Altered intracellular pH regulation in cells with high levels of P-glycoprotein expression

International Journal of Biochemistry and Molecular Biology

Volumn 2, Issue 3, 2011, Pages 219-227

  Young, Gregory ^a   Reuss, Luis ^a   Altenberg, Guillermo A ^a  

^a TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER SCHOOL OF MEDICINE   (United States)

Author keywords

Adriamycin; Intracellular ph regulation; MDR1; Multidrug resistance; Na + H + exchanger; Verapamil

Indexed keywords

DOXORUBICIN; GLYCOPROTEIN P; IONOPHORE; RHODAMINE 123; VINBLASTINE;

ACIDIFICATION; ALKALINIZATION; ANIMAL CELL; ARTICLE; CELL CYCLE REGULATION; CELL PH; CONTROLLED STUDY; CYTOTOXICITY; FIBROBLAST; GENE OVEREXPRESSION; MEMBRANE TRANSPORT; NONHUMAN; PROTEIN EXPRESSION;

EID: 84855939028     PISSN: None     EISSN: 21524114     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Goda K, Bacsó Z, Szabó G. Multidrug resistance through the spectacle of P-glycoprotein. Curr Cancer Drug Targets 2009; 9:281-97.
2. Seeger MA, van Veen HW. Molecular basis of multidrug transport by ABC transporters. Bio-chim Biophys Acta 2009; 1794:725-37.
3. Gutmann DA, Ward A, Urbatsch IL, Chang G, van Veen HW. Understanding polyspecificity of multidrug ABC transporters: closing in on the gaps in ABCB1. Trends Biochem Sci 2010; 35:36-42.
4. Keizer HG, Joenje H. Increased cytosolic pH in multidrug-resistant human lung tumor cells: effect of verapamil. J Natl Cancer Inst 1989; 81:706-9.
5. Boscoboinik D, Gupta RS, Epand RM. Investi-gation of the relationship between altered intracellular pH and multidrug resistance in mammalian cells. Br J Cancer 1990; 61:568-72.
6. Thiebaut F, Currier SJ, Whitaker J. Haugland RP, Gottesman MM, Pastan I, Willingham MC. Activity of the multidrug transporter results in alkalinization of the cytosol: measurement of cytosolic pH by microinjection of a pH-sensitive dye. J Histochem Cytochem 1990; 38: 685-90.
7. Roepe PD. Analysis of steady-state and initial rate of doxorubicin efflux from a series of mul-tidrug-resistant cells expressing different levels of P-glycoprotein. Biochemistry 1992; 31: 12555-125.
8. - exchange in Chinese hamster ovary cells. Biochemistry 1994; 33:7239- 49.
9. Simon S, Roy D, Schindler M. Intracellular pH and the control of multidrug resistance. Proc Natl Acad Sci USA 1994; 91:1128-32.
10. Simon SM, Schindler M. Cell biological mechanisms of multidrug resistance in tumors. Proc Natl Acad Sci USA 1994; 91:3497-3504.
11. Wei LY, Hoffman MM, Roepe PD. Altered pHi regulation in 3T3/CFTR clones and their che-motherapeutic drug-selected derivatives. Am J Physiol 1997; 272:C1642-53.
12. Roepe PD. What is the precise role of human MDR 1 protein in chemotherapeutic drug resistance? Curr Pharm Des 2000; 6:241-60.
13. Pearce HL, Winter MA, Beck WT. Structural characteristics of compounds that modulate P -glycoprotein-associated multidrug resistance. Adv Enzyme Regul 1990; 30:357-73.
14. Wang RB, Kuo CL, Lien LL, Lien EJ. Structure-activity relationship: analyses of P-glycoprotein substrates and inhibitors. J Clin Pharm Ther 2003; 28:203-28.
15. Sognier MA, Zhang Y, Eberle RL, Belli JA. Characterization of adriamycin-resistant and radiation-sensitive Chinese hamster cell lines. Bio-chem Pharmacol 1992; 44:1859-68.
16. Altenberg, G.A., Young, G., Horton, J.K., Glass, D., Belli, J.A., and Reuss, L. Changes in intra-or extracellular pH do not mediate P-glycoprotein-dependent multidrug resistance. Proc Natl Acad Sci USA 1993; 90:9735-38.
17. Howell N, Belli TA, Zaczkiewicz LT, Belli JA. High-level, unstable adriamycin resistance in a Chinese hamster mutant cell line with double minute chromosomes. Cancer Res 1984; 44:4023-9.
18. Altenberg GA, Vanoye CG, Han ES, Deitmer JW, Reuss L. Relationships between rhodamine 123 transport, cell volume, and ion-channel function of P-glycoprotein. J Biol Chem 1994; 269:7145-9.
19. Thomas JA, Buchsbaum RN, Zimniak A, Racker E. Intracellular pH measurements in Ehrlich ascites tumor cells utilizing spectro-scopic probes generated in situ. Biochemistry 1979; 81:2210-8.
20. Roos A, Boron WF. Intracellular pH. Physiol Rev 1981; 61:296-434.
21. Ford JM. Experimental reversal of P-glycoprotein-mediated multidrug resistance by pharmacological chemosensitisers. Eur J Cancer 1996; 32A:991-1001.
22. Horton JK, Thimmaiah KN, Altenberg GA, Castro AF, Germain GS, Gowda GK, Houghton PJ. Characterization of a novel bisacridone and comparison with PSC 833 as a potent and poorly reversible modulator of P-glycoprotein. Mol Pharmacol 1997; 52:948-57.
23. Vayuvegula B, Slater L, Meador J, Gupta S. Correction of altered plasma membrane potentials. A possible mechanism of cyclosporin A and verapamil reversal of pleiotropic drug resistance in neoplasia. Cancer Chemother Pharmacol 1988; 22:163 8.
24. Litman T, Pedersen SF, Kramhøft B, Skovs-gaard T, Hoffmann EK. PH regulation in sensitive and multidrug resistant Ehrlich ascites tumor cells. Cell Physiol Biochem 1998; 8:138 -50.
25. Frezard F, Garnier-Suillerot A. Determination of the osmotic active drug concentration in the cytoplasm of anthracycline-resistant and -sensitive K562 cells. Biochim Biophys Acta 1991; 1091:29-35.
26. Sehested M, Skovsgaard T, van Deurs B, Win-ther-Nielsen H. Increased plasma membrane traffic in daunorubicin resistant P388 leukae-mic cells. Effect of daunorubicin and verapa-mil. Br J Cancer 1987; 56:747-51.
27. + channel current associated with multidrug resistance in human leukemia cells. Cancer Res 1987;47:3736-41.
28. Fritz F, Howard EM, Hoffman MM, Roepe PD. Evidence for altered ion transport in Saccharo-myces cerevisiae overexpressing human MDR 1 protein. Biochemistry 1999; 38:4214-26.
29. - currents. Am J Physiol 1999; 276:C370-8.
30. Porcelli AM, Scotlandi K, Strammiello R, Gis-limberti G, Baldini N, Rugolo M. Intracellular pH regulation in U-2 OS human osteosarcoma cells transfected with P-glycoprotein. Biochim Biophys Acta 2002; 1542:125-38.
31. Mizutani T, Masuda M, Nakai E, Furumiya K, Togawa H, Nakamura Y, Kawai Y, Nakahira K, Shinkai S, Takahashi K. Genuine functions of P-glycoprotein (ABCB1). Curr Drug Metab 2008; 9:167-74.
32. Sulová Z, Seres M, Barancík M, Gibalová L, Uhrík B, Poleková L, Breier A. Does any rela- tionship exist between P-glycoprotein-mediated multidrug resistance and intracellu-lar calcium homeostasis? Gen Physiol Biophys 2009; 28:F89-95.
33. Poulsen KA, Andersen EC, Hansen CF, Klausen TK, Hougaard C, Lambert IH, Hoff- mann EK. Deregulation of apoptotic volume decrease and ionic movements in multidrug-resistant tumor cells: role of chloride channels. Am J Physiol Cell Physiol 2010; 298:C14-25.