Elucidation of a novel extracellular calcium-binding site on metabotropic glutamate receptor 1α (mGluR1α) that controls receptor activation

Journal of Biological Chemistry

Volumn 285, Issue 43, 2010, Pages 33463-33474

  Jiang, Yusheng ^a   Huang, Yun ^a   Wong, Hing Cheung ^a   Zhou, Yubin ^a   Wang, Xue ^a   Yang, Jun ^b   Hall, Randy A ^c   Brown, Edward M ^d   Yang, Jenny J ^a  

^a GEORGIA STATE UNIVERSITY   (United States)

^b HANGZHOU NORMAL UNIVERSITY   (China)

^c EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOSTERIC MODULATORS; BINDING RESIDUES; CALCIUM BINDING; COMPUTATIONAL ALGORITHM; DUAL ACTIVATION; EXTRACELLULAR; EXTRACELLULAR DOMAINS; HUMAN DISEASE; INTRACELLULAR CA; METABOTROPIC GLUTAMATE RECEPTORS; NEUROLOGICAL PROCESS; RECEPTOR ACTIVATION; SIDE CHAINS; STRUCTURAL DETERMINANTS;

BINDING ENERGY; BIOCHEMISTRY; CALCIUM; CARBOXYLATION; ENZYME ACTIVITY; GADOLINIUM; REDUCTION; SIGNALING;

BINDING SITES;

ASPARTIC ACID; CALCIUM ION; GADOLINIUM; GLUTAMINE; METABOTROPIC RECEPTOR; METABOTROPIC RECEPTOR 1ALPHA; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

ALGORITHM; ALLOSTERISM; ARTICLE; BINDING SITE; CALCIUM BINDING; CALCIUM CELL LEVEL; CONTROLLED STUDY; HUMAN; HUMAN CELL; MUTAGENESIS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; SIGNAL TRANSDUCTION;

ALGORITHMS; BINDING SITES; CALCIUM; CRYSTALLOGRAPHY, X-RAY; GLUTAMIC ACID; HUMANS; MODELS, MOLECULAR; MUTAGENESIS; PEPTIDE MAPPING; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, METABOTROPIC GLUTAMATE; SIGNAL TRANSDUCTION;

EID: 77958514966     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.147033     Document Type: Article

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