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Volumn 11, Issue , 2015, Pages 621-632

Continual evolution of type 2 diabetes: An update on pathophysiology and emerging treatment options

Author keywords

Diabetes; Hyperglycemia; Oral antidiabetic therapies; Pharmacotherapy; Sodium glucose cotransporter 2

Indexed keywords

AGENTS AFFECTING CARBOHYDRATE METABOLISM; ANTIDIABETIC AGENT; CANAGLIFLOZIN; DAPAGLIFLOZIN; EMPAGLIFLOZIN; FASIGLIFAM; G PROTEIN COUPLED RECEPTOR 119 AGONIST; INCB 13739; IPRAGLIFLOZIN; JNJ 38431055; SODIUM GLUCOSE COTRANSPORTER 2 INHIBITOR; UNCLASSIFIED DRUG;

EID: 84928108305     PISSN: 11766336     EISSN: 1178203X     Source Type: Journal    
DOI: 10.2147/TCRM.S67387     Document Type: Review
Times cited : (37)

References (128)
  • 1
    • 84928137193 scopus 로고    scopus 로고
    • International Diabetes Federation, IDF Atlas, Accessed July 10, 2014
    • International Diabetes Federation. 2013. IDF Atlas. Available from: http://www.idf.org/diabetesatlas. Accessed July 10, 2014.
    • (2013)
  • 2
    • 84928137192 scopus 로고    scopus 로고
    • Centers for Disease Control and Prevention, National diabetesstatistics report: estimates of diabetes and its burden in the United States, 2014, Accessed July 16, 2014
    • Centers for Disease Control and Prevention. 2014. National diabetes statistics report: estimates of diabetes and its burden in the United States, 2014. Available from: http://www.cdc.gov/diabetes/pubs/statsreport14/ national-diabetes-report-web.pdf. Accessed July 16, 2014.
    • (2014)
  • 3
    • 84865206426 scopus 로고    scopus 로고
    • Creating public awareness: State 2025 diabetes forecasts
    • Rowley WR, Bezold C. Creating public awareness: state 2025 diabetes forecasts. Popul Health Manag. 2012;15:194–200.
    • (2012) Popul Health Manag , vol.15 , pp. 194-200
    • Rowley, W.R.1    Bezold, C.2
  • 4
    • 64649104158 scopus 로고    scopus 로고
    • Banting Lecture. From the triumvirate to the ominous octet: A new paradigm for the treatment of type 2 diabetes mellitus
    • DeFronzo RA. Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus. Diabetes. 2009;58:773–795.
    • (2009) Diabetes , vol.58 , pp. 773-795
    • Defronzo, R.A.1
  • 5
    • 75549090118 scopus 로고    scopus 로고
    • Defning and characterizing the progression of type 2 diabetes
    • Fonseca VA. Defning and characterizing the progression of type 2 diabetes. Diabetes Care. 2009;32:S151–S156.
    • (2009) Diabetes Care , vol.32 , pp. S151-S156
    • Fonseca, V.A.1
  • 6
    • 0025663581 scopus 로고
    • Slowglucose removal rate and hyperinsulinemia precede the development of type II diabetes in the offspring of diabetic parents
    • Warram JH, Martin BC, Krolewski AS, Soeldner JS, Kahn CR. Slow glucose removal rate and hyperinsulinemia precede the development of type II diabetes in the offspring of diabetic parents. Ann Intern Med. 1990; 113:909–915.
    • (1990) Ann Intern Med , vol.113 , pp. 909-915
    • Warram, J.H.1    Martin, B.C.2    Krolewski, A.S.3    Soeldner, J.S.4    Kahn, C.R.5
  • 7
    • 2442670514 scopus 로고    scopus 로고
    • Heritability estimates for beta cell function and features of the insulin resistance syndrome in UK families with an increased susceptibility to type 2 diabetes
    • Mills GW, Avery PJ, McCarthy MI, et al. Heritability estimates for beta cell function and features of the insulin resistance syndrome in UK families with an increased susceptibility to type 2 diabetes. Diabetologia. 2004;47:732–738.
    • (2004) Diabetologia , vol.47 , pp. 732-738
    • Mills, G.W.1    Avery, P.J.2    McCarthy, M.I.3
  • 8
    • 66549087600 scopus 로고    scopus 로고
    • Genetic architecture of type 2 diabetes: Recent progress and clinical implications
    • Grant RW, Moore AF, Florez JC. Genetic architecture of type 2 diabetes: recent progress and clinical implications. Diabetes Care. 2009; 32:1107–1114.
    • (2009) Diabetes Care , vol.32 , pp. 1107-1114
    • Grant, R.W.1    Moore, A.F.2    Florez, J.C.3
  • 9
    • 0034853485 scopus 로고    scopus 로고
    • Clinical review 135: The importance of beta-cell failure in the development and progression of type 2 diabetes
    • Kahn SE. Clinical review 135: the importance of beta-cell failure in the development and progression of type 2 diabetes. J Clin Endocrinol Metab. 2001;86:4047–4058.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 4047-4058
    • Kahn, S.E.1
  • 11
    • 80051986265 scopus 로고    scopus 로고
    • Globalization of diabetes: The role of diet, lifestyle, and genes
    • Hu FB. Globalization of diabetes: the role of diet, lifestyle, and genes. Diabetes Care. 2011;34:1249–1257.
    • (2011) Diabetes Care , vol.34 , pp. 1249-1257
    • Hu, F.B.1
  • 12
    • 0036153256 scopus 로고    scopus 로고
    • Minireview: Secondary beta-cell failure in type 2 diabetes – a convergence of glucotoxicity and lipotoxicity
    • Poitout V, Robertson RP. Minireview: secondary beta-cell failure in type 2 diabetes – a convergence of glucotoxicity and lipotoxicity. Endocrinology. 2002;143:339–342.
    • (2002) Endocrinology , vol.143 , pp. 339-342
    • Poitout, V.1    Robertson, R.P.2
  • 13
    • 0034005968 scopus 로고    scopus 로고
    • Prolonged elevation of plasma free fatty acids impairs pancreatic beta-cell function in obese nondiabetic humans but not in individuals with type 2 diabetes
    • Carpentier A, Mittelman SD, Bergman RN, Giacca A, Lewis GF. Prolonged elevation of plasma free fatty acids impairs pancreatic beta-cell function in obese nondiabetic humans but not in individuals with type 2 diabetes. Diabetes. 2000;49:399–408.
    • (2000) Diabetes , vol.49 , pp. 399-408
    • Carpentier, A.1    Mittelman, S.D.2    Bergman, R.N.3    Giacca, A.4    Lewis, G.F.5
  • 14
    • 0141755328 scopus 로고    scopus 로고
    • A sustained increase in plasma free fatty acids impairs insulin secretion in nondiabetic subjects genetically predisposed to develop type 2 diabetes
    • Kashyap S, Belfort R, Gastaldelli A, et al. A sustained increase in plasma free fatty acids impairs insulin secretion in nondiabetic subjects genetically predisposed to develop type 2 diabetes. Diabetes. 2003;52: 2461–2474.
    • (2003) Diabetes , vol.52 , pp. 2461-2474
    • Kashyap, S.1    Belfort, R.2    Gastaldelli, A.3
  • 15
    • 0035125917 scopus 로고    scopus 로고
    • Lipotoxicity of beta-cells in obesity and in other causes of fatty acid spillover
    • Unger RH, Zhou YT. Lipotoxicity of beta-cells in obesity and in other causes of fatty acid spillover. Diabetes. 2001;50:S118–S121.
    • (2001) Diabetes , vol.50 , pp. S118-S121
    • Unger, R.H.1    Zhou, Y.T.2
  • 16
    • 0035146344 scopus 로고    scopus 로고
    • Renal gluconeogenesis: Its importance in human glucose homeostasis
    • Gerich JE, Meyer C, Woerle HJ, Stumvoll M. Renal gluconeogenesis: its importance in human glucose homeostasis. Diabetes Care. 2001;24:382–391.
    • (2001) Diabetes Care , vol.24 , pp. 382-391
    • Gerich, J.E.1    Meyer, C.2    Woerle, H.J.3    Stumvoll, M.4
  • 18
    • 0034524938 scopus 로고    scopus 로고
    • Lack of suppression of glucagon contributes to postprandial hyperglycemia in subjects with type 2 diabetes mellitus
    • Shah P, Vella A, Basu A, Basu R, Schwenk WF, Rizza RA. Lack of suppression of glucagon contributes to postprandial hyperglycemia in subjects with type 2 diabetes mellitus. J Clin Endocrinol Metab. 2000;85:4053–4059.
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 4053-4059
    • Shah, P.1    Vella, A.2    Basu, A.3    Basu, R.4    Schwenk, W.F.5    Rizza, R.A.6
  • 19
    • 33947596679 scopus 로고    scopus 로고
    • The GLUT4 glucose transporter
    • Huang S, Czech MP. The GLUT4 glucose transporter. Cell Metab. 2007; 5:237–252.
    • (2007) Cell Metab , vol.5 , pp. 237-252
    • Huang, S.1    Czech, M.P.2
  • 20
    • 33745848775 scopus 로고    scopus 로고
    • Glucose transport and sensing in the maintenance of glucose homeostasis and metabolic harmony
    • Herman MA, Kahn BB. Glucose transport and sensing in the maintenance of glucose homeostasis and metabolic harmony. J Clin Invest. 2006;116: 1767–1775.
    • (2006) J Clin Invest , vol.116 , pp. 1767-1775
    • Herman, M.A.1    Kahn, B.B.2
  • 21
    • 0033968126 scopus 로고    scopus 로고
    • Insulin resistance differentially affects the PI 3-kinase- and MAP kinase-mediated signaling in human muscle
    • Cusi K, Maezono K, Osman A, et al. Insulin resistance differentially affects the PI 3-kinase- and MAP kinase-mediated signaling in human muscle. J Clin Invest. 2000;105:311–320.
    • (2000) J Clin Invest , vol.105 , pp. 311-320
    • Cusi, K.1    Maezono, K.2    Osman, A.3
  • 22
    • 1442352339 scopus 로고    scopus 로고
    • Role of the adipocyte, free fatty acids, and ectopic fat in pathogenesis of type 2 diabetes mellitus: Peroxisomal proliferator-activated receptor agonists provide a rational therapeutic approach
    • Bays H, Mandarino L, DeFronzo RA. Role of the adipocyte, free fatty acids, and ectopic fat in pathogenesis of type 2 diabetes mellitus: peroxisomal proliferator-activated receptor agonists provide a rational therapeutic approach. J Clin Endocrinol Metab. 2004;89: 463–478.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 463-478
    • Bays, H.1    Mandarino, L.2    Defronzo, R.A.3
  • 23
    • 84155165144 scopus 로고    scopus 로고
    • Brown versus white adipose tissue: A mini-review
    • Saely CH, Geiger K, Drexel H. Brown versus white adipose tissue: a mini-review. Gerontology. 2012;58:15–23.
    • (2012) Gerontology , vol.58 , pp. 15-23
    • Saely, C.H.1    Geiger, K.2    Drexel, H.3
  • 24
    • 64349105205 scopus 로고    scopus 로고
    • Identifcation and importance of brown adipose tissue in adult humans
    • Cypess AM, Lehman S, Williams G, et al. Identifcation and importance of brown adipose tissue in adult humans. N Engl J Med. 2009; 360:1509–1517.
    • (2009) N Engl J Med , vol.360 , pp. 1509-1517
    • Cypess, A.M.1    Lehman, S.2    Williams, G.3
  • 25
    • 67650242165 scopus 로고    scopus 로고
    • High incidence of metabolically active brown adipose tissue in healthy adult humans: Effects of cold exposure and adiposity
    • Saito M, Okamatsu-Ogura Y, Matsushita M, et al. High incidence of metabolically active brown adipose tissue in healthy adult humans: effects of cold exposure and adiposity. Diabetes. 2009;58:1526–1531.
    • (2009) Diabetes , vol.58 , pp. 1526-1531
    • Saito, M.1    Okamatsu-Ogura, Y.2    Matsushita, M.3
  • 27
    • 64349123664 scopus 로고    scopus 로고
    • Functional brown adipose tissue in healthy adults
    • Virtanen KA, Lidell ME, Orava J, et al. Functional brown adipose tissue in healthy adults. N Engl J Med. 2009;360:1518–1525.
    • (2009) N Engl J Med , vol.360 , pp. 1518-1525
    • Virtanen, K.A.1    Lidell, M.E.2    Orava, J.3
  • 28
    • 84856529575 scopus 로고    scopus 로고
    • Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans
    • Ouellet V, Labbe SM, Blondin DP, et al. Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans. J Clin Invest. 2012;122:545–552.
    • (2012) J Clin Invest , vol.122 , pp. 545-552
    • Ouellet, V.1    Labbe, S.M.2    Blondin, D.P.3
  • 29
    • 84862776702 scopus 로고    scopus 로고
    • A PGC1-alpha-dependent myokine that drives brown-fat-like development of white fat and thermogenesis
    • Bostrom P, Wu J, Jedrychowski MP, et al. A PGC1-alpha-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature. 2012;481:463–468.
    • (2012) Nature , vol.481 , pp. 463-468
    • Bostrom, P.1    Wu, J.2    Jedrychowski, M.P.3
  • 30
    • 75549088596 scopus 로고    scopus 로고
    • Where does insulin resistance start? The brain
    • Pagotto U. Where does insulin resistance start? The brain. Diabetes Care. 2009;32:S174–S177.
    • (2009) Diabetes Care , vol.32 , pp. S174-S177
    • Pagotto, U.1
  • 31
    • 33747058235 scopus 로고    scopus 로고
    • The cerebrocortical response to hyperinsulinemia is reduced in overweight humans: A magnetoencephalographic study
    • Tschritter O, Preissl H, Hennige AM, et al. The cerebrocortical response to hyperinsulinemia is reduced in overweight humans: a magnetoencephalographic study. Proc Natl Acad Sci U S A. 2006;103: 12103–12108.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 12103-12108
    • Tschritter, O.1    Preissl, H.2    Hennige, A.M.3
  • 32
    • 62449325306 scopus 로고    scopus 로고
    • Implications of amylin receptor agonism: Integrated neurohormonal mechanisms and therapeutic applications
    • Roth JD, Maier H, Chen S, Roland BL. Implications of amylin receptor agonism: integrated neurohormonal mechanisms and therapeutic applications. Arch Neurol. 2009;66:306–310.
    • (2009) Arch Neurol , vol.66 , pp. 306-310
    • Roth, J.D.1    Maier, H.2    Chen, S.3    Roland, B.L.4
  • 34
    • 61449095573 scopus 로고    scopus 로고
    • Leptin at 14 y of age: An ongoing story
    • Friedman JM. Leptin at 14 y of age: an ongoing story. Am J Clin Nutr. 2009;89:973S–979S.
    • (2009) Am J Clin Nutr , vol.89 , pp. 973S-979S
    • Friedman, J.M.1
  • 35
    • 13344295079 scopus 로고    scopus 로고
    • Serum immunoreactive-leptin concentrations in normal-weight and obese humans
    • Considine RV, Sinha MK, Heiman ML, et al. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med. 1996;334:292–295.
    • (1996) N Engl J Med , vol.334 , pp. 292-295
    • Considine, R.V.1    Sinha, M.K.2    Heiman, M.L.3
  • 36
    • 79955584321 scopus 로고    scopus 로고
    • Leptin and the central nervous system control of glucose metabolism
    • Morton GJ, Schwartz M W. Leptin and the central nervous system control of glucose metabolism. Physiol Rev. 2011;91:389–411.
    • (2011) Physiol Rev , vol.91 , pp. 389-411
    • Morton, G.J.1    Schwartz, M.W.2
  • 37
    • 61449105725 scopus 로고    scopus 로고
    • Leptin: A pivotal regulator of human energy homeostasis
    • Farooqi IS, O’Rahilly S. Leptin: a pivotal regulator of human energy homeostasis. Am J Clin Nutr. 2009;89:980S–984S.
    • (2009) Am J Clin Nutr , vol.89 , pp. 980S-984S
    • Farooqi, I.S.1    O’Rahilly, S.2
  • 38
    • 77954269929 scopus 로고    scopus 로고
    • Leptin defciency causes insulin resistance induced by uncontrolled diabetes
    • German JP, Wisse BE, Thaler JP, et al. Leptin defciency causes insulin resistance induced by uncontrolled diabetes. Diabetes. 2010; 59:1626–1634.
    • (2010) Diabetes , vol.59 , pp. 1626-1634
    • German, J.P.1    Wisse, B.E.2    Thaler, J.P.3
  • 39
    • 79959431773 scopus 로고    scopus 로고
    • Recombinant human leptin treatment does not improve insulin action in obese subjects with type 2 diabetes
    • Mittendorfer B, Horowitz JF, DePaoli AM, McCamish MA, Patterson BW, Klein S. Recombinant human leptin treatment does not improve insulin action in obese subjects with type 2 diabetes. Diabetes. 2011;60:1474–1477.
    • (2011) Diabetes , vol.60 , pp. 1474-1477
    • Mittendorfer, B.1    Horowitz, J.F.2    Depaoli, A.M.3    McCamish, M.A.4    Patterson, B.W.5    Klein, S.6
  • 40
    • 84903519847 scopus 로고    scopus 로고
    • Mechanisms in endocrinology: Regulation of glucose metabolism by the ghrelin system: Multiple players and multiple actions
    • Heppner KM, Tong J. Mechanisms in endocrinology: regulation of glucose metabolism by the ghrelin system: multiple players and multiple actions. Eur J Endocrinol. 2014;171:R21–R32.
    • (2014) Eur J Endocrinol , vol.171 , pp. R21-R32
    • Heppner, K.M.1    Tong, J.2
  • 41
    • 0036097362 scopus 로고    scopus 로고
    • Ghrelin is present in pancreatic alpha-cells of humans and rats and stimulates insulin secretion
    • Date Y, Nakazato M, Hashiguchi S, et al. Ghrelin is present in pancreatic alpha-cells of humans and rats and stimulates insulin secretion. Diabetes. 2002;51:124–129.
    • (2002) Diabetes , vol.51 , pp. 124-129
    • Date, Y.1    Nakazato, M.2    Hashiguchi, S.3
  • 42
    • 0036959760 scopus 로고    scopus 로고
    • Expression of ghrelin and of the GH secretagogue receptor by pancreatic islet cells and related endocrine tumors
    • Volante M, Allia E, Gugliotta P, et al. Expression of ghrelin and of the GH secretagogue receptor by pancreatic islet cells and related endocrine tumors. J Clin Endocrinol Metab. 2002;87:1300–1308.
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 1300-1308
    • Volante, M.1    Allia, E.2    Gugliotta, P.3
  • 43
    • 0034751526 scopus 로고    scopus 로고
    • Ghrelin, a natural GH secretagogue produced by the stomach, induces hyperglycemia and reduces insulin secretion in humans
    • Broglio F, Arvat E, Benso A, et al. Ghrelin, a natural GH secretagogue produced by the stomach, induces hyperglycemia and reduces insulin secretion in humans. J Clin Endocrinol Metab. 2001;86:5083–5086.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 5083-5086
    • Broglio, F.1    Arvat, E.2    Benso, A.3
  • 44
    • 77956357163 scopus 로고    scopus 로고
    • Ghrelin suppresses glucose-stimulated insulin secretion and deteriorates glucose tolerance in healthy humans
    • Tong J, Prigeon RL, Davis HW, et al. Ghrelin suppresses glucose-stimulated insulin secretion and deteriorates glucose tolerance in healthy humans. Diabetes. 2010;59:2145–2151.
    • (2010) Diabetes , vol.59 , pp. 2145-2151
    • Tong, J.1    Prigeon, R.L.2    Davis, H.W.3
  • 45
    • 84877701181 scopus 로고    scopus 로고
    • Clinical review: The human experience with ghrelin administration
    • Garin MC, Burns CM, Kaul S, Cappola AR. Clinical review: the human experience with ghrelin administration. J Clin Endocrinol Metab. 2013; 98:1826–1837.
    • (2013) J Clin Endocrinol Metab , vol.98 , pp. 1826-1837
    • Garin, M.C.1    Burns, C.M.2    Kaul, S.3    Cappola, A.R.4
  • 46
    • 0141643291 scopus 로고    scopus 로고
    • Low plasma ghrelin is associated with insulin resistance, hypertension, and the prevalence of type 2 diabetes
    • Pöykkö SM, Kellokoski E, Hörkkö S, Kauma H, Kesäniemi YA, Ukkola O. Low plasma ghrelin is associated with insulin resistance, hypertension, and the prevalence of type 2 diabetes. Diabetes. 2003;52:2546–2553.
    • (2003) Diabetes , vol.52 , pp. 2546-2553
    • Pöykkö, S.M.1    Kellokoski, E.2    Hörkkö, S.3    Kauma, H.4    Kesäniemi, Y.A.5    Ukkola, O.6
  • 47
    • 74249117374 scopus 로고    scopus 로고
    • Role of the incretin pathway in the pathogenesis of type 2 diabetes mellitus
    • Freeman JS. Role of the incretin pathway in the pathogenesis of type 2 diabetes mellitus. Cleve Clin J Med. 2009;76:S12–S19.
    • (2009) Cleve Clin J Med , vol.76 , pp. S12-S19
    • Freeman, J.S.1
  • 48
    • 9444244529 scopus 로고    scopus 로고
    • Gastric inhibitory polypeptide and glucagon-like peptide-1 in the pathogenesis of type 2 diabetes
    • Nauck MA, Baller B, Meier JJ. Gastric inhibitory polypeptide and glucagon-like peptide-1 in the pathogenesis of type 2 diabetes. Diabetes. 2004;53:S190–S196.
    • (2004) Diabetes , vol.53 , pp. S190-S196
    • Nauck, M.A.1    Baller, B.2    Meier, J.J.3
  • 49
    • 22044452266 scopus 로고    scopus 로고
    • Glucagon-like peptide 1–based therapies for type 2 diabetes: A focus on exenatide
    • Dungan K, Buse JB. Glucagon-like peptide 1–based therapies for type 2 diabetes: a focus on exenatide. Clin Diabetes. 2005;23:56–62.
    • (2005) Clin Diabetes , vol.23 , pp. 56-62
    • Dungan, K.1    Buse, J.B.2
  • 50
    • 67349189212 scopus 로고    scopus 로고
    • Renal sodium-glucose transport: Role in diabetes mellitus and potential clinical implications
    • Bakris GL, Fonseca VA, Sharma K, Wright EM. Renal sodium-glucose transport: role in diabetes mellitus and potential clinical implications. Kidney Int. 2009;75:1272–1277.
    • (2009) Kidney Int , vol.75 , pp. 1272-1277
    • Bakris, G.L.1    Fonseca, V.A.2    Sharma, K.3    Wright, E.M.4
  • 51
    • 77954321998 scopus 로고    scopus 로고
    • Sodium-glucose transporter-2 inhibition as an antidiabetic therapy
    • Ferrannini E. Sodium-glucose transporter-2 inhibition as an antidiabetic therapy. Nephrol Dial Transplant. 2010;25:2041–2043.
    • (2010) Nephrol Dial Transplant , vol.25 , pp. 2041-2043
    • Ferrannini, E.1
  • 52
    • 84891865819 scopus 로고    scopus 로고
    • Characterization of renal glucose reabsorption in response to dapaglifozin in healthy subjects and subjects with type 2 diabetes
    • DeFronzo RA, Hompesch M, Kasichayanula S, et al. Characterization of renal glucose reabsorption in response to dapaglifozin in healthy subjects and subjects with type 2 diabetes. Diabetes Care. 2013;36:3169–3176.
    • (2013) Diabetes Care , vol.36 , pp. 3169-3176
    • Defronzo, R.A.1    Hompesch, M.2    Kasichayanula, S.3
  • 53
    • 0028872833 scopus 로고
    • Uptake and release of glucose by the human kidney. Postabsorptive rates and responses to epinephrine
    • Stumvoll M, Chintalapudi U, Perriello G, Welle S, Gutierrez O, Gerich J. Uptake and release of glucose by the human kidney. Postabsorptive rates and responses to epinephrine. J Clin Invest. 1995;96:2528–2533.
    • (1995) J Clin Invest , vol.96 , pp. 2528-2533
    • Stumvoll, M.1    Chintalapudi, U.2    Perriello, G.3    Welle, S.4    Gutierrez, O.5    Gerich, J.6
  • 55
    • 34247483998 scopus 로고    scopus 로고
    • Increasing cardiovascular disease burden due to diabetes mellitus: The Framingham Heart Study
    • Fox CS, Coady S, Sorlie PD, et al. Increasing cardiovascular disease burden due to diabetes mellitus: the Framingham Heart Study. Circulation. 2007;115:1544–1550.
    • (2007) Circulation , vol.115 , pp. 1544-1550
    • Fox, C.S.1    Coady, S.2    Sorlie, P.D.3
  • 56
    • 35848968871 scopus 로고    scopus 로고
    • Prevalence of chronic kidney disease in the United States
    • Coresh J, Selvin E, Stevens LA, et al. Prevalence of chronic kidney disease in the United States. JAMA. 2007;298:2038–2047.
    • (2007) JAMA , vol.298 , pp. 2038-2047
    • Coresh, J.1    Selvin, E.2    Stevens, L.A.3
  • 57
    • 34948911363 scopus 로고    scopus 로고
    • End-stage renal disease in the United States: An update from the United States Renal Data System
    • Foley RN, Collins AJ. End-stage renal disease in the United States: an update from the United States Renal Data System. J Am Soc Nephrol. 2007;18:2644–2648.
    • (2007) J am Soc Nephrol , vol.18 , pp. 2644-2648
    • Foley, R.N.1    Collins, A.J.2
  • 58
    • 0029147687 scopus 로고
    • Intensive insulin therapy prevents the progression of diabetic microvascular complications in Japanese patients with non-insulin-dependent diabetes mellitus: A randomized prospective 6-year study
    • Ohkubo Y, Kishikawa H, Araki E, et al. Intensive insulin therapy prevents the progression of diabetic microvascular complications in Japanese patients with non-insulin-dependent diabetes mellitus: a randomized prospective 6-year study. Diabetes Res Clin Pract. 1995;28:103–117.
    • (1995) Diabetes Res Clin Pract , vol.28 , pp. 103-117
    • Ohkubo, Y.1    Kishikawa, H.2    Araki, E.3
  • 59
    • 0032511566 scopus 로고    scopus 로고
    • UK Prospective Diabetes Study (UKPDS) Group
    • [No authors listed, Effect of intensive blood-glucose control withmetformin on complications in overweight patients with type 2 diabetes (UKPDS 34)
    • [No authors listed]. Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group. Lancet. 1998a;352:854–865.
    • (1998) Lancet , vol.352 , pp. 854-865
  • 60
    • 0032511583 scopus 로고    scopus 로고
    • Intensive blood-glucose control with sulphonylureas
    • No authors listed
    • [No authors listed]. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group. Lancet. 1998b;352:837–853.
    • (1998) Lancet , vol.352 , pp. 837-853
  • 61
    • 38949210220 scopus 로고    scopus 로고
    • Effect of a multifactorial intervention on mortality in type 2 diabetes
    • Gaede P, Lund-Andersen H, Parving HH, Pedersen O. Effect of a multifactorial intervention on mortality in type 2 diabetes. N Engl J Med. 2008;358:580–591.
    • (2008) N Engl J Med , vol.358 , pp. 580-591
    • Gaede, P.1    Lund-Andersen, H.2    Parving, H.H.3    Pedersen, O.4
  • 62
    • 84935860987 scopus 로고    scopus 로고
    • Approaches to glycemic treatment. Sec 7. In Standards of medical care in diabetes – 2015
    • American Diabetes Association
    • American Diabetes Association. Approaches to glycemic treatment. Sec 7. In Standards of medical care in diabetes – 2015. Diabetes Care. 2015;38(Suppl 1):S41–S48.
    • (2015) Diabetes Care , vol.38 , pp. S41-S48
  • 63
    • 84890566037 scopus 로고    scopus 로고
    • American Association of Clinical Endocrinologists’ comprehensive diabetes management algorithm 2013 consensus statement – executive summary
    • Garber AJ, Abrahamson MJ, Barzilay JI, et al. American Association of Clinical Endocrinologists’ comprehensive diabetes management algorithm 2013 consensus statement – executive summary. Endocr Pract. 2013;19:536–557.
    • (2013) Endocr Pract , vol.19 , pp. 536-557
    • Garber, A.J.1    Abrahamson, M.J.2    Barzilay, J.I.3
  • 64
    • 60449089649 scopus 로고    scopus 로고
    • American Diabetes Association; European Association for Study of Diabetes. Medical management of hyperglycemia in type 2 diabetes: A consensus algorithm for the initiation and adjustment of therapy: A consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes
    • Nathan DM, Buse JB, Davidson MB, et al; American Diabetes Association; European Association for Study of Diabetes. Medical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care. 2009;32:193–203.
    • (2009) Diabetes Care , vol.32 , pp. 193-203
    • Nathan, D.M.1    Buse, J.B.2    Davidson, M.B.3
  • 65
    • 0037034257 scopus 로고    scopus 로고
    • Diabetes Prevention Program Research Group. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
    • Knowler WC, Barrett-Connor E, Fowler SE, et al; Diabetes Prevention Program Research Group. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med. 2002; 346:393–403.
    • (2002) N Engl J Med , vol.346 , pp. 393-403
    • Knowler, W.C.1    Barrett-Connor, E.2    Fowler, S.E.3
  • 66
    • 64349083605 scopus 로고    scopus 로고
    • Diabetes prevalence and therapeutic target achievement in the United States, 1999 to 2006
    • Cheung BM, Ong KL, Cherny SS, Sham PC, Tso AW, Lam KS. Diabetes prevalence and therapeutic target achievement in the United States, 1999 to 2006. Am J Med. 2009;122:443–453.
    • (2009) Am J Med , vol.122 , pp. 443-453
    • Cheung, B.M.1    Ong, K.L.2    Cherny, S.S.3    Sham, P.C.4    Tso, A.W.5    Lam, K.S.6
  • 67
    • 42449136089 scopus 로고    scopus 로고
    • Why don’t diabetes patients achieve recommended risk factor targets? Poor adherence versus lack of treatment intensifcation
    • Schmittdiel JA, Uratsu CS, Karter AJ, et al. Why don’t diabetes patients achieve recommended risk factor targets? Poor adherence versus lack of treatment intensifcation. J Gen Intern Med. 2008;23:588–594.
    • (2008) J Gen Intern Med , vol.23 , pp. 588-594
    • Schmittdiel, J.A.1    Uratsu, C.S.2    Karter, A.J.3
  • 68
    • 78651406659 scopus 로고    scopus 로고
    • SGLT2 mediates glucose reabsorption in the early proximal tubule
    • Vallon V, Platt KA, Cunard R, et al. SGLT2 mediates glucose reabsorption in the early proximal tubule. J Am Soc Nephrol. 2011;22: 104–112.
    • (2011) J am Soc Nephrol , vol.22 , pp. 104-112
    • Vallon, V.1    Platt, K.A.2    Cunard, R.3
  • 69
    • 79952221451 scopus 로고    scopus 로고
    • Glucose dynamics and mechanistic implications of SGLT2 inhibitors in animals and humans
    • List JF, Whaley JM. Glucose dynamics and mechanistic implications of SGLT2 inhibitors in animals and humans. Kidney Int. 2011; 79:S20–S27.
    • (2011) Kidney Int , vol.79 , pp. S20-S27
    • List, J.F.1    Whaley, J.M.2
  • 70
    • 76249133903 scopus 로고    scopus 로고
    • Role of the kidney in normal glucose homeostasis and in thehyperglycaemia of diabetes mellitus: Therapeutic implications
    • Gerich JE. Role of the kidney in normal glucose homeostasis and in the hyperglycaemia of diabetes mellitus: therapeutic implications. Diabet Med. 2010;27:136–142.
    • (2010) Diabet Med , vol.27 , pp. 136-142
    • Gerich, J.E.1
  • 71
    • 84858020943 scopus 로고    scopus 로고
    • Effects of dapaglifozin on body weight, total fat mass, and regional adipose tissue distribution in patients with type 2 diabetes mellitus with inadequate glycemic control on metformin
    • Bolinder J, Ljunggren O, Kullberg J, et al. Effects of dapaglifozin on body weight, total fat mass, and regional adipose tissue distribution in patients with type 2 diabetes mellitus with inadequate glycemic control on metformin. J Clin Endocrinol Metab. 2012;97:1020–1031.
    • (2012) J Clin Endocrinol Metab , vol.97 , pp. 1020-1031
    • Bolinder, J.1    Ljunggren, O.2    Kullberg, J.3
  • 72
    • 77957128949 scopus 로고    scopus 로고
    • SGLT2 inhibitors: Glucuretic treatment for type 2 diabetes
    • Bailey CJ. SGLT2 inhibitors: glucuretic treatment for type 2 diabetes. Br J Diabetes Vasc Dis. 2010;10:193–199.
    • (2010) Br J Diabetes Vasc Dis , vol.10 , pp. 193-199
    • Bailey, C.J.1
  • 73
    • 80052362968 scopus 로고    scopus 로고
    • Role of sodium-glucose cotransporter 2 (SGLT 2) inhibitors in the treatment of type 2 diabetes
    • Abdul-Ghani MA, Norton L, Defronzo RA. Role of sodium-glucose cotransporter 2 (SGLT 2) inhibitors in the treatment of type 2 diabetes. Endocr Rev. 2011;32:515–531.
    • (2011) Endocr Rev , vol.32 , pp. 515-531
    • Abdul-Ghani, M.A.1    Norton, L.2    Defronzo, R.A.3
  • 74
    • 77954242599 scopus 로고    scopus 로고
    • SGLT2 inhibition – a novel strategy for diabetes treatment
    • Chao EC, Henry RR. SGLT2 inhibition – a novel strategy for diabetes treatment. Nat Rev Drug Discov. 2010;9:551–559.
    • (2010) Nat Rev Drug Discov , vol.9 , pp. 551-559
    • Chao, E.C.1    Henry, R.R.2
  • 75
    • 77956921439 scopus 로고    scopus 로고
    • Dapaglifozin monotherapy in type 2 diabetic patients with inadequate glycemic control by diet and exercise: A randomized, double-blind, placebo-controlled, phase 3 trial
    • Ferrannini E, Ramos SJ, Salsali A, Tang W, List JF. Dapaglifozin monotherapy in type 2 diabetic patients with inadequate glycemic control by diet and exercise: a randomized, double-blind, placebo-controlled, phase 3 trial. Diabetes Care. 2010;33:2217–2224.
    • (2010) Diabetes Care , vol.33 , pp. 2217-2224
    • Ferrannini, E.1    Ramos, S.J.2    Salsali, A.3    Tang, W.4    List, J.F.5
  • 76
    • 77953857048 scopus 로고    scopus 로고
    • Effect of dapaglifozin in patients with type 2 diabetes who have inadequate glycaemic control with metformin: A randomised, double-blind, placebo-controlled trial
    • Bailey CJ, Gross JL, Pieters A, Bastien A, List JF. Effect of dapaglifozin in patients with type 2 diabetes who have inadequate glycaemic control with metformin: a randomised, double-blind, placebo-controlled trial. Lancet. 2010;375:2223–2233.
    • (2010) Lancet , vol.375 , pp. 2223-2233
    • Bailey, C.J.1    Gross, J.L.2    Pieters, A.3    Bastien, A.4    List, J.F.5
  • 77
    • 80155124676 scopus 로고    scopus 로고
    • Dapaglifozin versus glip-izide as add-on therapy in patients with type 2 diabetes who have inadequate glycemic control with metformin: A randomized, 52-week, double-blind, active-controlled noninferiority trial
    • Nauck MA, Del Prato S, Meier JJ, et al. Dapaglifozin versus glip-izide as add-on therapy in patients with type 2 diabetes who have inadequate glycemic control with metformin: a randomized, 52-week, double-blind, active-controlled noninferiority trial. Diabetes Care. 2011;34:2015–2022.
    • (2011) Diabetes Care , vol.34 , pp. 2015-2022
    • Nauck, M.A.1    Del Prato, S.2    Meier, J.J.3
  • 78
    • 80052524011 scopus 로고    scopus 로고
    • Effect of dapaglifozin in patients with type 2 diabetes who have inadequate glycaemic control with glimepiride: A randomized, 24-week, double-blind, placebo-controlled trial
    • Strojek K, Yoon KH, Hruba V, Elze M, Langkilde AM, Parikh S. Effect of dapaglifozin in patients with type 2 diabetes who have inadequate glycaemic control with glimepiride: a randomized, 24-week, double-blind, placebo-controlled trial. Diabetes Obes Metab. 2011;13:928–938.
    • (2011) Diabetes Obes Metab , vol.13 , pp. 928-938
    • Strojek, K.1    Yoon, K.H.2    Hruba, V.3    Elze, M.4    Langkilde, A.M.5    Parikh, S.6
  • 79
    • 84862875221 scopus 로고    scopus 로고
    • Effects of dapaglifozin, an SGLT2 inhibitor, on HbA1c, body weight, and hypoglycemia risk in patients with type 2 diabetes inadequately controlled on pioglitazone monotherapy
    • Rosenstock J, Vico M, Wei L, Salsali A, List JF. Effects of dapaglifozin, an SGLT2 inhibitor, on HbA1c, body weight, and hypoglycemia risk in patients with type 2 diabetes inadequately controlled on pioglitazone monotherapy. Diabetes Care. 2012;35:1473–1478.
    • (2012) Diabetes Care , vol.35 , pp. 1473-1478
    • Rosenstock, J.1    Vico, M.2    Wei, L.3    Salsali, A.4    List, J.F.5
  • 80
    • 84875206602 scopus 로고    scopus 로고
    • Dapaglifozin as add-on therapy to sitagliptin with or without metformin: A randomized, double-blind, placebo-controlled study
    • Jabbour S, Hardy E, Sugg JE, Parikh S. Dapaglifozin as add-on therapy to sitagliptin with or without metformin: a randomized, double-blind, placebo-controlled study. Diabetes. 2012;61:A275.
    • (2012) Diabetes , vol.61 , pp. A275
    • Jabbour, S.1    Hardy, E.2    Sugg, J.E.3    Parikh, S.4
  • 81
    • 84858323889 scopus 로고    scopus 로고
    • Dapaglifozin 006 Study Group. Long-term effcacy of dapaglifozin in patients with type 2 diabetes mellitus receiving high doses of insulin
    • Wilding JPH, Woo V, Soler NG, et al; Dapaglifozin 006 Study Group. Long-term effcacy of dapaglifozin in patients with type 2 diabetes mellitus receiving high doses of insulin. Ann Intern Med. 2012b;156: 405–415.
    • (2012) Ann Intern Med , vol.156 , pp. 405-415
    • Wilding, J.1    Woo, V.2    Soler, N.G.3
  • 82
    • 84860218907 scopus 로고    scopus 로고
    • Dapaglifozin, metformin XR, or both: Initial pharmacotherapy for type 2 diabetes, a randomised controlled trial
    • Henry RR, Murray AV, Marmolejo MH, Hennicken D, Ptaszynska A, List JF. Dapaglifozin, metformin XR, or both: initial pharmacotherapy for type 2 diabetes, a randomised controlled trial. Int J Clin Pract. 2012;66:446–456.
    • (2012) Int J Clin Pract , vol.66 , pp. 446-456
    • Henry, R.R.1    Murray, A.V.2    Marmolejo, M.H.3    Hennicken, D.4    Ptaszynska, A.5    List, J.F.6
  • 83
    • 84897394040 scopus 로고    scopus 로고
    • Long-term study of patients with type 2 diabetes and moderate renal impairment shows that dapaglifozin reduces weight and blood pressure but does not improve glycemic control
    • Kohan DE, Fioretto P, Tang W, List JF. Long-term study of patients with type 2 diabetes and moderate renal impairment shows that dapaglifozin reduces weight and blood pressure but does not improve glycemic control. Kidney Int. 2014;85:962–971.
    • (2014) Kidney Int , vol.85 , pp. 962-971
    • Kohan, D.E.1    Fioretto, P.2    Tang, W.3    List, J.F.4
  • 85
    • 84892488179 scopus 로고    scopus 로고
    • Dapaglifozin 006
    • Dapaglifozin in patients with type 2 diabetes receiving , high doses of insulin: effcacy and safety over two years
    • Wilding JP, Woo V, Rohwedder K, Sugg J, Parikh S; Dapaglifozin 006 Study Group. Dapaglifozin in patients with type 2 diabetes receiving high doses of insulin: effcacy and safety over two years. Diabetes Obes Metab. 2014;16:124–136.
    • (2014) Diabetes Obes Metab , vol.16 , pp. 124-136
    • Wilding, J.P.1    Woo, V.2    Rohwedder, K.3    Sugg, J.4    Parikh, S.5
  • 86
    • 84873960885 scopus 로고    scopus 로고
    • Dapaglifozin add-on to metformin in type 2 diabetes inadequately controlled with metformin: A randomized, double-blind, placebo-controlled 102-week trial
    • Bailey CJ, Gross JL, Hennicken D, Iqbal N, Mansfeld TA, List JF. Dapaglifozin add-on to metformin in type 2 diabetes inadequately controlled with metformin: a randomized, double-blind, placebo-controlled 102-week trial. BMC Med. 2013;11:43.
    • (2013) BMC Med , vol.11 , pp. 43
    • Bailey, C.J.1    Gross, J.L.2    Hennicken, D.3    Iqbal, N.4    Mansfeld, T.A.5    List, J.F.6
  • 87
    • 84892479365 scopus 로고    scopus 로고
    • Dapaglifozin maintains glycaemic control while reducing weight and body fat mass over 2 years in patients with type 2 diabetes mellitus inadequately controlled on metformin
    • Bolinder J, Ljunggren O, Johansson L, et al. Dapaglifozin maintains glycaemic control while reducing weight and body fat mass over 2 years in patients with type 2 diabetes mellitus inadequately controlled on metformin. Diabetes Obes Metab. 2014;16:159–169.
    • (2014) Diabetes Obes Metab , vol.16 , pp. 159-169
    • Bolinder, J.1    Ljunggren, O.2    Johansson, L.3
  • 88
    • 84880850027 scopus 로고    scopus 로고
    • Dapa-glifozin a glucose-regulating drug with diuretic properties in subjects with type 2 diabetes
    • Lambers Heerspink HJ, de Zeeuw D, Wie L, Leslie B, List J. Dapa-glifozin a glucose-regulating drug with diuretic properties in subjects with type 2 diabetes. Diabetes Obes Metab. 2013;15:853–862.
    • (2013) Diabetes Obes Metab , vol.15 , pp. 853-862
    • Lambers Heerspink, H.J.1    De Zeeuw, D.2    Wie, L.3    Leslie, B.4    List, J.5
  • 92
    • 84874291673 scopus 로고    scopus 로고
    • Efficacy and safety of canaglifozin monotherapy in subjects with type 2 diabetes mellitus inadequately controlled with diet and exercise
    • Stenlof K, Cefalu WT, Kim KA, et al. Efficacy and safety of canaglifozin monotherapy in subjects with type 2 diabetes mellitus inadequately controlled with diet and exercise. Diabetes Obes Metab. 2013;15:372–382.
    • (2013) Diabetes Obes Metab , vol.15 , pp. 372-382
    • Stenlof, K.1    Cefalu, W.T.2    Kim, K.A.3
  • 93
    • 84884167643 scopus 로고    scopus 로고
    • Effcacy and safety of canagli-fozin versus glimepiride in patients with type 2 diabetes inadequately controlled with metformin (CANTATA-SU): 52 week results from a randomised, double-blind, phase 3 non-inferiority trial
    • Cefalu WT, Leiter LA, Yoon KH, et al. Effcacy and safety of canagli-fozin versus glimepiride in patients with type 2 diabetes inadequately controlled with metformin (CANTATA-SU): 52 week results from a randomised, double-blind, phase 3 non-inferiority trial. Lancet. 2013; 382:941–950.
    • (2013) Lancet , vol.382 , pp. 941-950
    • Cefalu, W.T.1    Leiter, L.A.2    Yoon, K.H.3
  • 94
    • 84875168195 scopus 로고    scopus 로고
    • Canaglifozin (CANA), a sodium glucose co-transporter 2 inhibitor, improves glycemic control and reduces body weight in subjects with type 2 diabetes (T2D) inadequately controlled with metformin (MET) and sulfonylurea (SU)
    • Wilding JP, Mathieu C, Vercruysse F, et al. Canaglifozin (CANA), a sodium glucose co-transporter 2 inhibitor, improves glycemic control and reduces body weight in subjects with type 2 diabetes (T2D) inadequately controlled with metformin (MET) and sulfonylurea (SU). Diabetes. 2012a;61:A262.
    • (2012) Diabetes , vol.61 , pp. A262
    • Wilding, J.P.1    Mathieu, C.2    Vercruysse, F.3
  • 95
    • 84891784200 scopus 로고    scopus 로고
    • Canaglifozin compared with sitagliptin for patients with type 2 diabetes who do not have adequate glycemic control with metformin plus sulfonylurea: A 52-week randomized trial
    • Schernthaner G, Gross JL, Rosenstock J, et al. Canaglifozin compared with sitagliptin for patients with type 2 diabetes who do not have adequate glycemic control with metformin plus sulfonylurea: a 52-week randomized trial. Diabetes Care. 2013;36:2508–2515.
    • (2013) Diabetes Care , vol.36 , pp. 2508-2515
    • Schernthaner, G.1    Gross, J.L.2    Rosenstock, J.3
  • 96
    • 84876311251 scopus 로고    scopus 로고
    • Effcacy and safety of canaglifozin in subjects with type 2 diabetes and chronic kidney disease
    • Yale JF, Bakris G, Cariou B, et al. Effcacy and safety of canaglifozin in subjects with type 2 diabetes and chronic kidney disease. Diabetes Obes Metab. 2013;15:463–473.
    • (2013) Diabetes Obes Metab , vol.15 , pp. 463-473
    • Yale, J.F.1    Bakris, G.2    Cariou, B.3
  • 97
    • 80052815931 scopus 로고    scopus 로고
    • Canaglifozin, an inhibitor of sodium glucose co-transporter 2, improves glycaemic control, lowers body weight, and improves beta cell function in subjects with type 2 diabetes on background metformin
    • Rosenstock J, Polodori D, Zhao Y, et al. Canaglifozin, an inhibitor of sodium glucose co-transporter 2, improves glycaemic control, lowers body weight, and improves beta cell function in subjects with type 2 diabetes on background metformin. Diabetologia. 2010b;53:S351.
    • (2010) Diabetologia , vol.53 , pp. S351
    • Rosenstock, J.1    Polodori, D.2    Zhao, Y.3
  • 98
    • 78651349221 scopus 로고    scopus 로고
    • Biology of human sodium glucose transporters
    • Wright EM, Loo DD, Hirayama BA. Biology of human sodium glucose transporters. Physiol Rev. 2011;91:733–794.
    • (2011) Physiol Rev , vol.91 , pp. 733-794
    • Wright, E.M.1    Loo, D.D.2    Hirayama, B.A.3
  • 99
    • 84877865378 scopus 로고    scopus 로고
    • Canaglifozin lowers postprandial glucose and insulin by delaying intestinal glucose absorption in addition to increasing urinary glucose excretion: Results of a randomized, placebo-controlled study
    • Polidori D, Sha S, Mudaliar S, et al. Canaglifozin lowers postprandial glucose and insulin by delaying intestinal glucose absorption in addition to increasing urinary glucose excretion: results of a randomized, placebo-controlled study. Diabetes Care. 2013;36:2154–2161.
    • (2013) Diabetes Care , vol.36 , pp. 2154-2161
    • Polidori, D.1    Sha, S.2    Mudaliar, S.3
  • 100
    • 84872291610 scopus 로고    scopus 로고
    • US Food and Drug Administration, Accessed July 16, 2014
    • US Food and Drug Administration. Endocrinologic and Metabolic Drugs Advisory Committee, January 10, 2013. Available from: http://www.fda.gov/AdvisoryCommittees/CommitteesMeetingMaterials/Drugs/EndocrinologicandMetabolicDrugsAdvisoryCommittee/ucm331504.htm. Accessed July 16, 2014.
    • Endocrinologic and Metabolic Drugs Advisory Committee, January 10, 2013
  • 101
    • 84899960517 scopus 로고    scopus 로고
    • Effcacy and safety of canagli-fozin compared with placebo in older patients with type 2 diabetes mellitus: A pooled analysis of clinical studies
    • Sinclair A, Bode B, Harris S, et al. Effcacy and safety of canagli-fozin compared with placebo in older patients with type 2 diabetes mellitus: a pooled analysis of clinical studies. BMC Endocr Disord. 2014;14:37.
    • (2014) BMC Endocr Disord , vol.14 , pp. 37
    • Sinclair, A.1    Bode, B.2    Harris, S.3
  • 102
    • 34547464547 scopus 로고    scopus 로고
    • Invokana® (canaglifozin, Titusville, NJ, USA: Janssen Pharmaceuticals
    • Invokana® (canaglifozin). Full Prescribing Information. Titusville, NJ, USA: Janssen Pharmaceuticals; 2013.
    • (2013) Full Prescribing Information
  • 103
    • 84879795546 scopus 로고    scopus 로고
    • A Phase IIb, randomized, placebo-controlled study of the SGLT2 inhibitor empaglifozin in patients with type 2 diabetes
    • Ferrannini E, Seman L, Seewaldt-Becker E, Hantel S, Pinnetti S, Woerle HJ. A Phase IIb, randomized, placebo-controlled study of the SGLT2 inhibitor empaglifozin in patients with type 2 diabetes. Diabetes Obes Metab. 2013a;15:721–728.
    • (2013) Diabetes Obes Metab , vol.15 , pp. 721-728
    • Ferrannini, E.1    Seman, L.2    Seewaldt-Becker, E.3    Hantel, S.4    Pinnetti, S.5    Woerle, H.J.6
  • 104
    • 84887191925 scopus 로고    scopus 로고
    • Effcacy and safety of empaglifozin, a sodium glucose cotransporter 2 (SGLT2) inhibitor, as add-on to metformin in type 2 diabetes with mild hyperglycaemia
    • Rosenstock J, Seman LJ, Jelaska A, et al. Effcacy and safety of empaglifozin, a sodium glucose cotransporter 2 (SGLT2) inhibitor, as add-on to metformin in type 2 diabetes with mild hyperglycaemia. Diabetes Obes Metab. 2013;15:1154–1160.
    • (2013) Diabetes Obes Metab , vol.15 , pp. 1154-1160
    • Rosenstock, J.1    Seman, L.J.2    Jelaska, A.3
  • 105
    • 84892477577 scopus 로고    scopus 로고
    • EMPA-REG PIO™ trial investigators. Empaglifozin improves glycaemic and weight control as add-on therapy to pioglitazone or pioglitazone plus metformin in patients with type 2 diabetes: A 24-week, randomized, placebo-controlled trial
    • Kovacs CS, Seshiah V, Swallow R, et al; EMPA-REG PIO™ trial investigators. Empaglifozin improves glycaemic and weight control as add-on therapy to pioglitazone or pioglitazone plus metformin in patients with type 2 diabetes: a 24-week, randomized, placebo-controlled trial. Diabetes Obes Metab. 2014;16:147–158.
    • (2014) Diabetes Obes Metab , vol.16 , pp. 147-158
    • Kovacs, C.S.1    Seshiah, V.2    Swallow, R.3
  • 106
    • 84885952950 scopus 로고    scopus 로고
    • EMPA-REG METSU Trial Investigators. Empaglifozin as add-on to metformin plus sulfonylurea in patients with type 2 diabetes: A 24-week, randomized, double-blind, placebo-controlled trial
    • Haring HU, Merker L, Seewaldt-Becker E, et al; EMPA-REG METSU Trial Investigators. Empaglifozin as add-on to metformin plus sulfonylurea in patients with type 2 diabetes: a 24-week, randomized, double-blind, placebo-controlled trial. Diabetes Care. 2013;36: 3396–3404.
    • (2013) Diabetes Care , vol.36 , pp. 3396-3404
    • Haring, H.U.1    Merker, L.2    Seewaldt-Becker, E.3
  • 107
    • 84875204252 scopus 로고    scopus 로고
    • Safety and efficacy of empaglifozin as monotherapy or add-on to metformin in a 78-week open-label extension study in patients with type 2 diabetes
    • LB13
    • Woerle HJ, Ferrannini E, Berk A, et al. Safety and efficacy of empaglifozin as monotherapy or add-on to metformin in a 78-week open-label extension study in patients with type 2 diabetes. Diabetes. 2012;61:LB13.
    • (2012) Diabetes , vol.61
    • Woerle, H.J.1    Ferrannini, E.2    Berk, A.3
  • 108
    • 84876899238 scopus 로고    scopus 로고
    • Active- and placebo-controlled dose-fnding study to assess the effcacy, safety, and tolerability of multiple doses of ipraglifozin in patients with type 2 diabetes mellitus
    • Fonseca VA, Ferrannini E, Wilding JP, et al. Active- and placebo-controlled dose-fnding study to assess the effcacy, safety, and tolerability of multiple doses of ipraglifozin in patients with type 2 diabetes mellitus. J Diabetes Complications. 2013;27:268–273.
    • (2013) J Diabetes Complications , vol.27 , pp. 268-273
    • Fonseca, V.A.1    Ferrannini, E.2    Wilding, J.P.3
  • 109
    • 84876344111 scopus 로고    scopus 로고
    • Effcacy and safety of ipraglifozin in patients with type 2 diabetes inadequately controlled on metformin: A dose-fnding study
    • Wilding JP, Ferrannini E, Fonseca VA, Wilpshaar W, Dhanjal P, Houzer A. Effcacy and safety of ipraglifozin in patients with type 2 diabetes inadequately controlled on metformin: a dose-fnding study. Diabetes Obes Metab. 2013a;15:403–409.
    • (2013) Diabetes Obes Metab , vol.15 , pp. 403-409
    • Wilding, J.P.1    Ferrannini, E.2    Fonseca, V.A.3    Wilpshaar, W.4    Dhanjal, P.5    Houzer, A.6
  • 110
    • 84876803427 scopus 로고    scopus 로고
    • Renal glucose handling: Impact of chronic kidney disease and sodium-glucose cotransporter 2 inhibition in patients with type 2 diabetes
    • Ferrannini E, Veltkamp SA, Smulders RA, Kadokura T. Renal glucose handling: impact of chronic kidney disease and sodium-glucose cotransporter 2 inhibition in patients with type 2 diabetes. Diabetes Care. 2013b;36:1260–1265.
    • (2013) Diabetes Care , vol.36 , pp. 1260-1265
    • Ferrannini, E.1    Veltkamp, S.A.2    Smulders, R.A.3    Kadokura, T.4
  • 111
    • 84875137677 scopus 로고    scopus 로고
    • Luseo-glifozin (TS-071), a selective SGLT2 inhibitor, improves glycemic control and lowers body weight in Japanese patients with type 2 diabetes mellitus
    • Seino Y, Sasaki T, Fukatsu A, Samukawa Y, Sakai S, Watanabe T. Luseo-glifozin (TS-071), a selective SGLT2 inhibitor, improves glycemic control and lowers body weight in Japanese patients with type 2 diabetes mellitus. Diabetes. 2012;61:A266.
    • (2012) Diabetes , vol.61 , pp. A266
    • Seino, Y.1    Sasaki, T.2    Fukatsu, A.3    Samukawa, Y.4    Sakai, S.5    Watanabe, T.6
  • 112
    • 84874075297 scopus 로고    scopus 로고
    • Tofoglifozin, a novel and selective SGLT2 inhibitor improves glycemic control and lowers body weight in patients with type 2 diabetes mellitus inadequately controlled on stable metformin or diet and excercise alone
    • Kadowaki T, Ikeda S, Takano Y, et al. Tofoglifozin, a novel and selective SGLT2 inhibitor improves glycemic control and lowers body weight in patients with type 2 diabetes mellitus inadequately controlled on stable metformin or diet and excercise alone. Diabetes. 2012;61:A22.
    • (2012) Diabetes , vol.61 , pp. A22
    • Kadowaki, T.1    Ikeda, S.2    Takano, Y.3
  • 113
    • 84878248309 scopus 로고    scopus 로고
    • Model-based meta-analysis of the HbA1c lowering effect of PF-04971729, a sodium glucose co-transporter-2 inhibitor (SGLT2i), in comparison with other SGLT2i and anti-diabetic agents (ADA)
    • Mandema J, Sweeney K, Terra S, Sahasrabudhe V. Model-based meta-analysis of the HbA1c lowering effect of PF-04971729, a sodium glucose co-transporter-2 inhibitor (SGLT2i), in comparison with other SGLT2i and anti-diabetic agents (ADA). Diabetes. 2012;61:A260.
    • (2012) Diabetes , vol.61 , pp. A260
    • Mandema, J.1    Sweeney, K.2    Terra, S.3    Sahasrabudhe, V.4
  • 114
    • 84864146681 scopus 로고    scopus 로고
    • LX4211, a dual SGLT1/ SGLT2 inhibitor, improved glycemic control in patients with type 2 diabetes in a randomized, placebo-controlled trial
    • Zambrowicz B, Freiman J, Brown PM, et al. LX4211, a dual SGLT1/ SGLT2 inhibitor, improved glycemic control in patients with type 2 diabetes in a randomized, placebo-controlled trial. Clin Pharmacol Ther. 2012;92:158–169.
    • (2012) Clin Pharmacol Ther , vol.92 , pp. 158-169
    • Zambrowicz, B.1    Freiman, J.2    Brown, P.M.3
  • 115
    • 40349114501 scopus 로고    scopus 로고
    • GPR119, a novel G protein-coupled receptor target for the treatment of type 2 diabetes and obesity
    • Overton HA, Fyfe MC, Reynet C. GPR119, a novel G protein-coupled receptor target for the treatment of type 2 diabetes and obesity. Br J Pharmacol. 2008;153:S76–S81.
    • (2008) Br J Pharmacol , vol.153 , pp. S76-S81
    • Overton, H.A.1    Fyfe, M.C.2    Reynet, C.3
  • 116
    • 84928137190 scopus 로고    scopus 로고
    • GlaxoSmithKline, Accessed July 16, 2014
    • GlaxoSmithKline. A study in type 2 diabetics of single and multiple doses of orally administered GSK1292263 to investigate the safety, tolerability, pharmacokinetics and pharmacodynamics. Available from: http://clinicaltrials.gov/ct2/show/NCT01119846?term=gsk12 92263&rank=1. Accessed July 16, 2014.
    • A Study in Type 2 Diabetics of Single and Multiple
  • 118
    • 84863307279 scopus 로고    scopus 로고
    • Effects of JNJ-38431055, a novel GPR119 receptor agonist, in randomized, double-blind, placebo-controlled studies in subjects with type 2 diabetes
    • Katz LB, Gambale JJ, Rothenberg PL, et al. Effects of JNJ-38431055, a novel GPR119 receptor agonist, in randomized, double-blind, placebo-controlled studies in subjects with type 2 diabetes. Diabetes Obes Metab. 2012;14:709–716.
    • (2012) Diabetesobes Metab , vol.14 , pp. 709-716
    • Katz, L.B.1    Gambale, J.J.2    Rothenberg, P.L.3
  • 120
    • 84859625938 scopus 로고    scopus 로고
    • TAK-875 versus placebo or glimepiride in type 2 diabetes mellitus: A phase 2, randomised, double-blind, placebo-controlled trial
    • Burant CF, Viswanathan P, Marcinak J, et al. TAK-875 versus placebo or glimepiride in type 2 diabetes mellitus: a phase 2, randomised, double-blind, placebo-controlled trial. Lancet. 2012;379: 1403–1411.
    • (2012) Lancet , vol.379 , pp. 1403-1411
    • Burant, C.F.1    Viswanathan, P.2    Marcinak, J.3
  • 121
    • 73249141243 scopus 로고    scopus 로고
    • 11Beta-hydroxysteroid dehydrogenase type 1 and its role in the hypothalamus-pituitary-adrenal axis, metabolic syndrome, and infammation
    • Cooper MS, Stewart PM. 11Beta-hydroxysteroid dehydrogenase type 1 and its role in the hypothalamus-pituitary-adrenal axis, metabolic syndrome, and infammation. J Clin Endocrinol Metab. 2009;94:4645–4654.
    • (2009) J Clin Endocrinol Metab , vol.94 , pp. 4645-4654
    • Cooper, M.S.1    Stewart, P.M.2
  • 122
    • 77955630861 scopus 로고    scopus 로고
    • INCB13739-202 Principal Investigators. The 11-beta-hydroxysteroid dehydrogenase type 1 inhibitor INCB13739 improves hyperglycemia in patients with type 2 diabetes inadequately controlled by metformin monotherapy
    • Rosenstock J, Banarer S, Fonseca VA, et al; INCB13739-202 Principal Investigators. The 11-beta-hydroxysteroid dehydrogenase type 1 inhibitor INCB13739 improves hyperglycemia in patients with type 2 diabetes inadequately controlled by metformin monotherapy. Diabetes Care. 2010a;33:1516–1522.
    • (2010) Diabetes Care , vol.33 , pp. 1516-1522
    • Rosenstock, J.1    Banarer, S.2    Fonseca, V.A.3
  • 123
    • 84866268783 scopus 로고    scopus 로고
    • American Diabetes Association (ADA); European Association for the Study of Diabetes (EASD). Management of hyperglycemia in type 2 diabetes: A patient-centered approach: Position statement of the American Diabetes Association and the European Association for the Study of Diabetes
    • Inzucchi SE, Bergenstal RM, Buse JB, et al; American Diabetes Association (ADA); European Association for the Study of Diabetes (EASD). Management of hyperglycemia in type 2 diabetes: a patient-centered approach: position statement of the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care. 2012;35:1364–1379.
    • (2012) Diabetes Care , vol.35 , pp. 1364-1379
    • Inzucchi, S.E.1    Bergenstal, R.M.2    Buse, J.B.3
  • 124
    • 84919999219 scopus 로고    scopus 로고
    • Management of hyperg-lycemia in type 2 diabetes, 2015: A patient-centered approach: Updateto a position statement of the American Diabetes Association and the European Association for the Study of Diabetes
    • Inzucchi SE, Bergenstal RM, Buse JB, et al; Management of hyperg-lycemia in type 2 diabetes, 2015: a patient-centered approach: update to a position statement of the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care. 2015;38:140–149.
    • (2015) Diabetes Care , vol.38 , pp. 140-149
    • Inzucchi, S.E.1    Bergenstal, R.M.2    Buse, J.B.3
  • 125
    • 74249114217 scopus 로고    scopus 로고
    • Current antihyperglycemic treatment strategies for patientswith type 2 diabetes mellitus
    • Blonde L. Current antihyperglycemic treatment strategies for patients with type 2 diabetes mellitus. Cleve Clin J Med. 2009;76 Suppl 5: S4–S11.
    • Cleve Clin J Med. 2009;76 Suppl , vol.5 , pp. SS4-S11
    • Blonde, L.1
  • 127
    • 79952610089 scopus 로고    scopus 로고
    • Welchol® (colesevelam HCl, Parsip-, pany, NJ, USA: Daiichi Sankyo, Inc
    • Welchol® (colesevelam HCl). Full Prescribing Information. Parsip-pany, NJ, USA: Daiichi Sankyo, Inc.; 2010.
    • (2010) Full Prescribing Information
  • 128
    • 79952610089 scopus 로고    scopus 로고
    • Cycloset® (bromocriptine mesylate, Tiverton, RI: VeroScience, LLC
    • Cycloset® (bromocriptine mesylate). Full Prescribing Information. Tiverton, RI: VeroScience, LLC; 2010.
    • (2010) Full Prescribing Information


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