Exploring natural product chemistry and biology with multicomponent reactions. 5. Discovery of a novel tubulin-targeting scaffold derived from the rigidin family of marine alkaloids

Journal of Medicinal Chemistry

Volumn 56, Issue 17, 2013, Pages 6886-6900

  Frolova, Liliya V ^a   Magedov, Igor V ^a   Romero, Anntherese E ^a   Karki, Menuka ^b   Otero, Isaiah ^a   Hayden, Kathryn ^a   Evdokimov, Nikolai M ^a   Banuls, Laetitia Moreno Y ^c   Rastogi, Shiva K ^f   Smith, W Ross ^f   Lu, Shi Long ^d   Kiss, Robert ^c   Shuster, Charles B ^b   Hamel, Ernest ^e   Betancourt, Tania ^f   Rogelj, Snezna ^a   Kornienko, Alexander ^f  

^a NEW MEXICO INSTITUTE OF MINING AND TECHNOLOGY   (United States)

^b NEW MEXICO STATE UNIVERSITY   (United States)

^c UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^d UNIVERSITY OF COLORADO   (United States)

^e NATIONAL CANCER INSTITUTE   (United States)

^f Texas State University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALOID DERIVATIVE; ANTINEOPLASTIC AGENT; COLCHICINE; TUBULIN; XANTHINE DERIVATIVE;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER CELL CULTURE; CHEMICAL REACTION; CONTROLLED STUDY; DRUG BINDING; DRUG STRUCTURE; DRUG TARGETING; HELA CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; METASTASIS; MICROTUBULE ASSEMBLY;

ALKALOIDS; BIOLOGICAL AGENTS; COLCHICINE; HELA CELLS; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; STRUCTURE-ACTIVITY RELATIONSHIP; TUBULIN;

EID: 84884225721     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm400711t     Document Type: Article

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