Fetal and neonatal nicotine exposure in wistar rats causes progressive pancreatic mitochondrial damage and beta cell dysfunction

PLoS ONE

Volumn 3, Issue 10, 2008, Pages

  Bruin, Jennifer E ^a   Petre, Maria A ^a   Raha, Sandeep ^a   Morrison, Katherine M ^a   Gerstein, Hertzel C ^a   Holloway, Alison C ^a  

^a MCMASTER UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; MITOCHONDRIAL ENZYME; NICOTINE TARTRATE; SODIUM CHLORIDE; NICOTINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DAMAGE; CELL FUNCTION; CELL ISOLATION; CELL STIMULATION; CELL STRUCTURE; CONTROLLED STUDY; DEGRANULATION; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DRUG SAFETY; ELECTRON MICROSCOPY; ENZYME ACTIVITY; ENZYME ASSAY; FEMALE; FETUS; GLUCOSE INTOLERANCE; HISTOPATHOLOGY; INSULIN RELEASE; NEWBORN; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; OXIDATIVE STRESS; PANCREAS ISLET BETA CELL; PERINATAL PERIOD; PRENATAL DRUG EXPOSURE; RAT; RESPIRATORY CHAIN; ANIMAL; CHEMICALLY INDUCED DISORDER; DRUG EFFECT; ENVIRONMENTAL EXPOSURE; MITOCHONDRION; PANCREAS; PATHOLOGY; PREGNANCY; ULTRASTRUCTURE; WISTAR RAT;

ANIMALIA; RATTUS; RATTUS NORVEGICUS;

ANIMALS; ANIMALS, NEWBORN; FEMALE; FETUS; GLUCOSE INTOLERANCE; INSULIN-SECRETING CELLS; MATERNAL EXPOSURE; MITOCHONDRIA; NICOTINE; PANCREAS; PREGNANCY; RATS; RATS, WISTAR;

EID: 54849425174     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0003371     Document Type: Article

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