Identification, synthesis, and biological evaluation of metabolites of the experimental cancer treatment drugs indotecan (LMP400) and indimitecan (LMP776) and investigation of isomerically hydroxylated indenoisoquinoline analogues as topoisomerase i poisons

Journal of Medicinal Chemistry

Volumn 55, Issue 24, 2012, Pages 10844-10862

  Cinelli, Maris A ^a   Reddy, P V Narasimha ^a   Lv, Peng Cheng ^a   Liang, Jian Hua ^a   Chen, Lian ^b   Agama, Keli ^c   Pommier, Yves ^c   Van Breemen, Richard B ^b   Cushman, Mark ^a  

^a PURDUE UNIVERSITY   (United States)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; DNA TOPOISOMERASE INHIBITOR; HYDROXYL GROUP; INDIMITECAN; INDOTECAN; LMP 400; LMP 776; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; LIVER MICROSOME; MASS FRAGMENTOGRAPHY;

ANTINEOPLASTIC AGENTS; BENZODIOXOLES; CELL LINE, TUMOR; DNA TOPOISOMERASES, TYPE I; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; HYDROXYLATION; INDENES; ISOQUINOLINES; MICROSOMES, LIVER; MODELS, MOLECULAR; RECOMBINANT PROTEINS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TOPOISOMERASE I INHIBITORS;

EID: 84871667389     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm300519w     Document Type: Article

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