-
1
-
-
0030882856
-
Alpha-synuclein in Lewy bodies
-
Spillantini, M.G.; Schmidt, M.L.; Lee, V.M.; Trojanowski, J.Q.; Jakes, R.; Goedert, M. Alpha-synuclein in Lewy bodies. Nature 1997, 388, 839-840.
-
(1997)
Nature
, vol.388
, pp. 839-840
-
-
Spillantini, M.G.1
Schmidt, M.L.2
Lee, V.M.3
Trojanowski, J.Q.4
Jakes, R.5
Goedert, M.6
-
2
-
-
0031941058
-
Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies
-
Baba, M.; Nakajo, S.; Tu, P.H.; Tomita, T.; Nakaya, K.; Lee, V.M.; Trojanowski, J.Q.; Iwatsubo, T. Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies. Am. J. Pathol. 1998, 152, 879-884.
-
(1998)
Am. J. Pathol.
, vol.152
, pp. 879-884
-
-
Baba, M.1
Nakajo, S.2
Tu, P.H.3
Tomita, T.4
Nakaya, K.5
Lee, V.M.6
Trojanowski, J.Q.7
Iwatsubo, T.8
-
3
-
-
13444252277
-
Release of long-range tertiary interactions potentiates aggregation of natively unstructured alpha-synuclein
-
Bertoncini, C.W.; Jung, Y.S.; Fernandez, C.O.; Hoyer, W.; Griesinger, C.; Jovin, T.M.; Zweckstetter, M. Release of long-range tertiary interactions potentiates aggregation of natively unstructured alpha-synuclein. Proc. Natl. Acad. Sci. USA 2005, 102, 1430-1435.
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 1430-1435
-
-
Bertoncini, C.W.1
Jung, Y.S.2
Fernandez, C.O.3
Hoyer, W.4
Griesinger, C.5
Jovin, T.M.6
Zweckstetter, M.7
-
4
-
-
12944304172
-
Mapping long-range interactions in alpha-synuclein using spin-label NMR and ensemble molecular dynamics simulations
-
Dedmon, M.M.; Lindorff-Larsen, K.; Christodoulou, J.; Vendruscolo, M.; Dobson, C.M. Mapping long-range interactions in alpha-synuclein using spin-label NMR and ensemble molecular dynamics simulations. J. Am. Chem. Soc. 2005, 127, 476-477.
-
(2005)
J. Am. Chem. Soc.
, vol.127
, pp. 476-477
-
-
Dedmon, M.M.1
Lindorff-Larsen, K.2
Christodoulou, J.3
Vendruscolo, M.4
Dobson, C.M.5
-
5
-
-
0034077041
-
Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system
-
Abeliovich, A.; Schmitz, Y.; Farinas, I.; Choi-Lundberg, D.; Ho, W.H.; Castillo, P.E.; Shinsky, N.; Verdugo, J.M.; Armanini, M.; Ryan, A.; et al. Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system. Neuron 2000, 25, 239-252.
-
(2000)
Neuron
, vol.25
, pp. 239-252
-
-
Abeliovich, A.1
Schmitz, Y.2
Farinas, I.3
Choi-Lundberg, D.4
Ho, W.H.5
Castillo, P.E.6
Shinsky, N.7
Verdugo, J.M.8
Armanini, M.9
Ryan, A.10
-
6
-
-
84857716290
-
Impaired neurotransmission caused by overexpression of alpha-synuclein in nigral dopamine neurons
-
Lundblad, M.; Decressac, M.; Mattsson, B.; Bjorklund, A. Impaired neurotransmission caused by overexpression of alpha-synuclein in nigral dopamine neurons. Proc. Natl. Acad. Sci. USA 2012, 109, 3213-3219.
-
(2012)
Proc. Natl. Acad. Sci. USA
, vol.109
, pp. 3213-3219
-
-
Lundblad, M.1
Decressac, M.2
Mattsson, B.3
Bjorklund, A.4
-
7
-
-
33746533924
-
Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models
-
Cooper, A.A.; Gitler, A.D.; Cashikar, A.; Haynes, C.M.; Hill, K.J.; Bhullar, B.; Liu, K.; Xu, K.; Strathearn, K.E.; Liu, F.; et al. Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models. Science 2006, 313, 324-328.
-
(2006)
Science
, vol.313
, pp. 324-328
-
-
Cooper, A.A.1
Gitler, A.D.2
Cashikar, A.3
Haynes, C.M.4
Hill, K.J.5
Bhullar, B.6
Liu, K.7
Xu, K.8
Strathearn, K.E.9
Liu, F.10
-
8
-
-
73549085595
-
Increased expression of alpha-synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosis
-
Nemani, V.M.; Lu, W.; Berge, V.; Nakamura, K.; Onoa, B.; Lee, M.K.; Chaudhry, F.A.; Nicoll, R.A.; Edwards, R.H. Increased expression of alpha-synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosis. Neuron 2010, 65, 66-79.
-
(2010)
Neuron
, vol.65
, pp. 66-79
-
-
Nemani, V.M.1
Lu, W.2
Berge, V.3
Nakamura, K.4
Onoa, B.5
Lee, M.K.6
Chaudhry, F.A.7
Nicoll, R.A.8
Edwards, R.H.9
-
9
-
-
0034527763
-
Physiology and pathophysiology of alpha-synuclein: Cell culture and transgenic animal models based on a Parkinson's disease-associated protein
-
Kahle, P.J.; Neumann, M.; Ozmen, L.; Haass, C. Physiology and pathophysiology of alpha-synuclein: Cell culture and transgenic animal models based on a Parkinson's disease-associated protein. Ann. N. Y. Acad. Sci. 2000, 920, 33-41.
-
(2000)
Ann. N. Y. Acad. Sci.
, vol.920
, pp. 33-41
-
-
Kahle, P.J.1
Neumann, M.2
Ozmen, L.3
Haass, C.4
-
10
-
-
77953796839
-
A pathologic cascade leading to synaptic dysfunction in alpha-synuclein-induced neurodegeneration
-
Scott, D.A.; Tabarean, I.; Tang, Y.; Cartier, A.; Masliah, E.; Roy, S. A pathologic cascade leading to synaptic dysfunction in alpha-synuclein-induced neurodegeneration. J. Neurosci. 2010, 30, 8083-8095.
-
(2010)
J. Neurosci.
, vol.30
, pp. 8083-8095
-
-
Scott, D.A.1
Tabarean, I.2
Tang, Y.3
Cartier, A.4
Masliah, E.5
Roy, S.6
-
11
-
-
84864258151
-
Alpha-synuclein inhibits intersynaptic vesicle mobility and maintains recycling-pool homeostasis
-
Scott, D.; Roy, S. Alpha-synuclein inhibits intersynaptic vesicle mobility and maintains recycling-pool homeostasis. J. Neurosci. 2012, 32, 10129-10135.
-
(2012)
J. Neurosci.
, vol.32
, pp. 10129-10135
-
-
Scott, D.1
Roy, S.2
-
12
-
-
33749570292
-
Phosphorylation of Ser-129 is the dominant pathological modification of alpha-synuclein in familial and sporadic Lewy body disease
-
Anderson, J.P.; Walker, D.E.; Goldstein, J.M.; de Laat, R.; Banducci, K.; Caccavello, R.J.; Barbour, R.; Huang, J.; Kling, K.; Lee, M.; et al. Phosphorylation of Ser-129 is the dominant pathological modification of alpha-synuclein in familial and sporadic Lewy body disease. J. Biol. Chem. 2006, 281, 29739-29752.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 29739-29752
-
-
Anderson, J.P.1
Walker, D.E.2
Goldstein, J.M.3
de Laat, R.4
Banducci, K.5
Caccavello, R.J.6
Barbour, R.7
Huang, J.8
Kling, K.9
Lee, M.10
-
13
-
-
0036174010
-
Alpha-synuclein is phosphorylated in synucleinopathy lesions
-
Fujiwara, H.; Hasegawa, M.; Dohmae, N.; Kawashima, A.; Masliah, E.; Goldberg, M.S.; Shen, J.; Takio, K.; Iwatsubo, T. Alpha-synuclein is phosphorylated in synucleinopathy lesions. Nat. Cell Biol. 2002, 4, 160-164.
-
(2002)
Nat. Cell Biol.
, vol.4
, pp. 160-164
-
-
Fujiwara, H.1
Hasegawa, M.2
Dohmae, N.3
Kawashima, A.4
Masliah, E.5
Goldberg, M.S.6
Shen, J.7
Takio, K.8
Iwatsubo, T.9
-
14
-
-
4143067071
-
Phosphorylated alpha-synuclein in normal mouse brain
-
Hirai, Y.; Fujita, S.C.; Iwatsubo, T.; Hasegawa, M. Phosphorylated alpha-synuclein in normal mouse brain. FEBS Lett. 2004, 572, 227-232.
-
(2004)
FEBS Lett.
, vol.572
, pp. 227-232
-
-
Hirai, Y.1
Fujita, S.C.2
Iwatsubo, T.3
Hasegawa, M.4
-
15
-
-
47749107973
-
Phosphorylation at Ser-129 but not the phosphomimics S129E/D inhibits the fibrillation of alpha-synuclein
-
Paleologou, K.E.; Schmid, A.W.; Rospigliosi, C.C.; Kim, H.-Y.; Lamberto, G.R.; Fredenburg, R.A.; Lansbury, P.T.; Fernandez, C.O.; Eliezer, D.; Zweckstetter, M.; et al. Phosphorylation at Ser-129 but not the phosphomimics S129E/D inhibits the fibrillation of alpha-synuclein. J. Biol. Chem. 2008, 283, 16895-16905.
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 16895-16905
-
-
Paleologou, K.E.1
Schmid, A.W.2
Rospigliosi, C.C.3
Kim, H.-Y.4
Lamberto, G.R.5
Fredenburg, R.A.6
Lansbury, P.T.7
Fernandez, C.O.8
Eliezer, D.9
Zweckstetter, M.10
-
16
-
-
17844406856
-
Alpha-synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease
-
Chen, L.; Feany, M.B. Alpha-synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease. Nat. Neurosci. 2005, 8, 657-663.
-
(2005)
Nat. Neurosci.
, vol.8
, pp. 657-663
-
-
Chen, L.1
Feany, M.B.2
-
17
-
-
67650496503
-
Relationship between alpha synuclein phosphorylation, proteasomal inhibition and cell death: Relevance to Parkinson's disease pathogenesis
-
Chau, K.Y.; Ching, H.L.; Schapira, A.H.; Cooper, J.M. Relationship between alpha synuclein phosphorylation, proteasomal inhibition and cell death: Relevance to Parkinson's disease pathogenesis. J. Neurochem. 2009, 110, 1005-1013.
-
(2009)
J. Neurochem.
, vol.110
, pp. 1005-1013
-
-
Chau, K.Y.1
Ching, H.L.2
Schapira, A.H.3
Cooper, J.M.4
-
18
-
-
60549109895
-
Phosphorylation does not prompt, nor prevent, the formation of alpha-synuclein toxic species in a rat model of Parkinson's disease
-
Azeredo da Silveira, S.; Schneider, B.L.; Cifuentes-Diaz, C.; Sage, D.; Abbas-Terki, T.; Iwatsubo, T.; Unser, M.L.; Aebischer, P. Phosphorylation does not prompt, nor prevent, the formation of alpha-synuclein toxic species in a rat model of Parkinson's disease. Hum. Mol. Genet. 2009, 18, 872-887.
-
(2009)
Hum. Mol. Genet.
, vol.18
, pp. 872-887
-
-
Azeredo da Silveira, S.1
Schneider, B.L.2
Cifuentes-Diaz, C.3
Sage, D.4
Abbas-Terki, T.5
Iwatsubo, T.6
Unser, M.L.7
Aebischer, P.8
-
19
-
-
38649084032
-
The phosphorylation state of Ser-129 in human alpha-synuclein determines neurodegeneration in a rat model of Parkinson disease
-
Gorbatyuk, O.S.; Li, S.; Sullivan, L.F.; Chen, W.; Kondrikova, G.; Manfredsson, F.P.; Mandel, R.J.; Muzyczka, N. The phosphorylation state of Ser-129 in human alpha-synuclein determines neurodegeneration in a rat model of Parkinson disease. Proc. Natl. Acad. Sci. USA 2008, 105, 763-768.
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 763-768
-
-
Gorbatyuk, O.S.1
Li, S.2
Sullivan, L.F.3
Chen, W.4
Kondrikova, G.5
Manfredsson, F.P.6
Mandel, R.J.7
Muzyczka, N.8
-
20
-
-
70149118325
-
Alpha-synuclein S129 phosphorylation mutants do not alter nigrostriatal toxicity in a rat model of Parkinson disease
-
McFarland, N.R.; Fan, Z.; Xu, K.; Schwarzschild, M.A.; Feany, M.B.; Hyman, B.T.; McLean, P.J. Alpha-synuclein S129 phosphorylation mutants do not alter nigrostriatal toxicity in a rat model of Parkinson disease. J. Neuropathol. Exp. Neurol. 2009, 68, 515-524.
-
(2009)
J. Neuropathol. Exp. Neurol.
, vol.68
, pp. 515-524
-
-
McFarland, N.R.1
Fan, Z.2
Xu, K.3
Schwarzschild, M.A.4
Feany, M.B.5
Hyman, B.T.6
McLean, P.J.7
-
21
-
-
0034614415
-
Constitutive phosphorylation of the Parkinson's disease associated alpha-synuclein
-
Okochi, M.; Walter, J.; Koyama, A.; Nakajo, S.; Baba, M.; Iwatsubo, T.; Meijer, L.; Kahle, P.J.; Haass, C. Constitutive phosphorylation of the Parkinson's disease associated alpha-synuclein. J. Biol. Chem. 2000, 275, 390-397.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 390-397
-
-
Okochi, M.1
Walter, J.2
Koyama, A.3
Nakajo, S.4
Baba, M.5
Iwatsubo, T.6
Meijer, L.7
Kahle, P.J.8
Haass, C.9
-
22
-
-
43249108653
-
Specificity and regulation of casein kinase-mediated phosphorylation of alpha-synuclein
-
Waxman, E.A.; Giasson, B.I. Specificity and regulation of casein kinase-mediated phosphorylation of alpha-synuclein. J. Neuropathol. Exp. Neurol. 2008, 67, 402-416.
-
(2008)
J. Neuropathol. Exp. Neurol.
, vol.67
, pp. 402-416
-
-
Waxman, E.A.1
Giasson, B.I.2
-
23
-
-
33748483511
-
The role of G-protein-coupled receptor kinase 5 in pathogenesis of sporadic Parkinson's disease
-
Arawaka, S.; Wada, M.; Goto, S.; Karube, H.; Sakamoto, M.; Ren, C.-H.; Koyama, S.; Nagasawa, H.; Kimura, H.; Kawanami, T.; et al. The role of G-protein-coupled receptor kinase 5 in pathogenesis of sporadic Parkinson's disease. J. Neurosci. Off. J. Soc. Neurosci. 2006, 26, 9227-9238.
-
(2006)
J. Neurosci. Off. J. Soc. Neurosci.
, vol.26
, pp. 9227-9238
-
-
Arawaka, S.1
Wada, M.2
Goto, S.3
Karube, H.4
Sakamoto, M.5
Ren, C.-H.6
Koyama, S.7
Nagasawa, H.8
Kimura, H.9
Kawanami, T.10
-
24
-
-
0034714204
-
Synucleins are a novel class of substrates for G protein-coupled receptor kinases
-
Pronin, A.N.; Morris, A.J.; Surguchov, A.; Benovic, J.L. Synucleins are a novel class of substrates for G protein-coupled receptor kinases. J. Biol. Chem. 2000, 275, 26515-26522.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 26515-26522
-
-
Pronin, A.N.1
Morris, A.J.2
Surguchov, A.3
Benovic, J.L.4
-
25
-
-
59149090357
-
Polo-like kinase 2 (PLK2) phosphorylates alpha-synuclein at serine 129 in central nervous system
-
Inglis, K.J.; Chereau, D.; Brigham, E.F.; Chiou, S.S.; Schobel, S.; Frigon, N.L.; Yu, M.; Caccavello, R.J.; Nelson, S.; Motter, R.; et al. Polo-like kinase 2 (PLK2) phosphorylates alpha-synuclein at serine 129 in central nervous system. J. Biol. Chem. 2009, 284, 2598-2602.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 2598-2602
-
-
Inglis, K.J.1
Chereau, D.2
Brigham, E.F.3
Chiou, S.S.4
Schobel, S.5
Frigon, N.L.6
Yu, M.7
Caccavello, R.J.8
Nelson, S.9
Motter, R.10
-
26
-
-
77449113371
-
Phosphorylation of synucleins by members of the Polo-like kinase family
-
Mbefo, M.K.; Paleologou, K.E.; Boucharaba, A.; Oueslati, A.; Schell, H.; Fournier, M.; Olschewski, D.; Yin, G.; Zweckstetter, M.; Masliah, E.; et al. Phosphorylation of synucleins by members of the Polo-like kinase family. J. Biol. Chem. 2010, 285, 2807-2822.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 2807-2822
-
-
Mbefo, M.K.1
Paleologou, K.E.2
Boucharaba, A.3
Oueslati, A.4
Schell, H.5
Fournier, M.6
Olschewski, D.7
Yin, G.8
Zweckstetter, M.9
Masliah, E.10
-
27
-
-
0036484302
-
Multiple phosphorylation of alpha-synuclein by protein tyrosine kinase Syk prevents eosin-induced aggregation
-
Negro, A.; Brunati, A.M.; Donella-Deana, A.; Massimino, M.L.; Pinna, L.A. Multiple phosphorylation of alpha-synuclein by protein tyrosine kinase Syk prevents eosin-induced aggregation. J. Off. Publ. Feder. Am. Soc. Exp. Biol. 2002, 16, 210-212.
-
(2002)
J. Off. Publ. Feder. Am. Soc. Exp. Biol.
, vol.16
, pp. 210-212
-
-
Negro, A.1
Brunati, A.M.2
Donella-Deana, A.3
Massimino, M.L.4
Pinna, L.A.5
-
28
-
-
0035830913
-
Alpha-synuclein is phosphorylated by members of the Src family of protein-tyrosine kinases
-
Ellis, C.E.; Schwartzberg, P.L.; Grider, T.L.; Fink, D.W.; Nussbaum, R.L. Alpha-synuclein is phosphorylated by members of the Src family of protein-tyrosine kinases. J. Biol. Chem. 2001, 276, 3879-3884.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 3879-3884
-
-
Ellis, C.E.1
Schwartzberg, P.L.2
Grider, T.L.3
Fink, D.W.4
Nussbaum, R.L.5
-
29
-
-
0034813638
-
Activated Fyn phosphorylates alpha-synuclein at tyrosine residue 125
-
Nakamura, T.; Yamashita, H.; Takahashi, T.; Nakamura, S. Activated Fyn phosphorylates alpha-synuclein at tyrosine residue 125. Biochem. Biophys. Res. Commun. 2001, 280, 1085-1092.
-
(2001)
Biochem. Biophys. Res. Commun.
, vol.280
, pp. 1085-1092
-
-
Nakamura, T.1
Yamashita, H.2
Takahashi, T.3
Nakamura, S.4
-
30
-
-
18544364794
-
Alpha-Synuclein interacts with phospholipase D isozymes and inhibits pervanadate-induced phospholipase D activation in human embryonic kidney-293 cells
-
Ahn, B.H.; Rhim, H.; Kim, S.Y.; Sung, Y.M.; Lee, M.Y.; Choi, J.Y.; Wolozin, B.; Chang, J.S.; Lee, Y.H.; Kwon, T.K.; et al. Alpha-Synuclein interacts with phospholipase D isozymes and inhibits pervanadate-induced phospholipase D activation in human embryonic kidney-293 cells. J. Biol. Chem. 2002, 277, 12334-12342.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 12334-12342
-
-
Ahn, B.H.1
Rhim, H.2
Kim, S.Y.3
Sung, Y.M.4
Lee, M.Y.5
Choi, J.Y.6
Wolozin, B.7
Chang, J.S.8
Lee, Y.H.9
Kwon, T.K.10
-
31
-
-
70449347241
-
Tyrosine and serine phosphorylation of alpha-synuclein have opposing effects on neurotoxicity and soluble oligomer formation
-
Chen, L.; Periquet, M.; Wang, X.; Negro, A.; McLean, P.J.; Hyman, B.T.; Feany, M.B. Tyrosine and serine phosphorylation of alpha-synuclein have opposing effects on neurotoxicity and soluble oligomer formation. J. Clin. Investig. 2009, 119, 3257-3265.
-
(2009)
J. Clin. Investig.
, vol.119
, pp. 3257-3265
-
-
Chen, L.1
Periquet, M.2
Wang, X.3
Negro, A.4
McLean, P.J.5
Hyman, B.T.6
Feany, M.B.7
-
32
-
-
79960692455
-
Comparative analysis of different peptidyl-prolyl isomerases reveals FK506-binding protein 12 as the most potent enhancer of alpha-synuclein aggregation
-
Deleersnijder, A.; van Rompuy, A.S.; Desender, L.; Pottel, H.; Buee, L.; Debyser, Z.; Baekelandt, V.; Gerard, M. Comparative analysis of different peptidyl-prolyl isomerases reveals FK506-binding protein 12 as the most potent enhancer of alpha-synuclein aggregation. J. Biol. Chem. 2011, 286, 26687-26701.
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 26687-26701
-
-
Deleersnijder, A.1
van Rompuy, A.S.2
Desender, L.3
Pottel, H.4
Buee, L.5
Debyser, Z.6
Baekelandt, V.7
Gerard, M.8
-
33
-
-
45249118270
-
FK506 binding protein 12 differentially accelerates fibril formation of wild type alpha-synuclein and its clinical mutants A30P or A53T
-
Gerard, M.; Debyser, Z.; Desender, L.; Baert, J.; Brandt, I.; Baekelandt, V.; Engelborghs, Y. FK506 binding protein 12 differentially accelerates fibril formation of wild type alpha-synuclein and its clinical mutants A30P or A53T. J. Neurochem. 2008, 106, 121-133.
-
(2008)
J. Neurochem.
, vol.106
, pp. 121-133
-
-
Gerard, M.1
Debyser, Z.2
Desender, L.3
Baert, J.4
Brandt, I.5
Baekelandt, V.6
Engelborghs, Y.7
-
34
-
-
77249126934
-
Inhibition of FK506 binding proteins reduces alpha-synuclein aggregation and Parkinson's disease-like pathology
-
Gerard, M.; Deleersnijder, A.; Daniels, V.; Schreurs, S.; Munck, S.; Reumers, V.; Pottel, H.; Engelborghs, Y.; van den Haute, C.; Taymans, J.M.; et al. Inhibition of FK506 binding proteins reduces alpha-synuclein aggregation and Parkinson's disease-like pathology. J. Neurosci. 2010, 30, 2454-2463.
-
(2010)
J. Neurosci.
, vol.30
, pp. 2454-2463
-
-
Gerard, M.1
Deleersnijder, A.2
Daniels, V.3
Schreurs, S.4
Munck, S.5
Reumers, V.6
Pottel, H.7
Engelborghs, Y.8
van den Haute, C.9
Taymans, J.M.10
-
35
-
-
52049098478
-
Structural characteristics of alpha-synuclein oligomers stabilized by the flavonoid baicalein
-
Hong, D.P.; Fink, A.L.; Uversky, V.N. Structural characteristics of alpha-synuclein oligomers stabilized by the flavonoid baicalein. J. Mol. Biol. 2008, 383, 214-223.
-
(2008)
J. Mol. Biol.
, vol.383
, pp. 214-223
-
-
Hong, D.P.1
Fink, A.L.2
Uversky, V.N.3
-
36
-
-
77950659588
-
Early aggregation steps in alpha-synuclein as measured by FCS and FRET: Evidence for a contagious conformational change
-
Nath, S.; Meuvis, J.; Hendrix, J.; Carl, S.A.; Engelborghs, Y. Early aggregation steps in alpha-synuclein as measured by FCS and FRET: Evidence for a contagious conformational change. Biophys. J. 2010, 98, 1302-1311.
-
(2010)
Biophys. J.
, vol.98
, pp. 1302-1311
-
-
Nath, S.1
Meuvis, J.2
Hendrix, J.3
Carl, S.A.4
Engelborghs, Y.5
-
37
-
-
0034773940
-
Solvent-induced collapse of alpha-synuclein and acid-denatured cytochrome c
-
Morar, A.S.; Olteanu, A.; Young, G.B.; Pielak, G.J. Solvent-induced collapse of alpha-synuclein and acid-denatured cytochrome c. Protein Sci. 2001, 10, 2195-2199.
-
(2001)
Protein Sci.
, vol.10
, pp. 2195-2199
-
-
Morar, A.S.1
Olteanu, A.2
Young, G.B.3
Pielak, G.J.4
-
38
-
-
77749341497
-
Phosphorylation at S87 is enhanced in synucleinopathies, inhibits alpha-synuclein oligomerization, and influences synuclein-membrane interactions
-
Paleologou, K.E.; Oueslati, A.; Shakked, G.; Rospigliosi, C.C.; Kim, H.Y.; Lamberto, G.R.; Fernandez, C.O.; Schmid, A.; Chegini, F.; Gai, W.P.; et al. Phosphorylation at S87 is enhanced in synucleinopathies, inhibits alpha-synuclein oligomerization, and influences synuclein-membrane interactions. J. Neurosci. 2010, 30, 3184-3198.
-
(2010)
J. Neurosci.
, vol.30
, pp. 3184-3198
-
-
Paleologou, K.E.1
Oueslati, A.2
Shakked, G.3
Rospigliosi, C.C.4
Kim, H.Y.5
Lamberto, G.R.6
Fernandez, C.O.7
Schmid, A.8
Chegini, F.9
Gai, W.P.10
-
39
-
-
33645832333
-
The aggregation of alpha-synuclein is stimulated by FK506 binding proteins as shown by fluorescence correlation spectroscopy
-
Gerard, M.; Debyser, Z.; Desender, L.; Kahle, P.J.; Baert, J.; Baekelandt, V.; Engelborghs, Y. The aggregation of alpha-synuclein is stimulated by FK506 binding proteins as shown by fluorescence correlation spectroscopy. FASEB J. 2006, 20, 524-526.
-
(2006)
FASEB J.
, vol.20
, pp. 524-526
-
-
Gerard, M.1
Debyser, Z.2
Desender, L.3
Kahle, P.J.4
Baert, J.5
Baekelandt, V.6
Engelborghs, Y.7
-
40
-
-
78049310914
-
The conformation and the aggregation kinetics of alpha-synuclein depend on the proline residues in its C-terminal region
-
Meuvis, J.; Gerard, M.; Desender, L.; Baekelandt, V.; Engelborghs, Y. The conformation and the aggregation kinetics of alpha-synuclein depend on the proline residues in its C-terminal region. Biochemistry 2010, 49, 9345-9352.
-
(2010)
Biochemistry
, vol.49
, pp. 9345-9352
-
-
Meuvis, J.1
Gerard, M.2
Desender, L.3
Baekelandt, V.4
Engelborghs, Y.5
-
41
-
-
84857693190
-
Phosphorylation of alpha-synuclein protein at Ser-129 reduces neuronal dysfunction by lowering its membrane binding property in Caenorhabditis elegans
-
Kuwahara, T.; Tonegawa, R.; Ito, G.; Mitani, S.; Iwatsubo, T. Phosphorylation of alpha-synuclein protein at Ser-129 reduces neuronal dysfunction by lowering its membrane binding property in Caenorhabditis elegans. J. Biol. Chem. 2012, 287, 7098-7109.
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 7098-7109
-
-
Kuwahara, T.1
Tonegawa, R.2
Ito, G.3
Mitani, S.4
Iwatsubo, T.5
-
42
-
-
80053912079
-
Effect of Ser-129 phosphorylation on interaction of alpha-synuclein with synaptic and cellular membranes
-
Visanji, N.P.; Wislet-Gendebien, S.; Oschipok, L.W.; Zhang, G.; Aubert, I.; Fraser, P.E.; Tandon, A. Effect of Ser-129 phosphorylation on interaction of alpha-synuclein with synaptic and cellular membranes. J. Biol. Chem. 2011, 286, 35863-35873.
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 35863-35873
-
-
Visanji, N.P.1
Wislet-Gendebien, S.2
Oschipok, L.W.3
Zhang, G.4
Aubert, I.5
Fraser, P.E.6
Tandon, A.7
-
43
-
-
0032551656
-
Human recombinant NACP/alpha-synuclein is aggregated and fibrillated in vitro: Relevance for Lewy body disease
-
Hashimoto, M.; Hsu, L.J.; Sisk, A.; Xia, Y.; Takeda, A.; Sundsmo, M.; Masliah, E. Human recombinant NACP/alpha-synuclein is aggregated and fibrillated in vitro: Relevance for Lewy body disease. Brain Res. 1998, 799, 301-306.
-
(1998)
Brain Res.
, vol.799
, pp. 301-306
-
-
Hashimoto, M.1
Hsu, L.J.2
Sisk, A.3
Xia, Y.4
Takeda, A.5
Sundsmo, M.6
Masliah, E.7
-
44
-
-
25144472591
-
Showing your ID: Intrinsic disorder as an ID for recognition, regulation and cell signaling
-
Uversky, V.N.; Oldfield, C.J.; Dunker, A.K. Showing your ID: Intrinsic disorder as an ID for recognition, regulation and cell signaling. J. Mol. Recognit. 2005, 18, 343-384.
-
(2005)
J. Mol. Recognit.
, vol.18
, pp. 343-384
-
-
Uversky, V.N.1
Oldfield, C.J.2
Dunker, A.K.3
-
45
-
-
0038404977
-
Nitration inhibits fibrillation of human alpha-synuclein in vitro by formation of soluble oligomers
-
Yamin, G.; Uversky, V.N.; Fink, A.L. Nitration inhibits fibrillation of human alpha-synuclein in vitro by formation of soluble oligomers. FEBS Lett. 2003, 542, 147-152.
-
(2003)
FEBS Lett.
, vol.542
, pp. 147-152
-
-
Yamin, G.1
Uversky, V.N.2
Fink, A.L.3
-
46
-
-
81455136019
-
Phosphorylation of alpha-synuclein at Y125 and S129 alters its metal binding properties: Implications for understanding the role of alpha-synuclein in the pathogenesis of Parkinson's disease and related disorders
-
Lu, Y.; Prudent, M.; Fauvet, B.; Lashuel, H.A.; Girault, H.H. Phosphorylation of alpha-synuclein at Y125 and S129 alters its metal binding properties: Implications for understanding the role of alpha-synuclein in the pathogenesis of Parkinson's disease and related disorders. ACS Chem. Neurosci. 2011, 2, 667-675.
-
(2011)
ACS Chem. Neurosci.
, vol.2
, pp. 667-675
-
-
Lu, Y.1
Prudent, M.2
Fauvet, B.3
Lashuel, H.A.4
Girault, H.H.5
-
47
-
-
84863349141
-
Elucidating the role of C-terminal post-translational modifications using protein semisynthesis strategies: Alpha-synuclein phosphorylation at tyrosine 125
-
Hejjaoui, M.; Butterfield, S.; Fauvet, B.; Vercruysse, F.; Cui, J.; Dikiy, I.; Prudent, M.; Olschewski, D.; Zhang, Y.; Eliezer, D.; et al. Elucidating the role of C-terminal post-translational modifications using protein semisynthesis strategies: Alpha-synuclein phosphorylation at tyrosine 125. J. Am. Chem. Soc. 2012, 134, 5196-5210.
-
(2012)
J. Am. Chem. Soc.
, vol.134
, pp. 5196-5210
-
-
Hejjaoui, M.1
Butterfield, S.2
Fauvet, B.3
Vercruysse, F.4
Cui, J.5
Dikiy, I.6
Prudent, M.7
Olschewski, D.8
Zhang, Y.9
Eliezer, D.10
-
48
-
-
52049121032
-
Impact of Tyr to Ala mutations on alpha-synuclein fibrillation and structural properties
-
Ulrih, N.P.; Barry, C.H.; Fink, A.L. Impact of Tyr to Ala mutations on alpha-synuclein fibrillation and structural properties. Biochim. Biophys. Acta 2008, 1782, 581-585.
-
(2008)
Biochim. Biophys. Acta
, vol.1782
, pp. 581-585
-
-
Ulrih, N.P.1
Barry, C.H.2
Fink, A.L.3
-
49
-
-
0032926319
-
Peptidyl-prolyl cis-trans isomerases, a superfamily of ubiquitous folding catalysts
-
Gothel, S.F.; Marahiel, M.A. Peptidyl-prolyl cis-trans isomerases, a superfamily of ubiquitous folding catalysts. Cell. Mol. Life Sci. 1999, 55, 423-436.
-
(1999)
Cell. Mol. Life Sci.
, vol.55
, pp. 423-436
-
-
Gothel, S.F.1
Marahiel, M.A.2
-
50
-
-
33744964249
-
The specific FKBP38 inhibitor N-(N', N'-dimethylcarboxamidomethyl)cycloheximide has potent neuroprotective and neurotrophic properties in brain ischemia
-
Edlich, F.; Weiwad, M.; Wildemann, D.; Jarczowski, F.; Kilka, S.; Moutty, M.C.; Jahreis, G.; Lucke, C.; Schmidt, W.; Striggow, F.; et al. The specific FKBP38 inhibitor N-(N', N'-dimethylcarboxamidomethyl)cycloheximide has potent neuroprotective and neurotrophic properties in brain ischemia. J. Biol. Chem. 2006, 281, 14961-14970.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 14961-14970
-
-
Edlich, F.1
Weiwad, M.2
Wildemann, D.3
Jarczowski, F.4
Kilka, S.5
Moutty, M.C.6
Jahreis, G.7
Lucke, C.8
Schmidt, W.9
Striggow, F.10
-
51
-
-
2942565668
-
Neuroregenerative and neuroprotective actions of neuroimmunophilin compounds in traumatic and inflammatory neuropathies
-
Gold, B.G.; Udina, E.; Bourdette, D.; Navarro, X. Neuroregenerative and neuroprotective actions of neuroimmunophilin compounds in traumatic and inflammatory neuropathies. Neurol. Res. 2004, 26, 371-380.
-
(2004)
Neurol. Res.
, vol.26
, pp. 371-380
-
-
Gold, B.G.1
Udina, E.2
Bourdette, D.3
Navarro, X.4
-
52
-
-
0031258791
-
A nonimmunosuppressant FKBP-12 ligand increases nerve regeneration
-
Gold, B.G.; Zeleny-Pooley, M.; Wang, M.S.; Chaturvedi, P.; Armistead, D.M. A nonimmunosuppressant FKBP-12 ligand increases nerve regeneration. Exp. Neurol 1997, 147, 269-278.
-
(1997)
Exp. Neurol
, vol.147
, pp. 269-278
-
-
Gold, B.G.1
Zeleny-Pooley, M.2
Wang, M.S.3
Chaturvedi, P.4
Armistead, D.M.5
-
53
-
-
33845358566
-
Quantitative morphological analysis reveals ultrastructural diversity of amyloid fibrils from alpha-synuclein mutants
-
Van Raaij, M.E.; Segers-Nolten, I.M.; Subramaniam, V. Quantitative morphological analysis reveals ultrastructural diversity of amyloid fibrils from alpha-synuclein mutants. Biophys. J. 2006, 91, L96-L98.
-
(2006)
Biophys. J.
, vol.91
-
-
Van Raaij, M.E.1
Segers-Nolten, I.M.2
Subramaniam, V.3
-
54
-
-
77649328234
-
The Parkinson's disease associated LRRK2 exhibits weaker in vitro phosphorylation of 4E-BP compared to autophosphorylation
-
Kumar, A.; Greggio, E.; Beilina, A.; Kaganovich, A.; Chan, D.; Taymans, J.M.; Wolozin, B.; Cookson, M.R. The Parkinson's disease associated LRRK2 exhibits weaker in vitro phosphorylation of 4E-BP compared to autophosphorylation. PLoS One 2010, 5, e8730.
-
(2010)
PLoS One
, vol.5
-
-
Kumar, A.1
Greggio, E.2
Beilina, A.3
Kaganovich, A.4
Chan, D.5
Taymans, J.M.6
Wolozin, B.7
Cookson, M.R.8
-
55
-
-
33744982893
-
Etiology of Parkinson's disease
-
Schapira, A.H. Etiology of Parkinson's disease. Neurology 2006, 66, S10-S23.
-
(2006)
Neurology
, vol.66
-
-
Schapira, A.H.1
-
56
-
-
34547975971
-
Oxidative stress-induced phosphorylation, degradation and aggregation of alpha-synuclein are linked to upregulated CK2 and cathepsin D
-
Takahashi, M.; Ko, L.W.; Kulathingal, J.; Jiang, P.; Sevlever, D.; Yen, S.H. Oxidative stress-induced phosphorylation, degradation and aggregation of alpha-synuclein are linked to upregulated CK2 and cathepsin D. Eur. J. Neurosci. 2007, 26, 863-874.
-
(2007)
Eur. J. Neurosci.
, vol.26
, pp. 863-874
-
-
Takahashi, M.1
Ko, L.W.2
Kulathingal, J.3
Jiang, P.4
Sevlever, D.5
Yen, S.H.6
-
57
-
-
80052828693
-
Kinases as targets for Parkinson's disease: From genetics to therapy
-
Vancraenenbroeck, R.; Lobbestael, E.; de Maeyer, M.; Baekelandt, V.; Taymans, J.M. Kinases as targets for Parkinson's disease: from genetics to therapy. CNS Neurol. Disord. Drug Targets 2011, 10, 724-740.
-
(2011)
CNS Neurol. Disord. Drug Targets
, vol.10
, pp. 724-740
-
-
Vancraenenbroeck, R.1
Lobbestael, E.2
de Maeyer, M.3
Baekelandt, V.4
Taymans, J.M.5
-
58
-
-
44849084558
-
Single particle characterization of iron-induced pore-forming alpha-synuclein oligomers
-
Kostka, M.; T. Hogen, K.M.; Danzer, J.; Levin, M.; Habeck, A.; Wirth, R.; Wagner, C.G.; Glabe, S.; Finger, U.; Heinzelmann, P.; et al. Single particle characterization of iron-induced pore-forming alpha-synuclein oligomers. J. Biol. Chem. 2008, 283, 10992-11003.
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 10992-11003
-
-
Kostka, M.T.1
Hogen, K.M.2
Danzer, J.3
Levin, M.4
Habeck, A.5
Wirth, R.6
Wagner, C.G.7
Glabe, S.8
Finger, U.9
Heinzelmann, P.10
-
59
-
-
38949147878
-
Precise measurement of diffusion coefficients using scanning fluorescence correlation spectroscopy
-
Petrásek, Z.; Schwille, P. Precise measurement of diffusion coefficients using scanning fluorescence correlation spectroscopy. Biophys. J. 2008, 94, 1437-1448.
-
(2008)
Biophys. J.
, vol.94
, pp. 1437-1448
-
-
Petrásek, Z.1
Schwille, P.2
-
60
-
-
0031936021
-
Semiautomated microtiter plate assay for monitoring peptidylprolyl cis/trans isomerase activity in normal and pathological human sera
-
Kullertz, G.; Luthe, S.; Fischer, G. Semiautomated microtiter plate assay for monitoring peptidylprolyl cis/trans isomerase activity in normal and pathological human sera. Clin. Chem. 1998, 44, 502-508.
-
(1998)
Clin. Chem.
, vol.44
, pp. 502-508
-
-
Kullertz, G.1
Luthe, S.2
Fischer, G.3
-
61
-
-
77951644400
-
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis
-
doi:10.1126/scisignal.2000475
-
Olsen, J.V.; Vermeulen, M.; Santamaria, A.; Kumar, C.; Miller, M.L.; Jensen, L.J.; Gnad, F.; Cox, J.; Jensen, T.S.; Nigg, E.A.; et al. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci. Signal 2010, doi:10.1126/scisignal.2000475.
-
(2010)
Sci. Signal
-
-
Olsen, J.V.1
Vermeulen, M.2
Santamaria, A.3
Kumar, C.4
Miller, M.L.5
Jensen, L.J.6
Gnad, F.7
Cox, J.8
Jensen, T.S.9
Nigg, E.A.10
|