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Volumn 70, Issue 21, 2010, Pages 8822-8831

EGFR promotes lung tumorigenesis by activating miR-7 through a Ras/ERK/Myc pathway that targets the Ets2 transcriptional repressor ERF

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; MICRORNA; MICRORNA 134; MICRORNA 17-5P; MICRORNA 182; MICRORNA 19A; MICRORNA 19B; MICRORNA 20A; MICRORNA 21; MICRORNA 210; MICRORNA 33A; MICRORNA 361-3P; MICRORNA 374B; MICRORNA 630; MICRORNA 7; MICRORNA 92A; MITOGEN ACTIVATED PROTEIN KINASE; RAS PROTEIN; TRANSCRIPTION FACTOR ETS 2; UNCLASSIFIED DRUG;

EID: 78449268612     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-10-0638     Document Type: Article
Times cited : (249)

References (37)
  • 3
    • 34347381855 scopus 로고    scopus 로고
    • EGFR kinase domainmutations - Functional impact and relevance for lung cancer therapy
    • Irmer D, FunkJO, Blaukat A. EGFR kinase domainmutations - functional impact and relevance for lung cancer therapy. Oncogene 2007;26:5693-701.
    • (2007) Oncogene , vol.26 , pp. 5693-5701
    • Irmer, D.1    Funk, J.O.2    Blaukat, A.3
  • 4
    • 65949121645 scopus 로고    scopus 로고
    • New tricks for animal microRNAs: Targeting of amino acid coding regions at conserved and nonconserved sites
    • Rigoutsos I. New tricks for animal microRNAs: targeting of amino acid coding regions at conserved and nonconserved sites. Cancer Res 2009;69:3245-8.
    • (2009) Cancer Res , vol.69 , pp. 3245-3248
    • Rigoutsos, I.1
  • 5
    • 34547441263 scopus 로고    scopus 로고
    • Target mRNAs are repressed as efficiently by microRNA-binding sites in the 5′ UTR as in the 3′ UTR
    • Lytle JR, Yario TA, Steitz JA. Target mRNAs are repressed as efficiently by microRNA-binding sites in the 5′ UTR as in the 3′ UTR. Proc Natl Acad Sci U S A 2007;104:9667-72.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 9667-9672
    • Lytle, J.R.1    Yario, T.A.2    Steitz, J.A.3
  • 7
    • 49749150573 scopus 로고    scopus 로고
    • microRNAs and cancer: An overview
    • Medina PP, Slack FJ. microRNAs and cancer: an overview. Cell Cycle 2008;7:2485-92.
    • (2008) Cell Cycle , vol.7 , pp. 2485-2492
    • Medina, P.P.1    Slack, F.J.2
  • 8
    • 54049156472 scopus 로고    scopus 로고
    • Control of cell proliferation pathways by microRNAs
    • Bueno MJ, de Castro IP, Malumbres M. Control of cell proliferation pathways by microRNAs. Cell Cycle 2008;7:3143-8.
    • (2008) Cell Cycle , vol.7 , pp. 3143-3148
    • Bueno, M.J.1    De Castro, I.P.2    Malumbres, M.3
  • 9
    • 29244437868 scopus 로고    scopus 로고
    • A microRNA mediates EGF receptor signaling and promotes photoreceptor differentiation in the Drosophila eye
    • Li X, Carthew RW. A microRNA mediates EGF receptor signaling and promotes photoreceptor differentiation in the Drosophila eye. Cell 2005;123:1267-77.
    • (2005) Cell , vol.123 , pp. 1267-1277
    • Li, X.1    Carthew, R.W.2
  • 10
    • 0033050069 scopus 로고    scopus 로고
    • Transcriptional repressor ERF is a Ras/mitogen-activated protein kinase target that regulates cellular proliferation
    • Le Gallic L, Sgouras D, Beal G, Jr., Mavrothalassitis G. Transcriptional repressor ERF is a Ras/mitogen-activated protein kinase target that regulates cellular proliferation. Mol Cell Biol 1999;19:4121-33.
    • (1999) Mol Cell Biol , vol.19 , pp. 4121-4133
    • Le Gallic, L.1    Sgouras, D.2    Beal Jr., G.3    Mavrothalassitis, G.4
  • 11
    • 1642580780 scopus 로고    scopus 로고
    • ERF nuclear shuttling, a continuous monitor of Erk activity that links it to cell cycle progression
    • Le Gallic L, Virgilio L, Cohen P, Biteau B, Mavrothalassitis G. ERF nuclear shuttling, a continuous monitor of Erk activity that links it to cell cycle progression. Mol Cell Biol 2004;24:1206-18.
    • (2004) Mol Cell Biol , vol.24 , pp. 1206-1218
    • Le Gallic, L.1    Virgilio, L.2    Cohen, P.3    Biteau, B.4    Mavrothalassitis, G.5
  • 12
    • 0041805364 scopus 로고    scopus 로고
    • ERF, an ETS-related transcriptional repressor, can induce erythroid differentiation
    • Athanasiou M, Blair DG, Mavrothalassitis G. ERF, an ETS-related transcriptional repressor, can induce erythroid differentiation. Anticancer Res 2003;23:2143-53.
    • (2003) Anticancer Res , vol.23 , pp. 2143-2153
    • Athanasiou, M.1    Blair, D.G.2    Mavrothalassitis, G.3
  • 13
    • 0029095176 scopus 로고
    • ERF: An ETS domain protein with strong transcriptional repressor activity, can suppress ets-associated tumorigenesis and is regulated by phosphorylation during cell cycle and mitogenic stimulation
    • Sgouras DN, Athanasiou MA, Beal GJ, Jr., Fisher RJ, Blair DG, Mavrothalassitis GJ. ERF: an ETS domain protein with strong transcriptional repressor activity, can suppress ets-associated tumorigenesis and is regulated by phosphorylation during cell cycle and mitogenic stimulation. EMBO J 1995;14:4781-93.
    • (1995) EMBO J , vol.14 , pp. 4781-4793
    • Sgouras, D.N.1    Athanasiou, M.A.2    Beal Jr., G.J.3    Fisher, R.J.4    Blair, D.G.5    Mavrothalassitis, G.J.6
  • 14
    • 0031226737 scopus 로고    scopus 로고
    • Selection of invasive and metastatic subpopulations from a human lung adenocarcinoma cell line
    • Chu YW, Yang PC, Yang SC, et al. Selection of invasive and metastatic subpopulations from a human lung adenocarcinoma cell line. Am J Respir Cell Mol Biol 1997;17:353-60.
    • (1997) Am J Respir Cell Mol Biol , vol.17 , pp. 353-360
    • Chu, Y.W.1    Yang, P.C.2    Yang, S.C.3
  • 15
    • 57449099865 scopus 로고    scopus 로고
    • MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification
    • Cox J, Mann M. MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification. Nat Biotechnol 2008;26:1367-72.
    • (2008) Nat Biotechnol , vol.26 , pp. 1367-1372
    • Cox, J.1    Mann, M.2
  • 16
    • 4644274700 scopus 로고    scopus 로고
    • Mutations and addiction to EGFR: The Achilles "heal" of lung cancers?
    • Gazdar AF, Shigematsu H, Herz J, Minna JD. Mutations and addiction to EGFR: the Achilles "heal" of lung cancers? Trends Mol Med 2004;10:481-6.
    • (2004) Trends Mol Med , vol.10 , pp. 481-486
    • Gazdar, A.F.1    Shigematsu, H.2    Herz, J.3    Minna, J.D.4
  • 17
    • 0028905520 scopus 로고
    • Ets-2 regulates cdc2 kinase activity in mammalian cells: Coordinated expression of cdc2 and cyclin a
    • Wen SC, Ku DH, De Luca A, Claudio PP, Giordano A, Calabretta B. Ets-2 regulates cdc2 kinase activity in mammalian cells: coordinated expression of cdc2 and cyclin A. Exp Cell Res 1995;217:8-14.
    • (1995) Exp Cell Res , vol.217 , pp. 8-14
    • Wen, S.C.1    Ku, D.H.2    De Luca, A.3    Claudio, P.P.4    Giordano, A.5    Calabretta, B.6
  • 18
    • 4644237189 scopus 로고    scopus 로고
    • Fast and effective prediction of microRNA/target duplexes
    • Rehmsmeier M, Steffen P, Hochsmann M, Giegerich R. Fast and effective prediction of microRNA/target duplexes. RNA 2004;10:1507-17.
    • (2004) RNA , vol.10 , pp. 1507-1517
    • Rehmsmeier, M.1    Steffen, P.2    Hochsmann, M.3    Giegerich, R.4
  • 19
    • 44249109706 scopus 로고    scopus 로고
    • Searching for a magic bullet in NSCLC: The role of epidermal growth factor receptor mutations and tyrosine kinase inhibitors
    • Wong KK. Searching for a magic bullet in NSCLC: the role of epidermal growth factor receptor mutations and tyrosine kinase inhibitors. Lung Cancer 2008;60 Suppl 2:S10-8.
    • (2008) Lung Cancer , vol.60 , Issue.SUPPL. 2
    • Wong, K.K.1
  • 20
    • 33750412872 scopus 로고    scopus 로고
    • Surviving cell death through epidermal growth factor (EGF) signal transduction pathways: Implications for cancer therapy
    • Henson ES, Gibson SB. Surviving cell death through epidermal growth factor (EGF) signal transduction pathways: implications for cancer therapy. Cell Signal 2006;18:2089-97.
    • (2006) Cell Signal , vol.18 , pp. 2089-2097
    • Henson, E.S.1    Gibson, S.B.2
  • 22
    • 37549008310 scopus 로고    scopus 로고
    • Widespread microRNA repression by Myc contributes to tumorigenesis
    • Chang TC, Yu D, Lee YS, et al. Widespread microRNA repression by Myc contributes to tumorigenesis. Nat Genet 2008;40:43-50.
    • (2008) Nat Genet , vol.40 , pp. 43-50
    • Chang, T.C.1    Yu, D.2    Lee, Y.S.3
  • 23
    • 0034640524 scopus 로고    scopus 로고
    • Epidermal growth factor receptor-dependent Akt activation by oxidative stress enhances cell survival
    • Wang X, McCullough KD, Franke TF, Holbrook NJ. Epidermal growth factor receptor-dependent Akt activation by oxidative stress enhances cell survival. J Biol Chem 2000;275:14624-31.
    • (2000) J Biol Chem , vol.275 , pp. 14624-14631
    • Wang, X.1    McCullough, K.D.2    Franke, T.F.3    Holbrook, N.J.4
  • 24
    • 0029562617 scopus 로고
    • The role of yan in mediating the choice between cell division and differentiation
    • Rogge R, Green PJ, Urano J, et al. The role of yan in mediating the choice between cell division and differentiation. Development 1995;121:3947-58.
    • (1995) Development , vol.121 , pp. 3947-3958
    • Rogge, R.1    Green, P.J.2    Urano, J.3
  • 25
    • 0029019928 scopus 로고
    • Yan functions as a general inhibitor of differentiation and is negatively regulated by activation of the Ras1/MAPK pathway
    • Rebay I, Rubin GM. Yan functions as a general inhibitor of differentiation and is negatively regulated by activation of the Ras1/MAPK pathway. Cell 1995;81:857-66.
    • (1995) Cell , vol.81 , pp. 857-866
    • Rebay, I.1    Rubin, G.M.2
  • 26
    • 35748955822 scopus 로고    scopus 로고
    • The RAS-dependent ERF control of cell proliferation and differentiation is mediated by c-Myc repression
    • Verykokakis M, Papadaki C, Vorgia E, Le Gallic L, Mavrothalassitis G. The RAS-dependent ERF control of cell proliferation and differentiation is mediated by c-Myc repression. J Biol Chem 2007;282:30285-94.
    • (2007) J Biol Chem , vol.282 , pp. 30285-30294
    • Verykokakis, M.1    Papadaki, C.2    Vorgia, E.3    Le Gallic, L.4    Mavrothalassitis, G.5
  • 28
    • 14844364472 scopus 로고    scopus 로고
    • Antisense inhibition of human miRNAs and indications for an involvement of miRNA in cell growth and apoptosis
    • Cheng AM, Byrom MW, Shelton J, Ford LP. Antisense inhibition of human miRNAs and indications for an involvement of miRNA in cell growth and apoptosis. Nucleic Acids Res 2005;33:1290-7.
    • (2005) Nucleic Acids Res , vol.33 , pp. 1290-1297
    • Cheng, A.M.1    Byrom, M.W.2    Shelton, J.3    Ford, L.P.4
  • 30
    • 33744472217 scopus 로고    scopus 로고
    • Significance of EGFR protein expression and gene amplification in non-small cell lung carcinoma
    • Dacic S, Flanagan M, Cieply K, et al. Significance of EGFR protein expression and gene amplification in non-small cell lung carcinoma. Am J Clin Pathol 2006;125:860-5.
    • (2006) Am J Clin Pathol , vol.125 , pp. 860-865
    • Dacic, S.1    Flanagan, M.2    Cieply, K.3
  • 31
    • 45549089973 scopus 로고    scopus 로고
    • microRNA-7 inhibits the epidermal growth factor receptor and the Akt pathway and is down-regulated in glioblastoma
    • Kefas B, Godlewski J, Comeau L, et al. microRNA-7 inhibits the epidermal growth factor receptor and the Akt pathway and is down-regulated in glioblastoma. Cancer Res 2008;68:3566-72.
    • (2008) Cancer Res , vol.68 , pp. 3566-3572
    • Kefas, B.1    Godlewski, J.2    Comeau, L.3
  • 32
    • 65549120766 scopus 로고    scopus 로고
    • Regulation of epidermal growth factor receptor signaling in human cancer cells by microRNA-7
    • Webster RJ, Giles KM, Price KJ, Zhang PM, Mattick JS, Leedman PJ. Regulation of epidermal growth factor receptor signaling in human cancer cells by microRNA-7. J Biol Chem 2009;284:5731-41.
    • (2009) J Biol Chem , vol.284 , pp. 5731-5741
    • Webster, R.J.1    Giles, K.M.2    Price, K.J.3    Zhang, P.M.4    Mattick, J.S.5    Leedman, P.J.6
  • 33
    • 51349103144 scopus 로고    scopus 로고
    • Four miRNAs associated with aggressiveness of lymph node-negative, estrogen receptor-positive human breast cancer
    • Foekens JA, Sieuwerts AM, Smid M, et al. Four miRNAs associated with aggressiveness of lymph node-negative, estrogen receptor-positive human breast cancer. Proc Natl Acad Sci U S A 2008;105:13021-6.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 13021-13026
    • Foekens, J.A.1    Sieuwerts, A.M.2    Smid, M.3
  • 34
    • 63449123568 scopus 로고    scopus 로고
    • MiRNA expression in urothelial carcinomas: Important roles of miR-10a, miR-222, miR-125b, miR-7 and miR-452 for tumor stage and metastasis, and frequent homozygous losses of miR-31
    • Veerla S, Lindgren D, Kvist A, et al. MiRNA expression in urothelial carcinomas: important roles of miR-10a, miR-222, miR-125b, miR-7 and miR-452 for tumor stage and metastasis, and frequent homozygous losses of miR-31. Int J Cancer 2009;124:2236-42.
    • (2009) Int J Cancer , vol.124 , pp. 2236-2242
    • Veerla, S.1    Lindgren, D.2    Kvist, A.3
  • 35
    • 54249093368 scopus 로고    scopus 로고
    • MicroRNA-7, a homeobox D10 target, inhibits p21-activated kinase 1 and regulates its functions
    • Reddy SD, Ohshiro K, Rayala SK, Kumar R. MicroRNA-7, a homeobox D10 target, inhibits p21-activated kinase 1 and regulates its functions. Cancer Res 2008;68:8195-200.
    • (2008) Cancer Res , vol.68 , pp. 8195-8200
    • Reddy, S.D.1    Ohshiro, K.2    Rayala, S.K.3    Kumar, R.4
  • 36
    • 64249144494 scopus 로고    scopus 로고
    • A micro-RNA imparts robustness against environmental fluctuation during development
    • Li X, Cassidy JJ, Reinke CA, Fischboeck S, Carthew RW. A micro-RNA imparts robustness against environmental fluctuation during development. Cell 2009;137:273-82.
    • (2009) Cell , vol.137 , pp. 273-282
    • Li, X.1    Cassidy, J.J.2    Reinke, C.A.3    Fischboeck, S.4    Carthew, R.W.5
  • 37
    • 70249083439 scopus 로고    scopus 로고
    • Drosophila maelstrom ensures proper germline stem cell lineage differentiation by repressing microRNA-7
    • Pek JW, Lim AK, Kai T. Drosophila maelstrom ensures proper germline stem cell lineage differentiation by repressing microRNA-7. Dev Cell 2009;17:417-24.
    • (2009) Dev Cell , vol.17 , pp. 417-424
    • Pek, J.W.1    Lim, A.K.2    Kai, T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.