Targeted inhibition of renal Rho kinase reduces macrophage infiltration and lymphangiogenesis in acute renal allograft rejection

European Journal of Pharmacology

Volumn 694, Issue 1-3, 2012, Pages 111-119

  Poosti, Fariba ^a   Yazdani, Saleh ^a   Dolman, M Emmy M ^b   Jan Kok, Robbert ^b   Chen, Cheng ^a,c   Ding, Guohua ^c   Lacombe, Marie ^d   Prakash, Jai ^a   Van Den Born, Jacob ^a   Hillebrands, Jan Luuk ^a   Van Goor, Harry ^a   De Borst, Martin H ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b UTRECHT UNIVERSITY   (Netherlands)

^c RENMIN HOSPITAL OF WUHAN UNIVERSITY   (China)

^d Kreatech Biotechnology BV   (Netherlands)

Author keywords

Drug targeting; Kidney transplantation; Lymphangiogenesis; Macrophage; Rho kinase

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; LYSOZYME; PROCOLLAGEN; RHO KINASE; SODIUM CHLORIDE; VIMENTIN;

ACUTE GRAFT REJECTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CELL INFILTRATION; CELL LINE; CONTROLLED STUDY; DRUG CONJUGATION; DRUG RELEASE; ENZYME INHIBITION; GENE EXPRESSION; IMMUNOSUPPRESSIVE TREATMENT; INFLAMMATION; KIDNEY ALLOGRAFT REJECTION; KIDNEY PROXIMAL TUBULE; KIDNEY TRANSPLANTATION; KIDNEY TUBULE CELL; LYMPHANGIOGENESIS; MACROPHAGE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RAT STRAIN; SYSTOLIC BLOOD PRESSURE;

AMIDES; ANIMALS; CHEMOKINE CCL2; EPITHELIAL CELLS; EPITHELIAL-MESENCHYMAL TRANSITION; FIBROSIS; GENE EXPRESSION REGULATION; GRAFT REJECTION; KIDNEY TRANSPLANTATION; KIDNEY TUBULES, PROXIMAL; LYMPHANGIOGENESIS; MACROPHAGES; MALE; PROTEIN KINASE INHIBITORS; PYRIDINES; RATS; RHO-ASSOCIATED KINASES;

EID: 84867335395     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2012.08.010     Document Type: Article

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