A key cytochrome P450 hydroxylase in pradimicin biosynthesis

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 1, 2012, Pages 606-609

  Napan, Kandy L ^a   Zeng, Jia ^a   Takemoto, Jon Y ^b   Zhan, Jixun ^a  

^a Utah State University   (United States)

^b UTAH STATE UNIVERSITY   (United States)

Author keywords

Actinomadura hibisca; Cytochrome P450 monooxygenase; Hydroxylation; Pradimicins; Substrate inhibition

Indexed keywords

CYTOCHROME P450; CYTOCHROME P450 HYDROXYLASE; CYTOCHROME P450 OXYGENASE; GLUCOSE DEHYDROGENASE; HYDROLASE; PRADIMICIN A; PRADIMICIN B; PRADIMICIN C; UNCLASSIFIED DRUG; UNSPECIFIC MONOOXYGENASE;

ACTINOMADURA; ACTINOMADURA HIBISCA; ARTICLE; BIOSYNTHESIS; COMPETITIVE INHIBITION; CONTROLLED STUDY; ENZYME INHIBITION; ESCHERICHIA COLI; GLYCOSYLATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NONHUMAN; PROTEIN EXPRESSION; VELOCITY;

AMINO ACID SEQUENCE; ANTHRACYCLINES; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, LIQUID; CYTOCHROME P-450 ENZYME SYSTEM; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; ESCHERICHIA COLI; KINETICS; MASS SPECTROMETRY; MODELS, CHEMICAL; MOLECULAR SEQUENCE DATA; POLYKETIDES; SEQUENCE HOMOLOGY, AMINO ACID; SUBSTRATE SPECIFICITY;

ACTINOMADURA HIBISCA; ESCHERICHIA COLI;

EID: 84655176305     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.10.075     Document Type: Article

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