5-Arylidenethioxothiazolidinones as Inhibitors of Tyrosyl-DNA Phosphodiesterase i

Journal of Medicinal Chemistry

Volumn 55, Issue 20, 2012, Pages 8671-8684

  Sirivolu, Venkata Ramana ^a   Vernekar, Sanjeev Kumar V ^a   Marchand, Christophe ^b   Naumova, Alena ^b   Chergui, Adel ^b   Renaud, Amelie ^b   Stephen, Andrew G ^c   Chen, Feng ^a   Sham, Yuk Y ^a   Pommier, Yves ^b   Wang, Zhengqiang ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c FREDERICK NATIONAL LABORATORY FOR CANCER RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 [(2 OXO 4 THIOXOTHIAZOLIDIN 5 YLIDENE)METHYL]BENZOIC ACID; 2[(2 OXO 4 THIOXOTHIAZOLIDIN 5 YLIDENE)METHYL] BENZENESULFONIC ACID; 3 [(2 OXO 4 THIOXOTHIAZOLIDIN 5 YLIDENE)METHYL]BENZOIC ACID; 4 [(2 OXO 4 THIOXOTHIAZOLIDIN 5 YLIDENE]METHYL)BENZONITRILE; 5 (2 BROMOBENZYLIDENE) 4 THIOXOTHIAZOLIDIN 2 ONE; 5 (2 HYDROXYBENZYLIDENE) 4 THIOXOTHIAZOLIDIN 2 ONE; 5 (3 HYDROXYBENZYLIDENE) 4 THIOXOTHIAZOLIDIN 2 ONE; 5 (4 HYDROXY 3 METHOXYBENZYLIDENE) 4 THIOXOTHIAZOLIDIN 2 ONE; 5 (4 HYDROXYBENZYLIDENE) 4 THIOXOTHIAZOLIDIN 2 ONE; 5 (4 NITROBENZYLIDENE) 4 THIOXOTHIAZOLIDIN 2 ONE; 5 (BENZO[B]THIOPHEN 3 YLMETHYLENE) 4 THIOXOTHIAZOLIDIN 2 ONE; 5 (PYRIDIN 3 YLMETHYLENE) 4 THIOXOTHIAZOLIDIN 2 ONE; 5 [(1 METHYL 1H INDOL 3 YL)METHYLENE] 4 THIOXOTHIAZOLIDIN 2 ONE; 5 [(5 PHENYLTHIOPHEN 2 YL)METHYLENE] 4 THIOXOTHIAZOLIDIN 2 ONE; 5 [2 (1H TETRAZOL 5 YL)BENZYLIDENE] 4 THIOXOTHIAZOLIDIN 2 ONE; 5 [4 (1H TETRAZOL 5 YL)BENZYLIDENE] 4 THIOXOTHIAZOLIDIN 2 ONE; [4 [(2 OXO 4 THIOXOTHIAZOLIDIN 5 YLIDENE)METHYL]PHENYL] PHOSPHONIC ACID; CELL EXTRACT; DIETHYL [4 [(2 OXO 4 THIOXOTHIAZOLIDIN 5 YLIDENE)METHYL] PHENYL]PHOSPHONATE; METHYL 3 [(2 OXO 4 THIOXOTHIAZOLIDIN 5 YLIDENE)METHYL] BENZOATE; METHYL 4 [(2 OXO 4 THIOXOTHIAZOLIDIN 5 YLIDENE)METHYL] BENZOATE; MOLECULAR SCAFFOLD; ORGANOLEAD COMPOUND; PHOSPHODIESTERASE I; PHOSPHODIESTERASE INHIBITOR; SODIUM 4 [(2 OXO 4 THIOXOTHIAZOLIDIN 5 YLIDENE)METHYL] BENZOATE; THIAZOLE DERIVATIVE; TYROSYL DNA PHOSPHODIESTERASE I; TYRPHOSTIN; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME INHIBITION; HUMAN; IC 50; MOLECULAR MODEL; NONHUMAN; STRUCTURE ACTIVITY RELATION; WHOLE CELL;

ANIMALS; CELL LINE; CHICKENS; MODELS, MOLECULAR; PHOSPHODIESTERASE INHIBITORS; PHOSPHORIC DIESTER HYDROLASES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLIDINES;

EID: 84867792955     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm3008773     Document Type: Article

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