Cloning of the biosynthetic gene cluster for naphthoxanthene antibiotic FD-594 from Streptomyces sp. TA-0256

Journal of Antibiotics

Volumn 64, Issue 1, 2011, Pages 123-132

  Kudo, Fumitaka ^a   Yonezawa, Takanori ^a   Komatsubara, Akiko ^a   Mizoue, Kazutoshi ^b   Eguchi, Tadashi ^a  

^a TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

^b TAISHO PHARMACEUTICAL CO LTD   (Japan)

Author keywords

angucyclic polyketide; aromatic polyketide; biosynthesis; glycosyltransferase; methyltransferase; streptomyces; type II PKS

Indexed keywords

AGLYCONE; ANTIBIOTIC AGENT; FD 594; FLAVINE ADENINE NUCLEOTIDE; GLYCOSYLTRANSFERASE; METHYLTRANSFERASE; NAPHTHOXANTHENE; OLIGOSACCHARIDE; OXIDOREDUCTASE; OXYGENASE; POLYKETIDE; RECOMBINANT PROTEIN; REDOX EFFECTOR FACTOR 1; UNCLASSIFIED DRUG; UNSPECIFIC MONOOXYGENASE; XANTHENE;

ARTICLE; BACTERIAL STRAIN; BIOSYNTHESIS; CATALYSIS; CLUSTER ANALYSIS; ENZYME MECHANISM; ESCHERICHIA COLI; GENE CLUSTER; GENE IDENTIFICATION; GENE PROBE; GENE SEQUENCE; METABOLISM; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; OXIDATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATOR GENE; RING OPENING; STREPTOMYCES;

ANTIBIOTICS, ANTINEOPLASTIC; CLONING, MOLECULAR; DNA, BACTERIAL; GENES, BACTERIAL; GLYCOSYLTRANSFERASES; METHYLTRANSFERASES; MULTIGENE FAMILY; POLYMERASE CHAIN REACTION; PYRANS; SEQUENCE ANALYSIS, DNA; STREPTOMYCES; XANTHENES;

ESCHERICHIA COLI; STREPTOMYCES; STREPTOMYCES SP.;

EID: 79251614776     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.1038/ja.2010.145     Document Type: Article

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