Renal tumours in a Tsc2+/- mouse model do not show feedback inhibition of Akt and are effectively prevented by rapamycin

Oncogene

Volumn 34, Issue 7, 2015, Pages 922-931

  Yang, J ^a   Kalogerou, M ^a   Samsel, P A ^a   Zhang, Y ^a   Griffiths, D F R ^b   Gallacher, J ^b   Sampson, J R ^a   Shen, M H ^a  

^a CARDIFF UNIVERSITY SCHOOL OF MEDICINE   (United Kingdom)

^b CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH FACTOR RECEPTOR BOUND PROTEIN 10; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 2; PROTEIN KINASE B; PROTEIN KINASE C ALPHA; RAPAMYCIN; RIBOSOME PROTEIN; S6 RIBOSOMAL PROTEIN; S6K RIBOSOMAL PROTEIN; TUBERIN; UNCLASSIFIED DRUG; ANTINEOPLASTIC ANTIBIOTIC; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MULTIPROTEIN COMPLEX; TARGET OF RAPAMYCIN KINASE; TOR COMPLEX 2; TUMOR SUPPRESSOR PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARCINOGENESIS; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; KIDNEY ADENOMA; KIDNEY CARCINOMA; KIDNEY CYST; KIDNEY PARENCHYMA; KIDNEY TUMOR; LONG TERM CARE; MOUSE; NEGATIVE FEEDBACK; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; ANIMAL; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; KIDNEY NEOPLASMS; METABOLISM; MUTANT MOUSE STRAIN; NEOPLASMS, EXPERIMENTAL; PATHOLOGY; PHOSPHORYLATION;

MAMMALIA;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; GENE EXPRESSION REGULATION, NEOPLASTIC; KIDNEY NEOPLASMS; MICE; MICE, MUTANT STRAINS; MULTIPROTEIN COMPLEXES; NEOPLASMS, EXPERIMENTAL; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; SIROLIMUS; TOR SERINE-THREONINE KINASES; TUMOR SUPPRESSOR PROTEINS;

EID: 84927171958     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2014.17     Document Type: Article

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