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Volumn 32, Issue 1, 2012, Pages 43-56

Convection-Enhanced delivery of neprilysin: A novel amyloid-β- degrading therapeutic strategy

Author keywords

Alzheimer's disease; amyloid ; convection enhanced delivery; neprilysin; therapy

Indexed keywords

AMYLOID BETA PROTEIN; BRAIN PROTEIN; GLIAL FIBRILLARY ACIDIC PROTEIN; MEMBRANE METALLOENDOPEPTIDASE; NEURON SPECIFIC NUCLEAR PROTEIN; SYNAPTOPHYSIN;

EID: 84867527566     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-2012-120658     Document Type: Article
Times cited : (39)

References (50)
  • 3
    • 79955662958 scopus 로고    scopus 로고
    • Amyloid clearance as a treatment target against Alzheimer's disease
    • Kurz A, Perneczky R (2011) Amyloid clearance as a treatment target against Alzheimer's disease. J Alzheimers Dis 24 (Suppl 2), 61-73.
    • (2011) J Alzheimers Dis , vol.24 , Issue.SUPPL. 2 , pp. 61-73
    • Kurz, A.1    Perneczky, R.2
  • 5
    • 84655160768 scopus 로고    scopus 로고
    • Are amyloid-degrading enzymes viable therapeutic targets in Alzheimer's disease
    • Nalivaeva NN, Beckett C, Belyaev ND, Turner AJ (2012) Are amyloid-degrading enzymes viable therapeutic targets in Alzheimer's disease? J Neurochem 120(Suppl 1), 167-185.
    • (2012) J Neurochem , vol.120 , Issue.SUPPL. 1 , pp. 167-185
    • Nalivaeva, N.N.1    Beckett, C.2    Belyaev, N.D.3    Turner, A.J.4
  • 12
    • 0346101885 scopus 로고    scopus 로고
    • Enhanced proteolysis of betaamyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death
    • Leissring MA, FarrisW, ChangAY,Walsh DM,WuX, Sun X, Frosch MP, Selkoe DJ (2003) Enhanced proteolysis of betaamyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death. Neuron 40, 1087-1093.
    • (2003) Neuron , vol.40 , pp. 1087-1093
    • Leissring, M.A.1    Farris, W.2    Chang, A.Y.3    Walsh, D.M.4    Wu, X.5    Sun, X.6    Frosch, M.P.7    Selkoe, D.J.8
  • 15
    • 84855906863 scopus 로고    scopus 로고
    • Distribution properties of lentiviral vectors administered into the striatum by convectionenhanced delivery
    • White E, Bienemann A, Megraw L, Bunnun C, Wyatt M, Taylor H, Gill S (2012) Distribution properties of lentiviral vectors administered into the striatum by convectionenhanced delivery. Hum Gene Ther 23, 115-127.
    • (2012) Hum Gene Ther , vol.23 , pp. 115-127
    • White, E.1    Bienemann, A.2    Megraw, L.3    Bunnun, C.4    Wyatt, M.5    Taylor, H.6    Gill, S.7
  • 18
    • 37349110365 scopus 로고    scopus 로고
    • Convection-enhanced delivery of cintredekin besudotox (interleukin-13-Pe38qqr) followed by radiation therapy with and without temozolomide in newly diagnosed malignant gliomas: Phase 1 study of final safety results
    • Vogelbaum MA, Sampson JH, Kunwar S, Chang SM, Shaffrey M, Asher AL, Lang FF, Croteau D, Parker K, Grahn AY, Sherman JW, Husain SR, Puri RK (2007) Convection-enhanced delivery of cintredekin besudotox (interleukin-13-Pe38qqr) followed by radiation therapy with and without temozolomide in newly diagnosed malignant gliomas: Phase 1 study of final safety results. Neurosurgery 61, 1031-1037.
    • (2007) Neurosurgery , vol.61 , pp. 1031-1037
    • Vogelbaum, M.A.1    Sampson, J.H.2    Kunwar, S.3    Chang, S.M.4    Shaffrey, M.5    Asher, A.L.6    Lang, F.F.7    Croteau, D.8    Parker, K.9    Grahn, A.Y.10    Sherman, J.W.11    Husain, S.R.12    Puri, R.K.13
  • 21
    • 79958080326 scopus 로고    scopus 로고
    • An evaluation of the relationships between catheter design and tissue mechanics in achieving high-flow convection-enhanced delivery
    • White E, Bienemann A, Malone J, Megraw L, Bunnun C, Wyatt M, Gill S (2011) An evaluation of the relationships between catheter design and tissue mechanics in achieving high-flow convection-enhanced delivery. J Neurosci Methods 199, 87-97.
    • (2011) J Neurosci Methods , vol.199 , pp. 87-97
    • White, E.1    Bienemann, A.2    Malone, J.3    Megraw, L.4    Bunnun, C.5    Wyatt, M.6    Gill, S.7
  • 22
    • 77953193048 scopus 로고    scopus 로고
    • Changes with age in the activities of beta-secretase and the Abeta-degrading enzymes neprilysin, insulin-degrading enzyme and angiotensin-converting enzyme
    • Miners JS, van Helmond Z, Kehoe PG, Love S (2010) Changes with age in the activities of beta-secretase and the Abeta-degrading enzymes neprilysin, insulin-degrading enzyme and angiotensin-converting enzyme. Brain Pathol 20, 794-802.
    • (2010) Brain Pathol , vol.20 , pp. 794-802
    • Miners, J.S.1    Van Helmond, Z.2    Kehoe, P.G.3    Love, S.4
  • 23
    • 69449102820 scopus 로고    scopus 로고
    • Neprilysin and insulin-degrading enzyme levels are increased in Alzheimer disease in relation to disease severity
    • Miners JS, Baig S, Tayler H, Kehoe PG, Love S (2009) Neprilysin and insulin-degrading enzyme levels are increased in Alzheimer disease in relation to disease severity. J Neuropathol Exp Neurol 68, 902-914.
    • (2009) J Neuropathol Exp Neurol , vol.68 , pp. 902-914
    • Miners, J.S.1    Baig, S.2    Tayler, H.3    Kehoe, P.G.4    Love, S.5
  • 24
    • 37049011221 scopus 로고    scopus 로고
    • Immunocapture-based fluorometric assay for the measurement of neprilysin-specific enzyme activity in brain tissue homogenates and cerebrospinal fluid
    • Miners JS, Verbeek MM, Rikkert MO, Kehoe PG, Love S (2008) Immunocapture-based fluorometric assay for the measurement of neprilysin-specific enzyme activity in brain tissue homogenates and cerebrospinal fluid. J Neurosci Methods 167, 229-236.
    • (2008) J Neurosci Methods , vol.167 , pp. 229-236
    • Miners, J.S.1    Verbeek, M.M.2    Rikkert, M.O.3    Kehoe, P.G.4    Love, S.5
  • 25
    • 22544461907 scopus 로고    scopus 로고
    • Glial cell line-derived neurotrophic factor induces neuronal sprouting in human brain
    • Love S, Plaha P, Patel NK, Hotton GR, Brooks DJ, Gill SS (2005) Glial cell line-derived neurotrophic factor induces neuronal sprouting in human brain. Nat Med 11, 703-704.
    • (2005) Nat Med , vol.11 , pp. 703-704
    • Love, S.1    Plaha, P.2    Patel, N.K.3    Hotton, G.R.4    Brooks, D.J.5    Gill, S.S.6
  • 26
    • 5644235607 scopus 로고    scopus 로고
    • Measurement of pre- and post-synaptic proteins in cerebral cortex: Effects of post-mortem delay
    • Siew LK, Love S, Dawbarn D,Wilcock GK, Allen SJ (2004) Measurement of pre- and post-synaptic proteins in cerebral cortex: Effects of post-mortem delay. J Neurosci Methods 139, 153-159.
    • (2004) J Neurosci Methods , vol.139 , pp. 153-159
    • Siew, L.K.1    Love, S.2    Dawbarn, D.3    Wilcock, G.K.4    Allen, S.J.5
  • 27
    • 75949101330 scopus 로고    scopus 로고
    • Oligomeric Abeta in Alzheimer's disease: Relationship to plaque and tangle pathology, APOE genotype and cerebral amyloid angiopathy
    • van Helmond Z, Miners JS, Kehoe PG, Love S (2010) Oligomeric Abeta in Alzheimer's disease: Relationship to plaque and tangle pathology, APOE genotype and cerebral amyloid angiopathy. Brain Pathol 20, 468-480.
    • (2010) Brain Pathol , vol.20 , pp. 468-480
    • Van Helmond, Z.1    Miners, J.S.2    Kehoe, P.G.3    Love, S.4
  • 28
    • 31744448129 scopus 로고    scopus 로고
    • Mechanisms to explain the reverse perivascular transport of solutes out of the brain
    • Schley D, Carare-Nnadi R, Please CP, Perry VH, Weller RO (2006) Mechanisms to explain the reverse perivascular transport of solutes out of the brain. J Theor Biol 238, 962-974.
    • (2006) J Theor Biol , vol.238 , pp. 962-974
    • Schley, D.1    Carare-Nnadi, R.2    Please, C.P.3    Perry, V.H.4    Weller, R.O.5
  • 29
    • 33745479790 scopus 로고    scopus 로고
    • Tissue affinity of the infusate affects the distribution volume during convection-enhanced delivery into rodent brains: Implications for local drug delivery
    • Saito R, Krauze MT, Noble CO, Tamas M, Drummond DC, Kirpotin DB, Berger MS, Park JW, Bankiewicz KS (2006) Tissue affinity of the infusate affects the distribution volume during convection-enhanced delivery into rodent brains: Implications for local drug delivery. J Neurosci Methods 154, 225-232.
    • (2006) J Neurosci Methods , vol.154 , pp. 225-232
    • Saito, R.1    Krauze, M.T.2    Noble, C.O.3    Tamas, M.4    Drummond, D.C.5    Kirpotin, D.B.6    Berger, M.S.7    Park, J.W.8    Bankiewicz, K.S.9
  • 30
    • 0031695197 scopus 로고    scopus 로고
    • Projections of Alzheimer's disease in the United States and the public health impact of delaying disease onset
    • Brookmeyer R, Gray S, Kawas C (1998) Projections of Alzheimer's disease in the United States and the public health impact of delaying disease onset. Am J Public Health 88, 1337-1342.
    • (1998) Am J Public Health , vol.88 , pp. 1337-1342
    • Brookmeyer, R.1    Gray, S.2    Kawas, C.3
  • 31
    • 33746649088 scopus 로고    scopus 로고
    • Anti-amyloidogenic therapies: Strategies for prevention and treatment of Alzheimer's disease
    • Hamaguchi T, Ono K, YamadaM(2006) Anti-amyloidogenic therapies: Strategies for prevention and treatment of Alzheimer's disease. Cell Mol Life Sci 63, 1538-1552.
    • (2006) Cell Mol Life Sci , vol.63 , pp. 1538-1552
    • Hamaguchi, T.1    Ono Yamada, K.M.2
  • 32
    • 33847711478 scopus 로고    scopus 로고
    • Disease-modifying therapies in Alzheimer's disease: How far have we come
    • Hull M, Berger M, HenekaM(2006) Disease-modifying therapies in Alzheimer's disease: How far have we come? Drugs 66, 2075-2093.
    • (2006) Drugs , vol.66 , pp. 2075-2093
    • Hull, M.1    Berger, M.2    Heneka, M.3
  • 33
    • 33846054061 scopus 로고    scopus 로고
    • Disrupting beta-amyloid aggregation for Alzheimer disease treatment
    • Estrada LD, Soto C (2007) Disrupting beta-amyloid aggregation for Alzheimer disease treatment. Curr Top Med Chem 7, 115-126.
    • (2007) Curr Top Med Chem , vol.7 , pp. 115-126
    • Estrada, L.D.1    Soto, C.2
  • 35
    • 0037393454 scopus 로고    scopus 로고
    • Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide:Acase report
    • Nicoll JA, Wilkinson D, Holmes C, Steart P, Markham H, Weller RO (2003) Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide:Acase report. Nat Med 9, 448-452.
    • (2003) Nat Med , vol.9 , pp. 448-452
    • Nicoll, J.A.1    Wilkinson, D.2    Holmes, C.3    Steart, P.4    Markham, H.5    Weller, R.O.6
  • 42
    • 35348984094 scopus 로고    scopus 로고
    • Immune responses to adenovirus and adenoassociated vectors used for gene therapy of brain diseases: The role of immunological synapses in understanding the cell biology of neuroimmune interactions
    • Lowenstein PR, Mandel RJ, Xiong WD, Kroeger K, Castro MG (2007) Immune responses to adenovirus and adenoassociated vectors used for gene therapy of brain diseases: The role of immunological synapses in understanding the cell biology of neuroimmune interactions. Curr Gene Ther 7, 347-360.
    • (2007) Curr Gene Ther , vol.7 , pp. 347-360
    • Lowenstein, P.R.1    Mandel, R.J.2    Xiong, W.D.3    Kroeger, K.4    Castro, M.G.5
  • 43
    • 43449092187 scopus 로고    scopus 로고
    • Neprilysin: An enzyme candidate to slow the progression of Alzheimer's disease
    • El-Amouri SS, Zhu H, Yu J, Marr R, Verma IM, Kindy MS (2008) Neprilysin: An enzyme candidate to slow the progression of Alzheimer's disease. Am J Pathol 172, 1342-1354.
    • (2008) Am J Pathol , vol.172 , pp. 1342-1354
    • El-Amouri, S.S.1    Zhu, H.2    Yu, J.3    Marr, R.4    Verma, I.M.5    Kindy, M.S.6
  • 44
    • 79951834251 scopus 로고    scopus 로고
    • Evaluation and optimization of the administration of recombinant adeno-associated viral vectors (serotypes 2/1, 2/2, 2/rh8, 2/9, and 2/rh10) by convectionenhanced delivery to the striatum
    • White E, Bienemann A, Sena-EstevesM,Taylor H, Bunnun C, Castrique E, Gill S (2011) Evaluation and optimization of the administration of recombinant adeno-associated viral vectors (serotypes 2/1, 2/2, 2/rh8, 2/9, and 2/rh10) by convectionenhanced delivery to the striatum. Hum Gene Ther 22, 237-251.
    • (2011) Hum Gene Ther , vol.22 , pp. 237-251
    • White, E.1    Bienemann, A.2    Sena-Esteves, M.3    Taylor, H.4    Bunnun, C.5    Castrique, E.6    Gill, S.7
  • 46
    • 13144282676 scopus 로고    scopus 로고
    • Intraputamenal infusion of glial cell linederived neurotrophic factor in PD:Atwo-year outcome study
    • Patel NK, Bunnage M, Plaha P, Svendsen CN, Heywood P, Gill SS (2005) Intraputamenal infusion of glial cell linederived neurotrophic factor in PD:Atwo-year outcome study. Ann Neurol 57, 298-302.
    • (2005) Ann Neurol , vol.57 , pp. 298-302
    • Patel, N.K.1    Bunnage, M.2    Plaha, P.3    Svendsen, C.N.4    Heywood, P.5    Gill, S.S.6
  • 49
    • 84859492616 scopus 로고    scopus 로고
    • Atrophy of the cholinergic basal forebrain over the adult age range and in early stages of Alzheimer's disease
    • Grothe M, Heinsen H, Teipel SJ (2012) Atrophy of the cholinergic basal forebrain over the adult age range and in early stages of Alzheimer's disease. Biol Psychiatry 71, 805-813.
    • (2012) Biol Psychiatry , vol.71 , pp. 805-813
    • Grothe, M.1    Heinsen, H.2    Teipel, S.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.