Antiapoptotic properties of recombinant human erythropoietin protects against tubular cyclosporine toxicity

Pharmacological Research

Volumn 61, Issue 1, 2010, Pages 71-75

  Pallet, Nicolas ^a   Bouvier, Nicolas ^a   Legendre, Christophe ^b   Beaune, Philippe ^a   Thervet, Eric ^a,b   Choukroun, Gabriel ^c   Martinez, Frank ^b  

^a INSERM   (France)

^b HÔPITAL NECKER ENFANTS MALADES   (France)

^c UNIVERSITÉ DE PICARDIE JULES VERNE   (France)

Author keywords

Apoptosis; Cyclosporine; Epoetin ; Erythropoietin; Human recombinant; Nephrotoxicity; Renal epithelium

Indexed keywords

CASPASE 3; CYCLOSPORIN; OLIVE OIL; PROTEIN KINASE B; RECOMBINANT ERYTHROPOIETIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DRUG TARGETING; ENZYME ACTIVATION; ENZYME DEGRADATION; ENZYME PHOSPHORYLATION; HISTOPATHOLOGY; KIDNEY TUBULE DAMAGE; KIDNEY TUBULE NECROSIS; MALE; NEPHROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RENAL PROTECTION; SIGNAL TRANSDUCTION;

ACUTE DISEASE; ANIMALS; APOPTOSIS; BIOLOGICAL MARKERS; BLOTTING, WESTERN; CASPASE 3; CREATININE; CYCLOSPORINE; CYTOPROTECTION; DISEASE MODELS, ANIMAL; ERYTHROPOIETIN, RECOMBINANT; HUMANS; IN SITU NICK-END LABELING; KIDNEY CORTEX NECROSIS; KIDNEY TUBULES; MALE; NECROSIS; PHOSPHORYLATION; PROTECTIVE AGENTS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION;

EID: 72749093288     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2009.08.010     Document Type: Article

References (28)

1. Halloran P.F. Immunosuppressive drugs for kidney transplantation. N Engl J Med 351 26 (2004) 2715
2. Nankivell B.J., Borrows R.J., Fung C.L., O'Connell P.J., Allen R.D., and Chapman J.R. The natural history of chronic allograft nephropathy. N Engl J Med 349 24 (2003) 2326
3. Nankivell B.J., Borrows R.J., Fung C.L., O'Connell P.J., Chapman J.R., and Allen R.D. Calcineurin inhibitor nephrotoxicity: longitudinal assessment by protocol histology. Transplantation 78 4 (2004) 557
4. Nankivell B.J., and Chapman J.R. Chronic allograft nephropathy: current concepts and future directions. Transplantation 81 5 (2006) 643
5. Perico N., Cattaneo D., Sayegh M.H., and Remuzzi G. Delayed graft function in kidney transplantation. Lancet 364 9447 (2004) 1814
6. Novick A.C., Hwei H.H., Steinmuller D., Streem S.B., Cunningham R.J., Steinhilber D., et al. Detrimental effect of cyclosporine on initial function of cadaver renal allografts following extended preservation. Results of a randomized prospective study. Transplantation 42 2 (1986) 154
7. Szczech L.A., Berlin J.A., Aradhye S., Grossman R.A., and Feldman H.I. Effect of anti-lymphocyte induction therapy on renal allograft survival: a meta-analysis. J Am Soc Nephrol 8 11 (1997) 1771
8. Goggins W.C., Pascual M.A., Powelson J.A., Magee C., Tolkoff-Rubin N., Farrell M.L., et al. A prospective, randomized, clinical trial of intraoperative versus postoperative Thymoglobulin in adult cadaveric renal transplant recipients. Transplantation 76 5 (2003) 798
9. Campistol J.M., and Sacks S.H. Mechanisms of nephrotoxicity. Transplantation 69 Suppl 12 (2000) SS5
10. Justo P., Lorz C., Sanz A., Egido J., and Ortiz A. Intracellular mechanisms of cyclosporin A-induced tubular cell apoptosis. J Am Soc Nephrol 14 12 (2003) 3072
11. Scheid M.P., and Woodgett J.R. PKB/AKT: functional insights from genetic models. Nat Rev Mol Cell Biol 2 10 (2001) 760
12. Sanz A.B., Santamaria B., Ruiz-Ortega M., Egido J., and Ortiz A. Mechanisms of renal apoptosis in health and disease. J Am Soc Nephrol 19 9 (2008) 1634
13. Taylor R.C., Cullen S.P., and Martin S.J. Apoptosis: controlled demolition at the cellular level. Nat Rev Mol Cell Biol 9 3 (2008) 231
14. Remy I., Wilson I.A., and Michnick S.W. Erythropoietin receptor activation by a ligand-induced conformation change. Science 283 5404 (1999) 990
15. Fisher J.W. Erythropoietin: physiology and pharmacology update. Exp Biol Med (Maywood) 228 1 (2003) 1
16. Jelkmann W. Molecular biology of erythropoietin. Intern Med 43 8 (2004) 649
17. Yoshimura A., and Misawa H. Physiology and function of the erythropoietin receptor. Curr Opin Hematol 5 3 (1998) 171
18. Digicaylioglu M., and Lipton S.A. Erythropoietin-mediated neuroprotection involves cross-talk between Jak2 and NF-kappaB signalling cascades. Nature 412 6847 (2001) 641
19. Grimm C., Wenzel A., Groszer M., Mayser H., Seeliger M., Samardzija M., et al. HIF-1-induced erythropoietin in the hypoxic retina protects against light-induced retinal degeneration. Nat Med 8 7 (2002) 718
20. Lappin T.R., Maxwell A.P., and Johnston P.G. EPO's alter ego: erythropoietin has multiple actions. Stem Cells 20 6 (2002) 485
21. Sharples E.J., Patel N., Brown P., Stewart K., Mota-Philipe H., Sheaff M., et al. Erythropoietin protects the kidney against the injury and dysfunction caused by ischemia-reperfusion. J Am Soc Nephrol 15 8 (2004) 2115
22. Westenfelder C., Biddle D.L., and Baranowski R.L. Human, rat, and mouse kidney cells express functional erythropoietin receptors. Kidney Int 55 3 (1999) 808
23. Lee S.H., Li C., Lim S.W., Ahn K.O., Choi B.S., Kim Y.S., et al. Attenuation of interstitial inflammation and fibrosis by recombinant human erythropoietin in chronic cyclosporine nephropathy. Am J Nephrol 25 1 (2005) 64
24. Salahudeen A.K., Haider N., Jenkins J., Joshi M., Patel H., Huang H., et al. Antiapoptotic properties of erythropoiesis-stimulating proteins in models of cisplatin-induced acute kidney injury. Am J Physiol Renal Physiol 294 6 (2008) F1354
25. Kasap B., Soylu A., Kuralay F., Sarioglu S., Kiray M., Tugyan K., et al. Protective effect of Epo on oxidative renal injury in rats with cyclosporine nephrotoxicity. Pediatr Nephrol 23 11 (2008) 1991
26. Gwinner W., Hinzmann K., Erdbruegger U., Scheffner I., Broecker V., Vaske B., et al. Acute tubular injury in protocol biopsies of renal grafts: prevalence, associated factors and effect on long-term function. Am J Transplant 8 8 (2008) 1684
27. Kamar N., Garrigue V., Karras A., Mourad G., Lefrancois N., Charpentier B., et al. Impact of early or delayed cyclosporine on delayed graft function in renal transplant recipients: a randomized, multicenter study. Am J Transplant 6 5 Pt 1 (2006) 1042
28. Lieberthal W., Koh J.S., and Levine J.S. Necrosis and apoptosis in acute renal failure. Semin Nephrol 18 5 (1998) 505