Synthesis and biological evaluation of indenoisoquinolines that inhibit both tyrosyl-DNA phosphodiesterase i (Tdp1) and topoisomerase i (Top1)

Journal of Medicinal Chemistry

Volumn 56, Issue 1, 2013, Pages 182-200

  Conda Sheridan, Martin ^a   Reddy, P V Narasimha ^a   Morrell, Andrew ^a   Cobb, Brooklyn T ^a   Marchand, Christophe ^b   Agama, Keli ^b   Chergui, Adel ^b   Renaud, Amélie ^b   Stephen, Andrew G ^c   Bindu, Lakshman K ^c   Pommier, Yves ^b   Cushman, Mark ^a  

^a PURDUE UNIVERSITY   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c SAIC FREDERICK INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA TOPOISOMERASE; INDENOISOQUINOLINE; ISOQUINOLINE DERIVATIVE; PHOSPHODIESTERASE I; TYROSYL DNA PHOSPHODIESTERASE I; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CYTOTOXICITY; DRUG DESIGN; DRUG INHIBITION; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; STRUCTURE ACTIVITY RELATION; THEORY;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DNA TOPOISOMERASES, TYPE I; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INDENES; ISOQUINOLINES; MODELS, MOLECULAR; PHOSPHODIESTERASE INHIBITORS; PHOSPHORIC DIESTER HYDROLASES; STRUCTURE-ACTIVITY RELATIONSHIP; TOPOISOMERASE I INHIBITORS;

EID: 84872336712     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm3014458     Document Type: Article

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