Lithium Controls Central Nervous System Autoimmunity through Modulation of IFN-γ Signaling

PLoS ONE

Volumn 7, Issue 12, 2012, Pages

  Rowse, Amber L ^b   Naves, Rodrigo ^c,d   Cashman, Kevin S ^b   McGuire, Donald J ^b   Mbana, Tethia ^c   Raman, Chander ^b,c   de Sarno, Patrizia ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b University of Alabama at Birmingham   (United States)

^c University of Alabama at Birmingham   (United States)

^d PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE   (Chile)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERFERON RECEPTOR; INTERFERON RECEPTOR 1; INTERLEUKIN 17; LITHIUM; STAT1 PROTEIN; UNCLASSIFIED DRUG;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFICACY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; HELPER CELL; MALE; MOUSE; NEUROMODULATION; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; TH17 CELL; TREATMENT RESPONSE;

ANIMALS; AUTOIMMUNITY; CENTRAL NERVOUS SYSTEM; DISEASE MODELS, ANIMAL; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; GLYCOGEN SYNTHASE KINASE 3; INTERFERON-GAMMA; INTERLEUKINS; LITHIUM; MALE; MICE; MICE, KNOCKOUT; MULTIPLE SCLEROSIS; PHOSPHORYLATION; SIGNAL TRANSDUCTION; STAT1 TRANSCRIPTION FACTOR; TH1 CELLS; TH17 CELLS;

MUS;

EID: 84871688961     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0052658     Document Type: Article

References (37)

1. Mayo L, Quintana FJ, Weiner HL, (2012) The innate immune system in demyelinating disease. Immunol Rev 248: 170-187.
2. Nylander A, Hafler DA, (2012) Multiple sclerosis. J Clin Invest 122: 1180-1188.
3. Dardalhon V, Korn T, Kuchroo VK, Anderson AC, (2008) Role of Th1 and Th17 cells in organ-specific autoimmunity. J Autoimmun 31: 252-256.
4. Steinman L, (2008) A rush to judgment on Th17. J Exp Med 205: 1517-1522.
5. Stromnes IM, Cerretti LM, Liggitt D, Harris RA, Goverman JM, (2008) Differential regulation of central nervous system autoimmunity by T(H)1 and T(H)17 cells. Nat Med 14: 337-342.
6. El-behi M, Rostami A, Ciric B, (2010) Current views on the roles of Th1 and Th17 cells in experimental autoimmune encephalomyelitis. J Neuroimmune Pharmacol 5: 189-197.
7. Schulz EG, Mariani L, Radbruch A, Höfer T, (2009) Sequential polarization and imprinting of type 1 T helper lymphocytes by interferon-gamma and interleukin-12. Immunity 30: 673-683.
8. Bettelli E, Carrier Y, Gao W, Korn T, Strom TB, et al. (2006) Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 441: 235-238.
9. Mangan PR, Harrington LE, O'Quinn DB, Helms WS, Bullard DC, et al. (2006) Transforming growth factor-beta induces development of the T(H)17 lineage. Nature 441: 231-234.
10. Korn T, Bettelli E, Oukka M, Kuchroo VK, (2009) IL-17 and Th17 Cells. Annu Rev Immunol 27: 485-517.
11. Hu X, Ivashkiv LB, (2009) Cross-regulation of signaling pathways by interferon-gamma: implications for immune responses and autoimmune diseases. Immunity 31: 539-550.
12. Kroenke MA, Carlson TJ, Andjelkovic AV, Segal BM, (2008) IL-12- and IL-23-modulated T cells induce distinct types of EAE based on histology, CNS chemokine profile, and response to cytokine inhibition. J Exp Med 205: 1535-1541.
13. Haak S, Gyülveszi G, Becher B, (2009) Th17 cells in autoimmune disease: changing the verdict. Immunotherapy 1: 199-203.
14. Lee YK, Turner H, Maynard CL, Oliver JR, Chen D, et al. (2009) Late developmental plasticity in the T helper 17 lineage. Immunity 30: 92-107.
15. Axtell R, de Jong B, Boniface K, van der Voort L, Bhat R, et al. (2010) T helper type 1 and 17 cells determine efficacy of interferon-beta in multiple sclerosis and experimental encephalomyelitis. Nat Med 16: 406-412.
16. Wang H, Brown J, Martin M, (2011) Glycogen synthase kinase 3: a point of convergence for the host inflammatory response. Cytokine 53: 130-140.
17. De Sarno P, Axtell R, Raman C, Roth K, Alessi D, et al. (2008) Lithium prevents and ameliorates experimental autoimmune encephalomyelitis. J Immunol 181: 338-345.
18. Hu X, Chen J, Wang L, Ivashkiv LB, (2007) Crosstalk among Jak-STAT, Toll-like receptor, and ITAM-dependent pathways in macrophage activation. J Leukoc Biol 82: 237-243.
19. Beurel E, Jope R, (2008) Differential regulation of STAT family members by glycogen synthase kinase-3. J Biol Chem 283: 21934-21944.
20. Beurel E, Jope RS, (2009) Glycogen synthase kinase-3 promotes the synergistic action of interferon-gamma on lipopolysaccharide-induced IL-6 production in RAW264.7 cells. Cell Signal 21: 978-985.
21. Beeton C, Chandy KG (2007) Isolation of mononuclear cells from the central nervous system of rats with EAE. J Vis Exp: 527.
22. Guo B, Chang EY, Cheng G, (2008) The type I IFN induction pathway constrains Th17-mediated autoimmune inflammation in mice. J Clin Invest 118: 1680-1690.
23. Prinz M, Kalinke U, (2010) New lessons about old molecules: how type I interferons shape Th1/Th17-mediated autoimmunity in the CNS. Trends Mol Med 16: 379-386.
24. Ramgolam VS, Sha Y, Jin J, Zhang X, Markovic-Plese S, (2009) IFN-beta inhibits human Th17 cell differentiation. J Immunol 183: 5418-5427.
25. Zhang L, Yuan S, Cheng G, Guo B, (2011) Type I IFN promotes IL-10 production from T cells to suppress Th17 cells and Th17-associated autoimmune inflammation. PLoS One 6: e28432.
26. Beurel E, Yeh WI, Michalek SM, Harrington LE, Jope RS, (2011) Glycogen synthase kinase-3 is an early determinant in the differentiation of pathogenic Th17 cells. J Immunol 186: 1391-1398.
27. Codarri L, Gyülvészi G, Tosevski V, Hesske L, Fontana A, et al. (2011) RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation. Nat Immunol 12: 560-567.
28. El-Behi M, Ciric B, Dai H, Yan Y, Cullimore M, et al. (2011) The encephalitogenicity of T(H)17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF. Nat Immunol 12: 568-575.
29. Shen F, Li N, Gade P, Kalvakolanu DV, Weibley T, et al. (2009) IL-17 receptor signaling inhibits C/EBPbeta by sequential phosphorylation of the regulatory 2 domain. Sci Signal 2: ra8.
30. Berenson LS, Ota N, Murphy KM, (2004) Issues in T-helper 1 development-resolved and unresolved. Immunol Rev 202: 157-174.
31. Maldonado RA, Irvine DJ, Schreiber R, Glimcher LH, (2004) A role for the immunological synapse in lineage commitment of CD4 lymphocytes. Nature 431: 527-532.
32. Tsai C, Kai J, Huang W, Wang C, Wang Y, et al. (2009) Glycogen synthase kinase-3beta facilitates IFN-gamma-induced STAT1 activation by regulating Src homology-2 domain-containing phosphatase 2. J Immunol 183: 856-864.
33. Platanias LC, (2005) Mechanisms of type-I- and type-II-interferon-mediated signalling. Nat Rev Immunol 5: 375-386.
34. Batten M, Li J, Yi S, Kljavin NM, Danilenko DM, et al. (2006) Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells. Nat Immunol 7: 929-936.
35. Fitzgerald DC, Ciric B, Touil T, Harle H, Grammatikopolou J, et al. (2007) Suppressive effect of IL-27 on encephalitogenic Th17 cells and the effector phase of experimental autoimmune encephalomyelitis. J Immunol 179: 3268-3275.
36. Murugaiyan G, Mittal A, Lopez-Diego R, Maier LM, Anderson DE, et al. (2009) IL-27 is a key regulator of IL-10 and IL-17 production by human CD4+ T cells. J Immunol 183: 2435-2443.
37. Martín-Saavedra FM, González-García C, Bravo B, Ballester S, (2008) Beta interferon restricts the inflammatory potential of CD4+ cells through the boost of the Th2 phenotype, the inhibition of Th17 response and the prevalence of naturally occurring T regulatory cells. Mol Immunol 45: 4008-4019.