Shikonin inhibits prostate cancer cells metastasis by reducing matrix metalloproteinase-2/-9 expression via AKT/mTOR and ROS/ERK1/2 pathways

International Immunopharmacology

Volumn 21, Issue 2, 2014, Pages 447-455

  Chen, Yongqiang ^a   Zheng, Lu ^a   Liu, Junquan ^a   Zhou, Zhonghai ^a   Cao, Xiliang ^a   Lv, Xiaoting ^a   Chen, Fuxing ^a  

^a 97th Hospital of PLA   (China)

Author keywords

Human prostate cancer; Invasion; Matrix metalloproteinase; Migration; Shikonin

Indexed keywords

DITHIOTHREITOL; GELATINASE A; GELATINASE B; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; SHIKONIN; STRESS ACTIVATED PROTEIN KINASE; MTOR PROTEIN, HUMAN; NAPHTHOQUINONE; TARGET OF RAPAMYCIN KINASE;

ARTICLE; CANCER CELL; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL GROWTH; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG MECHANISM; DRUG POTENCY; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; METASTASIS; PRIORITY JOURNAL; PROSTATE CANCER; PROSTATE CANCER CELL LINE; PROTEIN EXPRESSION; REDUCTION; SIGNAL TRANSDUCTION; CELL CYCLE CHECKPOINT; CELL MOTION; DRUG EFFECTS; GENE EXPRESSION REGULATION; MALE; METABOLISM; NEOPLASM METASTASIS; PHOSPHORYLATION; PROSTATIC NEOPLASMS; TUMOR CELL LINE;

CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; G2 PHASE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MALE; MAP KINASE SIGNALING SYSTEM; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; NAPHTHOQUINONES; NEOPLASM METASTASIS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROSTATIC NEOPLASMS; PROTO-ONCOGENE PROTEINS C-AKT; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES;

EID: 84902649166     PISSN: 15675769     EISSN: 18781705     Source Type: Journal    
DOI: 10.1016/j.intimp.2014.05.026     Document Type: Article

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