E4BP4: An unexpected player in the immune response

Trends in Immunology

Volumn 33, Issue 2, 2012, Pages 98-102

  Male, Victoria ^a   Nisoli, Ilaria ^a   Gascoyne, Duncan M ^b   Brady, Hugh J M ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BASIC LEUCINE ZIPPER TRANSCRIPTION FACTOR; E4BP4 TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

BONE MARROW; CELL MATURATION; DENDRITIC CELL; HEMATOPOIETIC STEM CELL; HUMAN; IMMUNE RESPONSE; IMMUNOREGULATION; MACROPHAGE; NATURAL KILLER CELL; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW;

ANIMALS; BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTORS; CYTOKINES; DENDRITIC CELLS; HUMANS; KILLER CELLS, NATURAL; T-LYMPHOCYTES, HELPER-INDUCER;

EID: 84856530312     PISSN: 14714906     EISSN: 14714981     Source Type: Journal    
DOI: 10.1016/j.it.2011.10.002     Document Type: Review

References (39)

1. Cowell I.G., et al. Transcriptional repression by a novel member of the bZIP family of transcription factors. Mol. Cell. Biol. 1992, 12:3070-3077.
2. Zhang W., et al. Molecular cloning and characterization of NF-IL3A, a transcriptional activator of the human interleukin-3 promoter. Mol. Cell. Biol. 1995, 15:6055-6063.
3. Ikushima S., et al. Pivotal role for the NFIL3/E4BP4 transcription factor in interleukin 3-mediated survival of pro-B lymphocytes. Proc. Natl. Acad. Sci. U.S.A. 1997, 94:2609-2614.
4. Yu Y.L., et al. GATA factors are essential for transcription of the survival gene E4bp4 and the viability response of interleukin-3 in Ba/F3 hematopoietic cells. J. Biol. Chem. 2002, 277:144-153.
5. Yeung J., et al. E4BP4 expression is regulated by the t(17;19)-associated oncoprotein E2A-HLF in pro-B cells. Br. J. Haematol. 2004, 125:560-567.
6. Kashiwada M., et al. IL-4-induced transcription factor NFIL3/E4BP4 controls IgE class switching. Proc. Natl. Acad. Sci. U.S.A. 2010, 107:821-826.
7. Mitsui S., et al. Antagonistic role of E4BP4 and PAR proteins in the circadian oscillatory mechanism. Genes Dev. 2001, 15:995-1006.
8. Doi M., et al. Negative control of circadian clock regulator E4BP4 by casein kinase 1epsilon-mediated phosphorylation. Curr. Biol. 2004, 14:975-980.
9. Junghans D., et al. The CES-2-related transcription factor E4BP4 is an intrinsic regulator of motoneuron growth and survival. Development 2004, 131:4425-4434.
10. MacGillavry H.D., et al. Genome-wide gene expression and promoter binding analysis identifies NFIL3 as a repressor of C/EBP target genes in neuronal outgrowth. Mol. Cell. Neurosci. 2011, 46:460-468.
11. Silvestris F., et al. Negative regulation of the osteoblast function in multiple myeloma through the repressor gene E4BP4 activated by malignant plasma cells. Clin. Cancer Res. 2008, 14:6081-6091.
12. Li F., et al. A role for nuclear factor interleukin-3 (NFIL3), a critical transcriptional repressor, in down-regulator of periovulatory gene expression. Mol. Endocrinol. 2011, 25:445-459.
13. Gascoyne D., et al. The basic leucine zipper transcription factor E4bp4 is essential for natural killer cell development. Nat. Immunol. 2009, 10:1118-1124.
14. Kamizono S., et al. Nfil3/E4bp4 is required for the development and maturation of NK cells in vivo. J. Exp. Med. 2009, 206:2977-2986.
15. Motomura Y., et al. The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4(+) T cells. Nat. Immunol. 2011, 12:450-459.
16. Huntington N.D., et al. Developmental pathways that generate natural-killer-cell diversity in mice and humans. Nat. Rev. Immunol. 2007, 7:703-714.
17. Rosmaraki E.E., et al. Identification of committed NK cell progenitors in adult bone marrow. Eur. J. Immunol. 2001, 31:1900-1909.
18. Williams N.S., et al. Differentiation of NK1.1+Ly49+ NK cells from flt3+ multipotent marrow progenitor cells. J. Immunol. 1999, 163:2648-2656.
19. Colucci F., et al. What does it take to make a natural killer?. Nat. Rev. Immunol. 2003, 3:413-425.
20. Nutt S.L., et al. Commitment to the B-lymphoid lineage depends on the transcription factor Pax5. Nature 1999, 401:556-562.
21. Yokota Y., et al. Development of peripheral lymphoid organs and natural killer cells depends on the helix-loop-helix inhibitor Id2. Nature 1999, 397:702-706.
22. Ikawa T., et al. Commitment to natural killer cells requires the helix-loop-helix inhibitor Id2. Proc. Natl. Acad. Sci. U.S.A. 2001, 98:5164-5169.
23. Boos M.D., et al. Mature natural killer cell and lymphoid tissue-inducing cell development requires Id2-mediated suppression of E protein activity. J. Exp. Med. 2007, 204:1119-1130.
24. Samson S.I., et al. GATA-3 promotes maturation, IFN-gamma production, and liver-specific homing of NK cells. Immunity 2003, 19:701-711.
25. Spits H., Di Santo J.P. The expanding family of innate lymphoid cells: regulators and effectors of immunity and tissue remodelling. Nat. Immunol. 2011, 12:21-27.
26. Vosshenrich C.A., et al. A thymic pathway of mouse natural killer cell development characterized by expression of GATA-3 and CD127. Nat. Immunol. 2006, 7:1217-1224.
27. Li P., et al. Reprogramming of T cells to natural killer-like cells upon Bcl11b deletion. Science 2010, 329:85-89.
28. Kashiwada M., et al. NFIL3/E4BP4 is a key transcription factor for CD8{alpha}+ dendritic cell development. Blood 2011, 10.1182/blood-2010-07-295873.
29. Villadangos J.A., Schnorrer P. Intrinsic and cooperative antigen-presenting functions of dendritic-cell subsets in vivo. Nat. Rev. Immunol. 2007, 7:543-555.
30. Hildner K., et al. Batf deficiency reveals a critical role for CD8alpha+ dendritic cells in cytotoxic T cell immunity. Science 2008, 322:1097-1100.
31. Márquez C., et al. Identification of a common developmental pathway for thymic natural killer cells and dendritic cells. Blood 1998, 91:2760-2771.
32. Grzywacz B., et al. Natural killer-cell differentiation by myeloid progenitors. Blood 2011, 117:3548-3558.
33. Kuibara R., et al. Two distinct interleukin-3-mediated signal pathways, Ras-NFIL3 (E4BP4) and Bcl-xL, regulate the survival of murine pro-B lymphocytes. Mol. Cell. Biol. 1999, 19:2754-2762.
34. Schroder A.J., et al. Cutting edge: STAT6 serves as a positive and negative regulator of gene expression in IL-4-stimulated B lymphocytes. J. Immunol. 2002, 168:996-1000.
35. Baek Y.S., et al. Identification of novel transcriptional regulators involved in macrophage differentiation and activation in U937 cells. BMC Immunol. 2009, 10:18.
36. Lang R., et al. Shaping gene expression in activated and resting primary macrophages by IL-10. J. Immunol. 2002, 169:2253-2263.
37. Kobayashi T., et al. NFIL3 is a regulator of IL-12 p40 in macrophages and mucosal immunity. J. Immunol. 2011, 186:4649-4655.
38. Smith A.M., et al. A distal enhancer in Il12b is the target of transcriptional repression by the STAT3 pathway and requires the basic leucine zipper (B-ZIP) protein NFIL3. J. Biol. Chem. 2011, 286:23582-23590.
39. Kashiwada M., et al. NFIL3/E4BP4 controls type 2 T helper cell cytokine expression. EMBO J. 2011, 30:2071-2082.