Experimental evidence for the use of CCR2 antagonists in the treatment of type 2 diabetes

Metabolism: Clinical and Experimental

Volumn 62, Issue 11, 2013, Pages 1623-1632

  Sullivan, Timothy J ^a   Miao, Zhenhua ^a   Zhao, Bin N ^a   Ertl, Linda S ^a   Wang, Yu ^a   Krasinski, Antoni ^a   Walters, Matthew J ^a   Powers, Jay P ^a   Dairaghi, Daniel J ^a   Baumgart, Trageen ^a   Seitz, Lisa C ^a   Berahovich, Robert D ^a   Schall, Thomas J ^a   Jaen, Juan C ^a  

^a ChemoCentryx Inc   (United States)

Author keywords

Adipose; Hyperglycemia; Insulin; Macrophage; MCP 1

Indexed keywords

ADIPONECTIN; CCX 417; CCX140; CHEMOKINE RECEPTOR CCR2; CHEMOKINE RECEPTOR CCR2 ANTAGONIST; GLUCOSE; GLUCOSE 6 PHOSPHATASE; GLYCOGEN; INSULIN; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ADIPOSE TISSUE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GLUCOSE URINE LEVEL; GLYCOGEN LIVER LEVEL; HUMAN; HUMAN CELL; HYPERGLYCEMIA; INFLAMMATION; INSULIN SENSITIVITY; INSULINEMIA; INTRAABDOMINAL FAT; LIVER METABOLISM; MACROPHAGE; MALE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PANCREAS ISLET; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION; STEADY STATE; URINE VOLUME;

ADIPOSE; ADIPOSE TISSUE; AT; DIET-INDUCED OBESE; DIO; G-6-PASE; GLUCOSE-6-PHOSPHATASE); HFD; HIGH-FAT DIET; HYPERGLYCEMIA; INSULIN; MACROPHAGE; MCP-1; RECEPTOR ENGAGEMENT INDEX; REI; T2D; TYPE 2 DIABETES;

ADIPONECTIN; ADIPOSE TISSUE; ANIMALS; BIOLOGICAL MARKERS; BLOOD GLUCOSE; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 2; DIET, HIGH-FAT; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUCOSE-6-PHOSPHATASE; GLYCOGEN; GLYCOSURIA; HYPOGLYCEMIC AGENTS; INFLAMMATION; INSULIN; INSULIN RESISTANCE; INSULIN-SECRETING CELLS; LIVER; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; OBESITY; RECEPTORS, CCR2; TRIGLYCERIDES;

EID: 84886415833     PISSN: 00260495     EISSN: 15328600     Source Type: Journal    
DOI: 10.1016/j.metabol.2013.06.008     Document Type: Article

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