Shikonin selectively induces apoptosis in human prostate cancer cells through the endoplasmic reticulum stress and mitochondrial apoptotic pathway

Journal of Biomedical Science

Volumn 22, Issue 1, 2015, Pages

  Gara, Rishi Kumar ^a,b   Srivastava, Vikas Kumar ^c   Duggal, Shivali ^c   Bagga, Jaspreet Kaur ^a   Bhatt, M L B ^c   Sanyal, Sabyasachi ^a   Mishra, Durga Prasad ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

^b UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^c KING GEORGE'S MEDICAL UNIVERSITY   (India)

Author keywords

Calpain pathway; Endoplasmic reticulum stress; Mitochondrial dysfunction; Prostate cancer; ROS; Shikonin

Indexed keywords

CALCIUM; CALPAIN; CASPASE 3; CASPASE 9; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; SALUBRINAL; SHIKONIN; ANTINEOPLASTIC AGENT; NAPHTHOQUINONE;

APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DRUG MECHANISM; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; HUMAN; HUMAN CELL; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROSTATE CANCER; PROSTATE CANCER CELL LINE; PROSTATE EPITHELIUM CELL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; CELL PROLIFERATION; DRUG EFFECTS; PROSTATE TUMOR; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; ENDOPLASMIC RETICULUM STRESS; HUMANS; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; NAPHTHOQUINONES; PROSTATIC NEOPLASMS;

EID: 84926434128     PISSN: 10217770     EISSN: 14230127     Source Type: Journal    
DOI: 10.1186/s12929-015-0127-1     Document Type: Article

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