Maternal nicotine exposure leads to impaired disulfide bond formation and augmented endoplasmic reticulum stress in the rat placenta

PLoS ONE

Volumn 10, Issue 3, 2015, Pages

  Wong, Michael K ^a   Nicholson, Catherine J ^b   Holloway, Alison C ^b   Hardy, Daniel B ^a  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

^b MCMASTER UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; AMINO ACID; BIOLOGICAL MARKER; DISULFIDE; GLUCOSE REGULATED PROTEIN 78; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 2ALPHA; INITIATION FACTOR 2ALPHA; MESSENGER RNA; NICOTINE TARTRATE; PROTEIN DISULFIDE ISOMERASE; PROTEIN GCN2; PROTEIN KINASE; PROTEIN QSOX1; RESERPINE; SODIUM CHLORIDE; UNCLASSIFIED DRUG; DNA BINDING PROTEIN; NICOTINE; OXIDOREDUCTASE; REGULATORY FACTOR X TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREEDING; DISULFIDE BOND; DRUG EXPOSURE; ENDOPLASMIC RETICULUM STRESS; FEMALE; HYPOXIA; IN VIVO STUDY; KWASHIORKOR; MATING; NONHUMAN; PLACENTA; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING; ADVERSE EFFECTS; ANIMAL; APOPTOSIS; GENE EXPRESSION REGULATION; GENETICS; MATERNAL EXPOSURE; METABOLISM; PREGNANCY; RNA SPLICING; SIGNAL TRANSDUCTION; UNFOLDED PROTEIN RESPONSE;

RATTUS; RATTUS NORVEGICUS;

AMINO ACIDS; ANIMALS; APOPTOSIS; BIOMARKERS; DNA-BINDING PROTEINS; ENDOPLASMIC RETICULUM STRESS; FEMALE; GENE EXPRESSION REGULATION; HYPOXIA; MATERNAL EXPOSURE; NICOTINE; OXIDOREDUCTASES; PLACENTA; PREGNANCY; PROTEIN DISULFIDE-ISOMERASES; RATS; REGULATORY FACTOR X TRANSCRIPTION FACTORS; RNA SPLICING; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR CHOP; TRANSCRIPTION FACTORS; UNFOLDED PROTEIN RESPONSE;

EID: 84926198430     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0122295     Document Type: Article

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