elastase release and adhesion. Am J Physiol Cell Physiol 283: C1102-C1113, 2002
18. Llorca O: Extended and bent conformations of the mannose receptor family. Cell Mol Life Sci 65: 1302-1310, 2008
19. East L, Isacke CM: The mannose receptor family. Biochim Biophys Acta 1572: 364-386, 2002
20. Zvaritch E, Lambeau G, Lazdunski M: Endocytic properties of the M-type 180-kDa receptor for secretory phospholipases A2. J Biol Chem 271: 250-257, 1996
21. Hanasaki K, Arita H: Phospholipase A2 receptor: A regulator of biological functions of secretory phospholipase A2. Prostaglandins Other Lipid Mediat 68-69: 71-82, 2002
22. Murakami M, Taketomi Y, Girard C, Yamamoto K, Lambeau G: Emerging roles of secreted phospholipase A2 enzymes: Lessons from transgenic and knockout mice. Biochimie 92: 561-582, 2010
23. Augert A, Payré C, de Launoit Y, Gil J, Lambeau G, Bernard D: The M-type receptor PLA2R regulates senescence through the p53 pathway. EMBO Rep 10: 271-277, 2009
24. Boskovic J, Arnold JN, Stilion R, Gordon S, Sim RB, Rivera-Calzada A, Wienke D, Isacke CM, Martinez-Pomares L, Llorca O: Structural model for the mannose receptor family uncovered by electron microscopy of Endo180 and the mannose receptor. J Biol Chem 281: 8780-8787, 2006
25. Coenen MJ, Hofstra JM, Debiec H, Stanescu HC, Medlar AJ, Stengel B, Boland-Augé A, Groothuismink JM, Bockenhauer D, Powis SH, Mathieson PW, Brenchley PE, Kleta R, Wetzels JF, Ronco P: Phospholipase A2 receptor (PLA2R1) sequence variants in idiopathic membranous nephropathy. J Am Soc Nephrol 24: 677-683, 2013
26. Stanescu HC, Arcos-Burgos M, Medlar A, Bockenhauer D, Kottgen A, Dragomirescu L, Voinescu C, Patel N, Pearce K, Hubank M, Stephens HA, Laundy V, Padmanabhan S, Zawadzka A, Hofstra JM, Coenen MJ, den Heijer M, Kiemeney LA, Bacq-Daian D, Stengel B, Powis SH, Brenchley P, Feehally J, Rees AJ, Debiec H, Wetzels JF, Ronco P, Mathieson PW, Kleta R: Risk HLA-DQA1 and PLA(2)R1 alleles in idiopathic membranous nephropathy. N Engl J Med 364: 616-626, 2011
27. Behnert A, Fritzler MJ, Teng B, Zhang M, Bollig F, Haller H, Skoberne A, Mahler M, Schiffer M: An anti-phospholipase A2 receptor quantitative immunoassay and epitope analysis in membranous nephropathy reveals different antigenic domains of the receptor. PLoS ONE 8: e61669, 2013
28. Fresquet M, Jowitt TA, Gummadova JO, McKenzie EA, Lennon R, Brenchley PE: Understanding the structure of PLA2R: Insights into formation of the immunodominant epitope recognized by autoantibodies in patients with idiopathic membranous nephropathy. J Am Soc Nephrol 24: 21A, 2013
29. Salant DJ: Genetic variants in membranous nephropathy: Perhaps a perfect storm rather than a straightforward conformeropathy? J Am Soc Nephrol 24: 525-528, 2013