Cytotoxicity of cardiotonic steroids in sensitive and multidrug-resistant leukemia cells and the link with Na+/K+-ATPase

Journal of Steroid Biochemistry and Molecular Biology

Volumn 150, Issue , 2015, Pages 97-111

  Zeino, Maen ^a   Brenk, Ruth ^a   Gruber, Lisa ^a   Zehl, Martin ^b   Urban, Ernst ^b   Kopp, Brigitte ^b   Efferth, Thomas ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b UNIVERSITY OF VIENNA   (Austria)

Author keywords

Cardiotonic steroids; Multidrug resistance; Na+ K+ ATPase signalosome; Next generation sequencing

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); AMINO ACID; BUFADIENOLIDE DERIVATIVE; BUFALIN; CARDENOLIDE; CARDIOTONIC AGENT; CARDIOTONIC STEROID DERIVATIVE; CYTOTOXIC AGENT; DIGOXIN; DOXORUBICIN; MULTIDRUG RESISTANCE PROTEIN; RESAZURIN; STEROID; UNCLASSIFIED DRUG; VERAPAMIL; ANTINEOPLASTIC AGENT; CARDIAC GLYCOSIDE;

ACUTE LYMPHOBLASTIC LEUKEMIA; AFFINITY LABELING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BLOOD SAMPLING; CANCER RESISTANCE; CHEMICAL REACTION; CONTROLLED STUDY; CYTOTOXICITY; HUMAN; IC50; LEUKEMIA CELL; LYMPHATIC LEUKEMIA; MOLECULAR DOCKING; MULTIDRUG RESISTANCE; NEXT GENERATION SEQUENCING; NONHUMAN; OUTCOME ASSESSMENT; POTASSIUM CELL LEVEL; PROTEIN EXPRESSION; QUANTITATIVE STRUCTURE ACTIVITY RELATION; SENSITIVITY ANALYSIS; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ANTAGONISTS AND INHIBITORS; CELL SURVIVAL; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; DRUG RESISTANCE; ENZYMOLOGY; GENE EXPRESSION; GENETICS; METABOLISM; MONONUCLEAR CELL; PRIMARY CELL CULTURE; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; BUFANOLIDES; CARDIAC GLYCOSIDES; CELL LINE, TUMOR; CELL SURVIVAL; DIGOXIN; DOXORUBICIN; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; GENE EXPRESSION; HUMANS; LEUKOCYTES, MONONUCLEAR; MOLECULAR DOCKING SIMULATION; PRIMARY CELL CULTURE; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; SIGNAL TRANSDUCTION; SODIUM-POTASSIUM-EXCHANGING ATPASE; VERAPAMIL;

EID: 84926167944     PISSN: 09600760     EISSN: 18791220     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2015.03.008     Document Type: Article

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