Tyrosyl-DNA phosphodiesterase 1 (TDP1) repairs DNA damage induced by topoisomerases I and II and base alkylation in vertebrate cells

Journal of Biological Chemistry

Volumn 287, Issue 16, 2012, Pages 12848-12857

  Murai, Junko ^a,b   Huang, Shar Yin N ^b   Das, Benu Brata ^b   Dexheimer, Thomas S ^b   Takeda, Shunichi ^a   Pommier, Yves ^b  

^a KYOTO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMICAL ASSAY; BLEOMYCINS; CAMPTOTHECIN (CPT); DNA DAMAGES; DNA REPAIR; DT40 CELL; ETOPOSIDE; KNOCK OUTS; METHANESULFONATES; PARALLEL PATHWAYS; PHOSPHODIESTERASES; TOPOISOMERASE I; TOPOISOMERASES; VERTEBRATE CELLS;

CELLS; CYTOLOGY; ESTERS; HYDROLYSIS; IONIZING RADIATION; PEPTIDES; REPAIR;

DNA;

BLEOMYCIN; BRCA1 PROTEIN; CAMPTOTHECIN; CELL PROTEIN; DNA; DNA TOPOISOMERASE; DNA TOPOISOMERASE (ATP HYDROLYSING); ETOPOSIDE; HYDROGEN PEROXIDE; PHOSPHODIESTERASE; RECOMBINANT ENZYME; THIOMESYLIC ACID METHYL ESTER; TOPOISOMERASE II DNA CLEAVAGE COMPLEX PROTEIN; TYROSYL DNA PHOSPHODIESTERASE 1; UNCLASSIFIED DRUG;

ALKYLATION; ANIMAL CELL; ARTICLE; CHICKEN; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; ENZYME ACTIVITY; GENE INACTIVATION; HYPERSENSITIVITY; IONIZING RADIATION; MITOCHONDRIAL RESPIRATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN HYDROLYSIS; PROTEIN PROTEIN INTERACTION; SEQUENCE ALIGNMENT;

ALKYLATION; AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, NEOPLASM; CARRIER PROTEINS; CELLS, CULTURED; CHICKENS; DNA DAMAGE; DNA REPAIR; DNA TOPOISOMERASES, TYPE I; DNA TOPOISOMERASES, TYPE II; DNA, SINGLE-STRANDED; DNA-BINDING PROTEINS; HUMANS; MOLECULAR SEQUENCE DATA; NEOPLASMS; NUCLEAR PROTEINS; PHOSPHORIC DIESTER HYDROLASES; SUBSTRATE SPECIFICITY; VERTEBRATES;

VERTEBRATA;

EID: 84859761985     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.333963     Document Type: Article

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