-
1
-
-
15844375853
-
Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death
-
Baines C.P., Kaiser R.A., Purcell N.H., Blair N.S., Osinska H., Hambleton M.A., Brunskill E.W., Sayen M.R., Gottlieb R.A., Dorn G.W., et al. Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death. Nature 2005, 434:658-662.
-
(2005)
Nature
, vol.434
, pp. 658-662
-
-
Baines, C.P.1
Kaiser, R.A.2
Purcell, N.H.3
Blair, N.S.4
Osinska, H.5
Hambleton, M.A.6
Brunskill, E.W.7
Sayen, M.R.8
Gottlieb, R.A.9
Dorn, G.W.10
-
2
-
-
79251587803
-
Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy
-
Egan D.F., Shackelford D.B., Mihaylova M.M., Gelino S., Kohnz R.A., Mair W., Vasquez D.S., Joshi A., Gwinn D.M., Taylor R., et al. Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy. Science 2011, 331:456-461.
-
(2011)
Science
, vol.331
, pp. 456-461
-
-
Egan, D.F.1
Shackelford, D.B.2
Mihaylova, M.M.3
Gelino, S.4
Kohnz, R.A.5
Mair, W.6
Vasquez, D.S.7
Joshi, A.8
Gwinn, D.M.9
Taylor, R.10
-
3
-
-
61649088435
-
PINK1-associated Parkinson's disease is caused by neuronal vulnerability to calcium-induced cell death
-
Gandhi S., Wood-Kaczmar A., Yao Z., Plun-Favreau H., Deas E., Klupsch K., Downward J., Latchman D.S., Tabrizi S.J., Wood N.W., et al. PINK1-associated Parkinson's disease is caused by neuronal vulnerability to calcium-induced cell death. Mol. Cell 2009, 33:627-638.
-
(2009)
Mol. Cell
, vol.33
, pp. 627-638
-
-
Gandhi, S.1
Wood-Kaczmar, A.2
Yao, Z.3
Plun-Favreau, H.4
Deas, E.5
Klupsch, K.6
Downward, J.7
Latchman, D.S.8
Tabrizi, S.J.9
Wood, N.W.10
-
4
-
-
3442886811
-
The pathophysiology of mitochondrial cell death
-
Green D.R., Kroemer G. The pathophysiology of mitochondrial cell death. Science 2004, 305:626-629.
-
(2004)
Science
, vol.305
, pp. 626-629
-
-
Green, D.R.1
Kroemer, G.2
-
5
-
-
42949139481
-
AMPK phosphorylation of raptor mediates a metabolic checkpoint
-
Gwinn D.M., Shackelford D.B., Egan D.F., Mihaylova M.M., Mery A., Vasquez D.S., Turk B.E., Shaw R.J. AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol. Cell 2008, 30:214-226.
-
(2008)
Mol. Cell
, vol.30
, pp. 214-226
-
-
Gwinn, D.M.1
Shackelford, D.B.2
Egan, D.F.3
Mihaylova, M.M.4
Mery, A.5
Vasquez, D.S.6
Turk, B.E.7
Shaw, R.J.8
-
6
-
-
78649728763
-
The mitochondrial UPR-protecting organelle protein homeostasis
-
Haynes C.M., Ron D. The mitochondrial UPR-protecting organelle protein homeostasis. J. Cell Sci. 2010, 123:3849-3855.
-
(2010)
J. Cell Sci.
, vol.123
, pp. 3849-3855
-
-
Haynes, C.M.1
Ron, D.2
-
7
-
-
80755143201
-
The role of PKR/eIF2α signaling pathway in prognosis of non-small cell lung cancer
-
He Y., Correa A.M., Raso M.G., Hofstetter W.L., Fang B., Behrens C., Roth J.A., Zhou Y., Yu L., Wistuba I.I., et al. The role of PKR/eIF2α signaling pathway in prognosis of non-small cell lung cancer. PLoS ONE 2011, 6:e24855.
-
(2011)
PLoS ONE
, vol.6
-
-
He, Y.1
Correa, A.M.2
Raso, M.G.3
Hofstetter, W.L.4
Fang, B.5
Behrens, C.6
Roth, J.A.7
Zhou, Y.8
Yu, L.9
Wistuba, I.I.10
-
8
-
-
69749123786
-
Fine-tuning of the unfolded protein response: assembling the IRE1α interactome
-
Hetz C., Glimcher L.H. Fine-tuning of the unfolded protein response: assembling the IRE1α interactome. Mol. Cell 2009, 35:551-561.
-
(2009)
Mol. Cell
, vol.35
, pp. 551-561
-
-
Hetz, C.1
Glimcher, L.H.2
-
9
-
-
56749176442
-
LKB1; linking cell structure and tumor suppression
-
Hezel A.F., Bardeesy N. LKB1; linking cell structure and tumor suppression. Oncogene 2008, 27:6908-6919.
-
(2008)
Oncogene
, vol.27
, pp. 6908-6919
-
-
Hezel, A.F.1
Bardeesy, N.2
-
10
-
-
0345167800
-
TSC2 mediates cellular energy response to control cell growth and survival
-
Inoki K., Zhu T., Guan K.L. TSC2 mediates cellular energy response to control cell growth and survival. Cell 2003, 115:577-590.
-
(2003)
Cell
, vol.115
, pp. 577-590
-
-
Inoki, K.1
Zhu, T.2
Guan, K.L.3
-
11
-
-
35348887850
-
Regulation of tumor cell mitochondrial homeostasis by an organelle-specific Hsp90 chaperone network
-
Kang B.H., Plescia J., Dohi T., Rosa J., Doxsey S.J., Altieri D.C. Regulation of tumor cell mitochondrial homeostasis by an organelle-specific Hsp90 chaperone network. Cell 2007, 131:257-270.
-
(2007)
Cell
, vol.131
, pp. 257-270
-
-
Kang, B.H.1
Plescia, J.2
Dohi, T.3
Rosa, J.4
Doxsey, S.J.5
Altieri, D.C.6
-
12
-
-
65649128567
-
Combinatorial drug design targeting multiple cancer signaling networks controlled by mitochondrial Hsp90
-
Kang B.H., Plescia J., Song H.Y., Meli M., Colombo G., Beebe K., Scroggins B., Neckers L., Altieri D.C. Combinatorial drug design targeting multiple cancer signaling networks controlled by mitochondrial Hsp90. J. Clin. Invest. 2009, 119:454-464.
-
(2009)
J. Clin. Invest.
, vol.119
, pp. 454-464
-
-
Kang, B.H.1
Plescia, J.2
Song, H.Y.3
Meli, M.4
Colombo, G.5
Beebe, K.6
Scroggins, B.7
Neckers, L.8
Altieri, D.C.9
-
13
-
-
79951673830
-
Targeted inhibition of mitochondrial Hsp90 suppresses localised and metastatic prostate cancer growth in a genetic mouse model of disease
-
Kang B.H., Tavecchio M., Goel H.L., Hsieh C.C., Garlick D.S., Raskett C.M., Lian J.B., Stein G.S., Languino L.R., Altieri D.C. Targeted inhibition of mitochondrial Hsp90 suppresses localised and metastatic prostate cancer growth in a genetic mouse model of disease. Br. J. Cancer 2011, 104:629-634.
-
(2011)
Br. J. Cancer
, vol.104
, pp. 629-634
-
-
Kang, B.H.1
Tavecchio, M.2
Goel, H.L.3
Hsieh, C.C.4
Garlick, D.S.5
Raskett, C.M.6
Lian, J.B.7
Stein, G.S.8
Languino, L.R.9
Altieri, D.C.10
-
14
-
-
0036086064
-
The unfolded protein response in nutrient sensing and differentiation
-
Kaufman R.J., Scheuner D., Schröder M., Shen X., Lee K., Liu C.Y., Arnold S.M. The unfolded protein response in nutrient sensing and differentiation. Nat. Rev. Mol. Cell Biol. 2002, 3:411-421.
-
(2002)
Nat. Rev. Mol. Cell Biol.
, vol.3
, pp. 411-421
-
-
Kaufman, R.J.1
Scheuner, D.2
Schröder, M.3
Shen, X.4
Lee, K.5
Liu, C.Y.6
Arnold, S.M.7
-
15
-
-
36749078674
-
Under normoxia, 2-deoxy-D-glucose elicits cell death in select tumor types not by inhibition of glycolysis but by interfering with N-linked glycosylation
-
Kurtoglu M., Gao N., Shang J., Maher J.C., Lehrman M.A., Wangpaichitr M., Savaraj N., Lane A.N., Lampidis T.J. Under normoxia, 2-deoxy-D-glucose elicits cell death in select tumor types not by inhibition of glycolysis but by interfering with N-linked glycosylation. Mol. Cancer Ther. 2007, 6:3049-3058.
-
(2007)
Mol. Cancer Ther.
, vol.6
, pp. 3049-3058
-
-
Kurtoglu, M.1
Gao, N.2
Shang, J.3
Maher, J.C.4
Lehrman, M.A.5
Wangpaichitr, M.6
Savaraj, N.7
Lane, A.N.8
Lampidis, T.J.9
-
16
-
-
33745840203
-
5'-AMP-activated protein kinase (AMPK) is induced by low-oxygen and glucose deprivation conditions found in solid-tumor microenvironments
-
Laderoute K.R., Amin K., Calaoagan J.M., Knapp M., Le T., Orduna J., Foretz M., Viollet B. 5'-AMP-activated protein kinase (AMPK) is induced by low-oxygen and glucose deprivation conditions found in solid-tumor microenvironments. Mol. Cell. Biol. 2006, 26:5336-5347.
-
(2006)
Mol. Cell. Biol.
, vol.26
, pp. 5336-5347
-
-
Laderoute, K.R.1
Amin, K.2
Calaoagan, J.M.3
Knapp, M.4
Le, T.5
Orduna, J.6
Foretz, M.7
Viollet, B.8
-
17
-
-
45549104450
-
The ATPase cycle of the mitochondrial Hsp90 analog Trap1
-
Leskovar A., Wegele H., Werbeck N.D., Buchner J., Reinstein J. The ATPase cycle of the mitochondrial Hsp90 analog Trap1. J. Biol. Chem. 2008, 283:11677-11688.
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 11677-11688
-
-
Leskovar, A.1
Wegele, H.2
Werbeck, N.D.3
Buchner, J.4
Reinstein, J.5
-
18
-
-
10344222124
-
The role of the unfolded protein response in tumour development: friend or foe?
-
Ma Y., Hendershot L.M. The role of the unfolded protein response in tumour development: friend or foe?. Nat. Rev. Cancer 2004, 4:966-977.
-
(2004)
Nat. Rev. Cancer
, vol.4
, pp. 966-977
-
-
Ma, Y.1
Hendershot, L.M.2
-
19
-
-
33744930897
-
Suppression of apoptosis by cyclophilin D via stabilization of hexokinase II mitochondrial binding in cancer cells
-
Machida K., Ohta Y., Osada H. Suppression of apoptosis by cyclophilin D via stabilization of hexokinase II mitochondrial binding in cancer cells. J. Biol. Chem. 2006, 281:14314-14320.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 14314-14320
-
-
Machida, K.1
Ohta, Y.2
Osada, H.3
-
20
-
-
9744221185
-
Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak
-
Majewski N., Nogueira V., Bhaskar P., Coy P.E., Skeen J.E., Gottlob K., Chandel N.S., Thompson C.B., Robey R.B., Hay N. Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak. Mol. Cell 2004, 16:819-830.
-
(2004)
Mol. Cell
, vol.16
, pp. 819-830
-
-
Majewski, N.1
Nogueira, V.2
Bhaskar, P.3
Coy, P.E.4
Skeen, J.E.5
Gottlob, K.6
Chandel, N.S.7
Thompson, C.B.8
Robey, R.B.9
Hay, N.10
-
21
-
-
77955506092
-
Gymnastics of molecular chaperones
-
Mayer M.P. Gymnastics of molecular chaperones. Mol. Cell 2010, 39:321-331.
-
(2010)
Mol. Cell
, vol.39
, pp. 321-331
-
-
Mayer, M.P.1
-
22
-
-
80052511813
-
The AMPK signalling pathway coordinates cell growth, autophagy and metabolism
-
Mihaylova M.M., Shaw R.J. The AMPK signalling pathway coordinates cell growth, autophagy and metabolism. Nat. Cell Biol. 2011, 13:1016-1023.
-
(2011)
Nat. Cell Biol.
, vol.13
, pp. 1016-1023
-
-
Mihaylova, M.M.1
Shaw, R.J.2
-
23
-
-
60849097548
-
Mitochondrial dysfunction triggered by loss of HtrA2 results in the activation of a brain-specific transcriptional stress response
-
Moisoi N., Klupsch K., Fedele V., East P., Sharma S., Renton A., Plun-Favreau H., Edwards R.E., Teismann P., Esposti M.D., et al. Mitochondrial dysfunction triggered by loss of HtrA2 results in the activation of a brain-specific transcriptional stress response. Cell Death Differ. 2009, 16:449-464.
-
(2009)
Cell Death Differ.
, vol.16
, pp. 449-464
-
-
Moisoi, N.1
Klupsch, K.2
Fedele, V.3
East, P.4
Sharma, S.5
Renton, A.6
Plun-Favreau, H.7
Edwards, R.E.8
Teismann, P.9
Esposti, M.D.10
-
24
-
-
15844407874
-
Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death
-
Nakagawa T., Shimizu S., Watanabe T., Yamaguchi O., Otsu K., Yamagata H., Inohara H., Kubo T., Tsujimoto Y. Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death. Nature 2005, 434:652-658.
-
(2005)
Nature
, vol.434
, pp. 652-658
-
-
Nakagawa, T.1
Shimizu, S.2
Watanabe, T.3
Yamaguchi, O.4
Otsu, K.5
Yamagata, H.6
Inohara, H.7
Kubo, T.8
Tsujimoto, Y.9
-
25
-
-
79952842932
-
The critical role of GRP78 in physiologic and pathologic stress
-
Pfaffenbach K.T., Lee A.S. The critical role of GRP78 in physiologic and pathologic stress. Curr. Opin. Cell Biol. 2011, 23:150-156.
-
(2011)
Curr. Opin. Cell Biol.
, vol.23
, pp. 150-156
-
-
Pfaffenbach, K.T.1
Lee, A.S.2
-
27
-
-
33746927077
-
Mitochondrial hexokinases, novel mediators of the antiapoptotic effects of growth factors and Akt
-
Robey R.B., Hay N. Mitochondrial hexokinases, novel mediators of the antiapoptotic effects of growth factors and Akt. Oncogene 2006, 25:4683-4696.
-
(2006)
Oncogene
, vol.25
, pp. 4683-4696
-
-
Robey, R.B.1
Hay, N.2
-
28
-
-
34447498813
-
Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer
-
Rodina A., Vilenchik M., Moulick K., Aguirre J., Kim J., Chiang A., Litz J., Clement C.C., Kang Y., She Y., et al. Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer. Nat. Chem. Biol. 2007, 3:498-507.
-
(2007)
Nat. Chem. Biol.
, vol.3
, pp. 498-507
-
-
Rodina, A.1
Vilenchik, M.2
Moulick, K.3
Aguirre, J.4
Kim, J.5
Chiang, A.6
Litz, J.7
Clement, C.C.8
Kang, Y.9
She, Y.10
-
29
-
-
79953317434
-
Exploiting the mitochondrial unfolded protein response for cancer therapy in mice and human cells
-
Siegelin M.D., Dohi T., Raskett C.M., Orlowski G.M., Powers C.M., Gilbert C.A., Ross A.H., Plescia J., Altieri D.C. Exploiting the mitochondrial unfolded protein response for cancer therapy in mice and human cells. J. Clin. Invest. 2011, 121:1349-1360.
-
(2011)
J. Clin. Invest.
, vol.121
, pp. 1349-1360
-
-
Siegelin, M.D.1
Dohi, T.2
Raskett, C.M.3
Orlowski, G.M.4
Powers, C.M.5
Gilbert, C.A.6
Ross, A.H.7
Plescia, J.8
Altieri, D.C.9
-
30
-
-
79952264011
-
Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress
-
Tabas I., Ron D. Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress. Nat. Cell Biol. 2011, 13:184-190.
-
(2011)
Nat. Cell Biol.
, vol.13
, pp. 184-190
-
-
Tabas, I.1
Ron, D.2
-
31
-
-
77953916528
-
HSP90 at the hub of protein homeostasis: emerging mechanistic insights
-
Taipale M., Jarosz D.F., Lindquist S. HSP90 at the hub of protein homeostasis: emerging mechanistic insights. Nat. Rev. Mol. Cell Biol. 2010, 11:515-528.
-
(2010)
Nat. Rev. Mol. Cell Biol.
, vol.11
, pp. 515-528
-
-
Taipale, M.1
Jarosz, D.F.2
Lindquist, S.3
-
32
-
-
78650026924
-
GRP78 up-regulation is associated with androgen receptor status, Hsp70-Hsp90 client proteins and castrate-resistant prostate cancer
-
Tan S.S., Ahmad I., Bennett H.L., Singh L., Nixon C., Seywright M., Barnetson R.J., Edwards J., Leung H.Y. GRP78 up-regulation is associated with androgen receptor status, Hsp70-Hsp90 client proteins and castrate-resistant prostate cancer. J. Pathol. 2011, 223:81-87.
-
(2011)
J. Pathol.
, vol.223
, pp. 81-87
-
-
Tan, S.S.1
Ahmad, I.2
Bennett, H.L.3
Singh, L.4
Nixon, C.5
Seywright, M.6
Barnetson, R.J.7
Edwards, J.8
Leung, H.Y.9
-
33
-
-
77954945333
-
Targeting the dynamic HSP90 complex in cancer
-
Trepel J., Mollapour M., Giaccone G., Neckers L. Targeting the dynamic HSP90 complex in cancer. Nat. Rev. Cancer 2010, 10:537-549.
-
(2010)
Nat. Rev. Cancer
, vol.10
, pp. 537-549
-
-
Trepel, J.1
Mollapour, M.2
Giaccone, G.3
Neckers, L.4
-
34
-
-
66249108601
-
Understanding the Warburg effect: the metabolic requirements of cell proliferation
-
Vander Heiden M.G., Cantley L.C., Thompson C.B. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 2009, 324:1029-1033.
-
(2009)
Science
, vol.324
, pp. 1029-1033
-
-
Vander Heiden, M.G.1
Cantley, L.C.2
Thompson, C.B.3
-
35
-
-
78650008177
-
Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K
-
Villanueva J., Vultur A., Lee J.T., Somasundaram R., Fukunaga-Kalabis M., Cipolla A.K., Wubbenhorst B., Xu X., Gimotty P.A., Kee D., et al. Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K. Cancer Cell 2010, 18:683-695.
-
(2010)
Cancer Cell
, vol.18
, pp. 683-695
-
-
Villanueva, J.1
Vultur, A.2
Lee, J.T.3
Somasundaram, R.4
Fukunaga-Kalabis, M.5
Cipolla, A.K.6
Wubbenhorst, B.7
Xu, X.8
Gimotty, P.A.9
Kee, D.10
-
36
-
-
79951699777
-
Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme
-
Wolf A., Agnihotri S., Micallef J., Mukherjee J., Sabha N., Cairns R., Hawkins C., Guha A. Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme. J. Exp. Med. 2011, 208:313-326.
-
(2011)
J. Exp. Med.
, vol.208
, pp. 313-326
-
-
Wolf, A.1
Agnihotri, S.2
Micallef, J.3
Mukherjee, J.4
Sabha, N.5
Cairns, R.6
Hawkins, C.7
Guha, A.8
-
37
-
-
32044465506
-
TOR signaling in growth and metabolism
-
Wullschleger S., Loewith R., Hall M.N. TOR signaling in growth and metabolism. Cell 2006, 124:471-484.
-
(2006)
Cell
, vol.124
, pp. 471-484
-
-
Wullschleger, S.1
Loewith, R.2
Hall, M.N.3
-
38
-
-
79952229430
-
Pancreatic cancers require autophagy for tumor growth
-
Yang S., Wang X., Contino G., Liesa M., Sahin E., Ying H., Bause A., Li Y., Stommel J.M., Dell'antonio G., et al. Pancreatic cancers require autophagy for tumor growth. Genes Dev. 2011, 25:717-729.
-
(2011)
Genes Dev.
, vol.25
, pp. 717-729
-
-
Yang, S.1
Wang, X.2
Contino, G.3
Liesa, M.4
Sahin, E.5
Ying, H.6
Bause, A.7
Li, Y.8
Stommel, J.M.9
Dell'antonio, G.10
-
39
-
-
58649110598
-
Oncogenic B-RAF negatively regulates the tumor suppressor LKB1 to promote melanoma cell proliferation
-
Zheng B., Jeong J.H., Asara J.M., Yuan Y.Y., Granter S.R., Chin L., Cantley L.C. Oncogenic B-RAF negatively regulates the tumor suppressor LKB1 to promote melanoma cell proliferation. Mol. Cell 2009, 33:237-247.
-
(2009)
Mol. Cell
, vol.33
, pp. 237-247
-
-
Zheng, B.1
Jeong, J.H.2
Asara, J.M.3
Yuan, Y.Y.4
Granter, S.R.5
Chin, L.6
Cantley, L.C.7
-
40
-
-
79960400840
-
Novel mechanism of anti-apoptotic function of 78-kDa glucose-regulated protein (GRP78): endocrine resistance factor in breast cancer, through release of B-cell lymphoma 2 (BCL-2) from BCL-2-interacting killer (BIK)
-
Zhou H., Zhang Y., Fu Y., Chan L., Lee A.S. Novel mechanism of anti-apoptotic function of 78-kDa glucose-regulated protein (GRP78): endocrine resistance factor in breast cancer, through release of B-cell lymphoma 2 (BCL-2) from BCL-2-interacting killer (BIK). J. Biol. Chem. 2011, 286:25687-25696.
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 25687-25696
-
-
Zhou, H.1
Zhang, Y.2
Fu, Y.3
Chan, L.4
Lee, A.S.5
|