Arixanthomycins A-C: Phylogeny-guided discovery of biologically active eDNA-derived pentangular polyphenols

ACS Chemical Biology

Volumn 9, Issue 6, 2014, Pages 1267-1272

  Kang, Hahk Soo ^a   Brady, Sean F ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; ANTIFUNGAL AGENT; ANTINEOPLASTIC AGENT; ARIXANTHOMYCIN A; ARIXANTHOMYCIN B; ARIXANTHOMYCIN C; DNA; POLYKETIDE SYNTHASE; POLYPHENOL DERIVATIVE; UNCLASSIFIED DRUG; XANTHONE DERIVATIVE; POLYKETIDE; POLYPHENOL;

ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER CELL LINE; CONTROLLED STUDY; DRUG POTENCY; DRUG SYNTHESIS; EXPRESSED SEQUENCE TAG; GENE CLUSTER; GENE SEQUENCE; GENOTYPE PHENOTYPE CORRELATION; HETEROLOGOUS EXPRESSION; HUMAN; HUMAN CELL; IC 50; MICROBIOME; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR PHYLOGENY; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SEQUENCE TAGGED SITE; SOIL MICROFLORA; BIOLOGY; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; DNA SEQUENCE; DRUG DEVELOPMENT; DRUG EFFECTS; GENETICS; METAGENOME; MULTIGENE FAMILY; NEOPLASMS; PATHOLOGY; PHYLOGENY; TUMOR CELL CULTURE;

ANTINEOPLASTIC AGENTS; CELL PROLIFERATION; COMPUTATIONAL BIOLOGY; DNA; DRUG DISCOVERY; HUMANS; METAGENOME; MOLECULAR STRUCTURE; MULTIGENE FAMILY; NEOPLASMS; PHYLOGENY; POLYKETIDES; POLYPHENOLS; SEQUENCE ANALYSIS, DNA; TUMOR CELLS, CULTURED;

EID: 84903218940     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb500141b     Document Type: Article

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