Mitochondrial Hsp90s suppress calcium-mediated stress signals propagating from mitochondria to the ER in cancer cells

Molecular Cancer

Volumn 13, Issue 1, 2014, Pages

  Park, Hye Kyung ^a   Lee, Ji Eun ^a   Lim, Jaehwa ^a   Kang, Byoung H ^a  

^a Ulsan National Institute of Science and Technology   (South Korea)

Author keywords

Calcium signaling; Combination cancer therapy; Mitochondrial Hsp90s; Mitochondrial permeability transition pore; Ryanodine receptor

Indexed keywords

ANTINEOPLASTIC AGENT; CALCIUM; CCAAT ENHANCER BINDING PROTEIN; CEBP HOMOLOGOUS PROTEIN; GAMITRINIB; HEAT SHOCK PROTEIN 90; HEAT SHOCK PROTEIN 90 INHIBITOR; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; RYANODINE RECEPTOR; THAPSIGARGIN; UNCLASSIFIED DRUG; DDIT3 PROTEIN, HUMAN; GAMITRINIB-G4; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; GUANIDINE DERIVATIVE; MACROCYCLIC LACTAM;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CALCIUM DEPLETION; CALCIUM SIGNALING; CALCIUM TRANSPORT; CANCER CELL LINE; CANCER MODEL; CELLULAR STRESS SIGNAL; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG POTENTIATION; ENDOPLASMIC RETICULUM; FEMALE; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; HELA CELL LINE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INTRACELLULAR SIGNALING; MALE; MITOCHONDRION; MOUSE; MTT ASSAY; NONHUMAN; PROSTATE CANCER; PROSTATE CANCER CELL LINE; PROTEIN EXPRESSION; TUMOR XENOGRAFT; UNFOLDED PROTEIN RESPONSE; WESTERN BLOTTING; ANIMAL; BIOSYNTHESIS; ENDOPLASMIC RETICULUM STRESS; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PATHOLOGY; TUMOR CELL LINE;

ANIMALS; CALCIUM; CALCIUM SIGNALING; CELL LINE, TUMOR; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; GENE EXPRESSION REGULATION, NEOPLASTIC; GUANIDINES; HSP90 HEAT-SHOCK PROTEINS; HUMANS; LACTAMS, MACROCYCLIC; MICE; MITOCHONDRIA; THAPSIGARGIN; TRANSCRIPTION FACTOR CHOP;

EID: 84903215565     PISSN: None     EISSN: 14764598     Source Type: Journal    
DOI: 10.1186/1476-4598-13-148     Document Type: Article

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