4-Phenylbutyric acid prevent cytotoxicity induced by thapsigargin in rat cardiac fibroblast

Toxicology in Vitro

Volumn 28, Issue 8, 2014, Pages 1443-1448

  Humeres, C ^a   Montenegro, J ^a   Varela, M ^a   Ayala, P ^a   Vivar, R ^a   Letelier, A ^a   Olmedo, I ^a   Catalan M ^a   Rivas, C ^a   Baeza, P ^a   Munoz C ^a   Garcia L ^a   Lavandero, S ^b   Diaz Araya G ^a,b  

^a UNIVERSITY OF CHILE   (Chile)

^b Biofísica y Bioinformática   (Chile)

Author keywords

4 Phenylbutyric acid; Cardiac fibroblast; ER stress; Thapsigargin

Indexed keywords

4 PHENYLBUTYRIC ACID; ACTIVATING TRANSCRIPTION FACTOR 4; GLUCOSE REGULATED PROTEIN 78; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; PROCOLLAGEN; PROTEIN DISULFIDE ISOMERASE; THAPSIGARGIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CARDIAC FIBROBLAST; CELL DEATH; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; FIBROBLAST; NEWBORN; NONHUMAN; PROTEIN EXPRESSION; RAT; UNFOLDED PROTEIN RESPONSE;

EID: 84908122037     PISSN: 08872333     EISSN: 18793177     Source Type: Journal    
DOI: 10.1016/j.tiv.2014.07.013     Document Type: Article

References (43)

1. Ayala P., Montenegro J., Vivar R., Letelier A., Aránguiz P.A., Copaja M., Pivet D., Humeres C., Troncoso R., Vicencio J.M., Lavandero S., Díaz-Araya G. Attenuation of endoplasmic reticulum stress using the chemical chaperone 4-phenylbutyric acid prevents cardiac fibrosis induced by isoproterenol. Exp. Mol. Pathol. 2011, 92:97-104.
2. Choi S.E., Lee Y.J., Jang H.J., Lee K.W., Kim S.Y., Jun H.S., Kang S.S., Chun J., Kang Y. A chemical chaperone 4-PBA ameliorates palmitate-induced inhibition of glucose stimulated insulin secretion (GSIS). Arch. Biochem. Biophys. 2008, 475:109-114.
3. Clark C.C., Iannotti J.P., Misra S., Richards C.F. Effects of thapsigargin, an intracellular calcium-mobilizing agent, on synthesis and secretion of cartilage collagen and proteoglycan. J. Orthop. Res. 1994, 12:601-611.
4. De Almeida S.F., Picarote G., Fleming J.V., Carmo-Fonceca M., Azevedo J., Sousa M. Chemical chaperones reduce endoplasmic reticulum stress and prevent mutant HFE aggregate formation. J. Biol. Chem. 2007, 282:27907-27912.
5. Dianhong L., Yun H., Haifeng Z., Luyang Y., Hong C., Zhe X., Shibo T., Fumihiko U., Wang M. AIP1 is critical in transducing IRE1-mediated endoplasmic reticulum stress response. J. Biol. Chem. 2008, 283:11905-11912.
6. Díaz-Araya G., Borg T.K., Lavandero S., Loftis M.J., Carver W. IGF-1 modulation of rat cardiac fibroblast behavior and gene expression is age-dependent. Cell Commun. Adhes. 2003, 10:155-165.
7. Ferrari D.M., Soling H.D. The protein disulphide-isomerase family: unraveling a string of folds. Biochem. J. 1999, 339:1-10.
8. Freedman R.B., Hirst T.R., Tuite M.F. Protein disulphide isomerase: building bridges in protein folding. Trends Biochem. Sci. 1994, 19:331-336.
9. Gómez E., Powel M.L., Bevington A., Herbert T.P. A decrease in cellular energy status stimulates PERK-dependent eIF2α phosphorilation and regulates protein synthesis in pancreatic β-cells. Biochem. J. 2008, 410:485-493.
10. Gopalan A., Yu W., Sanders B.G., Kline K. Simvastatin inhibition of mevalonate pathway induces apoptosis in human breast cancer cells via activation of JNK/CHOP/DR5 signaling pathway. Cancer Lett. 2013, 329:9-16.
11. Gotoh T., Oyadomari S., Mori K., Mori M. Nitric oxide-induced apoptosis in RAW 264.7 macrophages is mediated by endoplasmic reticulum stress pathway involving ATF6 and CHOP. J. Biol. Chem. 2002, 277:12343-12350.
12. Harford T.J., Shaltouki A., Weyman C.M. Increased expression of the pro-apoptotic Bcl2 family member PUMA and apoptosis by the muscle regulatory transcription factor MyoD in response to a variety of stimuli. Apoptosis 2010, 15:71-82.
13. Hayakawa K., Takemura G., Kanoh M., Li Y., Koda M., Kawase Y., Maruyama R., Okada H., Minatoguchi S., Fujiwara T., Fujiwara H. Inhibition of granulation tissue cell apoptosis during the subacute stage of myocardial infarction improves cardiac remodeling and dysfunction at the chronic stage. Circulation 2003, 108:104-109.
14. Hetz C., Lee A.H., Gonzalez-Romero D., Thielen P., Castilla J., Soto C., Glimcher L.H. Unfolded protein response transcription factor XBP-1 does not influence prion replication or pathogenesis. PNAS 2008, 105:757-762.
15. Kaufman R.J. Stress signaling from the lumen of endoplasmic reticulum: coordination of gene transcriptional and translational controls. Genes Dev. 1999, 13:1211-1233.
16. Kim D.S., Li B., Rhew K.Y., Oh H.W., Lim H.D., Lee W., Chae H.J., Kim H.R. The regulatory mechanism of 4-phenylbutyric acid against ER stress-induced autophagy in human gingival fibroblasts. Archiv. Pharmacal. Res. 2012, 35:1269-1278.
17. Lamandé S.R., Bateman J.F. Procollagen folding and assembly: the role of endoplasmic reticulum. Matrix Biol. 1999, 22:15-24.
18. Lenna S., Trojanowska M. The role of endoplasmic reticulum stress and the unfolded protein response in fibrosis. Curr. Opin. Rheumatol. 2012, 24:663-668.
19. Li J., Ni M., Lee B., Barron E., Hinton D.R., Lee A.S. The unfolded protein response regulator GRP78/BiP is required for endoplasmic reticulum integrity and stress-induced autophagy in mammalian cells. Cell Death Differ. 2008, 15:1460-1471.
20. Lisse T.S., Thiele F., Fuchs H., Hans W., Przemeck G.K., Abe K., Rathkolb B., Quintanilla-Martinez L., Hoelzlwimmer G., Helfrich M., Wolf E., Ralston S.H., Hrabé de Angelis M. ER stress-mediated apoptosis in a new mouse model of osteogenesis imperfecta. PLoS Genet. 2008, 4:e7.
21. Marciniak S.J., Yun C.Y., Oyadomari S., Novoa I., Zhang Y., Jungreis R., Nagata K., Harding H.P., Ron D. CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum. Genes Dev. 2004, 18:3066-3077.
22. Masud A., Mohapatra A., Lakhani S.A., Ferrandino A., Hakem R., Flavell R.A. Endoplasmic reticulum stress-induced death of mouse embryonic fibroblasts requires the intrinsic pathway of apoptosis. J. Biol. Chem. 2007, 282:14132-14139.
23. McCullough K.D., Martindale J.L., Klotz L.O., Aw T.Y., Holbrook N.J. Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state. Mol. Cell. Biol. 2001, 21:1249-1259.
24. Myllyharju J. Prolyl 4-hydroxylases, the key enzymes of collagen biosynthesis. Matrix Biol. 2003, 22:15-24.
25. Nagata K. Expression and function of heat shock protein 47: a collagen-specific molecular chaperone in the endoplasmic reticulum. Matrix Biol. 1998, 16:379-386.
26. Nickson P., Toth A., Erhardt P. PUMA is critical for neonatal cardiomyocyte apoptosis induced by endoplasmic reticulum stress. Cardiovasc. Res. 2007, 73:48-56.
27. Nishitoh H., Matsuzawa A., Tobiume K., Saegusa K., Takeda K., Inoue K., Hori S., Kakizuka A., Ichijo H. ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats. Genes Dev. 2002, 16:1345-1355.
28. Novosyadlyy R., Kurshan N., Lann D., Vijayakumar A., Yakar S., LeRoith D. Insulin-like growth factor-I protects cells from ER stress-induced apoptosis via enhancement of the adaptive capacity of endoplasmic reticulum. Cell Death Differ. 2008, 15:1304-1317.
29. Oyadomari S., Takeda K., Takiguchi M., Gotoh T., Matsumoto M., Wada T., Akira S., Araki E., Mori M. Nitro oxide-induced apoptosis in pancreatic beta cells is mediated by the endoplasmic reticulum stress pathway. PNAS 2001, 98:10845-10850.
30. Özcan U., Yilmaz E., Ozcan L., Furuhashi M., Vaillancourt E., Smith R.O., Gorgum C.Z., Hotamisligil Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes. Science 2006, 313:11237-11240.
31. Park C.S., Cha H., Kwon E.J., Sreenivasaiah P.K., Kim D.H. The chemical chaperone 4-phenylbutyric acid attenuates pressure-overload cardiac hypertrophy by alleviating endoplasmic reticulum stress Biochem. Biophys. Res. Commun. 2012, 421:578-584.
32. Patil C., Walter P. Intracellular signaling from the endoplasmic reticulum to the nucleus: the unfolded protein response in yeast and mammals. Curr. Opin. Cell Biol. 2001, 13:349-355.
33. Porter K., Turner N. Cardiac fibroblasts: at the heart of myocardial remodeling. Pharmacol. Ther. 2009, 123:255-278.
34. Qi X., Hosoi T., Okuma Y., Kaneko M., Nomura Y. Sodium 4-phenylbutyrate protects against cerebral ischemic injury. Mol. Pharmacol. 2004, 66:899-908.
35. Rishikof D., Ricupero D., Liu H., Goldstein R. Phenylbutyrate decreases Type I collagen reduction in human lung fibroblasts. J. Cell. Biochem. 2004, 91:740-748.
36. Sakurai T., Itoh K., Liu Y., Higashitsuji H., Sumitomo Y., Sakamaki K., Fujita J. Low temperature protects mammalian cells from apoptosis initiated by various stimuli in vitro. Exp. Cell. Res. 2005, 309:264-272.
37. Stefanovic B., Stefanovic L., Schnabl B., Bataller R., Brenner D.A. TRAM2 protein interacts with endoplasmic reticulum Ca2+ pump Serca2b and is necessary for collagen type I synthesis. Mol. Cell. Biol. 2004, 24:1758-1768.
38. Sung B., Prasad S., Ravindran J., Yadav V.R., Aggarwal B.B. Capsazepine, a TRPV1 antagonist, sensitizes colorectal cancer cells to apoptosis by TRAIL through ROS-JNK-CHOP-mediated upregulation of death receptors. Free Radic. Biol. Med. 2012, 53:1977-1987.
39. Weber K. Cardiac interstitium. Heart Failure 1997, 13-31. Churchill Livingstone, New York, NY. P. Poole-Wilson, W. Colucci, B. Massie, K. Chatterjee, A. Coats (Eds.).
40. Welch W.J., Brown C.R. Influence of molecular and chemical chaperones on protein folding. Cell Stress Chaperones 1996, 1:109-115.
41. Wiley J.C., Meabon J.S., Frankowski H., Smith E.A., Schecterson L.C., Bothwell M., Ladiges W.C. Phenylbutyric acid rescues endoplasmic reticulum stress-induced suppression of APP proteolysis and prevents apoptosis in neuronal cells. PLoS One 2010, 5:e9135.
42. Wu J., Kaufman R.J. From acute ER stress to physiological roles of the unfolded protein response. Cell Death Differ. 2006, 13:374-384.
43. Yam G.H., Gaplovska-Kysela K., Zuber C., Roth J. Sodium 4-phenylbutyrate acts as a chemical chaperone on misfolded myocilin to rescue cells from endoplasmic reticulum stress and apoptosis. Invest. Ophthalmol. Vis. Sci. 2007, 48:1683-1690.