WJ9708012 exerts anticancer activity through PKC-α related crosstalk of mitochondrial and endoplasmic reticulum stresses in human hormone-refractory prostate cancer cells

Acta Pharmacologica Sinica

Volumn 32, Issue 1, 2011, Pages 89-98

  Kuo, Ting Chun ^a   Huang, Wei Jan ^b   Guh, Jih Hwa ^a  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Ca 2+ mobilization; endoplasmic reticulum tress; methoxyflavanone; mitochondrial stress; protein kinase C

Indexed keywords

6 (3 HYDROXY 3 METHYLBUTYL) 2' (7 HYDROXY 3,7 DIMETHYLOCTYL) 3',4',5,7 TETRAMETHOXYFLAVANONE; ANTINEOPLASTIC AGENT; CALCIUM ION; CALPAIN 1; CYCLIN D1; CYCLIN DEPENDENT KINASE 4; CYCLIN E; FLAVANONE DERIVATIVE; GLUCOSE REGULATED PROTEIN 78; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; INITIATION FACTOR 4E BINDING PROTEIN 1; MAMMALIAN TARGET OF RAPAMYCIN; PACLITAXEL; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN KINASE C ALPHA; S6 KINASE; UNCLASSIFIED DRUG; WJ 9708012;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; CANCER CELL; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE PROGRESSION; CELL GROWTH; CELL PROLIFERATION; CELL STRESS; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IC 50; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL STRESS; MITOCHONDRION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; TIME;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CALCIUM; CELL LINE, TUMOR; CELL PROLIFERATION; ENDOPLASMIC RETICULUM; FLAVONES; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MALE; MITOCHONDRIA; PROSTATIC NEOPLASMS; PROTEIN KINASE C-ALPHA; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES;

EID: 78651082604     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2010.173     Document Type: Article

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