Endoplasmic reticulum stress disrupts placental morphogenesis: Implications for human intrauterine growth restriction

Journal of Pathology

Volumn 228, Issue 4, 2012, Pages 554-564

  Yung, Hong Wa ^a   Hemberger, Myriam ^a,b   Watson, Erica D ^a   Senner, Claire E ^a,b   Jones, Carolyn P ^c   Kaufman, Randal J ^d   Charnock Jones, D Stephen ^a,e   Burton, Graham J ^a,e  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b BABRAHAM INSTITUTE   (United Kingdom)

^c UNIVERSITY OF MANCHESTER   (United Kingdom)

^d BURNHAM INSTITUTE   (United States)

^e Cambridge Comprehensive Biomedical Research Centre ^*  (United Kingdom)

Author keywords

Akt; Endoplasmic reticulum; Igf2; Intrauterine growth restriction; MTOR; Pdk1; Placental morphogenesis; Stress

Indexed keywords

GLYCOPROTEIN; INITIATION FACTOR 2ALPHA; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN KINASE B; GROWTH FACTOR; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; SOMATOMEDIN B; AKT1 PROTEIN, MOUSE; INITIATION FACTOR 2; MTOR PROTEIN, MOUSE; PROTEIN SERINE THREONINE KINASE; PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING) KINASE; TARGET OF RAPAMYCIN KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; FEMALE; GENE MUTATION; GLYCOSYLATION; INTRAUTERINE GROWTH RETARDATION; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PLACENTA DEVELOPMENT; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TROPHOBLAST; BIOACCUMULATION; EIF2S1 GENE; EMBRYO; FETUS GROWTH; FETUS WEIGHT; GENE; IN VITRO STUDY; PLACENTA WEIGHT; PROTEIN GLYCOSYLATION; PROTEIN PROCESSING; PROTEIN SECRETION; STEM CELL; TROPHOBLAST STEM CELL; ANIMAL; C57BL MOUSE; DISEASE MODEL; GENETICS; GROWTH, DEVELOPMENT AND AGING; HUMAN; METABOLISM; MUTANT MOUSE STRAIN; ORGAN SIZE; PATHOLOGY; PHYSIOLOGY; PLACENTA; PREGNANCY;

ANIMALS; CELL DIFFERENTIATION; DISEASE MODELS, ANIMAL; ENDOPLASMIC RETICULUM STRESS; EUKARYOTIC INITIATION FACTOR-2; FEMALE; FETAL GROWTH RETARDATION; GLYCOPROTEINS; GLYCOSYLATION; HUMANS; MICE, INBRED C57BL; MICE, MUTANT STRAINS; ORGAN SIZE; PLACENTA; PREGNANCY; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES;

EID: 84871237501     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.4068     Document Type: Article

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