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Volumn 179, Issue 13, 1997, Pages 4305-4310

Identification of a monooxygenase from Streptomyces coelicolor A3(2) involved in biosynthesis of actinorhodin: Purification and characterization of the recombinant enzyme

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ENZYME; HISTIDINE; MUTANT PROTEIN; POLYKETIDE; QUINONE DERIVATIVE; RECOMBINANT PROTEIN; UNSPECIFIC MONOOXYGENASE;

EID: 0030858888     PISSN: 00219193     EISSN: None     Source Type: Journal    
DOI: 10.1128/jb.179.13.4305-4310.1997     Document Type: Article
Times cited : (74)

References (33)
  • 1
    • 0024996111 scopus 로고
    • Biosynthesis of anthroquinones by interspecies cloning of actinorhodin biosynthesis genes in streptomycetes: Clarification of actinorhodin gene functions
    • Bartel, P. L., C.-B. Zhu, J. S. Lampel, D. C. Dosch, N. C. Connors, W. R. Strohl, J. M. Beale, Jr., and H. G. Floss. 1990. Biosynthesis of anthroquinones by interspecies cloning of actinorhodin biosynthesis genes in streptomycetes: clarification of actinorhodin gene functions. J. Bacteriol. 172:4816-4826.
    • (1990) J. Bacteriol. , vol.172 , pp. 4816-4826
    • Bartel, P.L.1    Zhu, C.-B.2    Lampel, J.S.3    Dosch, D.C.4    Connors, N.C.5    Strohl, W.R.6    Beale Jr., J.M.7    Floss, H.G.8
  • 2
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford, M. M. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:248-254.
    • (1976) Anal. Biochem. , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 3
    • 0025837029 scopus 로고
    • Translational organisation and regulation of an antibiotic export complex in the producing Streptomyces culture
    • Caballero, J. L., E. Martínez, F. Malpartida, and D. A. Hopwood. 1991. Translational organisation and regulation of an antibiotic export complex in the producing Streptomyces culture. Mol. Gen. Genet. 230:401-412.
    • (1991) Mol. Gen. Genet. , vol.230 , pp. 401-412
    • Caballero, J.L.1    Martínez, E.2    Malpartida, F.3    Hopwood, D.A.4
  • 4
    • 0023152999 scopus 로고
    • Biosynthesis of the antibiotic actinorhodin: Analysis of blocked mutants of Streptomyces coelicolor
    • Tokyo
    • Cole, S. P., B. A. Rudd, D. A. Hopwood, C.-J. Chang, and H. G. Floss. 1987. Biosynthesis of the antibiotic actinorhodin: analysis of blocked mutants of Streptomyces coelicolor. J. Antibiot. (Tokyo) 40:340-347.
    • (1987) J. Antibiot. , vol.40 , pp. 340-347
    • Cole, S.P.1    Rudd, B.A.2    Hopwood, D.A.3    Chang, C.-J.4    Floss, H.G.5
  • 5
    • 0029085632 scopus 로고
    • Polyketide synthase acyl carrier proteins from Streptomyce: Expression in Escherichia coli, purification and partial characterisation
    • Crosby, J., D. H. Sherman, M. J. Bibb, W. P. Revill, D. A. Hopwood, and T. J. Simpson. 1995. Polyketide synthase acyl carrier proteins from Streptomyce: expression in Escherichia coli, purification and partial characterisation. Biochim. Biophys. Acta 1251:32-42.
    • (1995) Biochim. Biophys. Acta , vol.1251 , pp. 32-42
    • Crosby, J.1    Sherman, D.H.2    Bibb, M.J.3    Revill, W.P.4    Hopwood, D.A.5    Simpson, T.J.6
  • 6
    • 0027971383 scopus 로고
    • DNA sequence and functions of the actVI region of the actinorhodin biosynthetic gene cluster of Streptomyces coelicolor A3(2)
    • Fernández-Moreno, M. A., E. Martínez, J. L. Caballero, K. Ichinose, D. A. Hopwood, and F. Malpartida. 1994. DNA sequence and functions of the actVI region of the actinorhodin biosynthetic gene cluster of Streptomyces coelicolor A3(2). J. Biol. Chem. 269:24854-24863.
    • (1994) J. Biol. Chem. , vol.269 , pp. 24854-24863
    • Fernández-Moreno, M.A.1    Martínez, E.2    Caballero, J.L.3    Ichinose, K.4    Hopwood, D.A.5    Malpartida, F.6
  • 7
    • 0026657813 scopus 로고
    • Nucleotide sequence and deduced functions of a set of cotranscribed genes of Streptomyces coelicolor A3(2) including the polyketide synthase for the antibiotic actinorhodin
    • Fernández-Moreno, M. A., E. Martínez, L. Boto, D. A. Hopwood, and F. Malpartida. 1992. Nucleotide sequence and deduced functions of a set of cotranscribed genes of Streptomyces coelicolor A3(2) including the polyketide synthase for the antibiotic actinorhodin. J. Biol. Chem. 267:19278-19290.
    • (1992) J. Biol. Chem. , vol.267 , pp. 19278-19290
    • Fernández-Moreno, M.A.1    Martínez, E.2    Boto, L.3    Hopwood, D.A.4    Malpartida, F.5
  • 8
    • 0025899144 scopus 로고
    • The actinorhodin gene cluster contains regulatory and antibiotic export genes that are direct targets for translational control by the bldA tRNA gene of Streptomyces coelicolor
    • Fernández-Moreno, M. A., J. L. Caballero, D. A. Hopwood, and F. Malpartida. 1991. The actinorhodin gene cluster contains regulatory and antibiotic export genes that are direct targets for translational control by the bldA tRNA gene of Streptomyces coelicolor. Cell 66:769-780.
    • (1991) Cell , vol.66 , pp. 769-780
    • Fernández-Moreno, M.A.1    Caballero, J.L.2    Hopwood, D.A.3    Malpartida, F.4
  • 9
    • 0025949383 scopus 로고
    • Overproduction and localization of components of the polyketide synthase of Streptomyces glaucescens involved in the production of the antibiotic tetracenomycin C
    • Gramajo, H. C. J. White, C. R. Hutchinson, and M. J. Bibb. 1991. Overproduction and localization of components of the polyketide synthase of Streptomyces glaucescens involved in the production of the antibiotic tetracenomycin C. J. Bacteriol. 173:6475-6483.
    • (1991) J. Bacteriol. , vol.173 , pp. 6475-6483
    • Gramajo, H.C.1    White, J.2    Hutchinson, C.R.3    Bibb, M.J.4
  • 10
    • 0024274121 scopus 로고
    • DNA sequence, transcription and deduced function of a gene in polyketide antibiotic synthesis in Streptomyces coelicolor
    • Hallam, S. E., F. Malpartida, and D. A. Hopwood. 1988. DNA sequence, transcription and deduced function of a gene in polyketide antibiotic synthesis in Streptomyces coelicolor. Gene 74:305-320.
    • (1988) Gene , vol.74 , pp. 305-320
    • Hallam, S.E.1    Malpartida, F.2    Hopwood, D.A.3
  • 11
    • 0025606149 scopus 로고
    • Molecular genetics of polyketides and its comparison to fatty acid biosynthesis
    • Hopwood, D. A., and D. H. Sherman. 1990. Molecular genetics of polyketides and its comparison to fatty acid biosynthesis. Annu. Rev. Genet. 24:37-66.
    • (1990) Annu. Rev. Genet. , vol.24 , pp. 37-66
    • Hopwood, D.A.1    Sherman, D.H.2
  • 13
    • 0028811381 scopus 로고
    • Polyketide gene manipulations: A structure-function approach in engineering novel antibiotics
    • Hutchinson, C. R., and I. Fujii. 1995. Polyketide gene manipulations: a structure-function approach in engineering novel antibiotics. Annu. Rev. Microbiol. 49:201-238.
    • (1995) Annu. Rev. Microbiol. , vol.49 , pp. 201-238
    • Hutchinson, C.R.1    Fujii, I.2
  • 14
    • 0027382486 scopus 로고
    • Polyketide synthesis: Prospects for hybrid antibiotics
    • Katz, L., and S. Donadio. 1993. Polyketide synthesis: prospects for hybrid antibiotics. Annu. Rev. Microbiol. 47:875-912.
    • (1993) Annu. Rev. Microbiol. , vol.47 , pp. 875-912
    • Katz, L.1    Donadio, S.2
  • 15
    • 0029090782 scopus 로고
    • Identification of a flavin:NADH oxidoreductase involved in the biosynthesis of actinorhodin: Purification and characterization of the recombinant enzyme
    • Kendrew, S. G., S. E. Harding, D. A. Hopwood, and E. N. G. Marsh. 1995. Identification of a flavin:NADH oxidoreductase involved in the biosynthesis of actinorhodin: purification and characterization of the recombinant enzyme. J. Biol. Chem. 270:17339-17343.
    • (1995) J. Biol. Chem. , vol.270 , pp. 17339-17343
    • Kendrew, S.G.1    Harding, S.E.2    Hopwood, D.A.3    Marsh, E.N.G.4
  • 16
  • 17
    • 0014949207 scopus 로고
    • Cleavage of structural proteins during the assembly of the head of bacteriophage T4
    • Laemmli, U. K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-685.
    • (1970) Nature , vol.227 , pp. 680-685
    • Laemmli, U.K.1
  • 18
    • 0021238139 scopus 로고
    • Molecular cloning of the whole biosynthetic pathway of a Streptomyces antibiotic and its expression in a heterologous host
    • Malpartida, F., and D. A. Hopwood. 1984. Molecular cloning of the whole biosynthetic pathway of a Streptomyces antibiotic and its expression in a heterologous host. Nature 309:462-464.
    • (1984) Nature , vol.309 , pp. 462-464
    • Malpartida, F.1    Hopwood, D.A.2
  • 19
    • 0023001541 scopus 로고
    • Physical and genetic characterization of the gene cluster for the antibiotic actinorhodin in Streptomyces coelicolor A3(2)
    • Malpartida, F., and D. A. Hopwood, 1986. Physical and genetic characterization of the gene cluster for the antibiotic actinorhodin in Streptomyces coelicolor A3(2). Mol. Gen. Genet. 205:66-73.
    • (1986) Mol. Gen. Genet. , vol.205 , pp. 66-73
    • Malpartida, F.1    Hopwood, D.A.2
  • 20
    • 0027499048 scopus 로고
    • Methylmalonyl-CoA mutase from Propionibacterium shermanii: Characterization of the cobalamin-inhibited form and subunit-cofactor interactions studied by analytical ultracentrifugation
    • Marsh, E. N., and S. E. Harding. 1993. Methylmalonyl-CoA mutase from Propionibacterium shermanii: characterization of the cobalamin-inhibited form and subunit-cofactor interactions studied by analytical ultracentrifugation. Biochem. J. 290:551-555.
    • (1993) Biochem. J. , vol.290 , pp. 551-555
    • Marsh, E.N.1    Harding, S.E.2
  • 22
    • 0028575694 scopus 로고
    • Engineered biosynthesis of novel polyketides: ActVII and ActIV encode aromatase and cyclase enzymes respectively
    • McDaniel, R., S. Ebert-Khosla, D. A. Hopwood, and C. Khosla. 1994. Engineered biosynthesis of novel polyketides: actVII and ActIV encode aromatase and cyclase enzymes respectively. J. Am. Chem. Soc. 116:10855-10859.
    • (1994) J. Am. Chem. Soc. , vol.116 , pp. 10855-10859
    • McDaniel, R.1    Ebert-Khosla, S.2    Hopwood, D.A.3    Khosla, C.4
  • 23
    • 0029064652 scopus 로고
    • Rational design of aromatic polyketide natural products by recombinant assembly of enzymatic subunits
    • McDaniel, R., S. Ebert-Khosla, D. A. Hopwood, and C. Khosla. 1995 Rational design of aromatic polyketide natural products by recombinant assembly of enzymatic subunits. Nature 375:549-554.
    • (1995) Nature , vol.375 , pp. 549-554
    • McDaniel, R.1    Ebert-Khosla, S.2    Hopwood, D.A.3    Khosla, C.4
  • 25
    • 0022646755 scopus 로고
    • Production of new hybrid antibiotics, mederrhodins A and B, by a genetically engineered strain
    • Õmura, S., H. Ikeda, F. Malpartida, H. M. Kieser, and D. A. Hopwood. 1986. Production of new hybrid antibiotics, mederrhodins A and B, by a genetically engineered strain. Antimicrob. Agents Chemother. 29:13-19.
    • (1986) Antimicrob. Agents Chemother. , vol.29 , pp. 13-19
    • Õmura, S.1    Ikeda, H.2    Malpartida, F.3    Kieser, H.M.4    Hopwood, D.A.5
  • 26
    • 0018320319 scopus 로고
    • Genetics of actinorhodin biosynthesis by Streptomyces coalicolor A3(2)
    • Rudd, B. A. M., and D. A. Hopwood. 1979. Genetics of actinorhodin biosynthesis by Streptomyces coalicolor A3(2). J. Gen. Microbiol. 114:35-43.
    • (1979) J. Gen. Microbiol. , vol.114 , pp. 35-43
    • Rudd, B.A.M.1    Hopwood, D.A.2
  • 28
    • 0027908038 scopus 로고
    • Enzymatic synthesis of a bacterial polyketide from acetyl and malonyl coenzyme A
    • Shen, B., and C. R. Hutchinson. 1993. Enzymatic synthesis of a bacterial polyketide from acetyl and malonyl coenzyme A. Science 262:1535-1540.
    • (1993) Science , vol.262 , pp. 1535-1540
    • Shen, B.1    Hutchinson, C.R.2
  • 29
    • 0027301951 scopus 로고
    • Tetracenomycin F1 monooxygenase: Oxidation of a naphthacenone to a naphthacenequinone in the biosynthesis of tetracenomycin C in Streptomyces glaucescens
    • Shen, B., and C. R. Hutchinson. 1993. Tetracenomycin F1 monooxygenase: oxidation of a naphthacenone to a naphthacenequinone in the biosynthesis of tetracenomycin C in Streptomyces glaucescens. Biochemistry 32:6656-6663.
    • (1993) Biochemistry , vol.32 , pp. 6656-6663
    • Shen, B.1    Hutchinson, C.R.2
  • 30
    • 0027239625 scopus 로고
    • Isolation and structural elucidation of tetracenomycin F2 and tetracenomycin F1: Early intermediates in the biosynthesis of tetracenomycin C in Streptomyces glaucescens
    • Shen, B., H. Nakayama, and C. R. Hutchinson. 1993. Isolation and structural elucidation of tetracenomycin F2 and tetracenomycin F1: early intermediates in the biosynthesis of tetracenomycin C in Streptomyces glaucescens. J. Nat. Prod. 56:1288-1293.
    • (1993) J. Nat. Prod. , vol.56 , pp. 1288-1293
    • Shen, B.1    Nakayama, H.2    Hutchinson, C.R.3
  • 31
    • 0023042283 scopus 로고
    • Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes
    • Studier, F. W., and B. A. Moffatt. 1986. Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes. J. Mol. Biol. 189:113-130.
    • (1986) J. Mol. Biol. , vol.189 , pp. 113-130
    • Studier, F.W.1    Moffatt, B.A.2
  • 32
    • 0021919826 scopus 로고
    • A bacteriophage T7 RNA polymerase/promoter system for controlled exclusive expression of specific genes
    • Tabor, S., and C. C. Richardson. 1985. A bacteriophage T7 RNA polymerase/promoter system for controlled exclusive expression of specific genes. Proc. Natl. Acad. Sci. USA 82:1074-1078.
    • (1985) Proc. Natl. Acad. Sci. USA , vol.82 , pp. 1074-1078
    • Tabor, S.1    Richardson, C.C.2


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