Tyrosyl-DNA phosphodiesterase as a target for anticancer therapy

Anti-Cancer Agents in Medicinal Chemistry

Volumn 8, Issue 4, 2008, Pages 381-389

  Dexheimer, Thomas S ^a   Antony, Smitha ^a   Marchand, Christophe ^a   Pommier, Yves ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 NITROPHENOL; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; BORTEZOMIB; CAMPTOTHECIN DERIVATIVE; DNA; DNA DIRECTED DNA POLYMERASE BETA; DNA TOPOISOMERASE; DNA TOPOISOMERASE INHIBITOR; FRAMYCETIN; HYMECROMONE; IRINOTECAN; LIGASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; PARA CRESOL; PHOSPHODIESTERASE; PHOSPHODIESTERASE INHIBITOR; PHOSPHOTUNGSTIC ACID; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; POLYNUCLEOTIDE 5' HYDROXYL KINASE; PROTEIN RAD1; PROTEIN RAD9; PROTEIN TYROSINE PHOSPHATASE; SINGLE STRANDED DNA; TOPOTECAN; VANADATE SODIUM; VANADIC ACID; XRCC1 PROTEIN;

3' UNTRANSLATED REGION; ANTINEOPLASTIC ACTIVITY; BIOCHEMISTRY; CELL ACTIVITY; CHEMOLUMINESCENCE; CHEMOSENSITIZATION; COVALENT BOND; DNA CLEAVAGE; DNA DAMAGE; DNA REPAIR; DRUG RESEARCH; DRUG STRUCTURE; DRUG TARGETING; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME STRUCTURE; ENZYME SUBSTRATE; EXCISION REPAIR; GENE MUTATION; HIGH THROUGHPUT SCREENING; HUMAN; HYDROLYSIS; IN VIVO STUDY; MALIGNANT NEOPLASTIC DISEASE; PATHOGENESIS; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN INTERACTION; PROTEIN PROCESSING; RECESSIVE INHERITANCE; REVIEW; SINGLE STRANDED DNA BREAK; SPINOCEREBELLAR DEGENERATION;

ANIMALS; ANTINEOPLASTIC AGENTS; DNA DAMAGE; DNA REPAIR; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NEOPLASMS; PHOSPHODIESTERASE INHIBITORS; PHOSPHORIC DIESTER HYDROLASES; PROTEIN BINDING; SUBSTRATE SPECIFICITY;

EID: 44449146141     PISSN: 18715206     EISSN: None     Source Type: Journal    
DOI: 10.2174/187152008784220357     Document Type: Review

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