Development of a Mitochondria-Targeted Hsp90 Inhibitor Based on the Crystal Structures of Human TRAP1

Journal of the American Chemical Society

Volumn 137, Issue 13, 2015, Pages 4358-4367

  Lee, Changwook ^a   Park, Hye Kyung ^a   Jeong, Hanbin ^a   Lim, Jaehwa ^a   Lee, An Jung ^a   Cheon, Keun Young ^a   Kim, Chul Su ^b   Thomas, Ajesh P ^b   Bae, Boram ^b   Kim, Nam Doo ^c   Kim, Seong Heon ^c   Suh, Pann Ghill ^a   Ryu, Ja Hyoung ^b   Kang, Byoung Heon ^a  

^a Department of Biological Sciences ^*  (South Korea)

^b Ulsan National Institute of Science and Technology   (South Korea)

^c Daegu Gyeongbuk Medical Innovation Foundation   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CELL DEATH; CELLS; CYTOLOGY; DISEASES; METABOLISM; PROTEINS;

ANTICANCER DRUG; ATP HYDROLYSIS; CHAPERONE FUNCTIONS; COMPARATIVE ANALYSIS; ENERGY METABOLISM; ISOPROPYL AMINE; MOLECULAR MECHANISM; TARGET PROTEINS;

MITOCHONDRIA;

ADENOSINE TRIPHOSPHATE; ADENYLYLIMIDODIPHOSPHATE; HEAT SHOCK PROTEIN 90 INHIBITOR; PROTEIN; TRAP1 PROTEIN; UNCLASSIFIED DRUG; 1,3 BENZODIOXOLE DERIVATIVE; 9H-PURINE-9-PROPANAMINE, 6-AMINO-8-((6-IODO-1,3-BENZODIOXOL-5-YL)THIO)-N-(1-METHYLETHYL)-; AMINE; HEAT SHOCK PROTEIN 90; ORGANOPHOSPHORUS COMPOUND; PURINE DERIVATIVE; TRAP1 PROTEIN, HUMAN;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; ATPASE ACTIVITY ASSAY; CANCER CELL; CARBOXY TERMINAL SEQUENCE; CELL VIABILITY; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLIZATION; CYTOTOXICITY; DRUG ACCUMULATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; HYDROLYSIS; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; MOLECULAR RECOGNITION; MOUSE; MTT ASSAY; NONHUMAN; PROTEIN ANALYSIS; PROTEIN STRUCTURE; WESTERN BLOTTING; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DRUG DESIGN; DRUG EFFECTS; METABOLISM; PROTEIN MULTIMERIZATION; PROTEIN QUATERNARY STRUCTURE; PROTEIN STABILITY; TUMOR CELL LINE; X RAY CRYSTALLOGRAPHY;

AMINES; BENZODIOXOLES; CELL LINE, TUMOR; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; HSP90 HEAT-SHOCK PROTEINS; HUMANS; MITOCHONDRIA; MODELS, MOLECULAR; ORGANOPHOSPHORUS COMPOUNDS; PROTEIN MULTIMERIZATION; PROTEIN STABILITY; PROTEIN STRUCTURE, QUATERNARY; PURINES;

EID: 84926429645     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja511893n     Document Type: Article

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