Exploiting the mitochondrial unfolded protein response for cancer therapy in mice and human cells

Journal of Clinical Investigation

Volumn 121, Issue 4, 2011, Pages 1349-1360

  Siegelin, Markus D ^a,d   Dohi, Takehiko ^a,b   Raskett, Christopher M ^c   Orlowski, Gregory M ^c   Powers, Christine M ^c   Gilbert, Candace A ^c   Ross, Alonzo H ^c   Plescia, Janet ^c   Altieri, Dario C ^a,b  

^a Prostate Cancer Discovery and Development Program   (United States)

^b WISTAR INSTITUTE   (United States)

^c UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^d NewYork Presbyterian Hospital   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE INHIBITOR; CCAAT ENHANCER BINDING PROTEIN; CHAPERONE; GAMITRINIB; HEAT SHOCK PROTEIN 90; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; RECOMBINANT TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; UNCLASSIFIED DRUG;

ADULT; AGED; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; AUTOPHAGY; CANCER THERAPY; CELL VIABILITY; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GLIOBLASTOMA; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; MITOCHONDRION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FOLDING; QUALITY CONTROL; TUMOR CELL; TUMOR GROWTH; UNFOLDED PROTEIN RESPONSE; UPREGULATION;

ANIMALS; APOPTOSIS; BRAIN NEOPLASMS; CCAAT-ENHANCER-BINDING PROTEINS; CELL LINE, TUMOR; GENE EXPRESSION; GENE KNOCKDOWN TECHNIQUES; GLIOBLASTOMA; GUANIDINES; HSP90 HEAT-SHOCK PROTEINS; HUMANS; LACTAMS, MACROCYCLIC; MICE; MICE, NUDE; MITOCHONDRIA; NEOPLASMS; NF-KAPPA B; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; STRESS, PHYSIOLOGICAL; TNF-RELATED APOPTOSIS-INDUCING LIGAND; UNFOLDED PROTEIN RESPONSE;

EID: 79953317434     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI44855     Document Type: Article

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