The Interface between Methyltransferase and Polymerase of NS5 Is Essential for Flavivirus Replication

PLoS Neglected Tropical Diseases

Volumn 8, Issue 5, 2014, Pages

  Li, Xiao Dan ^a,b   Shan, Chao ^a,b   Deng, Cheng Lin ^a   Ye, Han Qing ^a   Shi, Pei Yong ^c   Yuan, Zhi Ming ^a   Gong, Peng ^a   Zhang, Bo ^a  

^a WUHAN INSTITUTE OF VIROLOGY   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^c WADSWORTH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; METHYLTRANSFERASE; NONSTRUCTURAL PROTEIN 5; RNA DIRECTED RNA POLYMERASE; VIRUS RNA; DNA DIRECTED RNA POLYMERASE; NS5 PROTEIN, FLAVIVIRUS; VIRUS PROTEIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ELECTROPORATION; ENZYME ACTIVITY; FLAVIVIRUS INFECTION; GENE MUTATION; GENE SEQUENCE; GENETIC TRANSFECTION; IMMUNOFLUORESCENCE MICROSCOPY; IMMUNOFLUORESCENCE TEST; JAPANESE ENCEPHALITIS VIRUS; LUCIFERASE ASSAY; MOLECULAR INTERACTION; NONHUMAN; REPLICON; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; RNA REPLICATION; RNA TRANSCRIPTION; VIRUS GENOME; VIRUS MUTANT; VIRUS PLAQUE; VIRUS REPLICATION; AMINO ACID SEQUENCE; CELL LINE; CHEMICAL PHENOMENA; CHEMISTRY; FLAVIVIRUS; GENETICS; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; SEQUENCE ALIGNMENT;

AMINO ACID SEQUENCE; CELL LINE; CONSERVED SEQUENCE; DNA-DIRECTED RNA POLYMERASES; FLAVIVIRUS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; METHYLTRANSFERASES; MOLECULAR SEQUENCE DATA; SEQUENCE ALIGNMENT; VIRAL NONSTRUCTURAL PROTEINS; VIRUS REPLICATION;

EID: 84901767814     PISSN: 19352727     EISSN: 19352735     Source Type: Journal    
DOI: 10.1371/journal.pntd.0002891     Document Type: Article

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