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Volumn 21, Issue 11, 2013, Pages 3262-3271

Design and synthesis of l- and d-phenylalanine derived rhodanines with novel C5-arylidenes as inhibitors of HCV NS5B polymerase

(12) Patel, Bhargav A a Krishnan, Ramalingam b Khadtare, Nikhil a Gurukumar, K R b Basu, Amartya b Arora, Payal b Bhatt, Aaditya a Patel, Maulik R c Dana, Dibyendu d Kumar, Sanjai d Kaushik Basu, Neerja b Talele, Tanaji T a

a ST JOHN'S UNIVERSITY (United States)

b RUTGERS NEW JERSEY MEDICAL SCHOOL (United States)

c MEMORIAL SLOAN KETTERING CANCER CENTER (United States)

d CITY UNIVERSITY OF NEW YORK (United States)

Author keywords

d Phenylalanine; HCV NS5B polymerase; Knoevenagel condensation; l Phenylalanine; Rhodanine; Ullmann condensation

Indexed keywords

2 (4 OXO 2 THIOXOTHIAZOLIDIN 3 YL) 3 PHENYLPROPANOIC ACID; 2 [5 (2 PHENOXYBENZYLIDENE) 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL] 3 PHENYLPROPANOIC ACID; 2 [5 (3 BENZOYLBENZYLIDENE) 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL] 3 PHENYLPROPANOIC ACID; 2 [5 (3 BENZYLBENZYLIDENE) 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL] 3 PHENYLPROPANOIC ACID; 2 [5 (3 BENZYLOXYBENZYLIDENE) 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL] 3 PHENYLPROPANOIC ACID; 2 [5 (3 BROMOBENZYLIDENE) 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL] 3 PHENYLPROPANOIC ACID; 2 [5 (3 CHLOROBENZYLIDENE) 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL] 3 PHENYLPROPANOIC ACID; 2 [5 (3 CINNAMYLOXYBENZYLIDENE) 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL] 3 PHENYLPROPANOIC ACID; 2 [5 (3 CYANOBENZYLIDENE) 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL] 3 PHENYLPROPANOIC ACID; 2 [5 (3 PHENOXYBENZYLIDENE) 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL] 3 PHENYLPROPANOIC ACID; 2 [5 (3 PHENYLBENZYLIDENE) 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL] 3 PHENYLPROPANOIC ACID; 2 [5 (3,4 DICHLOROBENZYLIDENE) 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL] 3 PHENYLPROPANOIC ACID; 2 [5 (3,5 DIFLUOROBENZYLIDENE) 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL] 3 PHENYLPROPANOIC ACID; 2 [5 (4 BROMOBENZYLIDENE) 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL] 3 PHENYLPROPANOIC ACID; 2 [5 (4 CHLOROBENZYLIDENE) 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL] 3 PHENYLPROPANOIC ACID; 2 [5 (4 FLUOROBENZYLIDENE) 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL] 3 PHENYLPROPANOIC ACID; 2 [5 (4 PHENOXYBENZYLIDENE) 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL] 3 PHENYLPROPANOIC ACID; 2 [5 [3 (3 CHLOROPHENOXY)BENZYLIDENE] 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL] 3 PHENYLPROPANOIC ACID; 2 [5 [3 (3 FLUOROPHENOXY)BENZYLIDENE] 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL] 3 PHENYLPROPANOIC ACID; 2 [5 [3 (3,4 DICHLOROPHENOXY)BENZYLIDENE] 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL] 3 PHENYLPROPANOIC ACID; 2 [5 [3 (4 CHLOROPHENOXY)BENZYLIDENE] 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL] 3 PHENYLPROPANOIC ACID; 2 [5 [3 (4 FLUOROPHENOXY)BENZYLIDENE] 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL] 3 PHENYLPROPANOIC ACID; 2 [5 [3 (4 METHOXYPHENOXY)BENZYLIDENE] 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL] 3 PHENYLPROPANOIC ACID; 3 PHENOXYBENZYLIDENE; ANTIVIRUS AGENT; ARYLIDENE DERIVATIVE; PHENYLALANINE DERIVATIVE; RHODANINE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; BINDING SITE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DESIGN; DRUG SYNTHESIS; ENANTIOMER; HEPATITIS C VIRUS; IC 50; IN VITRO STUDY; ISOMER; MOLECULAR DOCKING; MOLECULAR MODEL; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

ANTIVIRAL AGENTS; BINDING SITES; DRUG DESIGN; HEPACIVIRUS; MOLECULAR DOCKING SIMULATION; PHENYLALANINE; RNA REPLICASE; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLIDINES; VIRAL NONSTRUCTURAL PROTEINS;

HEPATITIS C VIRUS;

EID: 84877807074 PISSN: 09680896 EISSN: 14643391 Source Type: Journal
DOI: 10.1016/j.bmc.2013.03.041 Document Type: Article

Times cited : (20)

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