Environmental DNA-encoded antibiotics fasamycins A and B inhibit FabF in type II fatty acid biosynthesis

Journal of the American Chemical Society

Volumn 134, Issue 6, 2012, Pages 2981-2987

  Feng, Zhiyang ^a   Chakraborty, Debjani ^a   Dewell, Scott B ^a   Reddy, Boojala Vijay B ^a   Brady, Sean F ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC DISCOVERY; BIOCHEMICAL ASSAY; BIOSYNTHETIC GENE CLUSTER; CANDIDATE GENES; CLINICAL USE; FATTY ACID BIOSYNTHESIS; IN-SILICO; IN-VITRO; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; NATURALLY OCCURRING; OVER-EXPRESSION; PHARMACOPHORES; POLYKETIDES; TYPE II; VANCOMYCIN-RESISTANT ENTEROCOCCI; WILD TYPES;

BACILLI; BIOCHEMISTRY; BIOSYNTHESIS; CLONING; GENES; KETONES; PHARMACODYNAMICS;

ANTIBIOTICS;

ANTIBIOTIC AGENT; ENVIRONMENTAL DNA; FASAMYCIN A; FASAMYCIN B; FATTY ACID; GENOMIC DNA; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIUM CULTURE; BIOSYNTHESIS; DRUG ISOLATION; DRUG TARGETING; GENE CLUSTER; GENE OVEREXPRESSION; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PHARMACOPHORE; POLYMERASE CHAIN REACTION; SOIL; VANCOMYCIN RESISTANT ENTEROCOCCUS;

3-OXOACYL-(ACYL-CARRIER-PROTEIN) SYNTHASE; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BASE SEQUENCE; BIOCHEMISTRY; BIPHENYL COMPOUNDS; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY; CLONING, MOLECULAR; DNA; DNA PRIMERS; ENTEROCOCCUS FAECALIS; FATTY ACIDS; GENE LIBRARY; HUMANS; INHIBITORY CONCENTRATION 50; MODELS, CHEMICAL; MOLECULAR SEQUENCE DATA; MULTIGENE FAMILY; MUTATION; POLYCYCLIC HYDROCARBONS, AROMATIC;

EID: 84856917548     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja207662w     Document Type: Article

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