Receptor expression modulates calcium-sensing receptor mediated intracellular Ca2+ mobilization

Endocrinology (United States)

Volumn 156, Issue 4, 2015, Pages 1330-1342

  Brennan, Sarah C ^a,c   Mun, Hee Chang ^a   Leach, Katie ^b   Kuchel, Philip W ^a   Christopoulos, Arthur ^b   Conigrave, Arthur D ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

^b MONASH UNIVERSITY   (Australia)

^c CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM SENSING RECEPTOR; CINACALCET; PHENYLALANINE; TETRACYCLINE; CALCIUM; NAPHTHALENE DERIVATIVE;

ARTICLE; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; CALCIUM SIGNALING; CELL MEMBRANE; CONCENTRATION RESPONSE; CONTROLLED STUDY; EMBRYO; GENE EXPRESSION SYSTEM; HUMAN; HUMAN CELL; MOLECULAR WEIGHT; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; RECEPTOR UPREGULATION; CYTOPLASM; DRUG EFFECTS; GENETICS; HEK293 CELL LINE; METABOLISM;

CALCIUM; CALCIUM SIGNALING; CYTOPLASM; HEK293 CELLS; HUMANS; NAPHTHALENES; PHENYLALANINE; RECEPTORS, CALCIUM-SENSING;

EID: 84926429652     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2014-1771     Document Type: Article

References (56)

1. Riccardi D, Kemp PJ. The calcium-sensing receptor beyond extracellular calcium homeostasis: conception, development, adult physiology, and disease. Annu Rev Physiol. 2012;74:271-297.
2. Brown EM, MacLeod RJ. Extracellular calcium sensing and extracellular calcium signaling. Physiol Rev. 2001;81(1):239-297.
3. Chang W, Tu C, Chen TH, Bikle D, Shoback D. The extracellular calcium-sensing receptor (CaSR) is a critical modulator of skeletal development. Sci Signal. 2008;1(35):ra1.
4. 2+-sensing receptor. Proc Natl Acad Sci USA. 2000;97(9):4814-4819.
5. Wang M, Yao Y, Kuang D, Hampson DR. Activation of family C G-protein-coupled receptors by the tripeptide glutathione. J Biol Chem. 2006;281(13):8864-8870.
6. Ohsu T, Amino Y, Nagasaki H, et al. Involvement of the calcium-sensing receptor in human taste perception. J Biol Chem. 2010;285(2):1016-1022.
7. Broadhead GK, Mun HC, Avlani VA, et al. Allosteric modulation of the calcium-sensing receptor by γ-glutamyl peptides: inhibition of PTH secretion, suppression of intracellular cAMP levels, and a common mechanism of action with L-amino acids. J Biol Chem. 2011;286(11):8786-8797.
8. Nemeth EF, Steffey ME, Hammerland LG, et al. Calcimimetics with potent and selective activity on the parathyroid calcium receptor. Proc Natl Acad Sci USA. 1998;95(7):4040-4045.
9. Nemeth EF, Heaton WH, Miller M, et al. Pharmacodynamics of the type II calcimimetic compound cinacalcet HCl. J Pharmacol Exp Therap. 2004;308(2):627-635.
10. 2+-sensing receptor is required for L-amino acid sensing. J Biol Chem. 2004;279(50):51739-51744.
11. 2+-sensing receptor interact within overlapping but not identical binding sites in the transmembrane domain. J Biol Chem. 2004;279(18):18990-18997.
12. 2+-sensing receptor in primary and uremic secondary hyperparathyroidism. J Clin Endocrinol Metab. 1996;81(4):1598-1606.
13. Oda Y, Tu CL, Pillai S, Bikle DD. The calcium sensing receptor and its alternatively spliced form in keratinocyte differentiation. J Biol Chem. 1998;273(36):23344-23352.
14. Alam MU, Kirton JP, Wilkinson FL, et al. Calcification is associated with loss of functional calcium-sensing receptor in vascular smooth muscle cells. Cardiovasc Res. 2009;81(2):260-268.
15. 2+-sensing receptor require negative feedback by protein kinase C. J Biol Chem. 2002;277(49):46871-46876.
16. Davies SL, Ozawa A, McCormick WD, Dvorak MM, Ward DT. Protein kinase C-mediated phosphorylation of the calcium-sensing receptor is stimulated by receptor activation and attenuated by calyculin-sensitive phosphatase activity. J Biol Chem. 2007;282(20):15048-15056.
17. McCormick WD, Atkinson-Dell R, Campion KL, Mun HC, Conigrave AD, Ward DT. Increased receptor stimulation elicits differential calcium-sensing receptor(T888) dephosphorylation. J Biol Chem. 2010;285(19):14170-14177.
18. Thiel OR, Bernard C, Tormos W, et al. Practical synthesis of the calcimimetic agent, cinacalcet. Tetrahedron Lett . 2008;49(1):13-15.
19. Davey AE, Leach K, Valant C, Conigrave AD, Sexton PM, Christopoulos A. Positive and negative allosteric modulators promote biased signaling at the calcium-sensing receptor. Endocrinology. 2012;153(3):1232-1241.
20. Szekely D, Brennan SC, Mun HC, Conigrave AD, Kuchel PW. Effectors of the frequency of calcium oscillations in HEK-293 cells: wavelet analysis and a computer model. Eur Biophys J. 2009;39(1):149-165.
21. 2+o-sensing receptor. J Biol Chem. 1996;271(32):19537-19545.
22. Ray K, Clapp P, Goldsmith PK, Spiegel AM. Identification of the sites of N-linked glycosylation on the human calcium receptor and assessment of their role in cell surface expression and signal transduction. J Biol Chem. 1998;273(51):34558-34567.
23. Bai M, Janicic N, Trivedi S, et al. Markedly reduced activity of mutant calcium-sensing receptor with an inserted Alu element from a kindred with familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism. J Clin Invest. 1997;99(8):1917-1925.
24. Conigrave AD, Mun HC, Delbridge L, Quinn SJ, Wilkinson M, Brown EM. L-amino acids regulate parathyroid hormone secretion. J Biol Chem. 2004;279(37):38151-38159.
25. 2+ and inositol 1,4,5-trisphosphate oscillation frequency. Receptor density versus agonist concentration. J Biol Chem. 2002; 277(39):35947-35960.
26. Irannejad R, Tomshine J, Tomshine J, et al. Conformational biosensors reveal GPCR signalling from endosomes. Nature. 2013;495(7442):534-548.
27. 2+ signal integrators. Proc Natl Acad Sci USA. 2008;105(8):2859-2864.
28. Conigrave AD, Hampson DR. Broad-spectrum amino acid sensing by class 3 G-protein coupled receptors. Trends Endocrinol Metab. 2006;17(10):398-407.
29. Dvorak M, Siddiqua A, Ward D, et al. Physiological changes in extracellular calcium concentration directly control osteoblast function in the absence of calciotropic hormones. Proc Natl Acad Sci USA. 2004;101(14):5140-5145.
30. MacLeod RJ, Yano S, Chattopadhyay N, Brown EM. Extracellular calcium-sensing receptor transactivates the epidermal growth factor receptor by a triple-membrane-spanning signaling mechanism. Biochem Biophys Res Commun. 2004;320(2):455-460.
31. Feng J, Petersen CD, Coy DH, et al. Calcium-sensing receptor is a physiologic multimodal chemosensor regulating gastric G-cell growth and gastrin secretion. Proc Natl Acad Sci USA. 2010; 107(41):17791-17796.
32. Liou AP, Sei Y, Zhao X, et al. The extracellular calcium sensing receptor is required for cholecystokinin secretion in response to L-phenylalanine in acutely isolated intestinal I cells. Am J Physiol Gastrointest Liver Physiol. 2011;300(4):G538-G546.
33. Wang Y, Chandra R, Samsa LA, et al. Amino acids stimulate cholecystokinin release through the calcium-sensing receptor. Am J Physiol Gastrointest Liver Physiol. 2011;300(4):G528-G537.
34. Ray J, Squires P, Curtis S, Meloche M, Buchan A. Expression of the calcium-sensing receptor on human antral gastrin cells in culture. J Clin Invest. 1997;99(10):2328-2333.
35. Miedlich S, Gama L, Breitwieser GE. Calcium sensing receptor activation by a calcimimetic suggests a link between cooperativity and intracellular calcium oscillations. J Biol Chem. 2002;277(51):49691-49699.
36. 2+-sensing receptor. Am J Physiol Cell Physiol. 2002;282(6):C1414-C1422.
37. Breitwieser GE. Calcium sensing receptors and calcium oscillations: calcium as a first messenger. Curr Top Dev Biol. 2006;73:85-114.
38. 2+-sensing receptor are mediated by a phospholipase C/inositol 1,4,5-trisphosphate-independent pathway that requires G12, Rho, filamin-A, and the actin cytoskeleton. J Biol Chem. 2005;280(24):22875-22882.
39. Conigrave A, Ward D. Calcium-sensing receptor (CaSR): pharmacological properties and signaling pathways. Best Pract Res Clin Endocrinol Metab. 2013;27(3):315-331.
40. Rey O, Young SH, Jacamo R, Moyer MP, Rozengurt E. Extracellular calcium sensing receptor stimulation in human colonic epithelial cells induces intracellular calcium oscillations and proliferation inhibition. J Cell Physiol. 2010;225(1):73-83.
41. Soriano FX, Papadia S, Hofmann F, Hardingham NR, Bading H, Hardingham GE. Preconditioning doses of NMDA promote neuroprotection by enhancing neuronal excitability. J Neurosci. 2006;26(17):4509-4518.
42. Jiang Y, Huang Y, Wong HC, et al. Elucidation of a novel extracellular calcium-binding site on metabotropic glutamate receptor 1α(mGluR1α) that controls receptor activation. J Biol Chem. 2010;285(43):33463-33474.
43. Cetani F, Picone A, Cerrai P, et al. Parathyroid expression of calcium-sensing receptor protein and in vivo parathyroid hormone-Ca(2+) set-point in patients with primary hyperparathyroidism. J Clin Endocrinol Metab. 2000;85(12):4789-4794.
44. Farnebo F, Enberg U, Grimelius L, et al. Tumor-specific decreased expression of calcium sensing receptor messenger ribonucleic acid in sporadic primary hyperparathyroidism. J Clin Endocrinol Metab. 1997;82(10):3481-3486.
45. Mun HC, Brennan SC, Delbridge L, Wilkinson M, Brown EM, Conigrave AD. Adenomatous human parathyroid cells exhibit impaired sensitivity to L-amino acids. J Clin Endocrinol Metab. 2009;94(9):3567-3574.
46. Brennan SC, Thiem U, Roth S, et al. Calcium sensing receptor signalling in physiology and cancer. Biochim Biophys Acta. 2013;1833(7):1732-1744.
47. Kim JY, Kim N, Yenari MA, Chang W. Mild hypothermia suppresses calcium-sensing receptor (CaSR) Induction following foredoi: brain ischemia while increasing GABA-B Receptor 1 (GABA-B-R1) expression. Transl Stroke Res. 2011;2(2):195-201.
48. Saidak Z, Boudot C, Abdoune R, et al. Extracellular calcium promotes the migration of breast cancer cells through the activation of the calcium sensing receptor. Exp Cell Res. 2009;315(12):2072-2080.
49. Mizobuchi M, Hatamura I, Ogata H, et al. Calcimimetic compound upregulates decreased calcium-sensing receptor expression level in parathyroid glands of rats with chronic renal insufficiency. J Am Soc Nephrol. 2004;15(10):2579-2587.
50. Mendoza FJ, Lopez I, Canalejo R, et al. Direct upregulation of parathyroid calcium-sensing receptor and vitamin D receptor by calcimimetics in uremic rats. Am J Physiol Renal Physiol. 2009;296(3):F605-F613.
51. White E, McKenna J, Cavanaugh A, Breitwieser GE. Pharmaco-chaperone-mediated rescue of calcium-sensing receptor loss-of-function mutants. Mol Endocrinol. 2009;23(7):1115-1123.
52. Cavanaugh A, McKenna J, Stepanchick A, Breitwieser GE. Calcium-sensing receptor biosynthesis includes a cotranslational conformational checkpoint and endoplasmic reticulum retention. J Biol Chem. 2010;285(26):19854-19864.
53. Leach K, Wen A, Cook A, Sexton P, Conigrave A, Christopoulos A. Impact of clinically relevant mutations on the pharmacoregulation and signaling bias of the calcium-sensing receptor by positive and negative allosteric modulators. Endocrinology. 2013;154(3):1105-1116.
54. Grant MP, Stepanchick A, Cavanaugh A, Breitwieser GE. Agonistdriven maturation and plasma membrane insertion of calcium-sensing receptors dynamically control signal amplitude. Sci Signal. 2011;4(200):ra78.
55. Shoback DM, Bilezikian JP, Turner SA, McCary LC, Guo MD, Peacock M. The calcimimetic cinacalcet normalizes serum calcium in subjects with primary hyperparathyroidism. J Clin Endocrinol Metab. 2003;88(12):5644-5649.
56. Peacock M, Bilezikian JP, Klassen PS, Guo MD, Turner SA, Shoback D. Cinacalcet hydrochloride maintains long-term normocalcemia in patients with primary hyperparathyroidism. J Clin Endocrinol Metab. 2005;90(1):135-141.