The sodium pump and cardiotonic steroids-induced signal transduction protein kinases and calcium-signaling microdomain in regulation of transporter trafficking

Biochimica et Biophysica Acta - Molecular Basis of Disease

Volumn 1802, Issue 12, 2010, Pages 1237-1245

  Liu, Jiang ^a   Xie, Zi Jian ^a  

^a MEDICAL COLLEGE OF OHIO   (United States)

Author keywords

Calcium signaling; Cardiotonic steroids; Na K ATPase; Protein kinases; Renal sodium transporter

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); CARDIAC GLYCOSIDE; DIGITALIS LIKE FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; INTRACELLULAR CALCIUM SENSING PROTEIN; MARINOBUFAGENIN; OUABAIN; PROTEIN SH2; PROTEIN SH3; PROTEIN TYROSINE KINASE; SODIUM PROTON EXCHANGE PROTEIN 3;

CALCIUM SIGNALING; COMPLEX FORMATION; ENDOCYTOSIS; ENZYME ACTIVATION; HUMAN; KIDNEY PROXIMAL TUBULE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; REVIEW; SIGNAL TRANSDUCTION; SODIUM ABSORPTION; SODIUM URINE LEVEL;

ANIMALS; BUFANOLIDES; CALCIUM SIGNALING; HUMANS; HYPERTENSION; KIDNEY TUBULES, PROXIMAL; OUABAIN; PROTEIN KINASES; PROTEIN TRANSPORT; SODIUM-HYDROGEN ANTIPORTER; SODIUM-POTASSIUM-EXCHANGING ATPASE;

STROPHANTHUS GRATUS;

EID: 78049262472     PISSN: 09254439     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbadis.2010.01.013     Document Type: Review

References (197)

1. Feraille E., Doucet A. Sodium-potassium-adenosinetriphosphatase-dependent sodium transport in the kidney: hormonal control. Physiol. Rev. 2001, 81(1):345-418.
2. Schoner W., Scheiner-Bobis G. Endogenous and exogenous cardiac glycosides: their roles in hypertension, salt metabolism, and cell growth. Am. J. Physiol. Cell Physiol. 2007, 293(2):C509-C536.
3. Xie Z., Cai T. Na+-K+-ATPase-mediated signal transduction: from protein interaction to cellular function. Mol. Interv. 2003, 3(3):157-168.
4. Bagrov A.Y., Shapiro J.I., Fedorova O.V. Endogenous cardiotonic steroids: physiology, pharmacology, and novel therapeutic targets. Pharmacol. Rev. 2009, 61(1):9-38.
5. Blaustein M.P., et al. The pump, the exchanger, and endogenous ouabain: signaling mechanisms that link salt retention to hypertension. Hypertension 2009, 53(2):291-298.
6. Nelson W.J., Veshnock P.J. Ankyrin binding to (Na+ + K+)ATPase and implications for the organization of membrane domains in polarized cells. Nature 1987, 328(6130):533-536.
7. Skou J.C. The influence of some cations on an adenosine triphosphatase from peripheral nerves. Biochim. Biophys. Acta 1957, 23(2):394-401.
8. Kaplan J.H. Biochemistry of Na, K-ATPase. Annu. Rev. Biochem. 2002, 71:511-535.
9. Blanco G., Mercer R.W. Isozymes of the Na-K-ATPase: heterogeneity in structure, diversity in function. Am. J. Physiol. 1998, 275(5 Pt 2):F633-F650.
10. Lingrel J.B., Kuntzweiler T. Na+, K(+)-ATPase. J. Biol. Chem. 1994, 269(31):19659-19662.
11. Geering K. Function of FXYD proteins, regulators of Na, K-ATPase. J. Bioenerg. Biomembr. 2005, 37(6):387-392.
12. Toyoshima C., et al. Crystal structure of the calcium pump of sarcoplasmic reticulum at 2.6 A resolution. Nature 2000, 405(6787):647-655.
13. Sweadner K.J., Donnet C. Structural similarities of Na, K-ATPase and SERCA, the Ca(2+)-ATPase of the sarcoplasmic reticulum. Biochem. J. 2001, 356(Pt 3):685-704.
14. Morth J.P., et al. Crystal structure of the sodium-potassium pump. Nature 2007, 450(7172):1043-1049.
15. Barwe S.P., et al. Novel role for Na, K-ATPase in phosphatidylinositol 3-kinase signaling and suppression of cell motility. Mol. Biol. Cell 2005, 16(3):1082-1094.
16. Jordan C., et al. Identification of a binding motif for ankyrin on the alpha-subunit of Na+, K(+)-ATPase. J. Biol. Chem. 1995, 270(50):29971-29975.
17. Tian J., et al. Binding of Src to Na+/K+-ATPase forms a functional signaling complex. Mol. Biol. Cell 2006, 17(1):317-326.
18. Yudowski G.A., et al. Phosphoinositide-3 kinase binds to a proline-rich motif in the Na+, K+-ATPase alpha subunit and regulates its trafficking. Proc. Natl. Acad. Sci. U. S. A. 2000, 97(12):6556-6561.
19. Song H., et al. An N-terminal sequence targets and tethers Na+ pump alpha2 subunits to specialized plasma membrane microdomains. J. Biol. Chem. 2006, 281(18):12929-12940.
20. Zhang S., et al. Distinct role of the N-terminal tail of the Na, K-ATPase catalytic subunit as a signal transducer. J. Biol. Chem. 2006, 281(31):21954-21962.
21. Xie Z., Askari A. Na(+)/K(+)-ATPase as a signal transducer. Eur. J. Biochem. 2002, 269(10):2434-2439.
22. Li Z., Xie Z. The Na/K-ATPase/Src complex and cardiotonic steroid-activated protein kinase cascades. Pflugers Arch. 2009, 457(3):635-644.
23. Tian J., Xie Z.J. The Na-K-ATPase and calcium-signaling microdomains. Physiology (Bethesda) 2008, 23:205-211.
24. Peng M., et al. Partial inhibition of Na+/K+-ATPase by ouabain induces the Ca2+-dependent expressions of early-response genes in cardiac myocytes. J. Biol. Chem. 1996, 271(17):10372-10378.
25. Huang L., Kometiani P., Xie Z. Differential regulation of Na/K-ATPase alpha-subunit isoform gene expressions in cardiac myocytes by ouabain and other hypertrophic stimuli. J. Mol. Cell. Cardiol. 1997, 29(11):3157-3167.
26. Haas M., Askari A., Xie Z. Involvement of Src and epidermal growth factor receptor in the signal-transducing function of Na+/K+-ATPase. J. Biol. Chem. 2000, 275(36):27832-27837.
27. Haas M., et al. Src-mediated inter-receptor cross-talk between the Na+/K+-ATPase and the epidermal growth factor receptor relays the signal from ouabain to mitogen-activated protein kinases. J. Biol. Chem. 2002, 277(21):18694-18702.
28. Liu J., et al. Ouabain interaction with cardiac Na+/K+-ATPase initiates signal cascades independent of changes in intracellular Na+and Ca2+ concentrations. J. Biol. Chem. 2000, 275(36):27838-27844.
29. Tian J., Gong X., Xie Z. Signal-transducing function of Na+-K+-ATPase is essential for ouabain's effect on [Ca2+]i in rat cardiac myocytes. Am. J. Physiol Heart Circ. Physiol. 2001, 281(5):H1899-H1907.
30. Huang L., Li H., Xie Z. Ouabain-induced hypertrophy in cultured cardiac myocytes is accompanied by changes in expression of several late response genes. J. Mol. Cell. Cardiol. 1997, 29(2):429-437.
31. Akera T., Brody T.M. Inotropic action of digitalis and ion transport. Life Sci. 1976, 18(2):135-144.
32. Nguyen A.N., Wallace D.P., Blanco G. Ouabain binds with high affinity to the Na, K-ATPase in human polycystic kidney cells and induces extracellular signal-regulated kinase activation and cell proliferation. J. Am. Soc. Nephrol. 2007, 18(1):46-57.
33. Liu L., et al. Involvement of Na+/K+-ATPase in hydrogen peroxide-induced hypertrophy in cardiac myocytes. Free Radic. Biol. Med. 2006, 41(10):1548-1556.
34. Aizman O., et al. Ouabain, a steroid hormone that signals with slow calcium oscillations. Proc. Natl. Acad. Sci. U. S. A. 2001, 98(23):13420-13424.
35. Aydemir-Koksoy A., Abramowitz J., Allen J.C. Ouabain-induced signaling and vascular smooth muscle cell proliferation. J. Biol. Chem. 2001, 276(49):46605-46611.
36. Dmitrieva R.I., Doris P.A. Ouabain is a potent promoter of growth and activator of ERK1/2 in ouabain-resistant rat renal epithelial cells. J. Biol. Chem. 2003, 278(30):28160-28166.
37. Fedorova O.V., et al. Endogenous ligand of alpha(1) sodium pump, marinobufagenin, is a novel mediator of sodium chloride-dependent hypertension. Circulation 2002, 105(9):1122-1127.
38. Ferrandi M., et al. Organ hypertrophic signaling within caveolae membrane subdomains triggered by ouabain and antagonized by PST 2238. J. Biol. Chem. 2004, 279(32):33306-33314.
39. Yuan Z., et al. Na/K-ATPase tethers phospholipase C and IP3 receptor into a calcium-regulatory complex. Mol. Biol. Cell 2005, 16(9):4034-4045.
40. Kennedy D.J., et al. Central role for the cardiotonic steroid marinobufagenin in the pathogenesis of experimental uremic cardiomyopathy. Hypertension 2006, 47(3):488-495.
41. Wang H., et al. Ouabain assembles signaling cascades through the caveolar Na+/K+-ATPase. J. Biol. Chem. 2004, 279(17):17250-17259.
42. Liang M., et al. Functional characterization of Src-interacting Na/K-ATPase using RNA interference assay. J. Biol. Chem. 2006, 281(28):19709-19719.
43. Liang M., et al. Identification of a pool of non-pumping Na/K-ATPase. J. Biol. Chem. 2007, 282(14):10585-10593.
44. Schoner W., Scheiner-Bobis G. Endogenous and exogenous cardiac glycosides and their mechanisms of action. Am. J. Cardiovasc. Drugs 2007, 7(3):173-189.
45. Kaunitz J.D. Membrane transport proteins: not just for transport anymore. Am. J. Physiol. Renal Physiol. 2006, 290(5):F995-F996.
46. Comellas A.P., et al. Hypoxia-mediated degradation of Na,K-ATPase via mitochondrial reactive oxygen species and the ubiquitin-conjugating system. Circ. Res. 2006, 98(10):1314-1322.
47. Bertorello A.M., Sznajder J.I. The dopamine paradox in lung and kidney epithelia: sharing the same target but operating different signaling networks. Am. J. Respir. Cell Mol. Biol. 2005, 33(5):432-437.
48. Dada L.A., et al. Role of the small GTPase RhoA in the hypoxia-induced decrease of plasma membrane Na, K-ATPase in A549 cells. J. Cell Sci. 2007, 120(Pt 13):2214-2222.
49. Li Z., et al. NaKtide, a Na/K-ATPase-derived peptide Src inhibitor, antagonizes ouabain-activated signal transduction in cultured cells. J. Biol. Chem. 2009, 284(31):21066-21076.
50. Cai H., Wu L., Qu W., Malhotra D., Xie Z., Shapiro J.I., Liu J., Physiol Cell Physiol Am.J. Regulation of apical NHE3 trafficking by ouabain-induced activation of basolateral Na/K-ATPase receptor complex. Am. J. Physiol. Cell Physiol. 2008, 294(2):C555-C563.
51. Liu J., et al. Ouabain induces endocytosis of plasmalemmal Na/K-ATPase in LLC-PK1 cells by a clathrin-dependent mechanism. Kidney Int. 2004, 66(1):227-241.
52. Liu J., et al. Ouabain-induced endocytosis of the plasmalemmal Na/K-ATPase in LLC-PK1 cells requires caveolin-1. Kidney Int. 2005, 67(5):1844-1854.
53. Miyakawa-Naito A., et al. Cell signaling microdomain with Na, K-ATPase and inositol 1, 4, 5-trisphosphate receptor generates calcium oscillations. J. Biol. Chem. 2003, 278(50):50355-50361.
54. Saunders R., Scheiner-Bobis G. Ouabain stimulates endothelin release and expression in human endothelial cells without inhibiting the sodium pump. Eur. J. Biochem. 2004, 271(5):1054-1062.
55. Kotova O., et al. Cardiotonic steroids stimulate glycogen synthesis in human skeletal muscle cells via a Src- and ERK1/2-dependent mechanism. J. Biol. Chem. 2006, 281(29):20085-20094.
56. Khundmiri S.J., et al. Ouabain induces cell proliferation through calcium dependent phosphorylation of Akt (Protein Kinase B) in opossum kidney proximal tubule cells. Am. J. Physiol. Cell Physiol. 2006, 291(6):C1247-C1257.
57. Trevisi L., et al. Antiapoptotic effect of ouabain on human umbilical vein endothelial cells. Biochem. Biophys. Res. Commun. 2004, 321(3):716-721.
58. Ferrari P., et al. Targeting ouabain- and adducin-dependent mechanisms of hypertension and cardiovascular remodeling as a novel pharmacological approach. Med. Hypotheses 2007, 68(6):1307-1314.
59. Jung J., et al. Molecular mechanism of cofilin dephosphorylation by ouabain. Cell. Signal. 2006, 18(11):2033-2040.
60. Jiang X., Ren Y.P., Lv Z.R. Ouabain induces cardiac remodeling in rats independent of blood pressure. Acta Pharmacol. Sin. 2007, 28(3):344-352.
61. Blasiole B., et al. Separate Na, K-ATPase genes are required for otolith formation and semicircular canal development in zebrafish. Dev. Biol. 2006, 294(1):148-160.
62. Skoumal R., et al. Involvement of endogenous ouabain-like compound in the cardiac hypertrophic process in vivo. Life Sci. 2007, 80(14):1303-1310.
63. Thundathil J.C., Anzar M., Buhr M.M. Na+/K+ ATPase as a signaling molecule during bovine sperm capacitation. Biol. Reprod. 2006, 75(3):308-317.
64. Larre I., et al. Contacts and cooperation between cells depend on the hormone ouabain. Proc. Natl. Acad. Sci. U. S. A. 2006, 103(29):10911-10916.
65. Elkareh J., et al. Marinobufagenin stimulates fibroblast collagen production and causes fibrosis in experimental uremic cardiomyopathy. Hypertension 2007, 49:215-224.
66. Ihle J.N., Kerr I.M. Jaks and Stats in signaling by the cytokine receptor superfamily. Trends Genet. 1995, 11(2):69-74.
67. McGarrigle D., Huang X.Y. GPCRs signaling directly through Src-family kinases. Sci. STKE 2007, 2007(392). p. pe35.
68. Xu W., Harrison S.C., Eck M.J. Three-dimensional structure of the tyrosine kinase c-Src. Nature 1997, 385(6617):595-602.
69. Thomas S.M., Brugge J.S. Cellular functions regulated by Src family kinases. Annu. Rev. Cell Dev. Biol. 1997, 13:513-609.
70. Moarefi I., et al. Activation of the Src-family tyrosine kinase Hck by SH3 domain displacement. Nature 1997, 385(6617):650-653.
71. Sicheri F., Moarefi I., Kuriyan J. Crystal structure of the Src family tyrosine kinase Hck. Nature 1997, 385(6617):602-609.
72. Liu L., et al. Role of caveolae in signal-transducing function of cardiac Na+/K+-ATPase. Am. J. Physiol. Cell Physiol. 2003, 284(6):C1550-C1560.
73. Razani B., Woodman S.E., Lisanti M.P. Caveolae: from cell biology to animal physiology. Pharmacol. Rev. 2002, 54(3):431-467.
74. Hardin C.D., Vallejo J. Caveolins in vascular smooth muscle: form organizing function. Cardiovasc. Res. 2006, 69(4):808-815.
75. Mohammadi K., et al. Role of protein kinase C in the signal pathways that link Na+/K+-ATPase to ERK1/2. J. Biol. Chem. 2001, 276(45):42050-42056.
76. Liu L., et al. Association of PI3K-Akt signaling pathway with digitalis-induced hypertrophy of cardiac myocytes. Am. J. Physiol. Cell Physiol. 2007, 293(5):C1489-C1497.
77. Khundmiri S.J., et al. Ouabain stimulates protein kinase B (Akt) phosphorylation in opossum kidney proximal tubule cells through an ERK-dependent pathway. Am. J. Physiol. Cell Physiol. 2007, 293(3):C1171-C1180.
78. Tian J., et al. Changes in sodium pump expression dictate the effects of ouabain on cell growth. J. Biol. Chem. 2009, 284(22):14921-14929.
79. Kometiani P., Liu L., Askari A. Digitalis-induced signaling by Na+/K+-ATPase in human breast cancer cells. Mol. Pharmacol. 2005, 67(3):929-936.
80. Chen Y., et al. Regulation of intracellular cholesterol distribution by Na/K-ATPase. J. Biol. Chem. 2009, 284(22):14881-14890.
81. Akera T., Larsen F.S., Brody T.M. Correlation of cardiac sodium- and potassium-activated adenosine triphosphatase activity with ouabain-induced inotropic stimulation. J. Pharmacol. Exp. Ther. 1970, 173(1):145-151.
82. Blaustein M.P., Juhaszova M., Golovina V.A. The cellular mechanism of action of cardiotonic steroids: a new hypothesis. Clin. Exp. Hypertens. 1998, 20(5-6):691-703.
83. Langer G.A. Effects of digitalis on myocardial ionic exchange. Circulation 1972, 46(1):180-187.
84. Moore E.D., et al. Coupling of the Na+/Ca2+ exchanger, Na+/K+ pump and sarcoplasmic reticulum in smooth muscle. Nature 1993, 365(6447):657-660.
85. Juhaszova M., Blaustein M.P. Na+pump low and high ouabain affinity alpha subunit isoforms are differently distributed in cells. Proc. Natl. Acad. Sci. U. S. A. 1997, 94(5):1800-1805.
86. Arnon A., Hamlyn J.M., Blaustein M.P. Ouabain augments Ca2+ transients in arterial smooth muscle without raising cytosolic Na+. Am. J. Physiol. Heart Circ. Physiol. 2000, 279(2):H679-H691.
87. Arnon A., Hamlyn J.M., Blaustein M.P. Na(+) entry via store-operated channels modulates Ca(2+) signaling in arterial myocytes. Am. J. Physiol. Cell Physiol. 2000, 278(1):C163-C173.
88. Lee M.Y., et al. Local subplasma membrane Ca2+ signals detected by a tethered Ca2+ sensor. Proc. Natl. Acad. Sci. U. S. A. 2006, 103(35):13232-13237.
89. Hilgemann D.W., et al. Steady-state and dynamic properties of cardiac sodium-calcium exchange. Sodium-dependent inactivation. J. Gen. Physiol. 1992, 100(6):905-932.
90. Mak D.O., McBride S., Foskett J.K. Inositol 1, 4, 5-trisphosphate [correction of tris-phosphate] activation of inositol trisphosphate [correction of tris-phosphate] receptor Ca2+ channel by ligand tuning of Ca2+ inhibition. Proc. Natl. Acad. Sci. U. S. A. 1998, 95(26):15821-15825.
91. Tuvia S., et al. Ankyrin-B is required for intracellular sorting of structurally diverse Ca2+ homeostasis proteins. J. Cell Biol. 1999, 147(5):995-1008.
92. Dostanic I., et al. The alpha 1 isoform of Na, K-ATPase regulates cardiac contractility and functionally interacts and co-localizes with the Na/Ca exchanger in heart. J. Biol. Chem. 2004, 279(52):54053-54061.
93. Patterson R.L., Boehning D., Snyder S.H. Inositol 1, 4, 5-trisphosphate receptors as signal integrators. Annu. Rev. Biochem. 2004, 73:437-465.
94. Rebecchi M.J., Pentyala S.N. Structure, function, and control of phosphoinositide-specific phospholipase C. Physiol. Rev. 2000, 80(4):1291-1335.
95. Thomas A.P., et al. Spatial and temporal aspects of cellular calcium signaling. FASEB J. 1996, 10(13):1505-1517.
96. Liu X., et al. Ankyrin B modulates the function of Na, K-ATPase/inositol 1, 4, 5-trisphosphate receptor signaling microdomain. J. Biol. Chem. 2008, 283(17):11461-11468.
97. Zhang Z., et al. Structure of the ankyrin-binding domain of alpha-Na, K-ATPase. J. Biol. Chem. 1998, 273(30):18681-18684.
98. Devarajan P., et al. Na, K-ATPase transport from endoplasmic reticulum to Golgi requires the Golgi spectrin-ankyrin G119 skeleton in Madin Darby canine kidney cells. Proc. Natl. Acad. Sci. U. S. A. 1997, 94(20):10711-10716.
99. Bourguignon L.Y., Iida N., Jin H. The involvement of the cytoskeleton in regulating IP3 receptor-mediated internal Ca2+ release in human blood platelets. Cell Biol. Int. 1993, 17(8):751-758.
100. Singleton P.A., Bourguignon L.Y. CD44 interaction with ankyrin and IP3 receptor in lipid rafts promotes hyaluronan-mediated Ca2+ signaling leading to nitric oxide production and endothelial cell adhesion and proliferation. Exp. Cell Res. 2004, 295(1):102-118.
101. Liu X.L., et al. Na, K-ATPase generates calcium oscillations in hippocampal astrocytes. Neuroreport 2007, 18(6):597-600.
102. Chen Y., et al. Regulation of inositol 1, 4, 5-trisphosphate receptor-mediated calcium release by the Na/K-ATPase in cultured renal epithelial cells. J. Biol. Chem. 2008, 283(2):1128-1136.
103. Schoner W. Endogenous cardiac glycosides, a new class of steroid hormones. Eur. J. Biochem. 2002, 269(10):2440-2448.
104. Komiyama Y., et al. A novel endogenous digitalis, telocinobufagin, exhibits elevated plasma levels in patients with terminal renal failure. Clin. Biochem. 2005, 38(1):36-45.
105. Manunta P., Hamilton B.P., Hamlyn J.M. Salt intake and depletion increase circulating levels of endogenous ouabain in normal men. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2006, 290(3):R553-R559.
106. Gottlieb S.S., et al. Elevated concentrations of endogenous ouabain in patients with congestive heart failure. Circulation 1992, 86(2):420-425.
107. Manunta P., et al. Left ventricular mass, stroke volume, and ouabain-like factor in essential hypertension. Hypertension 1999, 34(3):450-456.
108. Fedorova O.V., Doris P.A., Bagrov A.Y. Endogenous marinobufagenin-like factor in acute plasma volume expansion. Clin. Exp. Hypertens. 1998, 20(5-6):581-591.
109. Hamlyn J.M., et al. Identification and characterization of a ouabain-like compound from human plasma. Proc. Natl. Acad. Sci. U. S. A. 1991, 88(14):6259-6263.
110. Fedorova O.V., et al. Marinobufagenin, an endogenous alpha-1 sodium pump ligand, in hypertensive Dahl salt-sensitive rats. Hypertension 2001, 37(2 Part 2):462-466.
111. Mijatovic T., et al. The cardenolide UNBS1450 is able to deactivate nuclear factor kappaB-mediated cytoprotective effects in human non-small cell lung cancer cells. Mol. Cancer Ther. 2006, 5(2):391-399.
112. Newman R.A., et al. Oleandrin-mediated oxidative stress in human melanoma cells. J. Exp. Ther. Oncol. 2006, 5(3):167-181.
113. Kaplan J.H. A moving new role for the sodium pump in epithelial cells and carcinomas. Sci. STKE 2005, 2005(289). p. pe31.
114. Ferrari P., et al. Rostafuroxin: an ouabain antagonist that corrects renal and vascular Na+-K+-ATPase alterations in ouabain and adducin-dependent hypertension. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2006, 290(3):R529-R535.
115. Dahl L.K., Knudsen K.D., Iwai J. Humoral transmission of hypertension: evidence from parabiosis. Circ. Res. 1969, 24(5). p. Suppl:21-33.
116. De Wardener H.E. Natriuretic hormone. Clin. Sci. Mol. Med. 1977, 53(1):1-8.
117. Haddy F.J., Overbeck H.W. The role of humoral agents in volume expanded hypertension. Life Sci. 1976, 19(7):935-947.
118. Blaustein M.P. Sodium ions, calcium ions, blood pressure regulation, and hypertension: a reassessment and a hypothesis. Am. J. Physiol. 1977, 232(5):C165-C173.
119. de Wardener H.E., MacGregor G.A. Dahl's hypothesis that a saluretic substance may be responsible for a sustained rise in arterial pressure: its possible role in essential hypertension. Kidney Int. 1980, 18(1):1-9.
120. Kelly R.A., Smith T.W. The search for the endogenous digitalis: an alternative hypothesis. Am. J. Physiol. 1989, 256(5 Pt 1):C937-C950.
121. Dostanic-Larson I., et al. The highly conserved cardiac glycoside binding site of Na, K-ATPase plays a role in blood pressure regulation. Proc. Natl. Acad. Sci. U. S. A. 2005, 102(44):15845-15850.
122. Loreaux E.L., et al. Ouabain-sensitive alpha1 Na,K-ATPase enhances natriuretic response to saline load. J. Am. Soc. Nephrol. 2008, 19(10):1947-1954.
123. Bricker N.S. The control of sodium excretion with normal and reduced nephron populations. The pre-eminence of third factor. Am. J. Med. 1967, 43(3):313-321.
124. Nesher M., et al. Physiological roles of endogenous ouabain in normal rats. Am. J. Physiol. Heart Circ. Physiol. 2009, 297(6):H2026-H2034.
125. Donowitz M., Li X. Regulatory binding partners and complexes of NHE3. Physiol. Rev. 2007, 87(3):825-872.
126. Alexander R.T., Grinstein S. Tethering, recycling and activation of the epithelial sodium-proton exchanger, NHE3. J. Exp. Biol. 2009, 212(Pt 11):1630-1637.
127. Bobulescu I.A., Moe O.W. Luminal Na(+)/H (+) exchange in the proximal tubule. Pflugers Arch. 2009, 458(1):5-21.
128. Amemiya M., et al. Expression of NHE-3 in the apical membrane of rat renal proximal tubule and thick ascending limb. Kidney Int. 1995, 48(4):1206-1215.
129. Biemesderfer D., et al. NHE3: a Na+/H+ exchanger isoform of renal brush border. Am. J. Physiol. 1993, 265(5 Pt 2):F736-F742.
130. D'Souza S., et al. The epithelial sodium-hydrogen antiporter Na+/H+ exchanger 3 accumulates and is functional in recycling endosomes. J. Biol. Chem. 1998, 273(4):2035-2043.
131. Gekle M., Freudinger R., Mildenberger S. Inhibition of Na+-H+ exchanger-3 interferes with apical receptor-mediated endocytosis via vesicle fusion. J. Physiol. 2001, 531(Pt 3):619-629.
132. LaPointe M.S., et al. Na+/H+ exchange activity and NHE-3 expression in renal tubules from the spontaneously hypertensive rat. Kidney Int. 2002, 62(1):157-165.
133. Li X.X., et al. D(1) dopamine receptor regulation of NHE3 during development in spontaneously hypertensive rats. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2001, 280(6):R1650-R1656.
134. Kelly M.P., et al. Activity and expression of Na+-H exchanger isoforms 1 and 3 in kidney proximal tubules of hypertensive rats. Circ. Res. 1997, 80(6):853-860.
135. Hayashi M., et al. Na+/H+-exchanger 3 activity and its gene in the spontaneously hypertensive rat kidney. J. Hypertens. 1997, 15(1):43-48.
136. Zhang Y., et al. Rapid redistribution and inhibition of renal sodium transporters during acute pressure natriuresis. Am. J. Physiol. 1996, 270(6 Pt 2):F1004-F1014.
137. McDonough A.A., Leong P.K., Yang L.E. Mechanisms of pressure natriuresis: how blood pressure regulates renal sodium transport. Ann. N. Y. Acad. Sci. 2003, 986:669-677.
138. Yang L., et al. Acute hypertension provokes internalization of proximal tubule NHE3 without inhibition of transport activity. Am. J. Physiol. Renal. Physiol. 2002, 282(4):F730-F740.
139. Yang L.E., et al. Differential traffic of proximal tubule Na+ transporters during hypertension or PTH: NHE3 to base of microvilli vs. NaPi2 to endosomes. Am. J. Physiol. Renal Physiol. 2004, 287(5):F896-F906.
140. Schultheis P.J., et al. Renal and intestinal absorptive defects in mice lacking the NHE3 Na+/H+ exchanger. Nat. Genet. 1998, 19(3):282-285.
141. Lorenz J.N., et al. Micropuncture analysis of single-nephron function in NHE3-deficient mice. Am. J. Physiol. 1999, 277(3 Pt 2):F447-F453.
142. Ledoussal C., et al. Renal salt wasting in mice lacking NHE3 Na+/H+ exchanger but not in mice lacking NHE2. Am. J. Physiol. Renal Physiol. 2001, 281(4):F718-F727.
143. Orlowski J., Grinstein S. Diversity of the mammalian sodium/proton exchanger SLC9 gene family. Pflugers Arch. 2004, 447(5):549-565.
144. Moe O.W. Acute regulation of proximal tubule apical membrane Na/H exchanger NHE-3: role of phosphorylation, protein trafficking, and regulatory factors. J. Am. Soc. Nephrol. 1999, 10(11):2412-2425.
145. Chow C.-W., et al. The epithelial Na+/H+ exchanger, NHE3, is internalized through a clathrin-mediated pathway. J. Biol. Chem. 1999, 274(53):37551-37558.
146. Li X., et al. Na+-H+ exchanger 3 (NHE3) is present in lipid rafts in the rabbit ileal brush border: a role for rafts in trafficking and rapid stimulation of NHE3. J. Physiol. 2001, 537(Pt 2):537-552.
147. Donowitz M., et al. Short-term regulation of NHE3 by EGF and protein kinase C but not protein kinase A involves vesicle trafficking in epithelial cells and fibroblasts. Ann. N. Y. Acad. Sci. 2000, 915:30-42.
148. Fan L., et al. Dual mechanisms of regulation of Na/H exchanger NHE-3 by parathyroid hormone in rat kidney. J. Biol. Chem. 1999, 274(16):11289-11295.
149. Kurashima K., et al. Endosomal recycling of the Na+/H+exchanger NHE3 isoform is regulated by the phosphatidylinositol 3-kinase pathway. J. Biol. Chem. 1998, 273(33):20828-20836.
150. Li X., et al. Carbachol regulation of rabbit ileal brush border Na+-H+exchanger 3 (NHE3) occurs through changes in NHE3 trafficking and complex formation and is Src dependent. J. Physiol. 2004, 556(Pt 3):791-804.
151. Tsuganezawa H., Preisig P.A., Alpern R.J. Dominant negative c-Src inhibits angiotensin II induced activation of NHE3 in OKP cells. Kidney Int. 1998, 54(2):394-398.
152. Janecki A.J., et al. Basic fibroblast growth factor stimulates surface expression and activity of Na(+)/H(+) exchanger NHE3 via mechanism involving phosphatidylinositol 3-kinase. J. Biol. Chem. 2000, 275(11):8133-8142.
153. Yang X., et al. Acid incubation causes exocytic insertion of NHE3 in OKP cells. Am. J. Physiol. Cell Physiol. 2000, 279(2):C410-C419.
154. Lee-Kwon W., et al. Constitutively active phosphatidylinositol 3-kinase and AKT are sufficient to stimulate the epithelial Na+/H+ exchanger 3. J. Biol. Chem. 2001, 276(33):31296-31304.
155. Collazo R., et al. Acute regulation of Na+/H+exchanger NHE3 by parathyroid hormone via NHE3 phosphorylation and dynamin-dependent endocytosis. J. Biol. Chem. 2000, 275(41):31601-31608.
156. Hu M.C., et al. Dopamine acutely stimulates Na+/H+exchanger (NHE3) endocytosis via clathrin-coated vesicles: dependence on protein kinase A-mediated NHE3 phosphorylation. J. Biol. Chem. 2001, 276(29):26906-26915.
157. El Mernissi G., Doucet A. Quantitation of [3H]ouabain binding and turnover of Na-K-ATPase along the rabbit nephron. Am. J. Physiol. 1984, 247(1 Pt 2):F158-F167.
158. Zhang Y., et al. Reversible effects of acute hypertension on proximal tubule sodium transporters. Am. J. Physiol. 1998, 274(4 Pt 1):C1090-C1100.
159. Yang L.E., et al. Effects of dietary salt on renal Na+ transporter subcellular distribution, abundance, and phosphorylation status. Am. J. Physiol. Renal Physiol. 2008, 295(4):F1003-F1016.
160. Pinho M.J., et al. Organ specific underexpression renal of Na+-dependent B0AT1 in the SHR correlates positively with overexpression of NHE3 and salt intake. Mol. Cell. Biochem. 2007, 306(1-2):9-18.
161. Pedrosa R., et al. Dopamine D3 receptor-mediated inhibition of Na+/H+ exchanger activity in normotensive and spontaneously hypertensive rat proximal tubular epithelial cells. Br. J. Pharmacol. 2004, 142(8):1343-1353.
162. Garg L.C., Narang N. Sodium-potassium-adenosine triphosphatase in nephron segments of spontaneously hypertensive rats. J. Lab. Clin. Med. 1985, 106(1):43-46.
163. Hinojos C.A., Doris P.A. Altered subcellular distribution of Na+, K+-ATPase in proximal tubules in young spontaneously hypertensive rats. Hypertension 2004, 44(1):95-100.
164. Aperia A.C. Intrarenal dopamine: a key signal in the interactive regulation of sodium metabolism. Annu. Rev. Physiol. 2000, 62:621-647.
165. Zeng C., et al. Functional genomics of the dopaminergic system in hypertension. Physiol. Genomics 2004, 19(3):233-246.
166. Hussain T., Lokhandwala M.F. Renal dopamine receptors and hypertension. Exp. Biol. Med. (Maywood) 2003, 228(2):134-142.
167. McDonald R.H., et al. Effect of dopamine in man: augmentation of sodium excretion, glomerular filtration rate, and renal plasma flow. J. Clin. Invest. 1964, 43:1116-1124.
168. Jose P.A., Eisner G.M., Felder R.A. Role of dopamine receptors in the kidney in the regulation of blood pressure. Curr. Opin. Nephrol. Hypertens. 2002, 11(1):87-92.
169. Wang X., et al. Dopamine, kidney, and hypertension: studies in dopamine receptor knockout mice. Pediatr. Nephrol. 2008, 23(12):2131-2146.
170. Bertorello A., Aperia A. Both DA1 and DA2 receptor agonists are necessary to inhibit NaKATPase activity in proximal tubules from rat kidney. Acta Physiol. Scand. 1988, 132(3):441-443.
171. Bertorello A., Aperia A. Inhibition of proximal tubule Na(+)-K(+)-ATPase activity requires simultaneous activation of DA1 and DA2 receptors. Am. J. Physiol. 1990, 259(6 Pt 2):F924-F928.
172. Bertorello A., et al. Proximal tubule Na+-K+-ATPase activity is inhibited during high-salt diet: evidence for DA-mediated effect. Am. J. Physiol. 1988, 254(6 Pt 2):F795-F801.
173. Chibalin A.V., et al. Receptor-mediated inhibition of renal Na(+)-K(+)-ATPase is associated with endocytosis of its alpha- and beta-subunits. Am. J. Physiol. 1997, 273(5 Pt 1):C1458-C1465.
174. Bacic D., et al. Dopamine acutely decreases apical membrane Na/H exchanger NHE3 protein in mouse renal proximal tubule. Kidney Int. 2003, 64(6):2133-2141.
175. Oweis S., et al. Cardiac glycoside downregulates NHE3 activity and expression in LLC-PK1 cells. Am. J. Physiol. Renal Physiol. 2006, 290(5):F997-F1008.
176. Periyasamy S.M., et al. Salt loading induces redistribution of the plasmalemmal Na/K-ATPase in proximal tubule cells. Kidney Int. 2005, 67(5):1868-1877.
177. Liu J., et al. Effects of cardiac glycosides on sodium pump expression and function in LLC-PK1 and MDCK cells. Kidney Int. 2002, 62(6):2118-2125.
178. Cook J.S., Tate E.H., Shaffer C. Uptake of [3H]ouabain from the cell surface into the lysosomal compartment of HeLa cells. J. Cell. Physiol. 1982, 110(1):84-92.
179. Algharably N., Owler D., Lamb J.F. The rate of uptake of cardiac glycosides into human cultured cells and the effects of chloroquine on it. Biochem. Pharmacol. 1986, 35(20):3571-3581.
180. Li H., Nord E.P. Functional caveolae are a prerequisite for CD40 signaling in human renal proximal tubule cells. Am. J. Physiol. Renal Physiol. 2004, 286(4):F711-F719.
181. Moriyama T., et al. Caveolar endocytosis is critical for BK virus infection of human renal proximal tubular epithelial cells. J. Virol. 2007, 81(16):8552-8562.
182. Harootunian A.T., et al. Fluorescence ratio imaging of cytosolic free Na+ in individual fibroblasts and lymphocytes. J. Biol. Chem. 1989, 264(32):19458-19467.
183. Nishi A., Bertorello A.M., Aperia A. High salt diet down-regulates proximal tubule Na+, K(+)-ATPase activity in Dahl salt-resistant but not in Dahl salt-sensitive rats: evidence of defective dopamine regulation. Acta Physiol. Scand. 1992, 144(3):263-267.
184. Nishi A., et al. Dopamine regulation of renal Na+, K(+)-ATPase activity is lacking in Dahl salt-sensitive rats. Hypertension 1993, 21(6 Pt 1):767-771.
185. Felder R.A., Jose P.A. Mechanisms of disease: the role of GRK4 in the etiology of essential hypertension and salt sensitivity. Nat. Clin. Pract. Nephrol. 2006, 2(11):637-650.
186. Hussain T., Lokhandwala M.F. Renal dopamine DA1 receptor coupling with G(S) and G(q/11) proteins in spontaneously hypertensive rats. Am. J. Physiol. 1997, 272(3 Pt 2):F339-F346.
187. Felder R.A., et al. G protein-coupled receptor kinase 4 gene variants in human essential hypertension. Proc. Natl. Acad. Sci. U. S. A. 2002, 99(6):3872-3877.
188. Fedorova O.V., Lakatta E.G., Bagrov A.Y. Endogenous Na,K pump ligands are differentially regulated during acute NaCl loading of Dahl rats. Circulation 2000, 102(24):3009-3014.
189. Guyton A.C. Blood pressure control-special role of the kidneys and body fluids. Science 1991, 252(5014):1813-1816.
190. Cowley A.W. Role of the renal medulla in volume and arterial pressure regulation. Am. J. Physiol. 1997, 273(1 Pt 2):R1-R15.
191. Johnson R.J., et al. Pathogenesis of essential hypertension: historical paradigms and modern insights. J. Hypertens. 2008, 26(3):381-391.
192. Ferrandi M., et al. Ouabain-dependent signaling in caveolae as a novel therapeutic target for hypertension. Cell. Mol. Biol. (Noisy-le-grand) 2006, 52(8):15-18.
193. Lopatin D.A., et al. Circulating bufodienolide and cardenolide sodium pump inhibitors in preeclampsia. J. Hypertens. 1999, 17(8):1179-1187.
194. Hamlyn J.M., Manunta P. Ouabain, digitalis-like factors and hypertension. J. Hypertens. Suppl. 1992, 10(7):S99-S111.
195. Dostanic I., et al. The alpha2-isoform of Na-K-ATPase mediates ouabain-induced hypertension in mice and increased vascular contractility in vitro. Am. J. Physiol. Heart Circ. Physiol. 2005, 288(2):H477-H485.
196. de Wardener H.E. Franz Volhard Lecture 1996, Sodium transport inhibitors and hypertension. J. Hypertens. Suppl. 1996, 14(5):S9-S18.
197. Buckalew V.M. Endogenous digitalis-like factors, An historical overview. Front. Biosci. 2005, 10:2325-2334.