-
1
-
-
4043181214
-
Cancer genes and the pathways they control
-
Vogelstein B, Kinzler KW. Cancer genes and the pathways they control. Nat Med. 2004; 10:789-799.
-
(2004)
Nat Med
, vol.10
, pp. 789-799
-
-
Vogelstein, B.1
Kinzler, K.W.2
-
2
-
-
33749335282
-
The Connectivity Map: using geneexpression signatures to connect small molecules, genes, and disease
-
Lamb J, Crawford ED, Peck D, Modell JW, Blat IC, Wrobel MJ, Lerner J, Brunet JP, Subramanian A, Ross KN, Reich M, Hieronymus H, Wei G, Armstrong SA, Haggarty SJ, Clemons PA et al. The Connectivity Map: using geneexpression signatures to connect small molecules, genes, and disease. Science. 2006; 313:1929-1935.
-
(2006)
Science
, vol.313
, pp. 1929-1935
-
-
Lamb, J.1
Crawford, E.D.2
Peck, D.3
Modell, J.W.4
Blat, I.C.5
Wrobel, M.J.6
Lerner, J.7
Brunet, J.P.8
Subramanian, A.9
Ross, K.N.10
Reich, M.11
Hieronymus, H.12
Wei, G.13
Armstrong, S.A.14
Haggarty, S.J.15
Clemons, P.A.16
-
3
-
-
20844432908
-
Can cell systems biology rescue drug discovery?
-
Butcher EC. Can cell systems biology rescue drug discovery? Nat Rev Drug Discov. 2005; 4:461-467.
-
(2005)
Nat Rev Drug Discov
, vol.4
, pp. 461-467
-
-
Butcher, E.C.1
-
4
-
-
77953916528
-
HSP90 at the hub of protein homeostasis: emerging mechanistic insights
-
Taipale M, Jarosz DF, Lindquist S. HSP90 at the hub of protein homeostasis: emerging mechanistic insights. Nat Rev Mol Cell Biol. 2010; 11:515-528.
-
(2010)
Nat Rev Mol Cell Biol
, vol.11
, pp. 515-528
-
-
Taipale, M.1
Jarosz, D.F.2
Lindquist, S.3
-
5
-
-
35348887850
-
Regulation of tumor cell mitochondrial homeostasis by an organelle-specific Hsp90 chaperone network
-
Kang BH, Plescia J, Dohi T, Rosa J, Doxsey SJ, Altieri DC. Regulation of tumor cell mitochondrial homeostasis by an organelle-specific Hsp90 chaperone network. Cell. 2007; 131:257-270.
-
(2007)
Cell
, vol.131
, pp. 257-270
-
-
Kang, B.H.1
Plescia, J.2
Dohi, T.3
Rosa, J.4
Doxsey, S.J.5
Altieri, D.C.6
-
6
-
-
79953317434
-
Exploiting the mitochondrial unfolded protein response for cancer therapy in mice and human cells
-
Siegelin MD, Dohi T, Raskett CM, Orlowski GM, Powers CM, Gilbert CA, Ross AH, Plescia J, Altieri DC. Exploiting the mitochondrial unfolded protein response for cancer therapy in mice and human cells. J Clin Invest. 2011; 121:1349-1360.
-
(2011)
J Clin Invest
, vol.121
, pp. 1349-1360
-
-
Siegelin, M.D.1
Dohi, T.2
Raskett, C.M.3
Orlowski, G.M.4
Powers, C.M.5
Gilbert, C.A.6
Ross, A.H.7
Plescia, J.8
Altieri, D.C.9
-
7
-
-
70350568650
-
Compartmentalized cancer drug discovery targeting mitochondrial Hsp90 chaperones
-
Kang BH, Altieri DC. Compartmentalized cancer drug discovery targeting mitochondrial Hsp90 chaperones. Oncogene. 2009; 28:3681-3688.
-
(2009)
Oncogene
, vol.28
, pp. 3681-3688
-
-
Kang, B.H.1
Altieri, D.C.2
-
8
-
-
78549293327
-
Heat shock protein 60 regulation of the mitochondrial permeability transition pore in tumor cells
-
Ghosh JC, Siegelin MD, Dohi T, Altieri DC. Heat shock protein 60 regulation of the mitochondrial permeability transition pore in tumor cells. Cancer Res. 2010; 70:8988-8993.
-
(2010)
Cancer Res
, vol.70
, pp. 8988-8993
-
-
Ghosh, J.C.1
Siegelin, M.D.2
Dohi, T.3
Altieri, D.C.4
-
9
-
-
77952671613
-
Signal transduction to the permeability transition pore
-
Rasola A, Sciacovelli M, Pantic B, Bernardi P. Signal transduction to the permeability transition pore. FEBS Lett. 2010; 584:1989-1996.
-
(2010)
FEBS Lett
, vol.584
, pp. 1989-1996
-
-
Rasola, A.1
Sciacovelli, M.2
Pantic, B.3
Bernardi, P.4
-
10
-
-
65649128567
-
Combinatorial drug design targeting multiple cancer signaling networks controlled by mitochondrial Hsp90
-
Kang BH, Plescia J, Song HY, Meli M, Colombo G, Beebe K, Scroggins B, Neckers L, Altieri DC. Combinatorial drug design targeting multiple cancer signaling networks controlled by mitochondrial Hsp90. J Clin Invest. 2009; 119:454-464.
-
(2009)
J Clin Invest
, vol.119
, pp. 454-464
-
-
Kang, B.H.1
Plescia, J.2
Song, H.Y.3
Meli, M.4
Colombo, G.5
Beebe, K.6
Scroggins, B.7
Neckers, L.8
Altieri, D.C.9
-
12
-
-
0029825891
-
Selective induction of mitochondrial chaperones in response to loss of the mitochondrial genome
-
Martinus RD, Garth GP, Webster TL, Cartwright P, Naylor DJ, Hoj PB, Hoogenraad NJ. Selective induction of mitochondrial chaperones in response to loss of the mitochondrial genome. Eur J Biochem. 1996; 240:98-103.
-
(1996)
Eur J Biochem
, vol.240
, pp. 98-103
-
-
Martinus, R.D.1
Garth, G.P.2
Webster, T.L.3
Cartwright, P.4
Naylor, D.J.5
Hoj, P.B.6
Hoogenraad, N.J.7
-
13
-
-
60849097548
-
Mitochondrial dysfunction triggered by loss of HtrA2 results in the activation of a brain-specific transcriptional stress response
-
Moisoi N, Klupsch K, Fedele V, East P, Sharma S, Renton A, Plun-Favreau H, Edwards RE, Teismann P, Esposti MD, Morrison AD, Wood NW, Downward J, Martins LM. Mitochondrial dysfunction triggered by loss of HtrA2 results in the activation of a brain-specific transcriptional stress response. Cell Death Differ. 2009; 16:449-464.
-
(2009)
Cell Death Differ
, vol.16
, pp. 449-464
-
-
Moisoi, N.1
Klupsch, K.2
Fedele, V.3
East, P.4
Sharma, S.5
Renton, A.6
Plun-Favreau, H.7
Edwards, R.E.8
Teismann, P.9
Esposti, M.D.10
Morrison, A.D.11
Wood, N.W.12
Downward, J.13
Martins, L.M.14
-
14
-
-
0037009521
-
A mitochondrial specific stress response in mammalian cells
-
Zhao Q, Wang J, Levichkin IV, Stasinopoulos S, Ryan MT, Hoogenraad NJ. A mitochondrial specific stress response in mammalian cells. EMBO J. 2002; 21:4411-4419.
-
(2002)
EMBO J
, vol.21
, pp. 4411-4419
-
-
Zhao, Q.1
Wang, J.2
Levichkin, I.V.3
Stasinopoulos, S.4
Ryan, M.T.5
Hoogenraad, N.J.6
-
15
-
-
58149202128
-
Is NF-[kappa]B a good target for cancer therapy? Hopes and pitfalls
-
Baud V, Karin M. Is NF-[kappa]B a good target for cancer therapy? Hopes and pitfalls. Nat Rev Drug Discov. 2009; 8:33-40.
-
(2009)
Nat Rev Drug Discov
, vol.8
, pp. 33-40
-
-
Baud, V.1
Karin, M.2
-
16
-
-
69749123786
-
Fine-tuning of the unfolded protein response: Assembling the IRE1alpha interactome
-
Hetz C, Glimcher LH. Fine-tuning of the unfolded protein response: Assembling the IRE1alpha interactome. Mol Cell. 2009; 35:551-561.
-
(2009)
Mol Cell
, vol.35
, pp. 551-561
-
-
Hetz, C.1
Glimcher, L.H.2
-
17
-
-
78649728763
-
The mitochondrial UPR - protecting organelle protein homeostasis
-
Haynes CM, Ron D. The mitochondrial UPR - protecting organelle protein homeostasis. J Cell Sci. 2010; 123:3849-3855.
-
(2010)
J Cell Sci
, vol.123
, pp. 3849-3855
-
-
Haynes, C.M.1
Ron, D.2
-
18
-
-
59149091608
-
Overexpression of mitochondrial Hsp70//Hsp75 in rat brain protects mitochondria, reduces oxidative stress, and protects from focal ischemia
-
Xu L, Voloboueva LA, Ouyang Y, Emery JF, Giffard RG. Overexpression of mitochondrial Hsp70//Hsp75 in rat brain protects mitochondria, reduces oxidative stress, and protects from focal ischemia. J Cereb Blood Flow Metab. 2008; 29:365-374.
-
(2008)
J Cereb Blood Flow Metab
, vol.29
, pp. 365-374
-
-
Xu, L.1
Voloboueva, L.A.2
Ouyang, Y.3
Emery, J.F.4
Giffard, R.G.5
-
19
-
-
55849122639
-
Mitochondrial biology and oxidative stress in Parkinson disease pathogenesis
-
Henchcliffe C, Beal MF. Mitochondrial biology and oxidative stress in Parkinson disease pathogenesis. Nat Clin Pract Neuro. 2008; 4:600-609.
-
(2008)
Nat Clin Pract Neuro
, vol.4
, pp. 600-609
-
-
Henchcliffe, C.1
Beal, M.F.2
-
20
-
-
0035901495
-
Mitochondria-to-nucleus stress signaling induces phenotypic changes, tumor progression and cell invasion
-
Amuthan G, Biswas G, Zhang SY, Klein-Szanto A, Vijayasarathy C, Avadhani NG. Mitochondria-to-nucleus stress signaling induces phenotypic changes, tumor progression and cell invasion. EMBO J. 2001; 20:1910-1920.
-
(2001)
EMBO J
, vol.20
, pp. 1910-1920
-
-
Amuthan, G.1
Biswas, G.2
Zhang, S.Y.3
Klein-Szanto, A.4
Vijayasarathy, C.5
Avadhani, N.G.6
-
21
-
-
22044454884
-
Bcl-2 expression predicts radiotherapy failure in laryngeal cancer
-
Nix P, Cawkwell L, Patmore H, Greenman J, Stafford N. Bcl-2 expression predicts radiotherapy failure in laryngeal cancer. Br J Cancer. 2005; 92:2185-2189.
-
(2005)
Br J Cancer
, vol.92
, pp. 2185-2189
-
-
Nix, P.1
Cawkwell, L.2
Patmore, H.3
Greenman, J.4
Stafford, N.5
-
22
-
-
76849100919
-
The matrix peptide exporter HAF-1 signals a mitochondrial UPR by activating the transcription factor ZC376
-
Haynes CM, Yang Y, Blais SP, Neubert TA, Ron D. The matrix peptide exporter HAF-1 signals a mitochondrial UPR by activating the transcription factor ZC376.7 in C. elegans. Mol Cell. 2010; 37:529-540.
-
(2010)
7 in C. elegans. Mol Cell.
, vol.37
, pp. 529-540
-
-
Haynes, C.M.1
Yang, Y.2
Blais, S.P.3
Neubert, T.A.4
Ron, D.5
-
23
-
-
69049098806
-
Structural and functional link between the mitochondrial network and the endoplasmic reticulum
-
Giorgi C, De Stefani D, Bononi A, Rizzuto R, Pinton P. Structural and functional link between the mitochondrial network and the endoplasmic reticulum. Int J Biochem Cell Biol. 2009; 41:1817-1827.
-
(2009)
Int J Biochem Cell Biol
, vol.41
, pp. 1817-1827
-
-
Giorgi, C.1
De Stefani, D.2
Bononi, A.3
Rizzuto, R.4
Pinton, P.5
-
24
-
-
1842665662
-
Mitochondrial signaling: the retrograde response
-
Butow RA, Avadhani NG. Mitochondrial signaling: the retrograde response. Mol Cell. 2004; 14:1-15
-
(2004)
Mol Cell
, vol.14
, pp. 1-15
-
-
Butow, R.A.1
Avadhani, N.G.2
|