Insights into substrate binding and catalytic mechanism of human tyrosyl-DNA phosphodiesterase (Tdp1) from vanadate and tungstate-inhibited structures

Journal of Molecular Biology

Volumn 324, Issue 5, 2002, Pages 917-932

  Davies, Douglas R ^a   Interthal, Heidrun ^a   Champoux, James J ^a   Hol, Wim G J ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

DNA repair; Substrate specificity; Tungstate; Tyrosyl DNA phosphodiesterase; Vanadate

Indexed keywords

CRYOPROTECTIVE AGENT; ESTER; GLYCEROL; HISTIDINE; PHOSPHATE; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; SINGLE STRANDED DNA; TUNGSTEN DERIVATIVE; TUNGSTIC ACID; TYROSYL DNA PHOSPHODIESTERASE; UNCLASSIFIED DRUG; VANADIC ACID; APOENZYME; PHOSPHODIESTERASE; PHOSPHODIESTERASE INHIBITOR; TDP1 PROTEIN, HUMAN; TYROSYL-DNA PHOSPHODIESTERASE;

ARTICLE; CATALYSIS; COVALENT BOND; DNA BINDING; ENZYME STRUCTURE; ENZYME SUBSTRATE; GEOMETRY; HUMAN; HYDROLYSIS; MOLECULAR MIMICRY; MOLECULE; PREDICTION; PRIORITY JOURNAL; PROTEIN BINDING; STRUCTURE ANALYSIS; BINDING SITE; CHEMICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; ENZYME SPECIFICITY; HYDROGEN BOND; METABOLISM; PROTEIN CONFORMATION;

EUKARYOTA;

APOENZYMES; BINDING SITES; CATALYSIS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; HYDROGEN BONDING; MODELS, CHEMICAL; MODELS, MOLECULAR; PHOSPHODIESTERASE INHIBITORS; PHOSPHORIC DIESTER HYDROLASES; PROTEIN CONFORMATION; SUBSTRATE SPECIFICITY; TUNGSTEN COMPOUNDS; VANADATES;

EID: 0037073479     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-2836(02)01154-3     Document Type: Article

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